Cited by 13Head and Neck Cancer StudiesAngiogenesis and VEGF in CancerBreast Cancer Treatment Studies

Antiangiogenic Effects of Radiotherapy but Not Initial Microvessel Density Predict Survival in Inoperable Oropharyngeal Squamous Cell Carcinoma

Lövey*, József, Lukits*, Júlia, Remenár, Eva, Koronczay, Krísztina, Kásler, Miklós, Németh, György, Tímár, József·2006·Strahlentherapie und Onkologie

Abstract

Purpose To evaluate the predictive value of intratumoral microvessel density (MVD) in patients with locally advanced, primarily inoperable oropharyngeal cancer (OPCC) treated with irradiation alone.Patients and methods Tumor samples of 35 patients with OPCC subjected to radiotherapy were taken before and after 20 Gy irradiation. Histological grade, mitotic activity index and MVD of OPCC were determined. Correlations with response and survival were analyzed.Results Stage and posttreatment MVD decrease showed significant correlation with objective response. Postirradiation MVD decrease correlated significantly with response to irradiation and overall survival, and a trend could be seen for progression-free survival.Conclusion This study has shown that the change in MVD after irradiation can be an indicator of the success of radiotherapy in locally advanced OPCC, and may serve as a predictive factor thus helping to select patients who could benefit from more aggressive treatment.

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Crossref · 10.1007/s00066-006-1447-6

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37 of 37 references verified0 citation errors · 0 not checkable

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  • Alteration of tumoral microvessel density upon irradiation is a sensitive prognostic factor for radiotherapy efficacy.

    “Accordingly, the alteration of tumoral microvessel density upon irradiation is a sensitive prognostic factor for radiotherapy efficacy [64].”

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Authors
Lövey*, J., Lukits*, J., Remenár, E., Koronczay, K., Kásler, M., Németh, G., & Tímár, J.
Affiliations
National Institute of Oncology (HU)
Venue
Strahlentherapie und Onkologie
Published
2006-03
Volume
182
Issue
3
Pages
149-156
ISSN
  • 0179-7158 (ISSN-L)
  • 1439-099X
OpenAlex
W226897309
Cited by
13
References
37
Citations by year
2021: 1 · 2017: 2 · 2013: 1 · 2012: 1
FWCI
2.51
Type
journal article
Language
en
Open access
closed
Locations
  • Strahlentherapie und Onkologie (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords
oropharyngeal squamous cell carcinoma, microvessel density, locally advanced oropharyngeal cancer, predictive biomarkers, tumor response to radiotherapy, overall survival, progression-free survival, mitotic activity index, histological grade
MeSH terms
Adult, Aged, Carcinoma, Squamous Cell, Female, Humans, Male, Microcirculation, Middle Aged, Neoplasm Staging, Neovascularization, Pathologic, Oropharyngeal Neoplasms, Radiotherapy, Survival Analysis, Treatment Outcome, Angiogenesis Inhibitors

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