Antiangiogenic Effects of Radiotherapy but Not Initial Microvessel Density Predict Survival in Inoperable Oropharyngeal Squamous Cell Carcinoma
Abstract
Purpose To evaluate the predictive value of intratumoral microvessel density (MVD) in patients with locally advanced, primarily inoperable oropharyngeal cancer (OPCC) treated with irradiation alone.Patients and methods Tumor samples of 35 patients with OPCC subjected to radiotherapy were taken before and after 20 Gy irradiation. Histological grade, mitotic activity index and MVD of OPCC were determined. Correlations with response and survival were analyzed.Results Stage and posttreatment MVD decrease showed significant correlation with objective response. Postirradiation MVD decrease correlated significantly with response to irradiation and overall survival, and a trend could be seen for progression-free survival.Conclusion This study has shown that the change in MVD after irradiation can be an indicator of the success of radiotherapy in locally advanced OPCC, and may serve as a predictive factor thus helping to select patients who could benefit from more aggressive treatment.
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Alteration of tumoral microvessel density upon irradiation is a sensitive prognostic factor for radiotherapy efficacy.
“Accordingly, the alteration of tumoral microvessel density upon irradiation is a sensitive prognostic factor for radiotherapy efficacy [64].”
From Hypoxia Signaling in Cancer: From Basics to Clinical Practice (2021) · cites this paper as [64]
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- Authors
- Lövey*, J., Lukits*, J., Remenár, E., Koronczay, K., Kásler, M., Németh, G., & Tímár, J.
- Affiliations
- National Institute of Oncology (HU)
- Venue
- Strahlentherapie und Onkologie
- Published
- 2006-03
- Volume
- 182
- Issue
- 3
- Pages
- 149-156
- ISSN
- 0179-7158 (ISSN-L)
- 1439-099X
- OpenAlex
- W226897309
- Cited by
- 13
- References
- 37
- Citations by year
- 2021: 1 · 2017: 2 · 2013: 1 · 2012: 1
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Strahlentherapie und Onkologie (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- oropharyngeal squamous cell carcinoma, microvessel density, locally advanced oropharyngeal cancer, predictive biomarkers, tumor response to radiotherapy, overall survival, progression-free survival, mitotic activity index, histological grade
- MeSH terms
- Adult, Aged, Carcinoma, Squamous Cell, Female, Humans, Male, Microcirculation, Middle Aged, Neoplasm Staging, Neovascularization, Pathologic, Oropharyngeal Neoplasms, Radiotherapy, Survival Analysis, Treatment Outcome, Angiogenesis Inhibitors
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