Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis?
Abstract
The integrity and functional activity of the endothelial monolayer play a crucial role in the prevention of atherosclerosis. Increasing evidence suggests that risk factors for coronary artery disease increase endothelial cell apoptosis and lead to a disturbance in the endothelial monolayer. Recent insights suggest that the injured endothelial monolayer is regenerated by circulating bone marrow derived endothelial progenitor cells, which accelerates reendothelialization and limits atherosclerotic lesion formation. However, risk factors for coronary artery disease such as age and diabetes reduce the number and functional activity of these circulating endothelial progenitor cells, thus limiting the regenerative capacity. The impairment of stem/progenitor cells by risk factors may contribute to atherogenesis and atherosclerotic disease progression. We discuss this novel concept of endothelial regeneration and highlight possible novel strategies to interfere with the balance of injury and repair mechanisms.
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Bone marrow-derived circulating angiogenic cells help restore and maintain endothelial function.
“Recent studies have demonstrated that bone marrowderived circulating angiogenic cells (CACs), also referred to as early endothelial progenitor cells (3), contribute to the recovery and maintenance of endothelial function (4).”
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References 60 · Cited by 294
- Authors
- Dimmeler, S., & Zeiher, A. M.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Dimmeler, Stefanie
- Venue
- Journal of Molecular Medicine
- Published
- 2004-08-20
- Volume
- 82
- Issue
- 10
- Pages
- 671-677
- ISSN
- 0946-2716 (ISSN-L)
- 1432-1440
- OpenAlex
- W2049035024
- Cited by
- 294
- References
- 60
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 8 · 2019: 5 · 2018: 5 · 2017: 8 · 2016: 10 · 2015: 14 · 2014: 18 · 2013: 16 · 2012: 19
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- endothelial progenitor cells, atherosclerosis, re-endothelialization, endothelial monolayer integrity, endothelial cell apoptosis, bone marrow-derived cells, coronary risk factors, diabetes mellitus, aging, vascular repair
- MeSH terms
- Animals, Arteriosclerosis, Coronary Vessels, Endothelium, Vascular, Hematopoietic Stem Cells, Humans, Models, Biological, Risk Factors, Endothelial Cells
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