The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Role of hypoxia-inducible factor-1α in angiogenic–osteogenic coupling
Open accessAbstract
Angiogenesis and osteogenesis are tightly coupled during bone development and regeneration. The vasculature supplies oxygen to developing and regenerating bone and also delivers critical signals to the stroma that stimulate mesenchymal cell specification to promote bone formation. Recent studies suggest that the hypoxia-inducible factors (HIFs) are required for the initiation of the angiogenic–osteogenic cascade. Genetic manipulation of individual components of the HIF/vascular endothelial growth factor (VEGF) pathway in mice has provided clues to how coupling is achieved. In this article, we review the current understanding of the cellular and molecular mechanisms responsible for angiogenic–osteogenic coupling. We also briefly discuss the therapeutic manipulation of HIF and VEGF in skeletal repair. Such discoveries suggest promising approaches for the development of novel therapies to improve bone accretion and repair.
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Citations
Cites
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717
VEGF receptor signalling ? in control of vascular function
Olsson, A.-K., Dimberg, A., Kreuger, J., & Claesson-Welsh, L. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1911 · Cited by 3,122
Regulation of Mammalian O 2 Homeostasis by Hypoxia-Inducible Factor 1
Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914 · cited 1×
“Hypoxic cells signal to vascular elements to ensure the proper differentiation and maintenance of the developing vasculature [5].”
BackgroundYoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789
Hypoxia signalling in cancer and approaches to enforce tumour regression
Pouysségur, J., Dayan, F., & Mazure, N. M. (2006) · Nature · doi:10.1038/nature04871 · Cited by 1,676
Hsu, H., Lacey, D. L., Dunstan, C. R., Solovyev, I., Colombero, A., Timms, E., Tan, H.-L., Elliott, G., Kelley, M. J., Sarosi, I., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3540 · Cited by 1,636
Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (2002) · Genes & Development · doi:10.1101/gad.991402 · Cited by 1,550 · cited 2×
“FIH hydroxylates an asparagine residue (N803) in the carboxy-terminal transcriptional activation domain.”
BackgroundBerra, E., Benizri, E., Ginouvès, A., Volmat, V., Roux, D., & Pouysségur, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg392 · Cited by 1,348
Cited by
Blood vessel formation and function in bone
Sivaraj, K. K., & Adams, R. H. (2016) · Development · doi:10.1242/dev.136861 · Cited by 441
Mesenchymal stem cells: Amazing remedies for bone and cartilage defects
Kangari, P., Talaei-Khozani, T., Razeghian-Jahromi, I., & Razmkhah, M. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02001-1 · Cited by 286
Role of HIF‐1α in skeletal development
Wan, C., Shao, J., Gilbert, S. R., Riddle, R. C., Long, F., Johnson, R. S., Schipani, E., & Clemens, T. L. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05238.x · Cited by 173
Self-citationUncoupled angiogenesis and osteogenesis in nicotine-compromised bone healing
Ma, L., Zheng, L. W., Sham, M. H., & Cheung, L. K. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.19 · Cited by 87
Man, K., Brunet, M. Y., Lees, R., Peacock, B., & Cox, S. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087564 · Cited by 25
Metadata
- Authors
- Riddle, R. C., Khatri, R., Schipani, E., & Clemens, T. L.
- Venue
- Journal of Molecular Medicine
- Published
- 2009-05-05
- Volume
- 87
- Issue
- 6
- Pages
- 583-590
- ISSN
- 0946-2716 (ISSN-L)
- 1432-1440
- OpenAlex
- W2000038050
- Cited by
- 186
- References
- 8
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Riddle, R. C., Khatri, R., Schipani, E., & Clemens, T. L. (2009). Role of hypoxia-inducible factor-1α in angiogenic–osteogenic coupling. Journal of Molecular Medicine. https://doi.org/10.1007/s00109-009-0477-9
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
