Hypoxia signalling in cancer and approaches to enforce tumour regression

The biology of VEGF and its receptors

Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591 · see citing works

Targeting HIF-1 for cancer therapy

Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717 · see citing works

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535 · see citing works

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O’Shea, K. S., Powell-Braxton, L., Hillan, K. J., & Moore, M. W. (1996) · Nature · doi:10.1038/380439a0 · Cited by 3,624 · see citing works

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570 · see citing works

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333 · see citing works

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894 · see citing works

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799 · see citing works

Angiogenesis as a therapeutic target

Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653 · see citing works

A conserved family of prolyl-4-hydroxylases that modify HIF

Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549 · see citing works

Regulation of angiogenesis by hypoxia: role of the HIF system

Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520 · see citing works

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Carmeliet, P., Dor, Y., Herbert, J.-M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. (1998) · Nature · doi:10.1038/28867 · Cited by 2,502 · see citing works

Purification and Characterization of Hypoxia-inducible Factor 1

Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,069 · see citing works

HIF-1α is essential for myeloid cell-mediated inflammation

Cramer, T., Yamanishi, Y., Clausen, B. E., Förster, I., Pawlinski, R., Mackman, N., Haase, V. H., Jaenisch, R., Corr, M., Nizet, V., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00154-5 · Cited by 2,046 · see citing works

Regulation of Mammalian O ₂ Homeostasis by Hypoxia-Inducible Factor 1

Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914 · see citing works

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308061100 · Cited by 1,797 · see citing works

Epithelial–mesenchymal transitions in development and pathologies

Thiery, J. P. (2003) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.10.006 · Cited by 1,709 · see citing works

The role of autophagy in cancer development and response to therapy

Kondo, Y., Kanzawa, T., Sawaya, R. A., & Kondo, S. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1692 · Cited by 1,657 · see citing works

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (2002) · Genes & Development · doi:10.1101/gad.991402 · Cited by 1,550 · cited 1× · see citing works

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

Lum, J. J., Bauer, D. E., Kong, M., Harris, M. H., Li, C., Lindsten, T., & Thompson, C. B. (2005) · Cell · doi:10.1016/j.cell.2004.11.046 · Cited by 1,487 · see citing works

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development · doi:10.1101/gad.1256804 · Cited by 1,384 · see citing works

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

Hara, K., Yonezawa, K., Weng, Q.-P., Kozlowski, M. T., BELHAM, C. M., & Avruch, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14484 · Cited by 1,370 · see citing works

HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

Berra, E., Benizri, E., Ginouvès, A., Volmat, V., Roux, D., & Pouysségur, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg392 · Cited by 1,348 · see citing works

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

Pennacchietti, S., Michieli, P., Galluzzo, M., Mazzone, M., Giordano, S., & Comoglio, P. M. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00085-0 · Cited by 1,311 · see citing works

Mechanisms and consequences of activation of protein kinase B/Akt

Downward, J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80149-x · Cited by 1,304 · see citing works

Phosphorylation and Functional Inactivation of TSC2 by Erk

Ma, L., Chen, Z., Erdjument-Bromage, H., Tempst, P., & Pandolfi, P. P. (2005) · Cell · doi:10.1016/j.cell.2005.02.031 · Cited by 1,268 · see citing works

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C., & Blenis, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00506-2 · Cited by 1,211 · see citing works

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1

Manalo, D. J., Rowan, A., Lavoie, T., Natarajan, L., Kelly, B. D., Ye, S. Q., Garcia, J. G. N., & Semenza, G. L. (2005) · Blood · doi:10.1182/blood-2004-07-2958 · Cited by 1,154 · see citing works

Hypoxia requires Notch signaling to maintain the undifferentiated cell state

Gustafsson, M. V., Zheng, X., Pereira, T., Gradin, K., Jin, S., Lundkvist, J., Ruas, J. L., Poellinger, L., Lendahl, U., & Bondesson, M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.010 · Cited by 1,109 · see citing works

The SLC16 gene family?from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond

Halestrap, A. P., & Meredith, D. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1067-2 · Cited by 1,054 · see citing works

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

Pagès, G., Lenormand, P., L’Allemain, G., Chambard, J., Meloche, S., & Pouysségur, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8319 · Cited by 984 · see citing works

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability

Isaacs, J. S., Jung, Y. J., Mole, D. R., Lee, S., Torres-Cabala, C., Chung, Y.-L., Merino, M., Trepel, J., Zbar, B., Toro, J., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.06.017 · Cited by 958 · see citing works

Role of VHL Gene Mutation in Human Cancer

Kim, W. Y., & Kaelin, W. G. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.05.061 · Cited by 940 · see citing works

Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level

Semenza, G. L. (2004) · Physiology · doi:10.1152/physiol.00001.2004 · Cited by 901 · see citing works

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis

Cardone, R. A., Casavola, V., & Reshkin, S. J. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1713 · Cited by 897 · see citing works

The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism

Ullah, M. S., Davies, A. J., & Halestrap, A. P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511397200 · Cited by 894 · see citing works

Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL

Staller, P., Sulitkova, J., Lisztwan, J., Moch, H., Oakeley, E. J., & Krek, W. (2003) · Nature · doi:10.1038/nature01874 · Cited by 870 · see citing works

Autophagy in metazoans: cell survival in the land of plenty

Lum, J., DeBerardinis, R., & Thompson, C. (2005) · Nature reviews. Molecular cell biology · doi:10.1038/nrm1660 · Cited by 842 · see citing works

The Role of Hypoxia-Induced Factors in Tumor Progression

Vaupel, P. W. (2004) · The Oncologist · doi:10.1634/theoncologist.9-90005-10 · Cited by 831 · see citing works

HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growthPreprint

Covello, K. L., Kehler, J., Yu, H., Gordan, J. D., Arsham, A. M., Hu, C., Labosky, P. A., Simon, M. C., & Keith, B. (2006) · Genes & Development · doi:10.1101/gad.1399906 · Cited by 818 · see citing works

Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells

Fukuda, R., Hirota, K., Fan, F., Jung, Y. D., Ellis, L. M., & Semenza, G. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203781200 · Cited by 815 · see citing works

p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1

Richard, D. E., Berra, E., Gothié, E., Roux, D., & Pouysségur, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.32631 · Cited by 790 · see citing works

Molecular cloning, primary structure, and expression of the human growth factor-activatable antiporter

Sardet, C., Franchi, A. J., & Pouysségur, J. (1989) · Cell · doi:10.1016/0092-8674(89)90901-x · Cited by 782 · see citing works

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

Bruick, R. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9082 · Cited by 767 · see citing works

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

Kondo, K., Klco, J., Nakamura, E., Lechpammer, M., & Kaelin, W. G. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00043-0 · Cited by 761 · see citing works

Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway

Kallio, P. J., Wilson, W. J., O’Brien, S. L., Makino, Y., & Poellinger, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6519 · Cited by 754 · see citing works

The Tie-2 ligand Angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies

Fiedler, U., Scharpfenecker, M., Koidl, S., Hegen, A., Grunow, V., Schmidt, J. M., Kriz, W., Thurston, G., & Augustin, H. G. (2004) · Blood · doi:10.1182/blood-2003-10-3685 · Cited by 742 · see citing works

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wallPreprint

Lindblom, P., Gerhardt, H., Liebner, S., Abramsson, A., Enge, M., Hellström, M., Bäckström, G., Fredriksson, S., Landegren, U. D., Nyström, H. C., et al. (2003) · Genes & Development · doi:10.1101/gad.266803 · Cited by 659 · see citing works

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

Thomas, G. V., Tran, C., Mellinghoff, I. K., Welsbie, D. S., Chan, E., Fueger, B., Czernin, J., & Sawyers, C. L. (2006) · Nature Medicine · doi:10.1038/nm1337 · Cited by 604 · see citing works

Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells

Ikeda, E., Achen, M. G., Breier, G., & Risau, W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.34.19761 · Cited by 593 · see citing works

An expanding role for mTOR in cancer

Guertin, D. A., & Sabatini, D. M. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.06.007 · Cited by 519 · see citing works

Blood vessels and nerves: common signals, pathways and diseases

Carmeliet, P. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1158 · Cited by 513 · see citing works

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity.

Kong, D., Park, E. J., Stephen, A. G., Calvani, M., Cardellina, J. H., Monks, A., Fisher, R. J., Shoemaker, R. H., & Melillo, G. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1235 · Cited by 508 · see citing works

Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2

Oliner, J. D., Min, H., Leal, J., Yu, D., Rao, S., You, E., Xiu, T., Kim, H. J., MEYER, S. R., Han, S. J., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.030 · Cited by 471 · see citing works

Hypoxia-responsive transcription factors

Cummins, E. P., & Taylor, C. T. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1413-7 · Cited by 462 · see citing works

The SLC4 family of HCO3 ? transporters

Romero, M. F., Fulton, C. M., & Boron, W. F. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1180-2 · Cited by 454 · see citing works

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

Koivunen, P., Hirsilä, M., Günzler, V., Kivirikko, K. I., & Myllyharju, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312254200 · Cited by 447 · see citing works

A molecular role for lysyl oxidase‐like 2 enzyme in Snail regulation and tumor progression

Peinado, H., la Cruz, M. D. C. I., Olmeda, D., Csiszár, K., Fong, K. S. K., Vega, S., Nieto, M. A., Cano, A., & Portillo, F. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600781 · Cited by 446 · see citing works

Transcriptional regulation of the Vascular Endothelial Growth Factor gene?a concert of activating factors

Pagès, G., & Pouysségur, J. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.09.032 · Cited by 443 · see citing works

Activation of the HIF pathway in cancer

Maxwell, P. H. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00193-3 · Cited by 426 · see citing works

Hypoxia-Inducible Factor-1-Dependent Repression of <i>E-cadherin</i> in von Hippel-Lindau Tumor Suppressor–Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B

Krishnamachary, B., Zagzag, D., Nagasawa, H., Rainey, K., Okuyama, H., Baek, J. H., & Semenza, G. L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3719 · Cited by 415 · see citing works

The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation

Peng, T., Golub, T. R., & Sabatini, D. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5575-5584.2002 · Cited by 397 · see citing works

Regulation of Angiopoietin-2 mRNA Levels in Bovine Microvascular Endothelial Cells by Cytokines and Hypoxia

Mandriota, S. J., & Pepper, M. S. (1998) · Circulation Research · doi:10.1161/01.res.83.8.852 · Cited by 382 · see citing works

Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells

Imai, T., Horiuchi, A., Wang, C., Oka, K., Ohira, S., Nikaido, T., & Konishi, I. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63501-8 · Cited by 377 · see citing works

The Expanding Family of Eucaryotic Na+/H+Exchangers

Counillon, L., & Pouysségur, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.1 · Cited by 371 · see citing works

Hypoxia-Inducible Factor-1-Dependent Repression of E-cadherin in von Hippel-Lindau Tumor Suppressor—Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B

Gordon, M. S. (2007) · Yearbook of Oncology · doi:10.1016/s1040-1741(08)70352-x · Cited by 346 · see citing works

A molecular role for lysyl oxidase in breast cancer invasion.

Kirschmann, D. A., Seftor, E. A., Fong, S. F. T., Nieva, D. R. C., Sullivan, C. M., Edwards, E. M., Sommer, P., Csiszar, K., & Hendrix, M. J. C. (2002) · PubMed · Cited by 332 · see citing works

Hypoxia-inducible Factor-1α mRNA Contains an Internal Ribosome Entry Site That Allows Efficient Translation during Normoxia and Hypoxia

Lang, K. J. D., Kappel, A., & Goodall, G. J. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-02-0017 · Cited by 314 · see citing works

Investigating hypoxic tumor physiology through gene expression patterns

Denko, N. C., Fontana, L., Hudson, K. M., Sutphin, P. D., Raychaudhuri, S., Altman, R. B., & Giaccia, A. J. (2003) · Oncogene · doi:10.1038/sj.onc.1206703 · Cited by 305 · see citing works

Two Independent Internal Ribosome Entry Sites Are Involved in Translation Initiation of Vascular Endothelial Growth Factor mRNA

Huez, I., Créancier, L., Audigier, S., Gensac, M.-C., Prats, A., & Prats, H. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6178 · Cited by 297 · see citing works

The Oxygen Sensor Factor-Inhibiting Hypoxia-Inducible Factor-1 Controls Expression of Distinct Genes through the Bifunctional Transcriptional Character of Hypoxia-Inducible Factor-1α

Dayan, F., Roux, D., Brahimi-Horn, M. C., Pouyssegur, J., & Mazure, N. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4564 · Cited by 294 · see citing works

The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in DrosophilaPreprint

Reiling, J. H., & Hafen, E. (2004) · Genes & Development · doi:10.1101/gad.322704 · Cited by 291 · see citing works

Identification of Two Sp1 Phosphorylation Sites for p42/p44 Mitogen-activated Protein Kinases

Milanini, J., Pouysségur, J., & Pagès, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201753200 · Cited by 288 · see citing works

Hypoxia Inducible Carbonic Anhydrase IX, Marker of Tumour: Hypoxia, Survival Pathway and Therapy Target

Potter, C. T., & Harris, A. L. (2004) · Cell Cycle · doi:10.4161/cc.3.2.618 · Cited by 279 · see citing works

Regulation of E-cadherin Expression by <i>VHL</i> and Hypoxia-Inducible Factor

Esteban, M. A., Tran, M. G. B., Harten, S. K., Hill, P., Castellanos, M. C., Chandra, A., Raval, R., O'Brien, T. S., & Maxwell, P. H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2670 · Cited by 262 · see citing works

New roles for the LKB1→AMPK pathway

Hardie, D. G. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.01.006 · Cited by 255 · see citing works

Monocarboxylate transporter MCT1 is a target for immunosuppression

Murray, C. M., Hutchinson, R., Bantick, J. R., Belfield, G., Benjamin, A., Brazma, D., Bundick, R. V., Cook, I. D., Craggs, R. I., Edwards, S., et al. (2005) · Nature Chemical Biology · doi:10.1038/nchembio744 · Cited by 253 · see citing works

Silencing of the Hypoxia-Inducible Cell Death Protein BNIP3 in Pancreatic Cancer

Okami, J., Simeone, D. M., & Logsdon, C. D. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0089 · Cited by 238 · see citing works

Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts.

Rak, J. W., Mitsuhashi, Y., Sheehan, C., Tamir, A., Viloria‐Petit, A., Filmus, J., Mansour, S. J., Ahn, N. G., & Kerbel, R. S. (2000) · PubMed · Cited by 237 · see citing works

Ras GTPases: integrins' friends or foes?

Kinbara, K., Goldfinger, L. E., Hansen, M. B., Chou, F.-L., & Ginsberg, M. H. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1229 · Cited by 228 · see citing works

MAP Kinases and Hypoxia in the Control of VEGF Expression

Berra, E., Pagès, G., & Pouysségur, J. (2000) · Cancer and Metastasis Reviews · doi:10.1023/a:1026506011458 · Cited by 221 · see citing works

Notch Activation Induces Endothelial Cell Cycle Arrest and Participates in Contact Inhibition: Role of p21 Cip1 Repression

Noseda, M., Chang, L., McLean, G. W., Grim, J. E., Clurman, B. E., Smith, L. L., & Karsan, A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.8813-8822.2004 · Cited by 218 · see citing works

Signalling via the hypoxia-inducible factor-1α requires multiple posttranslational modifications

Brahimi‐Horn, C., Mazure, N. M., & Pouysségur, J. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.04.010 · Cited by 213 · see citing works

The hypoxia‐inducible‐factor hydroxylases bring fresh air into hypoxia signalling

Berra, E., Ginouvès, A., & Pouysségur, J. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400598 · Cited by 196 · see citing works

Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity.

Newell, K. J., Franchi, A. J., Pouysségur, J., & Tannock, I. F. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.1127 · Cited by 196 · see citing works

Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability

Pagès, G., Berra, E., Milanini, J., Levy, A. P., & Pouysségur, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002104200 · Cited by 184 · see citing works

Fidelity and spatio‐temporal control in MAP kinase (ERKs) signalling

Pouysségur, J., & Lenormand, P. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03707.x · Cited by 171 · see citing works

How do small GTPase signal transduction pathways regulate cell cycle entry?

Marshall, C. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00044-7 · Cited by 162 · see citing works

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

Brugarolas, J., & Kaelin, W. G. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.020 · Cited by 162 · see citing works

HIF‐1‐dependent transcriptional activity is required for oxygen‐mediated HIF‐1α degradation

Berra, E., Richard, D. E., Gothié, E., & Pouysségur, J. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02159-7 · Cited by 147 · see citing works

The Pro-regions of Lysyl Oxidase and Lysyl Oxidase-like 1 Are Required for Deposition onto Elastic Fibers

Thomassin, L., WERNECK, C. C., Broekelmann, T. J., Gleyzal, C., Hornstra, I. K., Mecham, R. P., & Sommer, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506832200 · Cited by 144 · see citing works

The von Hippel-Lindau gene, kidney cancer, and oxygen sensing.

Kaelin, W. G. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000092803.69761.41 · Cited by 135 · see citing works

Expression of Angiopoietin-2 in Endothelial Cells Is Controlled by Positive and Negative Regulatory Promoter Elements

Hegen, A., Koidl, S., Weindel, K., Marmé, D., Augustin, H. G., & Fiedler, U. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000140819.81839.0e · Cited by 123 · see citing works

Hypoxia-inducible factors and hypoxic cell death in tumour physiology

Bacon, A., & Harris, A. L. (2004) · Annals of Medicine · doi:10.1080/07853890410018231 · Cited by 112 · see citing works

Identification of Alternative Spliced Variants of Human Hypoxia-inducible Factor-1α

Gothié, E., Richard, D. E., Berra, E., Pagès, G., & Pouysségur, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.6922 · Cited by 100 · see citing works

Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia

Funasaka, T., Yanagawa, T., Hogan, V. A., & Raz, A. (2005) · The FASEB Journal · doi:10.1096/fj.05-3699com · Cited by 93 · see citing works

BNip3 and signal-specific programmed death in the heart

Webster, K. A., Graham, R. M., & Bishopric, N. H. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.11.007 · Cited by 92 · see citing works

Bcl-2/Adenovirus E1B 19 kDa Interacting Protein-3 Knockdown Enables Growth of Breast Cancer Metastases in the Lung, Liver, and Bone

Manka, D. R., Spicer, Z., & Millhorn, D. E. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-3091 · Cited by 69 · see citing works

Cytostatic potential of novel agents that inhibit the regulation of intracellular pH

Wong, P. W., Kleemann, H., & Tannock, I. F. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600424 · Cited by 67 · see citing works

pH i , Aerobic Glycolysis and Vascular Endothelial Growth Factor in Tumour Growth

Pouysségur, J., Franchi, A., & Pagès, G. (2001) · Novartis Foundation symposium · doi:10.1002/0470868716.ch13 · Cited by 63 · see citing works

The mTOR/S6K Signalling Pathway: The Role of the TSC1/2 Tumour Suppressor Complex and the Proto‐Oncogene Rheb

Nobukuni, T., & Thomas, G. (2004) · Novartis Foundation symposium · doi:10.1002/0470869976.ch9 · Cited by 57 · see citing works

Regulation of E-cadherin: does hypoxia initiate the metastatic cascade?

Beavon, I. R. G. (1999) · Molecular Pathology · doi:10.1136/mp.52.4.179 · Cited by 49 · see citing works

Reactive oxygen species in cancer

Liou, G., & Störz, P. (2010) · Free Radical Research · doi:10.3109/10715761003667554 · Cited by 3,394 · see citing works

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

Supuran, C. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2467 · Cited by 3,226 · see citing works

Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?

Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121 · see citing works

Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation

Lunt, S. Y., & Vander Heiden, M. G. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154237 · Cited by 3,057 · see citing works

Tumor cell metabolism: cancer's Achilles' heel

Kroemer, G., & Pouyssegur, J. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.05.005 · Cited by 2,337 · see citing works

Drug Resistance and the Solid Tumor Microenvironment

Tredan, O., Galmarini, C. M., Patel, K., & Tannock, I. F. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm135 · Cited by 2,116 · see citing works

Adipose tissue remodeling and obesity

Sun, K., Kusminski, C. M., & Scherer, P. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45887 · Cited by 1,941 · see citing works

Principles of cancer therapy: oncogene and non-oncogene addiction

Luo, J., Solimini, N. L., & Elledge, S. J. (2009) · Cell · doi:10.1016/j.cell.2009.02.024 · Cited by 1,765 · see citing works

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693 · see citing works

Interfering with pH regulation in tumours as a therapeutic strategy

Neri, D., & Supuran, C. T. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3554 · Cited by 1,551 · see citing works

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

Mohyeldin, A., Garzón-Muvdi, T., & Quiñones‐Hinojosa, A. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.07.007 · Cited by 1,536 · see citing works

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

Bellot, G., Garcia-Medina, R., Gounon, P., Chiche, J., Roux, D., Pouysségur, J., & Mazure, N. M. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00166-09 · Cited by 1,501 · see citing works

Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells

Li, Z., Bao, S., Wu, Q., Wang, H., Eyler, C., Sathornsumetee, S., Shi, Q., Cao, Y., Lathia, J., McLendon, R. E., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.018 · Cited by 1,354 · see citing works

The Pancreas Cancer Microenvironment

Feig, C., Gopinathan, A., Neesse, A., Chan, D. S., Cook, N., & Tuveson, D. A. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-3114 · Cited by 1,316 · see citing works

Cellular Adaptation to Hypoxia through Hypoxia Inducible Factors and beyond

Lee, P., Chandel, N. S., & Simon, M. C. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0227-y · Cited by 1,272 · see citing works

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

Erler, J. T., Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., Le, Q.-T., & Giaccia, A. J. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.11.012 · Cited by 1,231 · see citing works

Hypoxia-Inducible Factors, Stem Cells, and Cancer

Keith, B., & Simon, M. C. (2007) · Cell · doi:10.1016/j.cell.2007.04.019 · Cited by 1,179 · see citing works

Treating metastatic cancer with nanotechnology

Schroeder, A., Heller, D. A., Winslow, M. M., Dahlman, J. E., Pratt, G. W., Langer, R., Jacks, T., & Anderson, D. G. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3180 · Cited by 1,161 · see citing works

Molecular Basis of Metastasis

Chiang, A. C., & Massagué, J. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0805239 · Cited by 1,049 · see citing works

The hypoxic tumour microenvironment

Petrova, V., Annicchiarico‐Petruzzelli, M., Melino, G., & Amelio, I. (2018) · Oncogenesis · doi:10.1038/s41389-017-0011-9 · Cited by 1,035 · see citing works

Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review

Kanamala, M., Wilson, W. R., Yang, M., Palmer, B. D., & Wu, Z. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.061 · Cited by 1,004 · see citing works

Circulating tumor cells (CTC) detection: Clinical impact and future directions

Paterlini-Bréchot, P., & Benali, N. L. (2007) · Cancer Letters · doi:10.1016/j.canlet.2006.12.014 · Cited by 953 · see citing works

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

Kucharzewska, P., Christianson, H. C., Welch, J. E., Svensson, K. J., Fredlund, E., Ringnér, M., Mörgelin, M., Bourseau-Guilmain, E., Bengzon, J., & Belting, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220998110 · Cited by 939 · see citing works

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

Dai, Y., Xu, C., Sun, X., & Chen, X. S. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00592f · Cited by 931 · see citing works

Reactive Oxygen Species: A Breath of Life or Death?

Fruehauf, J. P., & Meyskens, F. L. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2082 · Cited by 908 · see citing works

MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3

Fasanaro, P., D'Alessandra, Y., Di Stefano, V., Melchionna, R., Romani, S., Pompilio, G., Capogrossi, M. C., & Martelli, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800731200 · Cited by 912 · see citing works

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

Trayhurn, P. (2013) · Physiological Reviews · doi:10.1152/physrev.00017.2012 · Cited by 884 · see citing works

Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia

Liu, J., Bu, W., & Shi, J. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00525 · Cited by 840 · see citing works

Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications

Simard, J. M., Kent, T. A., Chen, M., Tarasov, K. V., & Gerzanich, V. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70055-8 · Cited by 799 · see citing works

Hypoxia and cancer

Brahimi-Horn, M. C., Chiche, J., & Pouysségur, J. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0281-3 · Cited by 765 · see citing works

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

Azad, M. B., Chen, Y., & Gibson, S. B. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2270 · Cited by 761 · see citing works

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

Chiche, J., Ilc, K., Laferrière, J., Trottier, E., Dayan, F., Mazure, N. M., Brahimi-Horn, M. C., & Pouysségur, J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2470 · Cited by 751 · see citing works

The role of ubiquitination in tumorigenesis and targeted drug discovery

Deng, L., Meng, T., Chen, L., Wei, W., & Wang, P. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0107-0 · Cited by 744 · see citing works

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

Schödel, J., Oikonomopoulos, S., Ragoussis, J., Pugh, C. W., Ratcliffe, P. J., & Mole, D. R. (2011) · Blood · doi:10.1182/blood-2010-10-314427 · Cited by 724 · see citing works

Mammalian target of rapamycin: a central node of complex signaling cascades.

Dobashi, Y., Watanabe, Y., Miwa, C., Suzuki, S., & Koyama, S. (2011) · PubMed Central · Cited by 721 · see citing works

Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond.

Ganapathy, V., Thangaraju, M., & Prasad, P. (2009) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2008.09.005 · Cited by 711 · see citing works

Tumor microvasculature and microenvironment: Targets for anti-angiogenesis and normalization

Fukumura, D., & Jain, R. K. (2007) · Microvascular Research · doi:10.1016/j.mvr.2007.05.003 · Cited by 699 · see citing works

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

Wigerup, C., Påhlman, S., & Bexell, D. (2016) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2016.04.009 · Cited by 687 · see citing works

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

Chen, C., Liu, Y., Liu, R., Ikenoue, T., Guan, K.-L., Liu, Y., & Zheng, P. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081297 · Cited by 682 · see citing works

Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular Metabolism

Jetten, A. M. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07003 · Cited by 675 · see citing works

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

Chiche, J., Brahimi-Horn, M. C., & Pouysségur, J. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00994.x · Cited by 671 · see citing works

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

Soeda, A., Park, M., Lee, D., Mintz, A., Androutsellis-Theotokis, A., McKay, R. D., Engh, J., Iwama, T., Kunisada, T., Kassam, A. B., et al. (2009) · Oncogene · doi:10.1038/onc.2009.252 · Cited by 656 · see citing works

Hypoxia-induced autophagy: cell death or cell survival?

Mazure, N. M., & Pouysségur, J. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.11.015 · Cited by 620 · see citing works

Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect

San-Millán, I., & Brooks, G. A. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw127 · Cited by 612 · see citing works

Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox

Rubartelli, A., & Lotze, M. T. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.08.004 · Cited by 614 · see citing works

Disrupting proton dynamics and energy metabolism for cancer therapy

Parks, S. K., Chiche, J., & Pouysségur, J. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3579 · Cited by 613 · see citing works

Cardiac Toxicity of Sunitinib and Sorafenib in Patients With Metastatic Renal Cell Carcinoma

Schmidinger, M., Zielinski, C. C., Vogl, U. M., Bojic, A., Bojić, M., Schukro, C., Ruhsam, M., Hejna, M., & Schmidinger, H. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.6331 · Cited by 611 · see citing works

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

Rohwer, N., & Cramer, T. (2011) · Drug Resistance Updates · doi:10.1016/j.drup.2011.03.001 · Cited by 608 · see citing works

The challenge of drug resistance in cancer treatment: a current overview

Nikolaou, M., Pavlopoulou, A., Georgakilas, A. G., & Kyrodimos, E. (2018) · Clinical & Experimental Metastasis · doi:10.1007/s10585-018-9903-0 · Cited by 610 · see citing works

Passing the baton: the HIF switch

Koh, M. Y., & Powis, G. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.06.004 · Cited by 589 · see citing works

Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize

Fukumura, D., & Jain, R. K. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21187 · Cited by 584 · see citing works

Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT

Zhang, X., Sai, B., Wang, F., Wang, L., Wang, Y., Zheng, L., Li, G., Tang, J., & Xiang, J. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0959-5 · Cited by 560 · see citing works

Nonlinear modelling of cancer: bridging the gap between cells and tumours

Lowengrub, J. S., Frieboes, H. B., Jin, F., Chuang, Y.-L., Li, X., Macklin, P., Wise, S. M., & Vittorio Cristini, C. (2009) · Nonlinearity · doi:10.1088/0951-7715/23/1/r01 · Cited by 549 · see citing works

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

Mole, D. R., Blancher, C., Copley, R. R., Pollard, P. J., Gleadle, J. M., Ragoussis, J., & Ratcliffe, P. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901790200 · Cited by 552 · see citing works

Emerging role of adipose tissue hypoxia in obesity and insulin resistance

Ye, J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.229 · Cited by 539 · see citing works

The Warburg effect then and now: From cancer to inflammatory diseases

Pålsson‐McDermott, E. M., & O'Neill, L. A. J. (2013) · BioEssays · doi:10.1002/bies.201300084 · Cited by 538 · see citing works

pH sensing and regulation in cancer

Damaghi, M., Wojtkowiak, J. W., & Gillies, R. J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00370 · Cited by 532 · see citing works

Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway

Cooke, V. G., LeBleu, V. S., Keskin, D., Khan, Z., O'Connell, J. T., Teng, Y., Duncan, M. B., Xie, L., Maeda, G., Vong, S., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2011.11.024 · Cited by 530 · see citing works

The renin–angiotensin system and cancer: old dog, new tricks

George, A. J., Thomas, W. G., & Hannan, R. D. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2945 · Cited by 528 · see citing works

HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo

Gao, P., Zhang, H., Dinavahi, R., Li, F., Xiang, Y., Raman, V., Bhujwalla, Z. M., Felsher, D. W., Cheng, L., Pevsner, J., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.004 · Cited by 523 · see citing works

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

Mathieu, J., Zhang, Z., Zhou, W., Wang, A. J., Heddleston, J. M., Pinna, C. M. A., Hubaud, A., Stadler, B., Choi, M. P., Bar, M., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3320 · Cited by 510 · see citing works

Mitochondrial Dysfunction in Cancer

Boland, M. L., Chourasia, A. H., & Macleod, K. F. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00292 · Cited by 502 · see citing works

Halfway between 2D and Animal Models: Are 3D Cultures the Ideal Tool to Study Cancer-Microenvironment Interactions?

Hoarau-Véchot, J., Rafii, A., Touboul, C., & Pasquier, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010181 · Cited by 489 · see citing works

Role of hypoxia in the hallmarks of human cancer

Ruan, K., Song, G., & Ouyang, G. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22214 · Cited by 485 · see citing works

Lactate/GPR81 signaling and proton motive force in cancer: Role in angiogenesis, immune escape, nutrition, and Warburg phenomenon

Brown, T., & Ganapathy, V. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107451 · Cited by 493 · see citing works

Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma

Hu, Y., DeLay, M., Jahangiri, A., Molinaro, A. M., Rose, S. D., Carbonell, W. S., & Aghi, M. K. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3831 · Cited by 484 · see citing works

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

Semenza, G. L. (2009) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.11.009 · Cited by 469 · see citing works

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

Wen, H., Ting, J. P. ‐., & O'Neill, L. A. J. (2012) · Nature Immunology · doi:10.1038/ni.2228 · Cited by 455 · see citing works

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

Seidel, S., Garvalov, B. K., Wirta, V., von Stechow, L., Schänzer, A., Meletis, K., Wolter, M., Sommerlad, D., Henze, A., Nistér, M., et al. (2010) · Brain · doi:10.1093/brain/awq042 · Cited by 438 · see citing works

CD147 subunit of lactate/H + symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

LeFloch, R., Chiche, J., Marchiq, I., Naiken, T., Ilc, K., Murray, C. M., Critchlow, S. E., Roux, D., Simon, M., & Pouysségur, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106123108 · Cited by 431 · see citing works

The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

Lum, J. J., Bui, T., Gruber, M., Gordan, J. D., DeBerardinis, R. J., Covello, K. L., Simon, M. C., & Thompson, C. B. (2007) · Genes &amp; Development · doi:10.1101/gad.1529107 · Cited by 429 · see citing works

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

Porporato, P. E., Dhup, S., Dadhich, R. K., Copetti, T., & Sonveaux, P. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00049 · Cited by 424 · see citing works

New Roles for Copper Metabolism in Cell Proliferation, Signaling, and Disease

Turski, M. L., & Thiele, D. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800055200 · Cited by 423 · see citing works

New insights into the role of <scp>EMT</scp> in tumor immune escape

Terry, S., Savagner, P., Ortiz‐Cuaran, S., Mahjoubi, L., Saintigny, P., Thiery, J., & Chouaib, S. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12093 · Cited by 414 · see citing works

Resveratrol: Its Biologic Targets and Functional Activity

Pervaiz, S., & Holme, A. L. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2412 · Cited by 411 · see citing works

Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF

Schipani, E., Maes, C., Carmeliet, G., & Semenza, G. L. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090602 · Cited by 407 · see citing works

The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate

Riganti, C., Gazzano, E., Polimeni, M., Aldieri, E., & Ghigo, D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.006 · Cited by 408 · see citing works

Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors

Sennino, B., Ishiguro‐Oonuma, T., Wei, Y., Naylor, R. M., Williamson, C. W., Bhagwandin, V. J., Tabruyn, S. P., You, W., Chapman, H. A., Christensen, J. G., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0240 · Cited by 404 · see citing works

HLA-G

Carosella, E. D., Rouas‐Freiss, N., Roux, D. T., Moreau, P., & LeMaoult, J. (2015) · Advances in immunology · doi:10.1016/bs.ai.2015.04.001 · Cited by 395 · see citing works

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

Xue, Y., Petrovič, N., Cao, R., Larsson, O. S., Lim, S., Chen, S., Feldmann, H. M., Liang, Z., Zhu, Z., Nedergaard, J., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.11.009 · Cited by 379 · see citing works

Oxygen, a source of life and stress

Brahimi-Horn, M. C., & Pouysségur, J. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.06.018 · Cited by 383 · see citing works

Autophagy Is a Renoprotective Mechanism During in Vitro Hypoxia and in Vivo Ischemia-Reperfusion Injury

Jiang, M., Liu, K., Luo, J., & Dong, Z. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090594 · Cited by 375 · see citing works

Stimuli‐Responsive Materials for Controlled Release of Theranostic Agents

Wang, Y., Shim, M. S., Levinson, N. S., Sung, H., & Younan Xia, A. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201400279 · Cited by 379 · see citing works

Immunologic tumor microenvironment modulators for turning cold tumors hot

Khosravi, G. R., Mostafavi, S., Bastan, S., Ebrahimi, N., Gharibvand, R. S., & Eskandari, N. (2024) · 癌症：英文版 · doi:10.1002/cac2.12539 · Cited by 382 · see citing works

Lipid Droplets in Cancer: Guardians of Fat in a Stressful World

Petan, T., Jovičić, E. J., & Jusović, M. (2018) · Molecules · doi:10.3390/molecules23081941 · Cited by 369 · see citing works

Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis

Sluimer, J. C., & Daemen, M. J. A. P. (2009) · The Journal of Pathology · doi:10.1002/path.2518 · Cited by 368 · see citing works

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

Eltzschig, H. K., Bratton, D. L., & Colgan, S. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4422 · Cited by 363 · see citing works

Multiscale modelling and nonlinear simulation of vascular tumour growth

Macklin, P., McDougall, S. R., Anderson, A. R. A., Chaplain, M. A. J., Vittorio Cristini, C., & Lowengrub, J. S. (2008) · Journal of Mathematical Biology · doi:10.1007/s00285-008-0216-9 · Cited by 364 · see citing works

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

Yu, L., Hu, P., & Chen, Y. (2018) · Advanced Materials · doi:10.1002/adma.201801964 · Cited by 361 · see citing works

pH control mechanisms of tumor survival and growth

Parks, S. K., Chiche, J., & Pouysségur, J. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22400 · Cited by 356 · see citing works

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

Shen, J., Xia, W., Khotskaya, Y. B., Huo, L., Nakanishi, K., Lim, S., Du, Y., Wang, Y., Chang, W., Chen, C., et al. (2013) · Nature · doi:10.1038/nature12080 · Cited by 358 · see citing works

Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathwayPreprint

Shiojima, I., & Walsh, K. X. (2006) · Genes & Development · doi:10.1101/gad.1492806 · Cited by 355 · see citing works

The molecular determinants of de novo nucleotide biosynthesis in cancer cells

Tong, X., Zhao, F., & Thompson, C. B. (2009) · Current Opinion in Genetics &amp; Development · doi:10.1016/j.gde.2009.01.002 · Cited by 351 · see citing works

Stress and mTORture signaling

Reiling, J. H., & Sabatini, D. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209889 · Cited by 338 · see citing works

The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine

Hanover, J. A., Krause, M., & Love, D. C. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.07.017 · Cited by 342 · see citing works

Manipulating extracellular tumour pH: an effective target for cancer therapy

Hao, G., Xu, Z. P., & Li, L. (2018) · RSC Advances · doi:10.1039/c8ra02095g · Cited by 342 · see citing works

The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF

Beyer, S., Kristensen, M. M., Jensen, K. S., Johansen, J. V., & Staller, P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804578200 · Cited by 341 · see citing works

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

Bernhardt, W. M., Wiesener, M. S., Scigalla, P., Chou, J., Schmieder, R. E., Günzler, V., & Eckardt, K.-U. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010010116 · Cited by 340 · see citing works

HIF-1 regulation: not so easy come, easy go

Koh, M. Y., Spivak-Kroizman, T. R., & Powis, G. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.08.002 · Cited by 339 · see citing works

Nanopreparations to overcome multidrug resistance in cancer

Patel, N. R., Pattni, B. S., Abouzeid, A. H., & Torchilin, V. P. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.08.004 · Cited by 334 · see citing works

The role of the hypoxia-inducible factor in tumor metabolism growth and invasion.

Brahimi‐Horn, C., & Pouysségur, J. (2006) · PubMed · Cited by 154 · see citing works

Hypoxia and energetic tumour metabolism

Brahimi-Horn, M. C., Bellot, G. L., & Pouysségur, J. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.10.006 · Cited by 228 · see citing works

Hypoxia in cancer cell metabolism and pH regulation

Brahimi-Horn, M. C., & Pouysségur, J. (2007) · Essays in Biochemistry · doi:10.1042/bse0430165 · Cited by 113 · see citing works

The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies

Henríquez, J. A., Sleeman, J. P., & Garvalov, B. K. (2018) · Clinical & Experimental Metastasis · doi:10.1007/s10585-018-9930-x · Cited by 37 · see citing works

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

Chiche, J., Brahimi-Horn, M. C., & Pouysségur, J. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00994.x · Cited by 671 · see citing works