Structural traces of past experience in the cerebral cortex
Abstract
It is widely assumed that changes in the connections between neurons mediate the integration and storage of information in the brain and thereby underlie our ability to learn and remember. In particular, long-term memory is thought to rely on a structural reorganisation of neuronal circuits, but the proof for such a mechanism in the complex mammalian brain remains elusive. Recent advances in scientists' ability to follow structural dynamics of neuronal networks in the intact brain in vivo by means of 2-photon laser scanning microscopy has provided new insight into how information about new experiences might be stored in brain circuits.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Synaptic consolidation leads to remodeling of synapses and spines of neurons contributing to a memory representation, eventually producing enduring changes in efficacy of participating synapses.
“Synaptic consolidation leads to the remodeling of the synapses and spines of the neurons contributing to a memory representation, eventually producing enduring changes in the efficacy of the participating synapses (e.g., Refs. 555,616,977).”
From About Sleep's Role in Memory (2013) · cites this paper as [555]
Cites
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,500 · see citing works
Long-term dendritic spine stability in the adult cortex
Grutzendler, J., Kasthuri, N., & Gan, W.-B. (2002) · Nature · doi:10.1038/nature01276 · Cited by 1,198 · see citing works
Cell type-specific structural plasticity of axonal branches and boutons in the adult neocortex
De Paola, V., Holtmaat, A., Knott, G., Song, S., Wilbrecht, L., Caroni, P., & Svoboda, K. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.017 · Cited by 419 · see citing works
Axons and synaptic boutons are highly dynamic in adult visual cortex
Stettler, D. D., Yamahachi, H., Li, W., Denk, W., & Gilbert, C. D. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.018 · Cited by 256 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
- Authors
- Hofer, S. B.
- Affiliations
- University College London (GB)
- Corresponding author
- Hofer, Sonja B.
- ORCID
- Hofer, Sonja B.
- Venue
- Journal of Molecular Medicine
- Published
- 2009-11-11
- Volume
- 88
- Issue
- 3
- Pages
- 235-239
- ISSN
- 0946-2716 (ISSN-L)
- 1432-1440
- OpenAlex
- W2135911361
- Cited by
- 8
- References
- 4
- Citations by year
- 2024: 1 · 2020: 1 · 2018: 2 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term memory, structural plasticity, memory storage, learning, cerebral cortex
- MeSH terms
- Animals, Cerebral Cortex, Humans, Memory, Neurons, Microscopy, Confocal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
