The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Empowering self-renewal and differentiation: the role of mitochondria in stem cells
Open accessAbstract
Stem cells are characterized by their multi-lineage differentiation potential (pluripotency) and their ability for self-renewal, which permits them to proliferate while avoiding lineage commitment and senescence. Recent studies demonstrate that undifferentiated, pluripotent stem cells display lower levels of mitochondrial mass and oxidative phosphorylation, and instead preferentially use non-oxidative glycolysis as a major source of energy. Hypoxia is a potent suppressor of mitochondrial oxidation and appears to promote “stemness” in adult and embryonic stem cells. This has lead to an emerging paradigm, that mitochondrial oxidative metabolism is not just an indicator of the undifferentiated state of stem cells, but may also regulate the pluripotency and self-renewal of stem cells. The identification of specific mitochondrial pathways that regulate stem cell fate may therefore enable metabolic programming and reprogramming of stem cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mitochondria: More Than Just a Powerhouse
McBride, H. M., Neuspiel, M., & Wasiak, S. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.054 · Cited by 1,985
Hypoxia, HIF1 and glucose metabolism in the solid tumour
Denko, N. C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2468 · Cited by 1,707
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population
Yang, L., Soonpaa, M. H., Adler, E. D., Roepke, T. K., Kattman, S. J., Kennedy, M., Henckaerts, E., Bonham, K., Abbott, G. W., Linden, R. M., et al. (2008) · Nature · doi:10.1038/nature06894 · Cited by 1,389
Functions and dysfunctions of mitochondrial dynamics
Detmer, S. A., & Chan, D. C. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2275 · Cited by 1,369
Hypoxia-Inducible Factors, Stem Cells, and Cancer
Keith, B., & Simon, M. C. (2007) · Cell · doi:10.1016/j.cell.2007.04.019 · Cited by 1,179
The Regulation of INK4/ARF in Cancer and Aging
Kim, W. Y., & Sharpless, N. E. (2006) · Cell · doi:10.1016/j.cell.2006.10.003 · Cited by 1,009 · cited 1×
“Selfrenewal of stem frequently also entails a resistance to the cellular senescence seen in mature differentiated cells, which lose their ability to proliferate after a specific number of cell divisions [3].”
Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation
Orford, K. W., & Scadden, D. T. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2269 · Cited by 851
Yamanaka, S. (2009) · Cell · doi:10.1016/j.cell.2009.03.034 · Cited by 659
Cited by
Hall, A. R., Burke, N., Dongworth, R. K., & Hausenloy, D. J. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12516 · Cited by 283
Quantitative metabolic imaging using endogenous fluorescence to detect stem cell differentiation
Quinn, K. P., Sridharan, G. V., Hayden, R. S., Kaplan, D. L., Lee, K., & Georgakoudi, I. (2013) · Scientific Reports · doi:10.1038/srep03432 · Cited by 278
ATAD3 proteins: brokers of a mitochondria–endoplasmic reticulum connection in mammalian cells
Baudier, J. (2018) · Biological Reviews · doi:10.1111/brv.12373 · Cited by 99
Metadata
- Authors
- Rehman, J.
- Venue
- Journal of Molecular Medicine
- Published
- 2010-09-01
- Volume
- 88
- Issue
- 10
- Pages
- 981-986
- ISSN
- 0946-2716 (ISSN-L)
- 1432-1440
- OpenAlex
- W2133810389
- Cited by
- 163
- References
- 8
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Empowering self-renewal and differentiation: the role of mitochondria in stem cells. https://app.cochat.ai/papers/10.1007/s00109-010-0678-2
- The paper
- Rehman, J. (2010). Empowering self-renewal and differentiation: the role of mitochondria in stem cells. Journal of Molecular Medicine. https://doi.org/10.1007/s00109-010-0678-2
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
