Mitochondria: More Than Just a Powerhouse

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>

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Rab proteins as membrane organizers

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Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

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Critical nodes in signalling pathways: insights into insulin action

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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

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The p53 pathway: positive and negative feedback loops

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Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells

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Innate immune recognition of viral infection

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VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

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p53 Has a Direct Apoptogenic Role at the Mitochondria

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

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The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

Li, Z., Okamoto, K.-I., Hayashi, Y., & Sheng, M. (2004) · Cell · doi:10.1016/j.cell.2004.11.003 · Cited by 1,498 · see citing works

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

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Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction

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OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

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OPA1 requires mitofusin 1 to promote mitochondrial fusion

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Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

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Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis

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A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

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ULTRASTRUCTURAL BASES FOR METABOLICALLY LINKED MECHANICAL ACTIVITY IN MITOCHONDRIA

Hackenbrock, C. R. (1966) · The Journal of Cell Biology · doi:10.1083/jcb.30.2.269 · Cited by 983 · see citing works

Mitochondrial Fusion and Fission in Mammals

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Structural Basis of Mitochondrial Tethering by Mitofusin Complexes

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Dynamics of mitochondria in living cells: Shape changes, dislocations, fusion, and fission of mitochondria

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Synaptic Mitochondria Are Critical for Mobilization of Reserve Pool Vesicles at Drosophila Neuromuscular Junctions

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Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism

Bach, D., Pich, S., Soriano, F. X., Vega, N., Baumgartner, B., Oriola, J., Daugaard, J. R., Lloberas, J., Camps, M., Zierath, J. R., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212754200 · Cited by 832 · see citing works

The ATP synthase is involved in generating mitochondrial cristae morphology

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Mitochondrial fission in apoptosis

Youle, R. J., & Karbowski, M. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1697 · Cited by 773 · see citing works

Mitochondrial Morphology and Dynamics in Yeast and Multicellular Eukaryotes

Okamoto, K., & Shaw, J. M. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.093019 · Cited by 737 · see citing works

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

Prior, I. A., Muncke, C., Parton, R. G., & Hancock, J. F. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200209091 · Cited by 735 · see citing works

Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity

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α-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY PHOSPHORYLATION AND DEPHOSPHORYLATION

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The GTPase dMiro Is Required for Axonal Transport of Mitochondria to Drosophila Synapses

Guo, X., Macleod, G. T., Wellington, A. J., Hu, F., Panchumarthi, S., Schoenfield, M., Marin, L., Charlton, M. P., Atwood, H. L., & Zinsmaier, K. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.027 · Cited by 619 · see citing works

Emerging functions of mammalian mitochondrial fusion and fission

Chen, H., & Chan, D. C. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi270 · Cited by 538 · see citing works

Division versus Fusion: Dnm1p and Fzo1p Antagonistically Regulate Mitochondrial Shape

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Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA.

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The Machinery of Mitochondrial Inheritance and Behavior

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Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation

Holness, M. J., & Sugden, M. C. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311143 · Cited by 479 · see citing works

Control of mitochondrial motility and distribution by the calcium signal

Yi, M., Weaver, D., & Hajnóczky, G. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200406038 · Cited by 476 · see citing works

Loss of the Intermembrane Space Protein Mgm1/OPA1 Induces Swelling and Localized Constrictions along the Lengths of Mitochondria

Griparić, L., van der Wel, N. N., Orozco, I. J., Peters, P. J., & van der Bliek, A. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400920200 · Cited by 468 · see citing works

H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton

Plowman, S. J., Muncke, C., Parton, R. G., & Hancock, J. F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504114102 · Cited by 468 · see citing works

Transcription-independent pro-apoptotic functions of p53

Moll, U. M., Wolff, S., Speidel, D., & Deppert, W. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.007 · Cited by 468 · see citing works

PKC Regulates a Farnesyl-Electrostatic Switch on K-Ras that Promotes its Association with Bcl-Xl on Mitochondria and Induces Apoptosis

Bivona, T. G., Quatela, S. E., Bodemann, B. O., Ahearn, I. M., Soskis, M. J., Mor, A., Miura, J., Wiener, H. H., Wright, L. P., Saba, S. G., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.012 · Cited by 467 · see citing works

The Mitochondrial Inner Membrane Protein Mitofilin Controls Cristae Morphology

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The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system

Pich, S., Bach, D., Briones, P., Liesa, M., Camps, M., Testar, X., Palacín, M., & Zorzano, A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi149 · Cited by 455 · see citing works

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism

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Genetic Basis of Mitochondrial Function and Morphology in Saccharomyces cerevisiae

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Ceramide: second messenger or modulator of membrane structure and dynamics?

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Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA

Nakada, K., Inoue, K., Ono, T., Isobe, K., Ogura, A., Goto, Y., Nonaka, I., & Hayashi, J. (2001) · Nature Medicine · doi:10.1038/90976 · Cited by 430 · see citing works

Mitochondrial fission in apoptosis, neurodegeneration and aging

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Mutation spectrum and splicing variants in the OPA1 gene

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Composition and dynamics of human mitochondrial nucleoids.

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Ceramide Channels Increase the Permeability of the Mitochondrial Outer Membrane to Small Proteins

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Organization and dynamics of human mitochondrial DNA

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Dysregulation of HSG triggers vascular proliferative disorders

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Expression of <i>Mfn2</i>, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle

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Mitochondrial Function and Actin Regulate Dynamin-Related Protein 1-Dependent Mitochondrial Fission

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Fzo1, a Protein Involved in Mitochondrial Fusion, Inhibits Apoptosis

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Endoplasmic reticulum BIK initiates DRP1‐regulated remodelling of mitochondrial cristae during apoptosis

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Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3‐kinase activation

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The Dynamin-like Protein DLP1 Is Essential for Normal Distribution and Morphology of the Endoplasmic Reticulum and Mitochondria in Mammalian Cells

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Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart

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Activated Mitofusin 2 Signals Mitochondrial Fusion, Interferes with Bax Activation, and Reduces Susceptibility to Radical Induced Depolarization

Neuspiel, M., Zunino, R., Gangaraju, S., Rippstein, P. U., & McBride, H. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501599200 · Cited by 308 · see citing works

Nerve Growth Factor Signaling Regulates Motility and Docking of Axonal Mitochondria

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Mammalian Dynamin-like Protein DLP1 Tubulates Membranes

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Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain.

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Mitochondrial Regulation of Cell Cycle Progression during Development as Revealed by the tenured Mutation in Drosophila

Mandal, S., Guptan, P., Owusu-Ansah, E., & Banerjee, U. K. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.11.006 · Cited by 269 · see citing works

Parkin enhances mitochondrial biogenesis in proliferating cells

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Mitochondrial Matrix Phosphoproteome: Effect of Extra Mitochondrial Calcium

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New roles for the LKB1→AMPK pathway

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Mitochondrial GTPase mitofusin 2 mutation in Charcot?Marie?Tooth neuropathy type 2A

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Propagation of the apoptotic signal by mitochondrial waves

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Topology of the Mitochondrial Inner Membrane: Dynamics and Bioenergetic Implications

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Defective TNF-α–mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice

García‐Ruiz, C., Colell, A., Marı́, M., Morales, A., Calvo, M., Enrich, C., & Fernández-Checa, J. C. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16010 · Cited by 228 · see citing works

Mitochondrial framework (reticulum mitochondriale) in rat diaphragm muscle

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Mitochondrial modulation: reversible phosphorylation takes center stage?

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Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics

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Regulation of mitochondrial metabolism by ER Ca 2+ release: an intimate connection

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Glycogen synthase kinase-3β is highly activated in nuclei and mitochondria

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Rab GTPases and Myosin Motors in Organelle Motility

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Arp2/3 complex and actin dynamics are required for actin-based mitochondrial motility in yeast

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Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein

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Role for CED-9 and Egl-1 as Regulators of Mitochondrial Fission and Fusion Dynamics

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The internal compartmentation of rat‐liver mitochondria: Tomographic study using the high‐voltage transmission electron microscope

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Regulating the actin cytoskeleton during vesicular transport

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Fluorescence microscopic studies of mitochondrial nucleoids during meiosis and sporulation in the yeast, Saccharomyces cerevisiae

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