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Cited by 50Ovarian function and disordersReproductive System and PregnancyReproductive Biology and Fertility

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Delayed endometrial decidualisation in polycystic ovary syndrome; the role of AR-MAGEA11

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Younas, Kinza, Quintela, Marcos, Thomas, Samantha, Garcia-Parra, Jetzabel, Blake, Lauren, Whiteland, Helen, Bunkheila, Adnan, Francis, Lewis W., Margarit, Lavinia, Gonzalez, Deyarina, Conlan, R. Steven·2019·Journal of Molecular Medicine
DOI 10.1007/s00109-019-01809-6PMC PMC6713698
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Abstract

Polycystic ovary syndrome (PCOS) is a common gynaecological disorder, with a prevalence of up to 12% of women of reproductive age, and is in part characterised by elevated circulating androgens and aberrant expression of androgen receptor (AR) in the endometrium. A high percentage of PCOS patients suffer from infertility, a condition that appears to be linked to mistimed and incomplete decidualisation critically affecting events surrounding embryo implantation. The aim of this study was to examine the involvement of MAGEA11, and the genome-wide role of AR in PCOS. We determined that elevated androgen levels on PCOS cells had an impact on the delayed and incomplete decidual transformation of endometrial cells. The AR co-regulator MAGEA11, a known enhancer of AR function, was constitutively overexpressed throughout the menstrual cycle of PCOS patients, co-localised in the nucleus of PCOS stromal tissue and cells and formed a molecular complex with AR. Genome-wide AR analysis in PCOS stromal cells revealed that AR targets included genes involved in cell death and apoptosis, as well as genes commonly dysregulated in endometrial cancer. Enhanced MAGEA11 and AR-mediated transcriptional regulation may impact on a correct endometrial decidualisation response, subsequently affecting endometrial receptivity in these infertile women. KEY MESSAGES: MAGEA11 and AR are overexpressed in hyperandrogenic PCOS patients. MAGEA11-AR overexpression in PCOS correlates with delayed decidualisation. AR and MAGEA11 associate in a molecular complex. AR directly regulates a unique set of genes controlling gene differentiation.

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  • Women with PCOS demonstrate incomplete and delayed decidualization.

    “Women with PCOS, in contrast to those with endometriosis, demonstrate incomplete and delayed decidualization (Younas et al., 2019).”

    From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Younas et al., 2019

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Metadata

Authors
Younas, K., Quintela, M., Thomas, S., Garcia-Parra, J., Blake, L., Whiteland, H., Bunkheila, A., Francis, L. W., Margarit, L., Gonzalez, D., & Conlan, R. S.
Affiliations
Swansea University (GB)
Corresponding author
Conlan, R. Steven
ORCID
Venue
Journal of Molecular Medicine
Publisher
Springer Science and Business Media LLC
Published
2019-06-29
Volume
97
Issue
9
Pages
1315-1327
ISSN
  • 0946-2716 (ISSN-L)
  • 1432-1440
DOI
10.1007/s00109-019-01809-6
PMC
PMC6713698
OpenAlex
W2953834653
Cited by
50
References
36
Citations by year
2026: 6 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 10 · 2021: 8 · 2020: 7 · 2019: 2
FWCI
6.46
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Molecular Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
Funders
Swansea University
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords
polycystic ovary syndrome, androgen receptor, hyperandrogenism, endometrial receptivity, endometrial stromal cells, apoptosis, embryo implantation, infertility
MeSH terms
Adult, Androgens, Antigens, Neoplasm, Decidua, Endometrium, Female, Gene Expression Regulation, Humans, Infertility, Female, Neoplasm Proteins, Embryo Implantation, Polycystic Ovary Syndrome, Receptors, Androgen, Endometrial Neoplasms, Cell Death, Stromal Cells, Apoptosis

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