Sleep disturbance as a predictor of type 2 diabetes mellitus in men and women from the general population
Open accessAbstract
Aims/hypothesis To examine gender specific associations between sleep disturbance and incident type 2 diabetes mellitus in a representative population sample in Germany.Methods The study was based on 4,140 men and 4,129 women (aged 25-74 years) who participated in one of the three MONICA Augsburg surveys between 1984 and 1995, and who were free of diabetes at baseline. Incident cases of type 2 diabetes were assessed using a follow-up questionnaire in 1998. Gender specific hazard ratios were estimated from Cox proportional hazard models.Results A total of 119 cases of incident type 2 diabetes among men and 69 among women were registered during the mean follow-up period of 7.5 years. In both sexes, difficulty maintaining sleep was associated with a higher risk of type 2 diabetes. After adjustment for age, survey, hypertension, dyslipidemia, parental history of diabetes, history of angina pectoris, regular smoking, physical activity, alcohol intake, body mass index and education, the hazard ratio in men was 1.60 (95% CI: 1.05-2.45) and the hazard ratio in women was 1.98 (95% CI: 1.20-3.29). In contrast, difficulty initiating sleep was not associated with a significantly increased risk of developing type 2 diabetes mellitus after multivariable adjustment in both sexes in the present study.Conclusions/interpretation Difficulty maintaining sleep was associated with an increased risk of type 2 diabetes in men and women from the general population. Although, the causal pathway is not entirely clear, it seems that both insulin resistance and chronic low-grade systemic inflammation may be involved.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
An increasing number of epidemiological studies have reported an association between short sleep duration and higher risk of developing obesity and type II diabetes.
“An increasing number of epidemiological studies have reported an association between short sleep duration and higher risk of developing obesity and type II diabetes [86–89].”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [88]
In smaller studies, the association between sleep duration and diabetes is more variable.
“In smaller studies, the association between sleep duration and diabetes is more variable.7–9,35”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [35]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 27 · Cited by 234
- Authors
- Study, T. M. A. C., Meisinger, C., Heier, M., & Loewel, H.
- Affiliations
- Helmholtz Munich (DE)
- Corresponding author
- Meisinger, C.
- Venue
- Diabetologia
- Published
- 2005-01-11
- Volume
- 48
- Issue
- 2
- Pages
- 235-241
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2052317391
- Cited by
- 234
- References
- 27
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 3 · 2022: 12 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 9 · 2017: 19 · 2016: 13 · 2015: 28 · 2014: 23 · 2013: 16 · 2012: 13
- FWCI
- 17.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- sleep disorders, type 2 diabetes, difficulty maintaining sleep, difficulty initiating sleep, incident diabetes risk, sex differences, insulin resistance
- MeSH terms
- Alcohol Drinking, Angina Pectoris, Diabetes Mellitus, Type 2, Female, Humans, Hypertension, Male, Middle Aged, Obesity, Predictive Value of Tests, Sex Characteristics, Sleep Wake Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
