Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia

Glucagon and regulation of glucose metabolism

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Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice

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Minireview: The Glucagon-Like Peptides

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EFFECT OF EPINEPHRINE ON RAT DIAPHRAGM

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Lack of Suppression of Glucagon Contributes to Postprandial Hyperglycemia in Subjects with Type 2 Diabetes Mellitus1

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Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance

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Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats

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Hepatic and glucagon-like peptide-1–mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors

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Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans

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Recent Progress in the Use of Glucagon and Glucagon Receptor Antago-nists in the Treatment of Diabetes Mellitus

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Effects of glucagon-like peptide-1 on glucagon secretion in patients with non-alcoholic fatty liver disease

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Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism

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A survey of small molecule glucagon receptor antagonists from recent patents (2006 – 2010)

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Insulin-like stimulation of cardiac fuel metabolism by physiological levels of glucagon: involvement of PI3K but not cAMP

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Glucagon resistance and metabolic-associated steatotic liver disease: a review of the evidence

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Liraglutide acutely suppresses glucagon, lipolysis and ketogenesis in type 1 diabetes

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GLP-2 receptor signaling controls circulating bile acid levels but not glucose homeostasis in Gcgr mice and is dispensable for the metabolic benefits ensuing after vertical sleeve gastrectomy

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LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia

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Glucagon induces airway smooth muscle relaxation by nitric oxide and prostaglandin E2

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Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin

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Pathways of Glucagon Secretion and Trafficking in the Pancreatic Alpha Cell: Novel Pathways, Proteins, and Targets for Hyperglucagonemia

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Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia

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High-fat diet impacts more changes in beta-cell compared to alpha-cell transcriptome

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Pro-α-cell-derived β-cells contribute to β-cell neogenesis induced by antagonistic glucagon receptor antibody in type 2 diabetic mice

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Chronic exposure to a pollutant mixture at low doses led to tissue-specific metabolic alterations in male mice fed standard and high-fat high-sucrose diet

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The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk

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Gut Hormones and Obesity

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PTEN Deletion in Pancreatic α-Cells Protects Against High-Fat Diet–Induced Hyperglucagonemia and Insulin Resistance

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G Protein-Coupled Receptors as Regulators of Energy Homeostasis

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Genetic deficiency for proprotein convertase subtilisin/kexin type 2 in mice is associated with decreased adiposity and protection from dietary fat-induced body weight gain

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Glucagon receptor is required for long-term survival: A natural history study of the Mahvash disease in a murine model

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Commonalities of genetic resistance to spontaneous autoimmune and free radical-mediated diabetes

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Proglucagon-Derived Peptides, Glucose-Dependent Insulinotropic Polypeptide, and Dipeptidyl Peptidase-4-Mechanisms of Action in Adipose Tissue

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Regulation of Hepatic Lipid and Glucose Metabolism by INSP3R1

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New Horizons: Emerging Antidiabetic Medications

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The human α cell in health and disease

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Something old, something new and something very old: drugs for treating type 2 diabetes

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Intranasal glucagon acutely increases energy expenditure without inducing hyperglycaemia in overweight/obese adults

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Central regulation of glucose metabolism in an insulin‐dependent and ‐independent manner

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Association of glucagon-to-insulin ratio and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

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Human Monoclonal Antibodies against Glucagon Receptor Improve Glucose Homeostasis by Suppression of Hepatic Glucose Output in Diet-Induced Obese Mice

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Integrated Metabolomics and Lipidomics Analysis Reveal Remodeling of Lipid Metabolism and Amino Acid Metabolism in Glucagon Receptor–Deficient Zebrafish

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Effects of Fasting and Feeding on Transcriptional and Posttranscriptional Regulation of Insulin-Degrading Enzyme in Mice

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Factors Affecting Insulin-Regulated Hepatic Gene Expression

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Exercise Ameliorates Endocrine Pancreas Damage Induced by Chronic Cola Drinking in Rats

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A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose

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Effects of short-term chemical ablation of glucagon signalling by peptide-based glucagon receptor antagonists on insulin secretion and glucose homeostasis in mice

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Islets of Langerhans from prohormone convertase‐2 knockout mice show α‐cell hyperplasia and tumorigenesis with elevated α‐cell neogenesis

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Current Insights and New Perspectives on the Roles of Hyperglucagonemia in Non-Insulin–Dependent Type 2 Diabetes

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Rat glucagon receptor mRNA is directly regulated by glucose through transactivation of the carbohydrate response element binding protein

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Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homoeostasis

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Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes

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Characterization of a naturally occurring mutation V368M in the human glucagon receptor and its association with metabolic disorders

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Hepatocyte cholesterol content modulates glucagon receptor signalling

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Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity

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Exciting advances in GPCR-based drugs discovery for treating metabolic disease and future perspectives

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Peroxisomal ERK mediates Akh/glucagon action and glycemic control

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Blockade of glucagon receptor induces α-cell hypersecretion by hyperaminoacidemia in mice

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Targeting Dipeptidyl Peptidase-4 (DPP-4) and Fibroblast Activation Protein (FAP) for Diabetes and Cancer Therapy

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A synopsis of factors regulating beta cell development and beta cell mass

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Glucagon in metabolic disease: a mini-review of emerging multi-organ roles beyond glycemic control

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Deletion of the Men1 Gene Prevents Streptozotocin-Induced Hyperglycemia in Mice

Yang, Y., Wang, H., & Hua, X. (2010) · Experimental Diabetes Research · doi:10.1155/2010/876701 · Cited by 12

Small molecule glucagon receptor antagonists: a patent review (2011 – 2014)

Filipski, K. J. (2015) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2015.1032250 · Cited by 12

Global Transcriptomic Analysis of Zebrafish Glucagon Receptor Mutant Reveals Its Regulated Metabolic Network

Kang, Q., Hu, M., Jia, J., Bai, X., Liu, C., Wu, Z., Chen, W., & Li, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030724 · Cited by 12

Preproglucagon Products and Their Respective Roles Regulating Insulin Secretion

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Glucagon-based therapy for people with diabetes and obesity: What is the sweet spot?

McGlone, E. R., & Tan, T. (2024) · Peptides · doi:10.1016/j.peptides.2024.171219 · Cited by 11

Glucose-Lowering by Leptin in the Absence of Insulin Does Not Fully Rely on the Central Melanocortin System in Male Mice

Singha, A. K., Yamaguchi, J., Gonzalez, N. S., Ahmed, N. I., Toney, G. M., & Fujikawa, T. (2019) · Endocrinology · doi:10.1210/en.2018-00907 · Cited by 11

Glucagon receptor blockage inhibits β-cell dedifferentiation through FoxO1

Wang, K., Cui, X., Li, F., Li, X., Wei, T., Liu, J., Fu, W., Yang, J., Hong, T., & Wei, R. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00101.2022 · Cited by 11

High‐fat diet induces early‐onset diabetes in heterozygous Pax6 mutant mice

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Deficiency of S100B confers resistance to experimental diabetes in mice

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Characterization of the gene expression profile of heterozygous liver-specific glucokinase knockout mice at a young age

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Glucose intolerance in monosodium glutamate obesity is linked to hyperglucagonemia and insulin resistance in α cells

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Postprandial Plasma Glucagon Kinetics in Type 2 Diabetes Mellitus: Comparison of Immunoassay and Mass Spectrometry

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Impaired Fat Absorption from Intestinal Tract in High-Fat Diet Fed Male Mice Deficient in Proglucagon-Derived Peptides

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Glucagon-producing cells are increased in Mas-deficient mice

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Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells

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Glucagon receptor signalling – backwards and forwards

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Sustained glucagon receptor antagonism in insulin-deficient high-fat-fed mice

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The uninhibited glucagon signaling pathway in Japanese flounder Paralichthys olivaceus: A link with the glucose intolerance?

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Positive association of glucagon with bone turnover markers in type 2 diabetes: A cross‐sectional study

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PIMT regulates hepatic gluconeogenesis in mice

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Physiological and Pathophysiological Control of Glucagon Secretion by Pancreatic α-Cells

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Potentiation of Insulin-Mediated Glucose Lowering without Elevated Hypoglycemia Risk by a Small Molecule Insulin Receptor Modulator

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An AlphaScreen Assay for the Discovery of Synthetic Chemical Inhibitors of Glucagon Production

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ErbB3 is required for hyperaminoacidemia-induced pancreatic α cell hyperplasia

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Regulation of feeding and therapeutic application of bioactive peptides

Ueno, H., Zhang, W., & Nakazato, M. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108187 · Cited by 7

Disruption of the glucagon receptor increases glucagon expression beyond α-cell hyperplasia in zebrafish

Kang, Q., Zheng, J., Jia, J., Xü, Y., Bai, X., Chen, X., Zhang, X.-K., Wong, F. S., Zhang, C., & Li, M. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102665 · Cited by 7

Ectopic expression of glucagon receptor in skeletal muscles improves glucose homeostasis in a mouse model of diabetes

Maharaj, A., Zhu, L., Huang, F., Qiu, H., Li, H., Zhang, C.-Y., Jin, T., & Wang, Q. (2012) · Diabetologia · doi:10.1007/s00125-012-2464-x · Cited by 8

Let-7e-5p Regulates GLP-1 Content and Basal Release From Enteroendocrine L Cells From DIO Male Mice

Handgraaf, S., Dusaulcy, R., Visentin, F., Philippé, J., & Gosmain, Y. (2019) · Endocrinology · doi:10.1210/endocr/bqz037 · Cited by 5

Glucagon Shows Higher Sensitivity than Insulin to Grapeseed Proanthocyanidin Extract (GSPE) Treatment in Cafeteria-Fed Rats

Grau‐Bové, C., Ginés, I., Beltrán‐Debón, R., Terra, X., Blay, M., Pinent, M., & Ardèvol, A. (2021) · Nutrients · doi:10.3390/nu13041084 · Cited by 6

The role of glucagon after bariatric/metabolic surgery: much more than an “anti-insulin” hormone

Pérez-Arana, G.-M., Díaz-Gómez, A., Reyes, J. B.-D. L., Romero, M. Á. G., Ribelles-García, A., Visiedo, F., González‐Domínguez, Á., Gomar, D. A., & Oliveira, J. A. P. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1236103 · Cited by 5

Glucagon-mediated impairments in hepatic and peripheral tissue nutrient disposal are not aggravated by increased lipid availability

Chen, S., Santomango, T. S., Williams, P. E., Lacy, D. B., & McGuinness, O. P. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90821.2008 · Cited by 5

Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice

Bruner, K. R., Byington, I. R., Marx, T. J., Vasileva, A., Fletcher, T., Ghimire, S., Zappia, I. J., Shaju, Y., Zeng, J., Wachsmuth, H. R., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01899-w · Cited by 7

Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes

Xu, G., Gaul, M. D., Song, F., Du, F., Liang, Y. T., DesJarlais, R. L., Diloreto, K. A., Shook, B. C., Rentzeperis, D., Santulli, R., et al. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.126668 · Cited by 4

Benzyl isothiocyanate ameliorates hepatic insulin resistance in mice with high-fat diet-induced nonalcoholic fatty liver disease

Lo, C., Lee, J., Tsai, W.-T., Huang, C., Yang, Y., Lii, C., & Chen, H. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.109981 · Cited by 3

Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors

Hunt, J. E., Yassin, M., Olsen, J., Hartmann, B., Holst, J. J., & Kissow, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.695145 · Cited by 3

Physiological and Pathophysiological Control of Glucagon Secretion by Pancreatic α-Cells

Gilon, P., Cheng, R., Lai, B. K., Chae, H., & Gómez-Ruiz, A. (2014) · Springer eBooks · doi:10.1007/978-94-007-6686-0_37 · Cited by 3

Female glucagon receptor knockout mice are prone to steatosis but resistant to weight gain when fed a MASH ‐promoting GAN diet and a high‐fat diet

Galsgaard, K. D., Elmelund, E., Hunt, J. E., Smits, M. M., Grevengoed, T. J., Christoffersen, C., Færgeman, N. J., Havelund, J. F., Albrechtsen, N. J. W., & Holst, J. J. (2025) · Physiological Reports · doi:10.14814/phy2.70235 · Cited by 2

G protein-coupled receptors in energy homeostasis

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The impact of glucagon to support postabsorptive glucose flux and glycemia in healthy rats and its attenuation in male Zucker diabetic fatty rats

Estes, S. K., Shiota, C., O’Brien, T. P., Printz, R. L., & Shiota, M. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00192.2023 · Cited by 1

Rise in fasting and dynamic glucagon levels in children and adolescents with obesity is moderate in subjects with impaired fasting glucose but accentuated in subjects with impaired glucose tolerance or type 2 diabetes

Pixner, T., Chaikouskaya, T., Lauth, W., Zimmermann, G., Mörwald, K., Lischka, J., Furthner, D., Awender, E., Geiersberger, S., Maruszczak, K., et al. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1368570 · Cited by 1

Partners for life

Eliasson, L., & Wendt, A. (2016) · eLife · doi:10.7554/elife.16798 · Cited by 1

Comparative Analysis of Islet Development

Poudel, A., Savari, O., Tekin, Z., & Hara, M. (2016) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-45307-1_2 · Cited by 1

The role of integrin alpha 7 in diet-induced obesity and signalling

Taylor, J. (2018) · UEA Digital Repository (University of East Anglia) · Cited by 1

Gut-brain Axis Regulation of Food Intake and Visceral Illness

Patel, A. R. (2021) · Deep Blue (University of Michigan) · doi:10.7302/1469 · Cited by 1

Intra-islet glucagon signalling regulates pulsatile insulin secretion and glucose homeostasisPreprint

Suba, K., Patel, Y., Martin-Alonso, A., Roberts, A. G., Hansen, B., Norton, M., Shrewsbury, J. V., Kwok, R., Kalogianni, V., Chen, S., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.01.506223 · Cited by 1

The effect of tea polyphenols on chronic disease: obesity, the metabolic syndrome, and colon cancer

Bose, M. (2007) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t3t72hwk

Effet hépatique propre du GLP-1 : vers un traitement adjuvant du diabète de type 1 ?

Dubois‐Laforgue, D. (2016) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(16)30105-5

The preproglucagon derived peptides and energy homeostasis

Parker, J. (2013) · doi:10.25560/10956

Novel insight into glucagon receptor action: lessons from knockout and transgenic mouse models

Vuguin, P. M., & Charron, M. J. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01447.x · Cited by 47

ORIGINAL ARTICLE Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice

Lee, Y., Wang, M.-Y., Du, X. Q., Charron, M. J., & Unger, R. H. (2013)

Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice

Lee, Y., Wang, M.-Y., Du, X. Q., Charron, M. J., & Unger, R. H. (2011) · Diabetes · doi:10.2337/db10-0426 · Cited by 327

Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia

Rivero‐Gutiérrez, B., Haller, A. M., Holland, J., Yates, E., Khrisna, R., Habegger, K. M., DiMarchi, R. D., D’Alessio, D. A., & Pérez–Tilve, D. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.07.012 · Cited by 24

Ectopic expression of glucagon receptor in skeletal muscles improves glucose homeostasis in a mouse model of diabetes

Maharaj, A., Zhu, L., Huang, F., Qiu, H., Li, H., Zhang, C.-Y., Jin, T., & Wang, Q. (2012) · Diabetologia · doi:10.1007/s00125-012-2464-x · Cited by 8