The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality
Open accessAbstract
The critical role of the beta cell in the pathogenesis of type 2 diabetes is now well established. When examined in patients with type 2 diabetes and individuals at increased risk, reductions in beta cell mass and abnormalities of beta cell function can both be demonstrated. The question of whether one alone is sufficient or both are necessary for the development of hyperglycaemia has been debated. Based on human and animal studies, it appears that neither alone is sufficient. Rather, for glucose to rise to the level at which diabetes would be diagnosed, defects in beta cell mass and in beta cell function are required.
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Citations
Cites
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β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
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Self-citationGlucolipotoxicity: fuel excess and β-cell dysfunction
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Pancreatic β‐cell mass in European subjects with type 2 diabetes
Rahier, J., Guiot, Y., Goebbels, R. M., Sempoux, C., & Henquin, J. C. (2008) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00969.x · Cited by 756
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“Interestingly, while it is well recognised that glucocorticoids induce insulin resistance [44], they also have islet effects that result in a disproportionate increase in proinsulin release and increased glucagon output as observed in type 2 diabetes [45–48]; yet, in otherwise healthy individuals they do not induce ma…”
BackgroundSakuraba, H., Mizukami, H., Yagihashi, N., Wada, R., Hanyu, C., & Yagihashi, S. (2002) · Diabetologia · doi:10.1007/s125-002-8248-z · Cited by 681
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Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea
Yoon, K. H., Ko, S. H., Cho, J. H., Lee, J. M., Ahn, Y. B., Song, K. H., Yoo, S. J., Kang, M. I., Cha, B. Y., Lee, K. W., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020735 · Cited by 649
Cited by
Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus
Westermark, P., Andersson, A., & Westermark, G. T. (2011) · Physiological Reviews · doi:10.1152/physrev.00042.2009 · Cited by 1,044
Pancreatic β‐cell mass in European subjects with type 2 diabetes
Rahier, J., Guiot, Y., Goebbels, R. M., Sempoux, C., & Henquin, J. C. (2008) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00969.x · Cited by 756
Chen, C., Cohrs, C. M., Stertmann, J., Bozsak, R., & Speier, S. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.06.019 · Cited by 489
Formation of a human β-cell population within pancreatic islets is set early in life
Gregg, B. E., Moore, P. C., Demozay, D., Hall, B. A., Li, M., Husain, A., Wright, A. J., Atkinson, M. A., & Rhodes, C. J. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1206 · Cited by 344
Pancreatic β-cell identity, glucose sensing and the control of insulin secretion
Rutter, G. A., Pullen, T. J., Hodson, D. J., & Martinez-Sanchez, A. (2015) · Biochemical Journal · doi:10.1042/bj20141384 · Cited by 339
Metadata
- Authors
- Kahn, S. E., Zraika, S., Utzschneider, K. M., & Hull, R. L.
- Venue
- Diabetologia
- Published
- 2009-03-27
- Volume
- 52
- Issue
- 6
- Pages
- 1003-1012
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2037857580
- Cited by
- 260
- References
- 63
- FWCI
- 22.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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