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Hepatic Overexpression of Glycerol-sn-3-phosphate Acyltransferase 1 in Rats Causes Insulin Resistance

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Insulin-induced Activation of Atypical Protein Kinase C, but Not Protein Kinase B, Is Maintained in Diabetic (ob/ob and Goto-Kakazaki) Liver

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Repletion of Atypical Protein Kinase C following RNA Interference-mediated Depletion Restores Insulin-stimulated Glucose Transport

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Tissue-Specific Differences in Activation of Atypical Protein Kinase C and Protein Kinase B in Muscle, Liver, and Adipocytes of Insulin Receptor Substrate-1 Knockout Mice

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CaV2.3 channel and PKCλ: new players in insulin secretion

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Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

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PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans

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Glycosphingolipids and insulin resistance

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Evaluation of loganin, iridoid glycoside from Corni Fructus, on hepatic and renal glucolipotoxicity and inflammation in type 2 diabetic db/db mice

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Phosphatidylinositol-3,4,5-Triphosphate and Cellular Signaling: Implications for Obesity and Diabetes

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Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications

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Metabolic functions of atypical protein kinase C: “good” and “bad” as defined by nutritional status

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High Fat Diet Regulation of β-Cell Proliferation and β-Cell Mass

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Glycosphingolipids and Insulin Resistance

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The tail wagging the dog – regulation of lipid metabolism by protein kinase C

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Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice

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The role of protein kinases as key drivers of metabolic dysfunction-associated fatty liver disease progression: New insights and future directions

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Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation

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Akt-Dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/ProF Scaffold and Is Selectively Inhibited by aPKC in Early Phases of Diet-Induced Obesity

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Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C–ι

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Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors

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Hypothalamic serotonin–insulin signaling cross-talk and alterations in a type 2 diabetic model

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Low‐Dose Aspirin Ameliorated Hyperlipidemia, Adhesion Molecule, and Chemokine Production Induced by High‐Fat Diet in Sprague‐Dawley Rats

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Requirements for Pseudosubstrate Arginine Residues during Autoinhibition and Phosphatidylinositol 3,4,5-(PO4)3-dependent Activation of Atypical PKC

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Insulin-Regulated Srebp-1c and Pck1 mRNA Expression in Primary Hepatocytes from Zucker Fatty but Not Lean Rats Is Affected by Feeding Conditions

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BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans

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The promising roles of medicinal plants and bioactive compounds on hepatic lipid metabolism in the treatment of non-alcoholic fatty liver disease in animal models: molecular targets

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Atypical PKC: a target for treating insulin-resistant disorders of obesity, the metabolic syndrome and type 2 diabetes mellitus

Farese, R. V., Lee, M. C., & Sajan, M. P. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.944897 · Cited by 21 · see citing works

Cocoa and cocoa flavanol epicatechin improve hepatic lipid metabolism in in vivo and in vitro models. Role of PKCζ

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Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5′-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression

Sajan, M. P., Ivey, R. A., & Farese, R. V. (2013) · Diabetologia · doi:10.1007/s00125-013-3010-1 · Cited by 20 · see citing works

Impact of maternal undernutrition around the time of conception on factors regulating hepatic lipid metabolism and microRNAs in singleton and twin fetuses

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A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance

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Factors Affecting Insulin-Regulated Hepatic Gene Expression

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Veratrilla baillonii Franch exerts anti-diabetic activity and improves liver injury through IRS/PI3K/AKT signaling pathways in type 2 diabetic db/db mice

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Par-complex aPKC and Par3 cross-talk with innate immunity NF-κB pathway in epithelial cells

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Insulin Signaling and Insulin Sensitizing in Muscle and Liver of Obese Monkeys: Peroxisome Proliferator-Activated Receptor Gamma Agonist Improves Defective Activation of Atypical Protein Kinase C

Ortmeyer, H. K., Sajan, M. P., Miura, A., Kanoh, Y., Rivas, J., Li, Y., Standaert, M. L., Ryan, A. S., Bodkin, N. L., Farese, R. V., et al. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3234 · Cited by 13 · see citing works

Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus

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Atypical protein kinase C in cardiometabolic abnormalities

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Common Pathogenetic Pathways of Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus

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Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis

Sajan, M. P., Jurzak, M. J., Samuels, V. T., Shulman, G. I., Braun, U., Leitges, M., & Farese, R. V. (2013) · Adipocyte · doi:10.4161/adip.26305 · Cited by 10 · see citing works

PKCλ Haploinsufficiency Prevents Diabetes by a Mechanism Involving Alterations in Hepatic Enzymes

Sajan, M. P., Ivey, R. A., Lee, M., Mastorides, S., Jurczak, M. J., Samuels, V. T., Shulman, G. I., Braun, U., Leitges, M., & Farese, R. V. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1025 · Cited by 10 · see citing works

Role of protein kinase C in diabetic complications

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Higher Protein Kinase C ζ in Fatty Rat Liver and Its Effect on Insulin Actions in Primary Hepatocytes

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Antidiabetic Effect of Fermented Mesembryanthemum crystallinum L. in db/db Mice Involves Regulation of PI3K-Akt Pathway

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Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance

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Expression of Protein Kinase C Isoforms in Pancreatic Islets and Liver of Male Goto-Kakizaki Rats, a Model of Type 2 Diabetes

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When type II diabetes mellitus meets COVID ‐19—Identification of the shared gene signatures and biological mechanism between the two diseases

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Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus

Farese, R. V., Lee, M., & Sajan, M. P. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3030724 · Cited by 3 · see citing works

Linkage of atypical protein kinase C to Alzheimer disease

Farese, R. V., & Sajan, M. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815868-5.00013-x · Cited by 1 · see citing works

Atypical Protein Kinase C Hyperactivity in Insulin-Resistant and Insulin-Sensitive Forms of Alzheimer’s Disease: A Potential Therapeutic Target

Farese, R. V., Kindy, M. S., & Sajan, M. P. (2020) · Exon Publications eBooks · doi:10.36255/exonpublications.alzheimersdisease.2020.ch6 · Cited by 1 · see citing works

Toward a Mechanistic Understanding of Hepatic Insulin Action and Resistance

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PI3K/PTEN signaling in liver diseases

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Current literature in diabetes

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Rôle des facteurs de transcription SREBP-1 dans la fonction musculaire : implication des répresseurs transcriptionnels BHLHB2 et BHLHB3

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A Role of Phosphoinositide 3-Kinase (PI3K) and Efficacy of Nanomaterials Against Kinase Inhibitors and Hepatic Insulin Resistance

Ponnusamy, R., Giriraj, K., Dharani, S., & Sowndhararajan, K. (2026) · Springer eBooks · doi:10.1007/978-3-032-17170-2_13

Impact de lipides bioactifs FAHFAs en particulier le 9-PAHPA ou le 9-OAHPA sur les désordres métaboliques associés à l'obésité chez la souris

Benlebna, M. (2020) · theses.fr (ABES) · doi:10.70675/96024305z5720z4c06z93e3zb13b83646849

Progranulin deficiency in the brain activates an insulin signaling pathway that may promote neurodegeneration

Sajan, M. P., Aggarwal, G., Hwang, J. J., Smith, D. M., Cooper, D. R., Duncan, M. A., HANSEN, B. C., Nguyen, A. D., & Farese, R. V. (2026) · iScience · doi:10.1016/j.isci.2026.115720

The Role and Regulatory Mechanisms of FOXO1 in Hepatic Lipid Deposition

Meng, J. I. A., Fang-Hui, L. I., Yan, S.-Z., Ai-Ju, L. I., Yi-Le, W. A. N. G., Ni, P., He, J., & Yin-Lu, L. I. (2026) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/j.pibb.2025.0518

Insulin-induced Activation of Atypical Protein Kinase C, but Not Protein Kinase B, Is Maintained in Diabetic (ob/ob and Goto-Kakazaki) Liver

Standaert, M. L., Sajan, M. P., Miura, A., Kanoh, Y., Chen, H. C., Farese, R. V., & Farese, R. V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402440200 · Cited by 79 · see citing works

The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFκB in obesity

Sajan, M. P., Standaert, M. L., Nimal, S., Varanasi, U., Pastoor, T. E., Mastorides, S., Braun, U., Leitges, M., & Farese, R. V. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800520-jlr200 · Cited by 58 · see citing works

Atypical protein kinase C in insulin action and insulin resistance

Farese, R. V., Sajan, M. P., & Standaert, M. L. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330350 · Cited by 114 · see citing works

Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus

Sajan, M. P., HANSEN, B. C., Acevedo-Duncan, M. E., Kindy, M. S., Cooper, D. R., & Farese, R. V. (2021) · MedComm · doi:10.1002/mco2.54 · Cited by 12 · see citing works

Atypical protein kinase C in cardiometabolic abnormalities

Farese, R. V., & Sajan, M. P. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328352c4c7 · Cited by 12 · see citing works