Association of inflammation with worsening HOMA-insulin resistance
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Aims/hypothesis We examined the cross-sectional and longitudinal relationships between C-reactive protein (CRP), a marker of low-grade inflammation, and insulin resistance and whether the association was independent of obesity and oxidative stress.Methods CRP and insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]) data were obtained in a population-based, prospective observational study, Coronary Artery Risk Development in Young Adults (CARDIA), during 1992-2006.Results CRP showed a significant positive association with insulin resistance, both cross-sectionally and longitudinally (5 year follow-up). The estimated increment in HOMA-IR was 0.34 log(e)(pmol/l x [mmol/l]/156.25) (p value for trend <0.0001) in the highest vs lowest CRP quartiles in cross-sectional analysis, whereas the corresponding estimate was 0.12 (p trend <0.0001) in the highest vs lowest CRP quartiles longitudinally over 5 years. The gradient of HOMA-IR across CRP was attenuated but remained statistically significant after controlling for body fat measurements (0.06 in the highest vs lowest CRP in both cross-sectional [p value for trend = 0.001] and longitudinal analyses [p value for trend = 0.01]), and was little changed by further adjustment for oxidative stress markers (F(2)-isoprostanes and oxidised LDL). There were consistent increments in the levels of HOMA-IR with increasing concentrations of CRP over time. In contrast, higher HOMA-IR did not predict future increases in CRP. Findings were similar using fibrinogen as the predictor variable.Conclusions/interpretation Although a substantial portion of this association was explained by obesity, CRP was independently related to concurrent and future insulin resistance.
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In observational studies, a reduction in HOMA-IR was associated with a reduction in CRP and cardiovascular risk.
“In observational studies, a reduction in HOMA-IR was also associated with a reduction in CRP 81 and cardiovascular risk. 82”
From <scp>Glucagon‐like peptide‐1 receptor agonists</scp> improve biomarkers of inflammation and oxidative stress: A systematic review and meta‐analysis of randomised controlled trials (2021) · cites this paper as [81]
The Results report a positive cross-sectional association between CRP and HOMA-IR, which supports an association between lower levels of the two measures. They do not show that a reduction in HOMA-IR over time was associated with a reduction in CRP; the paper instead reports that HOMA-IR did not predict future CRP. Cardiovascular risk is attached to a separate citation (82), so it is not assessed against this source. (LLM, conf=0.86)
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Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes
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“They comprised 6749 patients (inflammation evaluated in 6560, oxidative stress in 701 patients), included a median (IQR) study population of 60 (33-122) participants, and had a median (IQR) follow-up of 6 months (84-182 days).”
BackgroundAnholm, C., Kumarathurai, P., Pedersen, L. R., Samkani, A., Walzem, R. L., Nielsen, O. W., Kristiansen, O. P., Fenger, M., Madsbad, S., Sajadieh, A., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.07.007 · Cited by 75 · see citing works
- Authors
- Park, K., Steffes, M., Lee, D.-H., Himes, J. H., & Jacobs, D. R.
- Affiliations
- University of Minnesota (US)
- Kyungpook National University (KR)
- Corresponding author
- Jacobs, D. R.
- Venue
- Diabetologia
- Published
- 2009-08-13
- Volume
- 52
- Issue
- 11
- Pages
- 2337-2344
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- PMC
- PMC5643149
- OpenAlex
- W2020042157
- Cited by
- 72
- References
- 16
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 1 · 2021: 8 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 6
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc95095-66-0-1, n01hc48048-58-0-1, n01hc48047-55-0-1, n01hc48049-61-0-1, N01-HC-48047, N01-HC-95095, N01-HC-48048, N01-HC-48049)
- National Heart, Lung, and Blood Institute (N01 HC 95095, N01 HC048048, N01-HC-048049, N01 HC095095, N01-HC48048, R01 HL53560, N01-HC-48-049, R01HL053560, N01 HC048047, N01-HC-480-47)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- C-reactive protein, insulin resistance, HOMA-IR, low-grade inflammation, obesity, oxidative stress, isoprostanes, oxidized LDL, fibrinogen, gastric cardia, young adults
- MeSH terms
- Adolescent, Adult, C-Reactive Protein, Coronary Artery Disease, Cross-Sectional Studies, Demography, Female, Follow-Up Studies, Homeostasis, Humans, Inflammation, Insulin Resistance, Life Style, Longitudinal Studies, Male, Time Factors, Exercise, Body Mass Index, Waist Circumference
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