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Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets
Open accessAbstract
Aims/hypothesisAldosterone concentrations increase in obesity and predict the onset of diabetes. We investigated the effects of aldosterone on glucose homeostasis and insulin secretion in vivo and in vitro.MethodsWe assessed insulin sensitivity and insulin secretion in aldosterone synthase-deficient (As [also known as Cyp11b2]−/−) and wild-type mice using euglycaemic–hyperinsulinaemic and hyperglycaemic clamps, respectively. We also conducted studies during high sodium intake to normalise renin activity and potassium concentration in As−/− mice. We subsequently assessed the effect of aldosterone on insulin secretion in vitro in the presence or absence of mineralocorticoid receptor antagonists in isolated C57BL/6J islets and in the MIN6 beta cell line.ResultsFasting glucose concentrations were reduced in As−/− mice compared with wild-type. During hyperglycaemic clamps, insulin and C-peptide concentrations increased to a greater extent in As−/− than in wild-type mice. This was not attributable to differences in potassium or angiotensin II, as glucose-stimulated insulin secretion was enhanced in As−/− mice even during high sodium intake. There was no difference in insulin sensitivity between As−/− and wild-type mice in euglycaemic–hyperinsulinaemic clamp studies. In islet and MIN6 beta cell studies, aldosterone inhibited glucose- and isobutylmethylxanthine-stimulated insulin secretion, an effect that was not blocked by mineralocorticoid receptor antagonism, but was prevented by the superoxide dismutase mimetic tempol.Conclusions/interpretationWe demonstrated that aldosterone deficiency or excess modulates insulin secretion in vivo and in vitro via reactive oxygen species and in a manner that is independent of mineralocorticoid receptors. These findings provide insight into the mechanism of glucose intolerance in conditions of relative aldosterone excess.
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“We recently demonstrated that aldosterone directly impairs insulin secretion in isolated murine pancreatic islets”
From Primary aldosteronism decreases insulin secretion and increases insulin clearance in humans (2020) · cites this paper as [6]
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“genetic aldosterone deficiency markedly increases insulin secretion in mice (6, 7)”
From Primary aldosteronism decreases insulin secretion and increases insulin clearance in humans (2020) · cites this paper as [6]
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“aldosterone deficiency in mice increases insulin secretion in vivo without altering insulin sensitivity (6).”
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“Aldosterone impairs insulin secretion in isolated rodent islets and insulinoma cell lines”
From Primary aldosteronism decreases insulin secretion and increases insulin clearance in humans (2020) · cites this paper as [6]
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Citations
Cites
Mechanisms linking obesity to insulin resistance and type 2 diabetes
Kahn, S. E., Hull, R. L., & Utzschneider, K. M. (2006) · Nature · doi:10.1038/nature05482 · Cited by 5,448
Miyazaki, J., Araki, K., Yamato, E., Ikegami, H., Asano, T., Shibasaki, Y., Oka, Y., & Yamamura, K. (1990) · Endocrinology · doi:10.1210/endo-127-1-126 · Cited by 1,267
Effect of ramipril on the incidence of diabetes
(2006) · New England Journal of Medicine · doi:10.1056/nejmoa065061 · Cited by 737
Effect of valsartan on the incidence of diabetes and cardiovascular events
(2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001121 · Cited by 660
Tuck, M. L., Sowers, J. R., Dornfeld, L., Kledzik, G. S., & Maxwell, M. H. (1981) · New England Journal of Medicine · doi:10.1056/nejm198104163041602 · Cited by 643
Aldosterone: A Mediator of Myocardial Necrosis and Renal Arteriopathy
Rocha, R., Stier, C. T., Kifor, I., Ochoa-Maya, M. R., Rennke, H. G., Williams, G. H., & Adler, G. K. (2000) · Endocrinology · doi:10.1210/endo.141.10.7711 · Cited by 480
McMurray, J. J. V. (2010) · New England Journal of Medicine · doi:10.1056/nejmcp0909392 · Cited by 464
Considerations in the Design of Hyperinsulinemic-Euglycemic Clamps in the Conscious Mouse
Ayala, J. E., Bracy, D. P., McGuinness, O. P., & Wasserman, D. H. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-0686 · Cited by 406
Self-citationReduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin Secretion
Briššová, M., Shiota, M., Nicholson, W. E., GANNON, M. A., Knobel, S. M., Piston, D. W., Wright, C. V. E., & Powers, A. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111272200 · Cited by 376
Self-citationAldosterone: effects on the kidney and cardiovascular system
Briet, M. B., & Schiffrin, E. L. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.30 · Cited by 346
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Jaisser, F., & Farman, N. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.011106 · Cited by 348
The Renin Angiotensin Aldosterone System and Insulin Resistance in Humans
UNDERWOOD, P. C., & Adler, G. K. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0323-2 · Cited by 219
Zhou, M.-S., Schulman, I. H., & Zeng, Q. (2012) · Vascular Medicine · doi:10.1177/1358863x12450094 · Cited by 214
The renin–angiotensin–aldosterone system and glucose homeostasis
Luther, J. M., & Brown, N. J. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.07.006 · Cited by 185
Self-citationHanslik, G., Wallaschofski, H., Dietz, A., Riester, A., Reincke, M., Allolio, B., Lang, K., Quack, I., Rump, L. C., Willenberg, H. S., et al. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0450 · Cited by 155
Metadata
- Authors
- Luther, J. M., Luo, P., Kreger, M. T., Brissova, M., Dai, C., Whitfield, T. T., Kim, H. S., Wasserman, D. H., Powers, A. C., & Brown, N. J.
- Affiliations
- Vanderbilt University Medical Center (US)
- University of Tennessee Health Science Center (US)
- University of North Carolina at Chapel Hill (US)
- National Institutes of Health (US)
- VA Tennessee Valley Healthcare System (US)
- Corresponding author
- Luther, J. M.
- Venue
- Diabetologia
- Published
- 2011-04-26
- Volume
- 54
- Issue
- 8
- Pages
- 2152-2163
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- PMC
- PMC3216479
- OpenAlex
- W1986937962
- Semantic Scholar
- a0c1e95c299c0afa3836d90ecaf36d72f7b3fc26
- Cited by
- 109
- References
- 52
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 10 · 2020: 9 · 2019: 8 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 9 · 2014: 4 · 2013: 10 · 2012: 11
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 BX000666)
- Juvenile Diabetes Research Foundation International
- Vanderbilt University (DK59637, DK20593)
- National Institutes of Health (DK-59637, DK 20593, DK66636)
- Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center (DK-20593)
- National Heart, Lung, and Blood Institute (R01HL060906, R01HL067308, HL060906, HL07738, HL067308)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK68854, K23DK081662, R01DK068764, DK089572, U01DK089572, DK69603, DK66636, DK59637, R21DK066636, R21DK068854, DK072473, DK 20593, U24DK059637, DK081662, R01DK069603, R33DK066636, U01DK072473, P30DK020593)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- aldosterone, glucose-stimulated insulin secretion, aldosterone synthase deficiency, CYP11B2, mineralocorticoid receptor, reactive oxygen species, tempol, pancreatic beta cells, insulin sensitivity, impaired glucose tolerance, obesity, diabetes mellitus, sodium intake, renin-angiotensin system, islets
- MeSH terms
- Insulin Secretion, Aldosterone, Animals, Blood Glucose, Cell Line, Glucose, Insulin, Islets of Langerhans, Male, Mice, Inbred C57BL, Cytochrome P-450 CYP11B2, Insulin-Secreting Cells, Mice, In Vitro Techniques
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