The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets
Open accessAbstract
AIMS/HYPOTHESIS: Our understanding of the transcription factors that control the development and function of rodent islet beta cells is advancing rapidly, yet less is known of the role they play in similar processes in human islets. METHODS: To characterise the abundance and regulation of key proteins involved in glucose-regulated insulin secretion in human islets, we examined the expression of MAFA, MAFB, GLUT2 (also known as SLC2A2), βGK (also known as GCK) and PDX1 in isolated, highly purified human islets with an intact insulin secretory pattern. We also assessed these features in islets from two different mouse strains (C57BL/6J and FVB). RESULTS: Compared with mouse islets, human islets secreted more insulin at baseline glucose (5.6 mmol/l), but less upon stimulation with high glucose (16.7 mmol/l) or high glucose plus 3-isobutyl-1-methyl-xanthine. Human islets had relatively more MAFB than PDX1 mRNA, while mouse islets had relatively more Pdx1 than Mafb mRNA. However, v-maf musculoaponeurotic fibrosarcoma oncogene homologue (MAF) B protein was found in human islet alpha and beta cells. This is unusual as this regulator is only produced in islet alpha cells in adult mice. The expression of insulin, MAFA, βGK and PDX1 was not glucose-regulated in human islets with an intact insulin secretory pattern. CONCLUSIONS/INTERPRETATION: Our results suggest that human islets have a distinctive distribution and function of key regulators of the glucose-stimulated insulin secretion pathway, emphasising the urgent need to understand the processes that regulate human islet beta cell function.
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The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments
Bustin, S. A., Benes, V., Garson, J. A., Hellemans, J., Huggett, J., Kubista, M., Mueller, R., Nolan, T., Pfaffl, M. W., Shipley, G. L., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.112797 · Cited by 16,303
Brissova, M., Fowler, M. J., Nicholson, W. E., Chu, A., Hirshberg, B., Harlan, D. M., & Powers, A. C. (2005) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5c6684.2005 · Cited by 797
Self-citationHuman and rat beta cells differ in glucose transporter but not in glucokinase gene expression.
De Vos, A., Heimberg, H., Quartier, E., Huypens, P., Bouwens, L., Pipeleers, D., & Schuit, F. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118308 · Cited by 425
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“Other potential mechanisms may involve differences in sensitivity or number of ion channels downstream from glucokinase [5, 45, 46].”
The replication of β cells in normal physiology, in disease and for therapy
Butler, P. C., Meier, J. J., Butler, A. E., & Bhushan, A. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0647 · Cited by 268
Nutrient Control of Insulin Secretion in Isolated Normal Human Islets
Henquin, J.-C., Dufrane, D., & Nenquin, M. (2006) · Diabetes · doi:10.2337/db06-0868 · Cited by 228
Cited by
Inactivation of specific β cell transcription factors in type 2 diabetes
Guo, S., Dai, C., Guo, M., Taylor, B., Harmon, J. S., Sander, M., Robertson, R. P., Powers, A. C., & Stein, R. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65390 · Cited by 520
Self-citationNair, G. G., Liu, J. S., Russ, H. A., Tran, S., Saxton, M. S., Chen, R., Juang, C., Li, M.-L., Nguyen, V. Q., Giacometti, S., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0271-4 · Cited by 472
p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion
Helman, A., Klochendler, A., Azazmeh, N., Gabai, Y., Horwitz, E., Anzi, S., Swisa, A., Condiotti, R., Granit, R. Z., Nevo, Y., et al. (2016) · Nature Medicine · doi:10.1038/nm.4054 · Cited by 351
Self-citationBenner, C., van der Meulen, T., Cacéres, E., Tigyi, K., Donaldson, C. J., & Huising, M. O. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-620 · Cited by 302
Babon, J. A. B., DeNicola, M. E., Blodgett, D. M., Crèvecoeur, I., Buttrick, T. S., Maehr, R., Bottino, R., Naji, A., Kaddis, J., Elyaman, W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4203 · Cited by 300
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Metadata
- Authors
- Dai, C., Brissova, M., Hang, Y., Thompson, C., Poffenberger, G., Shostak, A., Chen, Z., Stein, R., & Powers, A. C.
- Venue
- Diabetologia
- Published
- 2011-12-14
- Volume
- 55
- Issue
- 3
- Pages
- 707-718
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2086837194
- Cited by
- 179
- References
- 6
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Dai, C., Brissova, M., Hang, Y., Thompson, C., Poffenberger, G., Shostak, A., Chen, Z., Stein, R., & Powers, A. C. (2012). Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets. Diabetologia. https://doi.org/10.1007/s00125-011-2369-0
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