CoChat
Sign Up
Cited by 181Air Quality and Health ImpactsEnvironmental Justice and Health DisparitiesUrban Transport and Accessibility

Long-term exposure to traffic-related air pollution and insulin resistance in children: results from the GINIplus and LISAplus birth cohorts

Open access
Thiering, E., Cyrys, J., Kratzsch, J., Meisinger, C., Hoffmann, B., Berdel, D., von Berg, A., Koletzko, S. +2 more·2013·Diabetologia
DOI 10.1007/s00125-013-2925-xPMC PMC3699704
Open this paper in CoChat — free account

Abstract

AIMS/HYPOTHESIS: Epidemiological studies that have examined associations between long-term exposure to traffic-related air pollution and type 2 diabetes mellitus in adults are inconsistent, and studies on insulin resistance are scarce. We aimed to assess the association between traffic-related air pollution and insulin resistance in children. METHODS: Fasting blood samples were collected from 397 10-year-old children in two prospective German birth cohort studies. Individual-level exposures to traffic-related air pollutants at the birth address were estimated by land use regression models. The association between air pollution and HOMA of insulin resistance (HOMA-IR) was analysed using a linear model adjusted for several covariates including birthweight, pubertal status and BMI. Models were also further adjusted for second-hand smoke exposure at home. Sensitivity analyses that assessed the impact of relocating, study design and sex were performed. RESULTS: In all crude and adjusted models, levels of insulin resistance were greater in children with higher exposure to air pollution. Insulin resistance increased by 17.0% (95% CI 5.0, 30.3) and 18.7% (95% CI 2.9, 36.9) for every 2SDs increase in ambient NO2 and particulate matter ≤10 μm in diameter, respectively. Proximity to the nearest major road increased insulin resistance by 7.2% (95% CI 0.8, 14.0) per 500 m. CONCLUSIONS/INTERPRETATION: Traffic-related air pollution may increase the risk of insulin resistance. Given the ubiquitous nature of air pollution and the high incidence of insulin resistance in the general population, the associations examined here may have potentially important public health effects despite the small/moderate effect sizes observed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s00125-013-2925-x

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The citation lists haven’t been fetched yet

References 46 · Cited by 181

Research works printed but not linked: 42

  1. [1]Rückerl R Schneider A Breitner S Cyrys J Peters A Health effects of particulate air pollution: a review of epidemiological evidence Inhal Toxicol 2011 23 555 592 10.3109/08958378.2011.593587 21864219 · DOI
  2. [2]Gan WQ Koehoorn M Davies HW Long-term exposure to traffic-related air pollution and the risk of coronary heart disease hospitalization and mortality Environ Health Perspect 2011 119 501 507 10.1289/ehp.1002511 21081301 PMC3080932 · DOI
  3. [3]Bauer M Moebus S Möhlenkamp S Urban particulate matter air pollution is associated with subclinical atherosclerosis: results from the HNR (Heinz Nixdorf Recall) study J Am Coll Cardiol 2010 56 1803 1808 10.1016/j.jacc.2010.04.065 21087707 · DOI
  4. [4]Künzli N Jerrett M Garcia-Esteban R Ambient air pollution and the progression of atherosclerosis in adults PLoS One 2010 5 e9096 10.1371/journal.pone.0009096 20161713 PMC2817007 · DOI
  5. [5]Brook RD Rajagopalan S Pope CA 3rd An update to the scientific statement from the American Heart Association Circulation 2010 121 2331 2378 10.1161/CIR.0b013e3181dbece1 20458016 · DOI · Paper page
  6. [6]Rajagopalan S Brook RD Air pollution and type 2 diabetes: mechanistic insights Diabetes 2012 61 3037 3045 10.2337/db12-0190 23172950 PMC3501850 · DOI
  7. [7]Sun Q Yue P Deiuliis JA Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity Circulation 2009 119 538 546 10.1161/CIRCULATIONAHA.108.799015 19153269 PMC3845676 · DOI
  8. [8]Xu X Liu C Xu Z Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue Toxicol Sci 2011 124 88 98 10.1093/toxsci/kfr211 21873646 PMC3196653 · DOI
  9. [9]Zhang L Curhan GC Hu FB Rimm EB Forman JP Association between passive and active smoking and incident type 2 diabetes in women Diabetes Care 2011 34 892 897 10.2337/dc10-2087 21355099 PMC3064047 · DOI
  10. [10]Weitzman M Cook S Auinger P Tobacco smoke exposure is associated with the metabolic syndrome in adolescents Circulation 2005 112 862 869 10.1161/CIRCULATIONAHA.104.520650 16061737 · DOI
  11. [11]Andersen ZJ Raaschou-Nielsen O Ketzel M Diabetes incidence and long-term exposure to air pollution: a cohort study Diabetes Care 2012 35 92 98 10.2337/dc11-1155 22074722 PMC3241311 · DOI
  12. [12]Raaschou-Nielsen O Sørensen M Ketzel M Long-term exposure to traffic-related air pollution and diabetes-associated mortality: a cohort study Diabetologia 2013 56 36 46 22918192
  13. [13]Puett RC Hart JE Schwartz J Are particulate matter exposures associated with risk of type 2 diabetes? Environ Health Perspect 2011 119 384 389 10.1289/ehp.1002344 21118784 PMC3060003 · DOI
  14. [14]Dijkema MB Mallant SF Gehring U Long-term exposure to traffic-related air pollution and type 2 diabetes prevalence in a cross-sectional screening-study in the Netherlands Environ Health 2011 10 76 10.1186/1476-069X-10-76 21888674 PMC3200985 · DOI
  15. [15]Krämer U Herder C Sugiri D Traffic-related air pollution and incident type 2 diabetes: results from the SALIA cohort study Environ Health Perspect 2010 118 1273 1279 10.1289/ehp.0901689 20504758 PMC2944089 · DOI
  16. [16]Coogan PF White LF Jerrett M Air pollution and incidence of hypertension and diabetes in African American women living in Los Angeles Circulation 2012 125 767 772 10.1161/CIRCULATIONAHA.111.052753 22219348 PMC3326581 · DOI
  17. [17]Brook RD Jerrett M Brook JR Bard RL Finkelstein MM The relationship between diabetes mellitus and traffic-related air pollution J Occup Environ Med 2008 50 32 38 10.1097/JOM.0b013e31815dba70 18188079 · DOI
  18. [18]Berg A Krämer U Link E Impact of early feeding on childhood eczema: development after nutritional intervention compared with the natural course: the GINIplus study up to the age of 6 years Clin Exp Allergy 2010 40 627 636 20082618
  19. [19]Zutavern A Brockow I Schaaf B Timing of solid food introduction in relation to atopic dermatitis and atopic sensitization: results from a prospective birth cohort study Pediatrics 2006 117 401 411 10.1542/peds.2004-2521 16452359 · DOI
  20. [21]Beelen R Hoek G Vienneau D Development of NO2 and NOx land use regression models for estimating air pollution exposure in 36 study areas in Europe—the ESCAPE project Atmos Environ 2013 72 10 23 10.1016/j.atmosenv.2013.02.037 · DOI
  21. [22]Eeftens M Beelen R Bellander T Development of land use regression models for PM(2.5), PM(2.5) absorbance, PM(10) and PM(coarse) in 20 European study areas: results of the ESCAPE project Environ Sci Technol 2012 46 11195 11205 10.1021/es301948k 22963366 · DOI
  22. [24]Eeftens M Tsai MY Ampe C Spatial variation of PM2.5, PM10, PM2.5 absorbance and PMcoarse concentrations between and within 20 European study areas and the relationship with NO2: results of the ESCAPE project Atmos Environ 2012 62 303 317 10.1016/j.atmosenv.2012.08.038 · DOI · Paper page
  23. [25]Thiering E Brüske I Kratzsch J Prenatal and postnatal tobacco smoke exposure and development of insulin resistance in 10 year old children Int J Hyg Environ Health 2011 214 361 368 10.1016/j.ijheh.2011.04.004 21570350 · DOI
  24. [27]Cole TJ Sympercents: symmetric percentage differences on the 100 log(e) scale simplify the presentation of log transformed data Stat Med 2000 19 3109 3125 10.1002/1097-0258(20001130)19:22<3109::AID-SIM558>3.0.CO;2-F 11113946 · DOI · Paper page
  25. [28]Kelishadi R Mirghaffari N Poursafa P Gidding SS Lifestyle and environmental factors associated with inflammation, oxidative stress and insulin resistance in children Atherosclerosis 2009 203 311 319 10.1016/j.atherosclerosis.2008.06.022 18692848 · DOI
  26. [29]Yan YH Chou CC Lee CT Liu JY Cheng TJ Enhanced insulin resistance in diet-induced obese rats exposed to fine particles by instillation Inhal Toxicol 2011 23 507 519 10.3109/08958378.2011.587472 21736501 · DOI
  27. [30]van den Hooven EH Pierik FH de Kluizenaar Y Air pollution exposure during pregnancy, ultrasound measures of fetal growth, and adverse birth outcomes: a prospective cohort study Environ Health Perspect 2012 120 150 156 10.1289/ehp.1003316 22222601 PMC3261932 · DOI
  28. [31]Dadvand P Parker J Bell ML Maternal exposure to particulate air pollution and term birth weight: a multi-country evaluation of effect and heterogeneity Environ Health Perspect 2013 121 367 373 10.1289/ehp.1205575 PMC3621183 23384584 · DOI
  29. [32]Slama R Morgenstern V Cyrys J Traffic-related atmospheric pollutants levels during pregnancy and offspring's term birth weight: a study relying on a land-use regression exposure model Environ Health Perspect 2007 115 1283 1292 10.1289/ehp.10047 17805417 PMC1964922 · DOI
  30. [33]Whincup PH Kaye SJ Owen CG Birth weight and risk of type 2 diabetes: a systematic review JAMA 2008 300 2886 2897 10.1001/jama.2008.886 19109117 · DOI
  31. [34]Lodovici M Bigagli E Oxidative stress and air pollution exposure J Toxicol 2011 2011 487074 21860622 PMC3155788
  32. [35]Møller P Loft S Oxidative damage to DNA and lipids as biomarkers of exposure to air pollution Environ Health Perspect 2010 118 1126 1136 10.1289/ehp.0901725 20423813 PMC2920082 · DOI
  33. [36]Sørensen M Daneshvar B Hansen M Personal PM2.5 exposure and markers of oxidative stress in blood Environ Health Perspect 2003 111 2 161 166 10.1289/ehp.5646 12573899 PMC1241344 · DOI
  34. [37]Chuang KJ Chan CC Su TC Lee CT Tang CS The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults Am J Respir Crit Care Med 2007 176 370 376 10.1164/rccm.200611-1627OC 17463411 · DOI · Paper page
  35. [38]Delfino RJ Staimer N Tjoa T Air pollution exposures and circulating biomarkers of effect in a susceptible population: clues to potential causal component mixtures and mechanisms Environ Health Perspect 2009 117 1232 1238 10.1289/journla.ehp.0800194 19672402 PMC2721866 · DOI
  36. [39]Hoffmann B Moebus S Dragano N Chronic residential exposure to particulate matter air pollution and systemic inflammatory markers Environ Health Perspect 2009 117 1302 1308 19672412 PMC2721876
  37. [40]Calderón-Garcidueñas L Villarreal-Calderon R Valencia-Salazar G Systemic inflammation, endothelial dysfunction, and activation in clinically healthy children exposed to air pollutants Inhal Toxicol 2008 20 499 506 10.1080/08958370701864797 18368620 · DOI
  38. [41]Forbes LJ Patel MD Rudnicka AR Chronic exposure to outdoor air pollution and markers of systemic inflammation Epidemiology 2009 20 245 253 10.1097/EDE.0b013e318190ea3f 19234416 · DOI
  39. [43]Ryan PH LeMasters GK Levin L A land-use regression model for estimating microenvironmental diesel exposure given multiple addresses from birth through childhood Sci Total Environ 2008 404 139 147 10.1016/j.scitotenv.2008.05.051 18625514 · DOI
  40. [44]Gruzieva O Bellander T Eneroth K Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life J Allergy Clin Immunol 2012 129 240 246 10.1016/j.jaci.2011.11.001 22104609 · DOI
  41. [45]Eeftens M Beelen R Fischer P Stability of measured and modelled spatial contrasts in NO2 over time Occup Environ Med 2011 68 765 770 10.1136/oem.2010.061135 21285243 · DOI
  42. [46]Wang R Henderson SB Sbihi H Allen RW Brauer M Temporal stability of land use regression models for traffic-related air pollution Atmos Environ 2013 64 312 319 10.1016/j.atmosenv.2012.09.056 · DOI

Authors
Thiering, E., Cyrys, J., Kratzsch, J., Meisinger, C., Hoffmann, B., Berdel, D., von Berg, A., Koletzko, S., Bauer, C.-P., & Heinrich, J.
Affiliations
  • Helmholtz Munich (DE)
  • University of Augsburg (DE)
  • University Hospital Leipzig (DE)
  • Leibniz Institute of Environmental Medicine (DE)
  • Marien Hospital Wesel (DE)
  • Ludwig-Maximilians-Universität München (DE)
  • Technical University of Munich (DE)
Corresponding author
Heinrich, J.
ORCID
Venue
Diabetologia
Publisher
Springer Science and Business Media LLC
Published
2013-05-11
Volume
56
Issue
8
Pages
1696-1704
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
DOI
10.1007/s00125-013-2925-x
PMC
PMC3699704
OpenAlex
W2157318524
Cited by
181
References
46
Citations by year
2026: 1 · 2025: 6 · 2024: 7 · 2023: 12 · 2022: 16 · 2021: 12 · 2020: 14 · 2019: 17 · 2018: 24 · 2017: 18 · 2016: 17 · 2015: 16 · 2014: 16 · 2013: 4 · 2012: 1
FWCI
12.99
Type
journal article
Language
en
Open access
Licence
Locations
  • Diabetologia (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • mediaTUM (Technical University of Munich) (submittedVersion)
  • Site cant be reached (submittedVersion, cc-by)
  • OPUS (Augsburg University) (submittedVersion, cc-by-nc)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Social Sciences › Sociology and Political Science › Environmental Justice and Health Disparities
  • Social Sciences › Transportation › Urban Transport and Accessibility
Keywords
traffic-related air pollution, insulin resistance, children, type 2 diabetes risk, nitrogen dioxide, particulate matter, road proximity, HOMA-IR, birth cohort, GINIplus, passive smoking
MeSH terms
Air Pollutants, Vehicle Emissions, Child, Female, Humans, Insulin Resistance, Male, Prospective Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review