The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults
Abstract
RATIONALE: The biological mechanisms linking air pollution to cardiovascular events still remain largely unclear. OBJECTIVES: To investigate whether biological mechanisms linking air pollution to cardiovascular events occurred concurrently in human subjects exposed to urban air pollutants. METHODS: We recruited a panel of 76 young, healthy students from a university in Taipei. Between April and June of 2004 or 2005, three measurements were made in each participant of high-sensitivity C-reactive protein (hs-CRP), 8-hydroxy-2'-deoxyguanosine (8-OHdG), plasminogen activator fibrinogen inhibitor-1 (PAI-1), tissue-type plasminogen activator (tPA) in plasma, and heart rate variability (HRV). Gaseous air pollutants were measured at one air-monitoring station inside their campus, and particulate air pollutants were measured at one particulate matter supersite monitoring station 1 km from their campus. We used linear mixed-effects models to associate biological endpoints with individual air pollutants averaged over 1- to 3-day periods before measurements were performed. MEASUREMENTS AND MAIN RESULTS: We found that increases in hs-CRP, 8-OHdG, fibrinogen, and PAI-1, and decreases in HRV indices were associated with increases in levels of particles with aerodynamic diameters less than 10 microm and 2.5 microm, sulfate, nitrate, and ozone (O(3)) in single-pollutant models. The increase in 8-OHdG, fibrinogen, and PAI-1, and the reduction in HRV remained significantly associated with 3-day averaged sulfate and O(3) levels in two-pollutant models. There were moderate correlations (r = -0.3) between blood markers of hs-CRP, fibrinogen, PAI-1, and HRV indices. CONCLUSIONS: Urban air pollution is associated with inflammation, oxidative stress, blood coagulation and autonomic dysfunction simultaneously in healthy young humans, with sulfate and O(3) as two major traffic-related pollutants contributing to such effects.
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Increased exposure to ambient ozone has been associated with increased levels of hemostatic markers, including fibrinogen, von Willebrand factor, and plasminogen activator inhibitor-1.
“Increased exposure to ambient ozone has been associated with increased levels of hemostatic markers, including fibrinogen (48–50), von Willebrand factor (49), and plasminogen activator inhibitor-1 (48).”
From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [48]
Cites
A new look at the statistical model identification
Akaike, H. (1974) · IEEE Transactions on Automatic Control · doi:10.1109/tac.1974.1100705 · Cited by 51,879 · see citing works
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159 · see citing works
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289 · see citing works
Rovere, M. T. L., Bigger, J. T., Marcus, F. I., Mortara, A., & Schwartz, P. J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11144-8 · Cited by 3,120 · see citing works
Fine Particulate Air Pollution and Hospital Admission for Cardiovascular and Respiratory Diseases
Dominici, F., Peng, R. D., Bell, M. L., Pham, L. D., McDermott, A., Zeger, S. L., & Samet, J. M. (2006) · JAMA · doi:10.1001/jama.295.10.1127 · Cited by 2,640 · see citing works
Pope, C. A., Burnett, R. T., Thurston, G. D., Thun, M. J., Calle, E. E., Krewski, D., & Godleski, J. J. (2004) · Circulation · doi:10.1161/01.cir.0000108927.80044.7f · Cited by 2,592 · see citing works
Air Pollution and Cardiovascular Disease
Brook, R. D., Franklin, B. A., Cascio, W. E., Hong, Y., Howard, G., D, M. L. M., Luepker, R. V., Mittleman, M. A., Samet, J. M., Smith, S. C., et al. (2004) · Circulation · doi:10.1161/01.cir.0000128587.30041.c8 · Cited by 2,417 · see citing works
Long-Term Follow-Up of Patients With Mild Coronary Artery Disease and Endothelial Dysfunction
Suwaidi, J. M. S. A., Hamasaki, S., Higano, S. T., Nishimura, R. A., Holmes, D. R., & Lerman, A. (2000) · Circulation · doi:10.1161/01.cir.101.9.948 · Cited by 2,044 · see citing works
Fibrinogen and risk of cardiovascular disease. The Framingham Study
Kannel, W. B. (1987) · JAMA · doi:10.1001/jama.258.9.1183 · Cited by 1,387 · see citing works
Laden, F., Neas, L., Dockery, D. W., & Schwartz, J. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108941 · Cited by 1,296 · see citing works
Ozone and short-term mortality in 95 US urban communities, 1987–2000
Bell, M. L. (2004) · JAMA · doi:10.1001/jama.292.19.2372 · Cited by 1,202 · see citing works
Fibrinogen and Risk of Cardiovascular Disease
Kannel, W. B. (1987) · JAMA · doi:10.1001/jama.1987.03400090067035 · Cited by 894 · see citing works
Ambient Pollution and Heart Rate Variability
Gold, D. R., Litonjua, A. A., Schwartz, J. D., Lovett, E. G., Larson, A. C., Nearing, B. D., Allen, G. A., Verrier, M., Cherry, R. C., & Verrier, R. L. (2000) · Circulation · doi:10.1161/01.cir.101.11.1267 · Cited by 869 · see citing works
Sun, Q. (2005) · JAMA · doi:10.1001/jama.294.23.3003 · Cited by 850 · see citing works
Devaraj, S., Xu, D. Y., & Jialal, I. (2003) · Circulation · doi:10.1161/01.cir.0000052617.91920.fd · Cited by 641 · see citing works
Thögersen, A. M., Jansson, J.-H., Boman, K., Nilsson, T. K., Weinehall, L., Huhtasaari, F., & Hallmans, G. (1998) · Circulation · doi:10.1161/01.cir.98.21.2241 · Cited by 602 · see citing works
Fibrinogen and risk of cardiovascular disease
Nguyen, V. (1988) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(88)80530-4 · Cited by 594 · see citing works
(1997) · PubMed · Cited by 581 · see citing works
Concentrated Ambient Air Particles Induce Mild Pulmonary Inflammation in Healthy Human Volunteers
Ghio, A. J., Chong, K., & Devlin, R. B. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.3.9911115 · Cited by 547 · see citing works
Pope, C. A., Hansen, M. L., Long, R., Nielsen, K. R., Eatough, N. L., Wilson, W. E., & Eatough, D. J. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6588 · Cited by 503 · see citing works
O’Neill, M. S., Veves, A., Zanobetti, A., Sarnat, J. A., Gold, D. R., Economides, P. A., Horton, E. S., & Schwartz, J. D. (2005) · Circulation · doi:10.1161/circulationaha.104.517110 · Cited by 464 · see citing works
Dubowsky, S. D., Suh, H. H., Schwartz, J. D., Coull, B. A., & Gold, D. R. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8469 · Cited by 431 · see citing works
Air Pollution and Markers of Inflammation and Coagulation in Patients with Coronary Heart Disease
Rückerl, R., Ibald-Mulli, A., Köenig, W., Schneider, A. E., Wölke, G., Cyrys, J., Heinrich, J., Marder, V. J., Frampton, M. W., Wichmann, H. ‐., et al. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200507-1123oc · Cited by 406 · see citing works
Air Pollution and Blood Markers of Cardiovascular Risk
Schwartz, J. D. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109s3405 · Cited by 397 · see citing works
Effects of Air Pollution on Heart Rate Variability: The VA Normative Aging Study
Park, S. K., O’Neill, M. S., Vokonas, P., Sparrow, D., & Schwartz, J. D. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7447 · Cited by 362 · see citing works
Ozone-induced Airway Inflammation in Human Subjects as Determined by Airway Lavage and Biopsy
Aris, R. M., Christian, D., Hearne, P. Q., Kerr, K. M., Finkbeiner, W. E., & Balmes, J. R. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/148.5.1363 · Cited by 318 · see citing works
Daily concentrations of air pollution and plasma fibrinogen in London
Pekkanen, J., Brunner, E. J., ANDERSON, H. R., Tiittanen, P., & Atkinson, R. W. (2000) · Occupational and Environmental Medicine · doi:10.1136/oem.57.12.818 · Cited by 283 · see citing works
Magari, S. R., Hauser, R. B., Schwartz, J. D., Williams, P. L., Smith, T. J., & Christiani, D. C. (2001) · Circulation · doi:10.1161/hc3401.095038 · Cited by 256 · see citing works
Plasminogen Activator Expression in Human Atherosclerotic Lesions
Lupu, F., Heim, D. A., Bachmann, F., et al. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.9.1444 · Cited by 191 · see citing works
Overview of hemostatic factors involved in atherosclerotic cardiovascular disease
Kannel, W. B. (2005) · Lipids · doi:10.1007/s11745-005-1488-8 · Cited by 177 · see citing works
Brevetti, G., Silvestro, A., Giacomo, S. D., Bucur, R., Donato, A. D., Schiano, V., & Scopacasa, F. (2003) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(03)00124-1 · Cited by 165 · see citing works
Thurston, G. D., Ito, K., Mar, T. F., Christensen, W. F., Eatough, D. J., Henry, R. C., Kim, E., Laden, F., Lall, R., Larson, T. V., et al. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7989 · Cited by 161 · see citing works
Riediker, M., Devlin, R. B., Griggs, T. R., Herbst, M., Bromberg, P. A., Williams, R. W., & Cascio, W. E. (2004) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-1-2 · Cited by 160 · see citing works
Santos, U. D. P., Braga, A. L. F., Giorgi, D. M. A., Pereira, L. A. A., Grupi, C., Lin, C. A., Bussacos, M. A., Zanetta, D. M. T., Saldiva, P. H. N., & Filho, M. T. (2004) · European Heart Journal · doi:10.1093/eurheartj/ehi035 · Cited by 139 · see citing works
Urban air pollution and emergency admissions for cerebrovascular diseases in Taipei, Taiwan
Chan, C., Chuang, K.-J., Chien, L.-C., Chen, W., & Chang, W. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi835 · Cited by 137 · see citing works
Self-citationPersonal Exposure to Submicrometer Particles and Heart Rate Variability in Human Subjects
Chan, C., Chuang, K.-J., Shiao, G.-M., & Lin, L. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.6897 · Cited by 115 · see citing works
Self-citationHuang, S., Hsu, M.-K., & Chan, C. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.5519 · Cited by 114 · see citing works
Self-citationThe Role of Soluble Components in Ambient Fine Particles-Induced Changes in Human Lungs and Blood
Huang, Y.-C. T., Ghio, A. J., Stonehuerner, J., McGee, J. K., Carter, J. D., Grambow, S. C., & Devlin, R. B. (2003) · Inhalation Toxicology · doi:10.1080/08958370304460 · Cited by 109 · see citing works
Chuang, K.-J., Chan, C., Chen, N.-T., Su, T., & Lin, L. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8145 · Cited by 106 · see citing works
Self-citationShort-Term Effects of Air Pollution on Heart Rate Variability in Senior Adults in Steubenville, Ohio
Luttmann‐Gibson, H., Suh, H. H., Coull, B. A., Dockery, D. W., Sarnat, S. E., Schwartz, J. D., Stone, P. H., & Gold, D. R. (2006) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000229781.27181.7d · Cited by 88 · see citing works
Peripheral vascular endothelial function testing for the diagnosis of coronary artery disease
Jambrik, Z., Venneri, L., Varga, A., Rigo, F., Borges, A. C., & Picano, E. (2004) · American Heart Journal · doi:10.1016/j.ahj.2004.04.016 · Cited by 84 · see citing works
Lei, Y.-C., Hwang, J., Chan, C., Lee, C.-T., & Cheng, T. (2005) · Environmental Research · doi:10.1016/j.envres.2005.03.011 · Cited by 82 · see citing works
Self-citationCheng, T., Hwang, J.-S., Wang, P., Tsai, C.-F., Chen, C., Lin, S., & Chan, C. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5464 · Cited by 61 · see citing works
Self-citationChanges in Arterial Expression of Fibrinolytic System Proteins in Atherogenesis
Schneider, D. J., Ricci, M. A., Taatjes, D. J., et al. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.3294 · Cited by 60 · see citing works
Salmony, S. E. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.112-a339 · Cited by 45 · see citing works
Ramage, L., & Guy, K. (2004) · Inhalation Toxicology · doi:10.1080/08958370490439614 · Cited by 43 · see citing works
Association between nitrogen dioxide and heart rate variability in a susceptible population
Chan, C., Chuang, K.-J., Su, T., & Lin, L. (2005) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000185975.44265.2e · Cited by 41 · see citing works
Self-citationPersonal Coronary Risk Profiles Modify Autonomic Nervous System Responses to Air Pollution
Chen, J., Stone, P. H., Verrier, R. L., Nearing, B. D., MacCallum, G., Kim, J., Herrick, R. F., You, J., Zhou, H., & Christiani, D. C. (2006) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000245675.85924.7e · Cited by 35 · see citing works
Particulate air pollution, C-reactive protein, and cardiac risk
Pope, C. A. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2593 · Cited by 35 · see citing works
Su, T., Chan, C., Liau, C., et al. (2006) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000219116.25415.c4 · Cited by 34 · see citing works
Self-citationHealth on the Banks of the Rio Grande
Barrett, J. R. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.113-a304 · Cited by 32 · see citing works
Particulate Pollution and Endothelial Function
Rajagopalan, S., Sun, Q., & Chen, L. (2005) · Circulation · doi:10.1161/circulationaha.105.540872 · Cited by 28 · see citing works
Air Pollution Mix and Emergency Room Visits for Respiratory and Cardiac Diseases in Taipei
Hwang, J., Hu, T., & Chan, C. (2021) · Journal of Data Science · doi:10.6339/jds.2004.02(4).209 · Cited by 18 · see citing works
Self-citationThe Elemental Contents and Fractal Dimensions of PM2.5 in Taipei City
Chen, J., Lee, C., Chang, S., et al. (2001) · Aerosol and Air Quality Research · doi:10.4209/aaqr.2001.06.0002 · Cited by 14 · see citing works
Self-citation
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Brook, R. D., Rajagopalan, S., Pope, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181dbece1 · Cited by 6,548 · see citing works
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Zhang, J. (., Wei, Y., & Fang, Z. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02518 · Cited by 828 · see citing works
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Di, Q., Dai, L., Wang, Y., Zanobetti, A., Choirat, C., Schwartz, J. D., & Dominici, F. (2017) · JAMA · doi:10.1001/jama.2017.17923 · Cited by 698 · see citing works
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Nuvolone, D., Petri, D., & Voller, F. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-9239-3 · Cited by 619 · see citing works
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Day, D. B., Xiang, J., Mo, J., Li, F., Chung, M., Gong, J., Weschler, C. J., Ohman-Strickland, P. A., Sundell, J., Weng, W., et al. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2017.2842 · Cited by 264 · see citing works
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Delfino, R. J., Staimer, N., & Vaziri, N. D. (2011) · Air Quality, Atmosphere & Health · doi:10.1007/s11869-010-0095-2 · Cited by 181 · see citing works
Wu, S., Deng, F., Wei, H., Huang, J., Wang, X., Hao, Y., Zheng, C., Qin, Y., Lv, H., Shima, M., et al. (2014) · Environmental Science & Technology · doi:10.1021/es404778w · Cited by 166 · see citing works
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Grevendonk, L., Janssen, B. G., Vanpoucke, C., Lefebvre, W., Hoxha, M., Bollati, V., & Nawrot, T. S. (2016) · Environmental Health · doi:10.1186/s12940-016-0095-2 · Cited by 145 · see citing works
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Liu, Y., Wang, L., Wang, F., & Li, C. (2016) · Medical Science Monitor · doi:10.12659/msm.897808 · Cited by 106 · see citing works
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Alexander, D., Northcross, A., Wilson, N., Dutta, A., Pandya, R., Ibigbami, T., Adu, D., Olamijulo, J., Morhason-Bello, O., Karrison, T., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201606-1177oc · Cited by 91 · see citing works
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Kim, H.-J., Bae, I.-H., Son, E. D., Park, J., Cha, N., Na, H.-W., Jung, C., Go, Y.-S., Kim, D.-Y., Lee, T. R., et al. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.03.010 · Cited by 58 · see citing works
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Breton, C. V., Mack, W. J., Yao, J., Berhane, K., Amadeus, M., Lurmann, F., Gilliland, F., McConnell, R., Hodis, H. N., Künzli, N., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0150825 · Cited by 53 · see citing works
Schwartz, J. D., Di, Q., Requia, W. J., Dominici, F., & Zanobetti, A. (2021) · Epidemiology · doi:10.1097/ede.0000000000001354 · Cited by 17 · see citing works
- Authors
- Chuang, K.-J., Chan, C.-C., Su, T.-C., Lee, C.-T., & Tang, C.-S.
- Affiliations
- Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, and
- National Taiwan University (TW)
- National Central University (TW)
- Fu Jen Catholic University (TW)
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-08
- Volume
- 176
- Issue
- 4
- Pages
- 370-376
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2148432391
- Cited by
- 685
- References
- 54
- Citations by year
- 2026: 8 · 2025: 32 · 2024: 44 · 2023: 36 · 2022: 48 · 2021: 47 · 2020: 39 · 2019: 38 · 2018: 35 · 2017: 40 · 2016: 37 · 2015: 36 · 2014: 32 · 2013: 39 · 2012: 46
- FWCI
- 22.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Social Sciences › Sociology and Political Science › Environmental Justice and Health Disparities
- Keywords
- urban air pollution, cardiovascular effects of air pollution, inflammation, oxidative stress, coagulation, autonomic dysfunction, heart rate variability, C-reactive protein, 8-hydroxy-2'-deoxyguanosine, fibrinogen, plasminogen activator inhibitor-1, tissue plasminogen activator, particulate matter, sulfate, ozone, young adults
- MeSH terms
- 8-Hydroxy-2'-Deoxyguanosine, Adolescent, Adult, Air Pollutants, Air Pollution, Blood Coagulation, C-Reactive Protein, Deoxyguanosine, Environmental Monitoring, Female, Fibrinogen, Heart Rate, Humans, Inflammation, Male, Particle Size, Tissue Plasminogen Activator, Taiwan, Urban Health, Urban Population, Biomarkers, Plasminogen Activator Inhibitor 1, Oxidative Stress
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