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Cited by 628Gestational Diabetes Research and ManagementBirth, Development, and HealthDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Gestational diabetes mellitus and long-term consequences for mother and offspring: a view from Denmark

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Damm, Peter, Houshmand-Oeregaard, Azadeh, Kelstrup, Louise, Lauenborg, Jeannet, Mathiesen, Elisabeth R., Clausen, Tine D.·2016·Diabetologia
DOI 10.1007/s00125-016-3985-5
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Abstract

Gestational diabetes mellitus (GDM) is defined as glucose intolerance of varying severity and is present in about 2-6% of all pregnancies in Europe, making it one of the most common pregnancy disorders. Aside from the short-term maternal, fetal and neonatal consequences associated with GDM, there are long-term consequences for both mother and child. Although maternal glucose tolerance often normalises shortly after pregnancy, women with GDM have a substantially increased risk of developing type 2 diabetes later in life. Studies have reported that women are more than seven times as likely to develop diabetes after GDM, and that approximately 50% of mothers with GDM will develop diabetes within 10 years, making GDM one of the strongest predictors of type 2 diabetes. In women with previous GDM, development of type 2 diabetes can be prevented or delayed by lifestyle intervention and/or medical treatment. Systematic follow-up programmes would be ideal to prevent progression of GDM to diabetes, but such programmes are unfortunately lacking in the routine clinical set-up in most countries. Studies have found that the risks of obesity, the metabolic syndrome, type 2 diabetes and impaired insulin sensitivity and secretion in offspring of mothers with GDM are two- to eightfold those in offspring of mothers without GDM. The underlying pathogenic mechanisms behind the abnormal metabolic risk profile in offspring are unknown, but epigenetic changes induced by exposure to maternal hyperglycaemia during fetal life are implicated. Animal studies indicate that treatment can prevent long-term metabolic complications in offspring, but this remains to be confirmed in humans. Thus, diabetes begets diabetes and it is likely that GDM plays a significant role in the global diabetes epidemic. This review summarises a presentation given at the 'Gestational diabetes: what's up?' symposium at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Marja Vääräsmäki, DOI: 10.1007/s00125-016-3976-6 , and by Cuilin Zhang and colleagues, DOI: 10.1007/s00125-016-3979-3 ) and an overview by the Session Chair, Kerstin Berntorp (DOI: 10.1007/s00125-016-3975-7 ).

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Metadata

Authors
Damm, P., Houshmand-Oeregaard, A., Kelstrup, L., Lauenborg, J., Mathiesen, E. R., & Clausen, T. D.
Affiliations
University of Copenhagen (DK)
Corresponding author
Damm, Peter
ORCID
Venue
Diabetologia
Publisher
Springer Science and Business Media LLC
Published
2016-05-12
Volume
59
Issue
7
Pages
1396-1399
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
DOI
10.1007/s00125-016-3985-5
OpenAlex
W2373764771
Cited by
620
References
32
Citations by year
2026: 39 · 2025: 67 · 2024: 73 · 2023: 63 · 2022: 101 · 2021: 70 · 2020: 94 · 2019: 38 · 2018: 37 · 2017: 33 · 2016: 4
FWCI
6.60
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Diabetologia (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
Funders
Novo Nordisk Fonden (NNF14OC0009275)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
gestational diabetes mellitus, type 2 diabetes risk, offspring metabolic risk, maternal hyperglycemia, epigenetic effects, metabolic syndrome, obesity, insulin secretion, lifestyle intervention, diabetes prevention, long-term maternal outcomes, Denmark
MeSH terms
Denmark, Diabetes Mellitus, Type 2, Female, Humans, Mothers, Pregnancy, Pregnancy Complications, Risk Factors, Diabetes, Gestational

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