A Multicenter, Randomized Trial of Treatment for Mild Gestational Diabetes
Open accessAbstract
BACKGROUND: It is uncertain whether treatment of mild gestational diabetes mellitus improves pregnancy outcomes. METHODS: Women who were in the 24th to 31st week of gestation and who met the criteria for mild gestational diabetes mellitus (i.e., an abnormal result on an oral glucose-tolerance test but a fasting glucose level below 95 mg per deciliter [5.3 mmol per liter]) were randomly assigned to usual prenatal care (control group) or dietary intervention, self-monitoring of blood glucose, and insulin therapy, if necessary (treatment group). The primary outcome was a composite of stillbirth or perinatal death and neonatal complications, including hyperbilirubinemia, hypoglycemia, hyperinsulinemia, and birth trauma. RESULTS: A total of 958 women were randomly assigned to a study group--485 to the treatment group and 473 to the control group. We observed no significant difference between groups in the frequency of the composite outcome (32.4% and 37.0% in the treatment and control groups, respectively; P=0.14). There were no perinatal deaths. However, there were significant reductions with treatment as compared with usual care in several prespecified secondary outcomes, including mean birth weight (3302 vs. 3408 g), neonatal fat mass (427 vs. 464 g), the frequency of large-for-gestational-age infants (7.1% vs. 14.5%), birth weight greater than 4000 g (5.9% vs. 14.3%), shoulder dystocia (1.5% vs. 4.0%), and cesarean delivery (26.9% vs. 33.8%). Treatment of gestational diabetes mellitus, as compared with usual care, was also associated with reduced rates of preeclampsia and gestational hypertension (combined rates for the two conditions, 8.6% vs. 13.6%; P=0.01). CONCLUSIONS: Although treatment of mild gestational diabetes mellitus did not significantly reduce the frequency of a composite outcome that included stillbirth or perinatal death and several neonatal complications, it did reduce the risks of fetal overgrowth, shoulder dystocia, cesarean delivery, and hypertensive disorders. (ClinicalTrials.gov number, NCT00069576.)
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Claims the paper makes
11 of 27 cited sources checked · 6 supported · 0 flagged · accuracy not yet measured
- Interpretationcitation
The trial findings confirm a modest benefit from identifying and treating women with mild carbohydrate intolerance during pregnancy.
“Overall, consistent with findings from the ACHOIS trial, the findings from our trial confirm a modest benefit from the identification and treatment of women with mild carbohydrate intolerance during pregnancy.8”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [8] source
- Premisecitation
Women with gestational diabetes and very elevated fasting blood glucose appear at increased risk for fetal macrosomia and perinatal complications if untreated.
“Women with gestational diabetes who have very elevated fasting blood glucose levels appear to be at an increased risk for fetal macrosomia and perinatal complications if treatment is not provide,5”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [5] source
Two searches of Langer et al. (2005), “Gestational diabetes: The consequences of not treating,” returned no full-text snippets, and an abstract was not available in the provided tool results. The closest unscoped match, “Association Between Maternal Fasting Plasma Glucose Value and Fetal Weight Among Singletons of Mothers with Gestational Diabetes Mellitus” (score 0.687), discusses glucose and macrosomia but does not establish the claim about untreated patients or attribute it to Langer et al. The citation is plausible, but this evidence cannot directly confirm it or justify a misattribution verdict. (LLM, conf=0.58)
Experimental — accuracy not yet measured
- Premisecitation
ACHOIS also showed a reduction in shoulder dystocia when women with mild gestational diabetes received treatment (1% vs 3% untreated).
“Consistent with the results of our trial, the ACHOIS trial also showed a reduction in the rate of shoulder dystocia when women with mild gestational diabetes mellitus received treatment (1%, vs. 3% in the untreated group).8”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [8] source
- Premisecitation
The HAPO study described a strong continuous association between maternal glucose concentrations and increasing birth weight, cord-blood serum C-peptide, and other perinatal complication markers, even below usual diagnostic thresholds for gestational diabetes.
“The recent Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study, however, described a strong continuous association between maternal glucose concentrations and increasing birth weight, cord-blood serum C-peptide levels, and other markers of perinatal complications, even at glucose concentrations below those that are usually diagnostic of gestational diabetes mellitus.6”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [6] sourceExperimental — accuracy not yet measured
- Findingown data
The frequency of shoulder dystocia was significantly lower in the treatment group than in the control group (1.5% vs 4.0%).
“However, there were significant reductions with treatment as compared with usual care in several prespecified secondary outcomes, including mean birth weight (3302 vs. 3408 g), neonatal fat mass (427 vs. 464 g), the frequency of large-for-gestational-age infants (7.1% vs. 14.5%), birth weight greater than 4000 g (5.9% vs. 14.3%), shoulder dystocia (1.5% vs. 4.0%), and cesarean delivery (26.9% vs.”
Quote in the paperSubstantial claim
- Findingown data
The frequency of admission to the neonatal intensive care unit did not differ significantly between treatment and control.
“In contrast, the frequency of small-for-gestational age infants and the frequency of admission to the neonatal intensive care unit did not differ significantly between the groups (Table 3).”
Quote in the paperNot a substantial claim - Findingown data
Adjusting for baseline reported alcohol consumption did not materially change the primary outcome relative risk (RR 0.88; 97% CI 0.72-1.07; P=0.16).
“Adjustment for the baseline reported consumption of any alcohol did not materially affect the relative risk for the primary outcome (relative risk with treatment, 0.88; 97% CI, 0.72 to 1.07; P = 0.16).”
Quote in the paperNot a substantial claim - Findingown data
Mean birth weight was significantly lower in the treatment group than in the control group (3302 vs 3408 g).
“However, there were significant reductions with treatment as compared with usual care in several prespecified secondary outcomes, including mean birth weight (3302 vs. 3408 g), neonatal fat mass (427 vs. 464 g), the frequency of large-for-gestational-age infants (7.1% vs. 14.5%), birth weight greater than 4000 g (5.9% vs. 14.3%), shoulder dystocia (1.5% vs. 4.0%), and cesarean delivery (26.9% vs.”
Quote in the paperSubstantial claim - Findingown data
Rates of labor induction were similar between treatment and control.
“The rates of labor induction were similar between the treatment and control groups”
Quote in the paperNot a substantial claim - Findingown data
Thirty-seven women in the treatment group required insulin therapy, compared with two in the control group.
“A total of 37 women in the treatment group required insulin therapy, as compared with 2 in the control group.”
Quote in the paperNot a substantial claim - Findingown data
The frequency of small-for-gestational-age infants did not differ significantly between treatment and control.
“In contrast, the frequency of small-for-gestational age infants and the frequency of admission to the neonatal intensive care unit did not differ significantly between the groups (Table 3).”
Quote in the paperNot a substantial claim - Findingown data
The frequency of birth weight greater than 4000 g was significantly lower in the treatment group than in the control group (5.9% vs 14.3%).
“However, there were significant reductions with treatment as compared with usual care in several prespecified secondary outcomes, including mean birth weight (3302 vs. 3408 g), neonatal fat mass (427 vs. 464 g), the frequency of large-for-gestational-age infants (7.1% vs. 14.5%), birth weight greater than 4000 g (5.9% vs. 14.3%), shoulder dystocia (1.5% vs. 4.0%), and cesarean delivery (26.9% vs.”
Quote in the paperSubstantial claim - Findingown data
Women in the treatment group attended an average of seven prenatal visits, compared with five in the control group (P<0.001).
“After enrollment, women in the treatment group attended an average of seven prenatal visits, as compared with an average of five attended by women in the control group (P < 0.001).”
Quote in the paperNot a substantial claim - Findingown data
Combined rates of preeclampsia and gestational hypertension were significantly lower in the treatment group than in the control group (8.6% vs 13.6%; P=0.01).
“Treatment of gestational diabetes mellitus, as compared with usual care, was also associated with reduced rates of preeclampsia and gestational hypertension (combined rates for the two conditions, 8.6% vs. 13.6%; P = 0.01).”
- Also stated in: § MATERNAL OUTCOMES · plain
“The treatment group had a significantly lower frequency of shoulder dystocia (P = 0.02) and preeclampsia or gestational hypertension (P = 0.01) (Table 4).”
Quote in the paperSubstantial claim - Also stated in: § MATERNAL OUTCOMES · plain
- Findingown data
The frequency of large-for-gestational-age infants was significantly lower in the treatment group than in the control group (7.1% vs 14.5%).
“However, there were significant reductions with treatment as compared with usual care in several prespecified secondary outcomes, including mean birth weight (3302 vs. 3408 g), neonatal fat mass (427 vs. 464 g), the frequency of large-for-gestational-age infants (7.1% vs. 14.5%), birth weight greater than 4000 g (5.9% vs. 14.3%), shoulder dystocia (1.5% vs. 4.0%), and cesarean delivery (26.9% vs.”
Quote in the paperSubstantial claim - Findingown data
Maternal glucose data from the treatment group indicated that target glycemic thresholds were achieved.
“Data on maternal glucose levels from women in the treatment group indicated that target glycemic thresholds were achieved (Table 5).”
Quote in the paperSubstantial claim - Findingown data
In women with mild gestational diabetes, treatment with dietary intervention, self-monitoring, and insulin if needed, compared with usual prenatal care, did not significantly reduce the composite primary outcome of stillbirth or perinatal death plus neonatal complications (32.4% vs 37.0%; RR 0.87; 97% CI 0.72-1.07; P=0.14).
“We observed no significant difference between groups in the frequency of the composite outcome (32.4% and 37.0% in the treatment and control groups, respectively; P = 0.14).”
- Also stated in: § PERINATAL AND NEONATAL OUTCOMES · plain
“We observed no significant difference between the treatment group and the control group in the frequency of the composite primary perinatal outcome (32.4% and 37.0 %, respectively; relative risk, 0.87; 97% confidence interval [CI], 0.72 to 1.07; P = 0.14) (Table 2).”
Quote in the paperSubstantial claim - Also stated in: § PERINATAL AND NEONATAL OUTCOMES · plain
- Findingown data
Neonatal fat mass was significantly lower in the treatment group than in the control group (427 vs 464 g).
“However, there were significant reductions with treatment as compared with usual care in several prespecified secondary outcomes, including mean birth weight (3302 vs. 3408 g), neonatal fat mass (427 vs. 464 g), the frequency of large-for-gestational-age infants (7.1% vs. 14.5%), birth weight greater than 4000 g (5.9% vs. 14.3%), shoulder dystocia (1.5% vs. 4.0%), and cesarean delivery (26.9% vs.”
Quote in the paperNot a substantial claim - Findingown data
No perinatal deaths occurred in either the treatment or control group.
“There were no perinatal deaths.”
- Also stated in: § PERINATAL AND NEONATAL OUTCOMES · plain
“There were no perinatal deaths in either group.”
Quote in the paperNot a substantial claim - Also stated in: § PERINATAL AND NEONATAL OUTCOMES · plain
- Findingown data
After excluding abnormal presentation, placenta previa, oligohydramnios, and previous cesarean delivery, the cesarean delivery rate remained lower in the treatment group than in the control group (13.0% vs 19.7%; P=0.01).
“After excluding cases of abnormal presentation, placenta previa, oligohydramnios, and previous cesarean delivery, the cesarean delivery rate remained lower in the treatment group than in the control group (13.0% vs. 19.7%, P = 0.01).”
Quote in the paperSubstantial claim - Findingown data
The frequency of intravenous glucose administration in the newborn did not differ significantly between treatment and control.
“The frequency of intravenous glucose administration in the newborn did not differ significantly between groups.”
Quote in the paperNot a substantial claim - Study design and conductreasoning
With an assumed control composite outcome rate of 25%, a sample of 950 (475 per group) gave at least 80% power to detect a 30% treatment difference in the composite outcome, with a two-sided type I error of 5%.
“Assuming a composite outcome rate in the control group of 25%, we calculated that with a sample size of 950 (475 per group), the study would have at least 80% power to show a 30% difference in the composite outcome with treatment, with a type I error of 5% (two-sided).”
Quote in the paperSubstantial claim - Study design and conductreasoning
Including a matched cohort of women without gestational diabetes in the control group masked control women's gestational diabetes status from patients, caregivers, and study staff.
“By including this group of women who did not have gestational diabetes mellitus, the patients, their caregivers, and the study staff were unaware of whether women in the control group met the criteria for the diagnosis of mild gestational diabetes mellitus.”
Quote in the paperSubstantial claim - Study design and conductreasoning
Oral glucose-tolerance test results were not disclosed to caregivers or control subjects, to minimize self-treatment.
“We did not disclose the results of oral glucose-tolerance tests to caregivers or subjects in the control group in order to minimize the likelihood of self-treatment, which has been a limitation in pilot studies of treatment of gestational diabetes mellitus.22,23”
Quote in the paperSubstantial claim0 of 2 sources checked - Study design and conductcitation
The sample size also gave more than 85% power to detect a 30% reduction in large-for-gestational-age infants and infants with birth weight greater than 4000 g.
“This sample size also provided more than 85% power to show a reduction of 30% in the rate of both large-for-gestational age infants (birth weight >90th percentile) and infants with birth weight greater than 4000 g.24”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [24] source
- Interpretationown data
Treatment of mild gestational diabetes reduces the risk of fetal overgrowth.
“Although treatment of mild gestational diabetes mellitus did not significantly reduce the frequency of a composite outcome that included stillbirth or perinatal death and several neonatal complications, it did reduce the risks of fetal overgrowth, shoulder dystocia, cesarean delivery, and hypertensive disorders.”
Quote in the paperSubstantial claim - Interpretationown data
Treatment of mild gestational diabetes reduces the risk of hypertensive disorders.
“Although treatment of mild gestational diabetes mellitus did not significantly reduce the frequency of a composite outcome that included stillbirth or perinatal death and several neonatal complications, it did reduce the risks of fetal overgrowth, shoulder dystocia, cesarean delivery, and hypertensive disorders.”
Quote in the paperSubstantial claim - Premisecitation
Insulin resistance, a characteristic of gestational diabetes, has been associated with development of preeclampsia.
“Insulin resistance, a characteristic of gestational diabetes mellitus, has been associated with the development of preeclampsia.31”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [31] source
- Study design and conductnone given
Both this trial and ACHOIS lacked sufficient power to detect significant differences in uncommon adverse outcomes such as brachial plexus injury.
“However, both trials lacked sufficient power to detect significant differences in uncommon adverse outcomes such as injury to the brachial plexus.”
Quote in the paperNot a substantial claim - Interpretationown data
Treatment of mild gestational diabetes reduces the risk of cesarean delivery.
“Although treatment of mild gestational diabetes mellitus did not significantly reduce the frequency of a composite outcome that included stillbirth or perinatal death and several neonatal complications, it did reduce the risks of fetal overgrowth, shoulder dystocia, cesarean delivery, and hypertensive disorders.”
Quote in the paperSubstantial claim - Premisecitation
The HAPO study suggested that a threshold for increased risk of clinical neonatal hypoglycemia may not appear until fasting maternal glucose exceeds 100 mg/dL.
“The results from the HAPO study suggested that a threshold for an increased risk of clinical neonatal hypoglycemia may not be apparent until fasting maternal glucose levels exceed 100 mg per deciliter (5.6 mmol per liter).6”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [6] source
- Study design and conductreasoning
Because control-group glycemia was not assessed, it is unknown whether intensive treatment reduced glycemic levels relative to standard obstetrical care.
“However, as a result, we could not assess glycemia in women in the control group, and thus it is not known whether intensive treatment of gestational diabetes mellitus reduced glycemic levels relative to standard obstetrical care.”
Quote in the paperSubstantial claim - Premisecitation
Cesarean delivery rates have been consistently higher in pregnancies with diagnosed gestational diabetes.
“Rates of cesarean delivery have been consistently higher in pregnancies in which gestational diabetes mellitus has been diagnosed.24,30”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [24] source
- cites [30] Cousins L. Obstetric complications in diabetic pregnancies. In: Reece EA, Coustan DR, Gabbe SG, eds. Diabetes in women: adolescence, pregnancy, and menopause. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2004:351-70.
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Premisecitation
The diagnostic thresholds developed by O'Sullivan and Mahan were based on later development of adult-onset diabetes and not on any association between gestational carbohydrate intolerance and adverse pregnancy outcomes.
“The diagnostic thresholds that they developed were based on the subsequent development of adult-onset diabetes and were not predicated on any association between carbohydrate intolerance discovered during gestation and adverse pregnancy outcomes.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [3] O'Sullivan JB, 1964, Diabetes
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Premisecitation
The HAPO study showed a continuous linear association between glucose-tolerance test results and rates of preeclampsia.
“The HAPO study showed a continuous linear association between the results of glucose-tolerance tests and rates of preeclampsia.6”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [6] source
- Premisecitation
Increased birth weight and neonatal fat mass may have long-term health implications for offspring of mothers with gestational diabetes, including higher risk of impaired glucose tolerance and childhood obesity.
“Increased birth weight and neonatal fat mass may have long-term health implications for the offspring of mothers with gestational diabetes mellitus, including an increased risk of impaired glucose tolerance and childhood obesity.27,28”
Quote in the paperNot a substantial claim0 of 2 sources checked - Interpretationreasoning
The absence of treatment effect on newborn metabolic abnormalities in this trial and ACHOIS may be partly because those outcomes are most consistently linked to more severe glucose elevations than those in the two study populations.
“The lack of treatment effect in reducing metabolic abnormalities of the newborn in our study as well as in the ACHOIS trial may be due in part to the fact that these adverse outcomes are most consistently associated with more severe glucose elevations than those that were present in these two study populations.”
Quote in the paperSubstantial claim - Interpretationown data
Treatment of mild gestational diabetes reduces the risk of shoulder dystocia.
“Although treatment of mild gestational diabetes mellitus did not significantly reduce the frequency of a composite outcome that included stillbirth or perinatal death and several neonatal complications, it did reduce the risks of fetal overgrowth, shoulder dystocia, cesarean delivery, and hypertensive disorders.”
Quote in the paperSubstantial claim
- Classified as probably not a substantial claim. 12
- May combine two claims. 12
- The quote only partly states this claim. 1
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductcitationRandomization was performed by the coordinating center using the simple urn method, stratified by clinical center.
“Women who met these criteria were randomly assigned by the coordinating center, with the use of the simple urn method,11 stratified by clinical center.”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [11] source
May combine two claims.
PremisecitationACHOIS showed that treatment did not reduce rates of symptomatic neonatal hypoglycemia or jaundice requiring phototherapy.
“The results of the ACHOIS trial showed that treatment did not reduce the rates of symptomatic neonatal hypoglycemia or jaundice requiring phototherapy.8”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [8] source
The primary-outcomes results report no significant difference in jaundice requiring phototherapy. Table 4 in the secondary-outcomes section reports no significant reduction in neonatal hypoglycemia requiring IV therapy, but the paper does not identify that outcome as symptomatic hypoglycemia. No page numbers are available in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measured
May combine two claims.
PremisecitationSeveral professional organizations have recommended screening most pregnant women for gestational diabetes despite little evidence that identifying and treating mild carbohydrate intolerance confers benefit.
“Several professional organizations have recommended screening for gestational diabetes mellitus for most pregnant women despite little evidence that the identification and treatment of mild carbohydrate intolerance during pregnancy confer a benefit.1,7”
Quote in the paperSubstantial claim2 of 2 sources checked- cites [1] 2006, Diabetes Care source
The “Diagnosis of GDM” section recommends testing women at average or high risk and says that earlier recommendations called for screening all pregnancies. It does not assess whether identifying and treating mild carbohydrate intolerance confers benefit, or establish recommendations by several professional organizations. (LLM, conf=0.87)
Experimental — accuracy not yet measured - cites [7] 2001, Obstet Gynecol sourceExperimental — accuracy not yet measured
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationGestational diabetes is a recognized marker for increased risk of subsequent diabetes.
“Although gestational diabetes mellitus is a recognized marker for an increased risk of subsequent diabetes, its clinical significance with respect to various adverse pregnancy outcomes has been uncertain.2,4”
Quote in the paperNot a substantial claim2 of 2 sources checked- cites [2] source
Two searches of Jovanovic’s 2001 JAMA paper, “Gestational Diabetes Mellitus,” returned no full-text snippets, so the attributed statement could not be checked directly. An unscoped search found the same general finding in “Characterization of Former Gestational Diabetes Mellitus” (score 0.711), but that does not show Jovanovic’s paper omits it or that the claim belongs exclusively to another source. The available evidence does not justify a misattribution verdict. (LLM, conf=0.62)
Experimental — accuracy not yet measured - cites [4] source
Semantic Scholar does not index the cited Buchanan and Kjos (1999) paper, so its abstract and full text could not be checked. Other papers support the general claim: a retrospective account of Buchanan and Kjos’s research reports that women with gestational diabetes had a high risk of developing diabetes within five years (search score 0.592). That account does not establish that the specific 1999 paper makes the claim, and no distinct source met the threshold for misattribution. (LLM, conf=0.60)
Experimental — accuracy not yet measured
Classified as probably not a substantial claim. May combine two claims.
PremisecitationACHOIS concluded that treatment reduces serious perinatal complications and may improve health-related quality of life.
“The Australian Carbohydrate Intolerance Study in Pregnant Women (ACHOIS), a large, randomized trial of treatment for gestational diabetes mellitus, concluded that treatment reduces serious perinatal complications and may also improve health-related quality of life.8”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [8] source
May combine two claims.
Findingown dataBody-mass index at delivery and weight gain from enrollment to delivery were lower in the treatment group than in the control group.
“Both the body-mass index at delivery and weight gain from enrollment to delivery were lower among women in the treatment group than among those in the control group (Table 4).”
Quote in the paperNot a substantial claimThe quote only partly states this claim.
Findingown dataCesarean delivery was significantly less common in the treatment group than in the control group (26.9% vs 33.8%; P=0.02).
“However, there were significant reductions with treatment as compared with usual care in several prespecified secondary outcomes, including mean birth weight (3302 vs. 3408 g), neonatal fat mass (427 vs. 464 g), the frequency of large-for-gestational-age infants (7.1% vs. 14.5%), birth weight greater than 4000 g (5.9% vs. 14.3%), shoulder dystocia (1.5% vs. 4.0%), and cesarean delivery (26.9% vs.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe rates of neonatal hypoglycemia, hyperbilirubinemia, birth trauma, and elevated cord-blood C-peptide did not differ significantly between treatment and control.
“The individual rates of neonatal hypoglycemia, hyperbilirubinemia, birth trauma, and elevated cord-blood C-peptide level did not differ significantly between the two groups.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenAn external data and safety monitoring committee periodically reviewed trial results.
“During the course of the trial, an external data and safety monitoring committee periodically reviewed the trial results.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductown dataCompliance with glycemic monitoring was verified, and whether target glucose thresholds were achieved was documented.
“In contrast with previous randomized trials involving women with gestational diabetes mellitus, we verified compliance with glycemic monitoring and documented whether target glucose thresholds were achieved.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenAll cases of hypertensive disorders and shoulder dystocia underwent masked central review by two authors to ensure diagnostic accuracy.
“All cases of hypertensive disorders and shoulder dystocia underwent masked central review by two of the authors to ensure that the diagnoses were accurate.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductnone givenThe primary analysis followed the intention-to-treat principle.
“The primary analysis of the clinical trial was conducted according to the intention-to-treat principle.”
Quote in the paperSubstantial claimMay combine two claims.
Study design and conductown dataBaseline demographic variables and oral glucose-tolerance test results did not differ significantly between treatment and control.
“There were no significant differences in demographic variables or results of the oral glucose-tolerance test between the women in the treatment group and those in the control group.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
PremisecitationAssociations among macrosomia, shoulder dystocia, and increased risk of brachial plexus injury in offspring of women with diabetes are well documented.
“Associations among macrosomia, shoulder dystocia, and the increased risk of brachial plexus injury in the offspring of women with diabetes are well documented.26”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [26] McFarland LV, 1986, Obstet Gynecol
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
May combine two claims.
InterpretationreasoningThe overall preeclampsia rate in this study was substantially lower than in ACHOIS, probably because this study used more stringent diagnostic criteria.
“The overall rate of preeclampsia in our study was substantially lower than that in the ACHOIS study, which is probably explained by our use of more stringent diagnostic criteria.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationNaylor and colleagues suggested that recognizing maternal gestational diabetes may lower the threshold for operative delivery, mitigating potential benefits of treatment in reducing fetal overgrowth.
“Naylor and colleagues suggested that simply the recognition that the mother has gestational diabetes mellitus may lead to a lower threshold for operative delivery, thus mitigating the potential benefits of treatment in reducing fetal overgrowth.24”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [24] source
May combine two claims.
Premisenone givenACHOIS included an ethnically homogeneous group with greater hyperglycemia than this study's more diverse population.
“The ACHOIS trial, however, included an ethnically homogeneous group of women who had a greater degree of hyperglycemia than that in our more diverse study population.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
PremisecitationDiagnosis or knowledge of gestational diabetes has been reported to be associated with an increase in several adverse maternal outcomes.
“The diagnosis of gestational diabetes mellitus, or the knowledge that it is present, has been reported to be associated with an increase in several adverse maternal outcomes.29”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [29] source
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationHypertensive disorders of pregnancy are associated with increased maternal complications and are a major contributor to preterm delivery among women with gestational diabetes.
“Hypertensive disorders of pregnancy are associated with an increased rate of maternal complications and are a major contributor to preterm delivery among women with gestational diabetes mellitus.30”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [30] Cousins L. Obstetric complications in diabetic pregnancies. In: Reece EA, Coustan DR, Gabbe SG, eds. Diabetes in women: adolescence, pregnancy, and menopause. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2004:351-70.
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Classified as probably not a substantial claim.
PremisecitationThe 2008 U.S. Preventive Services Task Force guidelines concluded that evidence was insufficient to assess the balance of benefit and harm for screening and treatment of gestational diabetes.
“Despite these findings, the 2008 guidelines of the U.S. Preventive Services Task Force again concluded that current evidence is insufficient to assess the balance between benefit and harm with respect to the screening and treatment of gestational diabetes mellitus.9”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [9] 2008, Ann Intern Med source
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Interpretationnone givenLabor induction and cesarean delivery may be less common in academic medical centers, including the centers in this study.
“Labor induction and cesarean delivery may be less commonly performed in academic medical centers, including the centers that participated in this study.”
Quote in the paperNot a substantial claim
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the ACHOIS study, the composite endpoint was significantly reduced with antihyperglycemic intervention, and there was lower weight gain by 1.7 kg on average and lower incidence of LGA.
“In the ACHOIS study, the composite endpoint (neonatal death, perinatal injury, hyperbilirubinemia, neonatal hypoglycemia and hyperinsulinemia) was significantly reduced with antihyperglycemic intervention, and there was also a lower weight gain (by 1.7 kg on average) and a lower incidence of LGA.”
From Gestational Diabetes Mellitus—Recent Literature Review (2022) · cites this paper as [29]
The Discussion reports that ACHOIS found fewer serious perinatal complications with treatment. But the listed composite components are this paper’s own primary outcome, not an ACHOIS endpoint established by the cited passages. The Results report lower weight gain and fewer large-for-gestational-age infants in this paper’s trial, without establishing the claimed 1.7 kg difference for ACHOIS. (LLM, conf=0.89)
Experimental — accuracy not yet measuredThe expected benefits of using IADPSG criteria to the offspring are inferred from intervention trials that focused on individuals with lower levels of hyperglycemia than those identified using older GDM diagnostic criteria; those trials found modest benefits, including reduced rates of large-for-gestational-age births and preeclampsia.
“The expected bene fi ts of using IADPSG criteria to the offspring are inferred from intervention trials that focused on individuals with lower levels of hyperglycemia than those identi fi ed using older GDM diagnostic criteria. Those trials found modest bene fi ts, including reduced rates of largefor-gestational-age births and preeclampsia (211,212).”
From 2. Diagnosis and Classification of Diabetes: <i>Standards of Care in Diabetes—2024</i> (2024) · cites this paper as [211]
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured80-90% of participants being treated for mild GDM in two randomized controlled trials could be managed with lifestyle therapy alone.
“It is important to note that 80 -90% of participants being treated for mild GDM in these two randomized controlled trials could be managed with lifestyle therapy alone.”
From 2. Diagnosis and Classification of Diabetes: <i>Standards of Care in Diabetes—2024</i> (2024) · cites this paper as [211]
The Results (Maternal Outcomes) report that 37 of 485 women in this trial’s treatment group required insulin, so about 92% did not. That supports the point that most were managed without insulin, but the figure is slightly above the stated 80–90% range. The paper’s Discussion mentions the ACHOIS trial but does not give a corresponding lifestyle-only percentage for it. (LLM, conf=0.85)
Experimental — accuracy not yet measured80-90% of participants being treated for mild GDM in these two randomized controlled trials could be managed with lifestyle therapy alone.
“Of note, 80-90% of participants being treated for mild GDM in these two randomized controlled trials could be managed with lifestyle therapy alone.”
From 2. Diagnosis and classification of diabetes: standards of care in diabetes-2025 (2025) · cites this paper as [194]
The Results (Maternal Outcomes) report that 37 of 485 women in the treatment group required insulin, implying that about 92% were managed without it. That supports the lifestyle-only point for this trial, though the figure is slightly above 80–90%; the Discussion mentions the second trial but does not give its insulin-use rate. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIdentification and treatment of gestational diabetes mellitus defined by elevated glucose concentrations following a glucose load is supported by high quality evidence.
“women should be counselled that identification and treatment of gestational diabetes mellitus defined by elevated glucose concentrations following a glucose load is supported by high quality evidence, 15 , 16”
From Australasian Diabetes in Pregnancy Society ( <scp>ADIPS</scp> ) 2025 consensus recommendations for the screening, diagnosis and classification of gestational diabetes (2025) · cites this paper as [16]
The Methods identify mild gestational diabetes using an oral glucose-tolerance test, and the Results report improvements in several outcomes with treatment. But the trial did not test whether identifying or screening for the condition improves outcomes, and its primary composite outcome did not differ significantly between groups. It therefore supports treatment for this defined group, not the full, unqualified claim about identification and treatment. (LLM, conf=0.85)
Experimental — accuracy not yet measured
The recommended approach to screening and diagnosis of gestational diabetes mellitus is based on available trial evidence.
“This approach is based on available trial evidence, 15 , 16”
From Australasian Diabetes in Pregnancy Society ( <scp>ADIPS</scp> ) 2025 consensus recommendations for the screening, diagnosis and classification of gestational diabetes (2025) · cites this paper as [16]
The Discussion (page not available) says this randomized trial provides evidence of a modest benefit from identifying and treating women with mild gestational diabetes, and that its findings complement work toward a diagnostic consensus. It does not establish that a recommended screening and diagnostic approach is based on trial evidence; the introductory passage notes that screening had been recommended despite limited evidence and that the USPSTF found the evidence insufficient. (LLM, conf=0.84)
Experimental — accuracy not yet measuredTwo randomized clinical trials in women with GDM demonstrated improvement of pregnancy outcomes in women identified with and treated for GDM compared with women left untreated.
“Two randomized clinical trials (RCTs) in women with GDM demonstrated the improvement of these pregnancy outcomes in women identified with and treated for GDM compared with women left untreated [6,7].”
From Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications (2022) · cites this paper as [6]
In the original study, treatment did not demonstrate a reduction in the incidence of the primary outcome compared to usual care.
“Although in the original study treatment did not demonstrate a reduction in the incidence of the primary outcome compared to usual care”
From Carpenter-Coustan Compared With National Diabetes Data Group Criteria for Diagnosing Gestational Diabetes (2016) · cites this paper as [12]
In the primary study, treatment of mild GDM reduced the risk of large for gestational age infants.
“large for gestational age infants”
From Carpenter-Coustan Compared With National Diabetes Data Group Criteria for Diagnosing Gestational Diabetes (2016) · cites this paper as [12]
In the primary study, treatment of mild GDM reduced the risk of shoulder dystocia.
“shoulder dystocia”
From Carpenter-Coustan Compared With National Diabetes Data Group Criteria for Diagnosing Gestational Diabetes (2016) · cites this paper as [12]
In the primary study, treatment of mild GDM reduced the risk of cesarean delivery.
“cesarean delivery”
From Carpenter-Coustan Compared With National Diabetes Data Group Criteria for Diagnosing Gestational Diabetes (2016) · cites this paper as [12]
In the primary study, treatment of mild GDM reduced neonatal fat mass.
“neonatal fat mass”
From Carpenter-Coustan Compared With National Diabetes Data Group Criteria for Diagnosing Gestational Diabetes (2016) · cites this paper as [12]
In the primary study, treatment of mild GDM reduced maternal gestational weight gain.
“Treatment of mild GDM also reduced maternal gestational weight gain”
From Carpenter-Coustan Compared With National Diabetes Data Group Criteria for Diagnosing Gestational Diabetes (2016) · cites this paper as [12]
In the primary study, treatment of mild GDM reduced the risk of pregnancy-induced hypertension.
“In the primary study, treatment of mild GDM reduced the risk of pregnancy-induced hypertension”
From Carpenter-Coustan Compared With National Diabetes Data Group Criteria for Diagnosing Gestational Diabetes (2016) · cites this paper as [12]
In the primary study, treatment of mild GDM reduced the risk of macrosomia.
“macrosomia”
From Carpenter-Coustan Compared With National Diabetes Data Group Criteria for Diagnosing Gestational Diabetes (2016) · cites this paper as [12]
The primary study's composite neonatal outcome was not reduced by treatment.
“A number needed to treat was not calculated for the composite neonatal outcome, as this was not reduced by treatment in the original study.”
From Carpenter-Coustan Compared With National Diabetes Data Group Criteria for Diagnosing Gestational Diabetes (2016) · cites this paper as [12]
Treatment of even mild forms of glucose intolerance in GDM offers an added benefit.
“The treatment of even mild forms of glucose intolerance in GDM offers an added benefit, as demonstrated by the Australian Carbohydrate Intolerance Study in Pregnant Women (ACHOIS) and Maternal-Fetal Medicine Units Network (MFMU).”
From Gestational Diabetes Mellitus—Recent Literature Review (2022) · cites this paper as [29]
In the MFMU study, no changes were noted in the composite endpoint, but the incidence of LGA and shoulder dystocia decreased significantly.
“In the MFMU study, no changes were noted in the composite endpoint, but the incidence of LGA and shoulder dystocia decreased significantly [2,29,30].”
From Gestational Diabetes Mellitus—Recent Literature Review (2022) · cites this paper as [29]
Although two RCTs found that treatment of GDM can reduce perinatal morbidity, it is not known whether treatment reduces long-term risks in children.
“Although two RCTs found that treatment of GDM can reduce perinatal morbidity (264,265), it is not known whether treatment reduces long-term risks in children.”
From Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus (2023) · cites this paper as [265]
Intervention trials focusing on individuals with lower levels of hyperglycemia than those identified using older GDM diagnostic criteria found modest benefits, including reduced rates of large-for-gestational-age births and preeclampsia.
“Those trials found modest benefits, including reduced rates of largefor-gestational-age births and preeclampsia (194,195).”
From 2. Diagnosis and classification of diabetes: standards of care in diabetes-2025 (2025) · cites this paper as [194]
Follow-up of the children in both these studies at 4 to 5 and 7 years of age, respectively, failed to observe differences in limited indicators of child adiposity between children of mothers with treated GDM and those with untreated GDM.
“Follow-up of the children in both these studies at 4 to 5 (264-266) and 7 years of age (267), respectively, failed to observe differences in limited indicators of child adiposity between children of mothers with treated GDM and those with untreated GDM.”
From Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus (2023) · cites this paper as [265]
The Results (Perinatal and Neonatal Outcomes; page unavailable) report birth weight and neonatal fat mass, not adiposity at ages 4–5 or 7. The Discussion says long-term follow-up studies are needed to determine whether treatment affects childhood outcomes. Searches for follow-up and childhood adiposity found no results at either age in our copy. (LLM, conf=0.78)
Experimental — accuracy not yet measuredBlood glucose-lowering pharmacological therapy is effective at improving outcomes in women with gestational diabetes whose hyperglycemia does not respond sufficiently to lifestyle therapy.
“Blood glucose-lowering pharmacological therapy is effective at improving outcomes in women with gestational diabetes whose hyperglycemia does not respond sufficiently to lifestyle therapy (71, 82, 88–90).”
From Diabetes and Pregnancy: An Endocrine Society Clinical Practice Guideline (2013) · cites this paper as [71]
The ACHOIS and MFMU RCTs, despite using different diagnostic tests and criteria, produced quite similar treatment outcomes.
“Although the diagnostic tests and criteria used in the 2 RCTs differed substantially, treatment outcomes were quite similar (Table 1)”
From Gestational Diabetes Mellitus (2019) · cites this paper as [13]
Lifestyle interventions have been attributed with decreased risk of macrosomia, decreased neonatal adiposity, and increased likelihood of achieving postpartum weight goals.
“Multiple benefits have been attributed to lifestyle interventions, including decreased risk of macrosomia, decreased neonatal adiposity, and increased likelihood to achieve postpartum weight goals.12,13,50”
From Gestational Diabetes Mellitus (2019) · cites this paper as [13]
MNT is a cornerstone of therapy for all women with GDM, and approximately 80% to 90% of women meet therapeutic targets with MNT alone.
“Medical nutrition therapy (MNT) is a cornerstone of therapy for all women with GDM, and approximately 80% to 90% of women are able to meet therapeutic targets with MNT alone.12,13”
From Gestational Diabetes Mellitus (2019) · cites this paper as [13]
Maternal glycemia relates to birth weight.
“which fits with other data showing that maternal glycemia relates to birth weight.21–23”
From Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition and metabolic outcomes at 7-9 years of age (2018) · cites this paper as [22]
Two randomized trials showed that treatment of mild gestational diabetes, predominantly with diet, compared with standard pregnancy care was associated with improved pregnancy outcomes.
“There are two randomized trials showing that treatment of mild GDM (predominantly with diet) compared with standard pregnancy care was associated with improved pregnancy outcomes (22,23)”
From Metformin in Gestational Diabetes: The Offspring Follow-Up (MiG TOFU) (2011) · cites this paper as [23]
When mild gestational diabetes was recognized and treated, relative risks for some major immediate adverse outcomes were significantly reduced by similar proportions: 40% to 60% for large-for-gestational-age and macrosomic babies and 30% to 40% for hypertensive disorders of pregnancy.
“As shown in Table 3, the relative risk for some of the main adverse immediate outcomes were significantly reduced, by similar proportions of 40% to 60% for LGA and macrosomic babies and 30% to 40% for hypertensive disorders of pregnancy, when mild GDM was recognized and treated.”
From One-step or 2-step testing for gestational diabetes: which is better? (2021) · cites this paper as [29]
Applying Landon et al's 51% large-for-gestational-age reduction and 37% preeclampsia/hypertensive disorder reduction yields relative risks of 1.16 for large-for-gestational-age and 1.12 for hypertensive disorders, below the 1.2 used in sample size estimates.
“The Landon et al 29 study, a similar RCT to the ACHOIS study, but which used the more stringent diagnostic criteria of the 2-step procedure as long as the fasting plasma glucose was <95 mg/ dL, demonstrated a 51% reduction in LGA and a 37% reduction in preeclampsia and hypertensive disorders.Applying these reductions as above would yield relative risks of 1.16 for LGA Clinical Opinion ajog.org and”
From One-step or 2-step testing for gestational diabetes: which is better? (2021) · cites this paper as [29]
The Maternal-Fetal Medicine Units Network study had a design similar to ACHOIS but used Carpenter and Coustan criteria for the 100 g 3-hour OGTT when fasting plasma glucose was below 95 mg/dL.
“The Maternal-Fetal Medicine Units Network study 29 was similar to ACHOIS in its design but used the Carpenter and Coustan criteria for the 100 g, 3-hour OGTT 9 as long as the fasting plasma glucose level was <95 mg/dL.”
From One-step or 2-step testing for gestational diabetes: which is better? (2021) · cites this paper as [29]
In the two trials of mild gestational diabetes, 10% to 20% of patients required pharmacologic treatment in addition to medical nutritional therapy.
“the two trials that focused on the treatment of”
From Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus (2011) · cites this paper as [175]
Treatment of gestational diabetes mellitus reduces the frequency of macrosomia.
“Both studies found that treatment of GDM can reduce both serious adverse outcomes and the frequency of large babies (macrosomia) (174,175).”
From Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus (2011) · cites this paper as [175]
Two randomized clinical trials showed that treating mild gestational diabetes mellitus provides benefit.
“Two randomized clinical trials have now demonstrated a benefit from the treatment of”
From Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus (2011) · cites this paper as [175]
Treatment of gestational diabetes mellitus reduces serious adverse outcomes.
“Both studies found that treatment of GDM can reduce both serious adverse outcomes and the frequency of large babies (macrosomia) (174,175).”
From Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus (2011) · cites this paper as [175]
Unlike this study, the studies by Metzger et al., Crowther et al., and Landon et al. excluded women with greater degrees of hyperglycaemia.
“Unlike our study, Metzger et al. [2], Crowther et al. [10] and Landon et al. [11] excluded women with greater degrees of hyperglycaemia.”
From Atlantic Diabetes in Pregnancy (DIP): the prevalence and outcomes of gestational diabetes mellitus using new diagnostic criteria (2011) · cites this paper as [11]
The prevalence of maternal adverse events in this study is similar to the routine care groups in the Crowther et al. and Landon et al. studies.
“Considering this, the prevalence of the various maternal adverse events is similar to the 'routine care' groups in the Crowther et al. [10] and Landon et al. [11] studies.”
From Atlantic Diabetes in Pregnancy (DIP): the prevalence and outcomes of gestational diabetes mellitus using new diagnostic criteria (2011) · cites this paper as [11]
Expected benefits to pregnancies and offspring of women diagnosed with GDM by the new criteria are inferred from intervention trials that focused on women with more mild hyperglycemia than identified using older GDM diagnostic criteria and that found modest benefits.
“Expected benefits to their pregnancies and offspring is inferred from intervention trials that focused on women with more mild hyperglycemia than identified using older GDM diagnostic criteria and that found modest benefits (15,16).”
From Diagnosis and classification of diabetes mellitus (2013) · cites this paper as [15]
80-90% of women in both mild GDM studies could be managed with lifestyle therapy alone.
“It is important to note that 80–90% of women in both of the mild GDM studies (whose glucose values overlapped with the thresholds recommended herein) could be managed with lifestyle therapy alone.”
From Diagnosis and classification of diabetes mellitus (2013) · cites this paper as [15]
Positive fasting glucose-birthweight effects were also seen in the IV of glucose as an intermediate in an RCT and IV MR studies.
“Positive fasting glucose-birthweight effects were also seen in the IV of glucose as an intermediate in an RCT57 and IV MR studies.55”
From Triangulation in aetiological epidemiology (2017) · cites this paper as [57]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Birth-weight cutoff differs between methods and results
MinorThe prespecified outcome excludes infants weighing exactly 4000 g, but the results describe an outcome that includes them. The text does not establish which cutoff was used for the reported comparison.
“Secondary prespecified neonatal outcome measures included birth weight greater than 4000 g”
“the frequency of large-for-gestational age infants and of infants with a birth weight of 4000 g or greater, were significantly reduced in the treatment group”
Birth-weight threshold changes at exactly 4000 g
MinorThe prespecified outcome excludes infants weighing exactly 4000 g, but the results describe the outcome as including them. The two definitions classify infants at that weight differently.
“Secondary prespecified neonatal outcome measures included birth weight greater than 4000 g, large size for gestational age”
“the frequency of large-for-gestational age infants and of infants with a birth weight of 4000 g or greater, were significantly reduced”
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Cites a retracted work: W4300627291
InfoThe cited work was retracted; the date of the notice is not on record.
Cited work W4300627291 · retraction date not known · this paper published 2009-10
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“Both studies found that treatment of GDM can reduce both serious adverse outcomes and the frequency of large babies (macrosomia) (174,175).”
2. Diagnosis and classification of diabetes: standards of care in diabetes-2025
American Diabetes Association Professional Practice Committee, ElSayed, N. A., McCoy, R. G., Aleppo, G., Balapattabi, K., Beverly, E. A., Briggs Early, K., Bruemmer, D., Ebekozien, O., Echouffo-Tcheugui, J. B., et al. (2025) · Diabetes Care · doi:10.2337/dc25-s002 · Cited by 1,393 · see citing works
Wang, H., Li, N., Chivese, T., Werfalli, M., Sun, H., Yuen, L., Hoegfeldt, C. A., Elise Powe, C., Immanuel, J., Karuranga, S., et al. (2022) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.109050 · Cited by 1,260 · see citing works
Triangulation in aetiological epidemiology
Lawlor, D. A., Tilling, K., & Davey Smith, G. (2017) · International Journal of Epidemiology · doi:10.1093/ije/dyw314 · Cited by 1,129 · see citing works
“This enabled us to compare results from multivariable regression in pregnancy cohorts,55 a cross-context comparison using data from the Born in Bradford (BiB) study,56 an MR study55 and IV analyses of an intermediate (fasting glucose) in an RCT.57 Table 3 Figure 2.”
Method2. Classification and Diagnosis of Diabetes
American Diabetes Association (2015) · Diabetes Care · doi:10.2337/dc16-s005 · Cited by 1,087 · see citing works
The Hyperglycemia and Adverse Pregnancy Outcome Study
Catalano, P. M., McIntyre, H. D., Cruickshank, J. K., McCance, D. R., Dyer, A. R., Metzger, B. E., Lowe, L. P., Trimble, E. R., Coustan, D. R., Hadden, D. R., et al. (2012) · Diabetes Care · doi:10.2337/dc11-1790 · Cited by 954 · see citing works
Self-citationType 2 diabetes across generations: from pathophysiology to prevention and management
Nolan, C. J., Damm, P., & Prentki, M. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60614-4 · Cited by 923 · see citing works
A Clinical Update on Gestational Diabetes Mellitus
Sweeting, A., Wong, J., Murphy, H. R., & Ross, G. P. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac003 · Cited by 928 · see citing works
Gestational diabetes mellitus: mechanisms, treatment, and complications
Johns, E. C., Denison, F. C., Norman, J. E., & Reynolds, R. M. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2018.09.004 · Cited by 828 · see citing works
Thangaratinam, S., Rogozinska, E., Jolly, K., Glinkowski, S., Roseboom, T., Tomlinson, J. W., Kunz, R., Mol, B. W., Coomarasamy, A., & Khan, K. S. (2012) · BMJ · doi:10.1136/bmj.e2088 · Cited by 802 · see citing works
Hod, M., Kapur, A., Sacks, D. A., Hadar, E., Agarwal, M., Di Renzo, G. C., Roura, L. C., McIntyre, H. D., Morris, J. L., & Divakar, H. (2015) · International Journal of Gynecology & Obstetrics · doi:10.1016/s0020-7292(15)30033-3 · Cited by 767 · see citing works
“[26] demonstrated that newborns of diabetic mothers suffered from hypoglycemia and hypothesized that this was due to fetal hyperinsulinism as a result of increased transplacental transfer of sugar.”
BackgroundGestational Diabetes Mellitus: Risks and Management during and after Pregnancy
Buchanan, T. A., Xiang, A. H., & Page, K. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.96 · Cited by 718 · see citing works
Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Kirkman, M. S., Lernmark, A., Metzger, B. E., & Nathan, D. M. (2011) · Diabetes Care · doi:10.2337/dc11-9998 · Cited by 718 · see citing works
“Both studies found that treatment of GDM can reduce both serious adverse outcomes and the frequency of large babies (macrosomia) (174,175).”
Clinical Care Guidelines for Cystic Fibrosis–Related Diabetes
Moran, A., Brunzell, C., Cohen, R. C., Katz, M., Marshall, B. C., Onady, G. M., Robinson, K. A., Sabadosa, K. A., Stecenko, A. A., & Slovis, B. S. (2010) · Diabetes Care · doi:10.2337/dc10-1768 · Cited by 733 · see citing works
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works
“The hyperglycemic condition in DM may result in chronic vascular effects such as nephropathy, neuropathy, stroke, cardiovascular disease, kidney damage, and fatty liver.(72,73) For the management of diabetes, a monitoring programme is necessary to help to control the conditions and consequence complications through th…”
BackgroundPoston, L., Bell, R., Croker, H., Flynn, A. C., Godfrey, K. M., Goff, L., Hayes, L., Khazaezadeh, N., Nelson, S. M., Oteng-Ntim, E., et al. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00227-2 · Cited by 642 · see citing works
Damm, P., Houshmand-Oeregaard, A., Kelstrup, L., Lauenborg, J., Mathiesen, E. R., & Clausen, T. D. (2016) · Diabetologia · doi:10.1007/s00125-016-3985-5 · Cited by 620 · see citing works
“These findings are discouraging compared with the wellestablished effect of treatment on short-term perinatal outcome [3, 4].”
Diabetes and Pregnancy: An Endocrine Society Clinical Practice Guideline
Blumer, I., Hadar, E., Hadden, D. R., Jovanovič, L., Mestman, J. H., Murad, M. H., & Yogev, Y. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2465 · Cited by 561 · see citing works
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“95).(127,128) Metformin is associated with a reduced risk of preeclampsia”
BackgroundDiagnostic Criteria and Classification of Hyperglycaemia First Detected in Pregnancy
Agarwal, M., Boulvain, M., Coetzee, E. J., Colagiuri, S., Falavigna, M., Hod, M., Meltzer, S. J., Metzger, B. E., Omori, Y., Rasa, I., et al. (2013) · Cited by 536 · see citing works
Gestational diabetes mellitus: an updated overview
CHIEFARI, E. D., Arcidiacono, B., FOTI, D. P., & Brunetti, A. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-016-0607-5 · Cited by 529 · see citing works
“Thus, early and efficacious treatment of these women is decisive to reduce perinatal and obstetrical complications [64, 65].”
BackgroundGestational diabetes: opportunities for improving maternal and child health
Saravanan, P., Magee, L. A., Banerjee, A., Coleman, M. A., von Dadelszen, P., Denison, F. C., Farmer, A. A., Finer, S., Fox-Rushby, J. A., Holt, R. I. G., et al. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30161-3 · Cited by 436 · see citing works
Epidemiology and management of gestational diabetes
Sweeting, A., Hannah, W., Backman, H., Catalano, P., Feghali, M., Herman, W. H., Hivert, M.-F., Immanuel, J., Meek, C., Oppermann, M. L., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00825-0 · Cited by 431 · see citing works
Self-citationSchellong, K., Schulz, S., Harder, T., & Plagemann, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047776 · Cited by 410 · see citing works
“overweight risk in formerly macrosomic newborns, respective preventive measures may therefore not only improve the peripartal and perinatal outcome [151,152], but even the longterm overweight risk and resulting disease dispositions.”
BackgroundCoustan, D. R., Lowe, L. P., Metzger, B. E., & Dyer, A. R. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.04.006 · Cited by 398 · see citing works
Hartling, L., Dryden, D. M., Guthrie, A., Muise, M., Vandermeer, B., & Donovan, L. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-159-2-201307160-00661 · Cited by 395 · see citing works
“Study, Year (Reference) Mean (SD), kg RCTs Bonomo et al, 2005 (13) Crowther et al, 2005 (6) Garner et al, 1997 (15) Landon et al, 2009 (12) Cohort studies Adams et al, 1998 (18) Fassett et al, 2007 (16) 13.1 (4.3) 8.1 (0.3) 12.54 (16.50) 2.8 (4.5) 12.26 (7.09) 10.34 (8.8) Total,…”
InfluentialMetformin in Gestational Diabetes: The Offspring Follow-Up (MiG TOFU)
Rowan, J. A., Rush, E. C., Obolonkin, V., Battin, M., Wouldes, T., & Hague, W. M. (2011) · Diabetes Care · doi:10.2337/dc11-0660 · Cited by 379 · see citing works
2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2026
American Diabetes Association Professional Practice Committee for Diabetes*, Bajaj, M., McCoy, R. G., Balapattabi, K., Bannuru, R. R., Bellini, N. J., Bennett, A. K., Beverly, E. A., Briggs Early, K., ChallaSivaKanaka, S., et al. (2026) · Diabetes Care · doi:10.2337/dc26-s002 · Cited by 473 · see citing works
Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications
Moon, J. H., & Jang, H. C. (2022) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2021.0335 · Cited by 377 · see citing works
“Two randomized clinical trials (RCTs) in women with GDM demonstrated the improvement of these pregnancy outcomes in women identified with and treated for GDM compared with women left untreated [6,7].”
BackgroundThompson, D. M., Berger, H. M., Feig, D. S., Gagnon, R. J., Kader, T., Keely, E., Kozak, S. E., Ryan, E. A., Sermer, M., & Vinokuroff, C. (2013) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2013.01.044 · Cited by 381 · see citing works
Maternal metabolism and obesity: modifiable determinants of pregnancy outcome
Nelson, S. M., Matthews, P., & Poston, L. (2009) · Human Reproduction Update · doi:10.1093/humupd/dmp050 · Cited by 367 · see citing works
Horvath, K., Koch, K., Jeitler, K., Matyas, E., Bender, R., Bastian, H., Lange, S., & Siebenhofer, A. (2010) · BMJ · doi:10.1136/bmj.c1395 · Cited by 359 · see citing works
Treatment of Gestational Diabetes Mellitus Diagnosed Early in Pregnancy
Simmons, D., Immanuel, J., Hague, W. M., Teede, H., Nolan, C. J., Peek, M. J., Flack, J. R., McLean, M., Wong, V., Hibbert, E., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2214956 · Cited by 366 · see citing works
Buckley, B. S., Harreiter, J., Damm, P., Corcoy, R., Chico, A., Simmons, D., Vellinga, A., Dunne, F., & on behalf of the DALI Core Investigator Group (2012) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03541.x · Cited by 360 · see citing works
Szmuilowicz, E. D., Josefson, J. L., & Metzger, B. E. (2019) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2019.05.001 · Cited by 364 · see citing works
Weissgerber, T. L., & Mudd, L. M. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0579-4 · Cited by 364 · see citing works
Feig, D. S., Berger, H., Donovan, L., Godbout, A., Kader, T., Keely, E., & Sanghera, R. (2018) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.10.038 · Cited by 344 · see citing works
“7 mmol/L (86–89) and are close to the targets of the 2 randomized controlled trials showing benefit for the treatment of GDM (85,256).”
BackgroundPractice Bulletin No. 180: gestational diabetes mellitus.
(2017) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000002159 · Cited by 324 · see citing works
Duran, A., Sáenz, S., Torrejón, M. J., Bordiú, E., del Valle, L., Galindo, M., Perez, N., Herraiz, M. A., Izquierdo, N., Rubio, M. A., et al. (2014) · Diabetes Care · doi:10.2337/dc14-0179 · Cited by 335 · see citing works
Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Lernmark, Å., Metzger, B. E., Nathan, D. M., & Kirkman, M. S. (2023) · Diabetes Care · doi:10.2337/dci23-0036 · Cited by 351 · see citing works
“Both studies found that treatment of GDM can reduce both serious adverse outcomes and the frequency of large babies (macrosomia) (174,175).”
(2019) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000003606 · Cited by 340 · see citing works
Is it time to revisit the Pedersen hypothesis in the face of the obesity epidemic?
Catalano, P. M., & Mouzon, S. H. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.11.039 · Cited by 331 · see citing works
Self-citationGestational diabetes: A clinical update
Kampmann, U. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i8.1065 · Cited by 330 · see citing works
Gestational diabetes mellitus: results from a survey of country prevalence and practices
Jiwani, A. Z., Marseille, E. A., Lohse, N., Damm, P., Hod, M., & Kahn, J. G. (2011) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2011.587921 · Cited by 318 · see citing works
Wilson, R. D., Caughey, A. B., Wood, S. L., Macones, G. A., Wrench, I. J., Huang, J., Norman, M., Pettersson, K., Fawcett, W. J., Shalabi, M. M., et al. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2018.09.015 · Cited by 315 · see citing works
collaborators, O. B. O. T. A. D., O’Sullivan, E. P., Avalos, G., O’Reilly, M., Dennedy, M. C., Gaffney, G., & Dunne, F. (2011) · Diabetologia · doi:10.1007/s00125-011-2150-4 · Cited by 307 · see citing works
“[11] excluded women with greater degrees of hyperglycaemia.”
BackgroundThe fetal and maternal consequences of gestational diabetes mellitus
Reece, E. A. (2010) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767050903550659 · Cited by 306 · see citing works
Rowan, J. A., Rush, E. C., Plank, L. D., Lu, J., Obolonkin, V., Coat, S., & Hague, W. M. (2018) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2017-000456 · Cited by 305 · see citing works
Yamamoto, J. M., Kellett, J. E., Balsells, M., García-Patterson, A., Hadar, E., Solà, I., Gich, I., van der Beek, E. M., Castañeda-Gutiérrez, E., Heinonen, S., et al. (2018) · Diabetes Care · doi:10.2337/dc18-0102 · Cited by 301 · see citing works
U.S. Preventive Services Task Force* (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-10-200805200-00008 · Cited by 291 · see citing works
Jenum, A. K., Mørkrid, K., Sletner, L., Vange, S., Torper, J. L., Nakstad, B., Voldner, N., Rognerud-Jensen, O. H., Berntsen, S., Mosdøl, A., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0866 · Cited by 288 · see citing works
Lifestyle interventions for the treatment of women with gestational diabetes
Brown, J., Alwan, N. A., West, J., Brown, S., McKinlay, C. J., Farrar, D., & Crowther, C. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011970.pub2 · Cited by 284 · see citing works
Poston, L., Harthoorn, L. F., & van der Beek, E. M. (2010) · Pediatric Research · doi:10.1203/pdr.0b013e3182055ede · Cited by 283 · see citing works
“This and the recent RCT of similar design in women with mild GDM (38) provide some evidence for a causal relationship between maternal glycemic control and delivery of an LGA and fatter infant.”
BackgroundInfluentialNielsen, K. K., Kapur, A., Damm, P., de Courten, M., & Bygbjerg, I. C. (2014) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-14-41 · Cited by 273 · see citing works
“Studies show that achieving glycaemic control with lifestyle modifications and/or pharmaceutical intervention during pregnancy prevents or considerably reduces the risk of adverse pregnancy outcomes [10,11].”
A pragmatic, randomized clinical trial of gestational diabetes screening
Hillier, T. A., Pedula, K. L., Ogasawara, K. K., Vesco, K. K., Oshiro, C. E. S., Lubarsky, S. L., & Van Marter, J. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2026028 · Cited by 270 · see citing works
Effect of treatment of gestational diabetes mellitus on obesity in the next generation
Gillman, M. W., Oakey, H., Baghurst, P. A., Volkmer, R. E., Robinson, J. S., & Crowther, C. A. (2010) · Diabetes Care · doi:10.2337/dc09-1810 · Cited by 269 · see citing works
Aznar, L. A. M., Ral, P. C., Anta, R. M. O., Martín, J. J. D., Baladia, E., Basulto, J., Serrat, S. B., Altaba, I. I., López-Sobaler, A. M., Manera, M., et al. (2013) · PubMed · doi:10.3305/nutrhosp.v28in06.6691 · Cited by 268 · see citing works
Endocrine Disorders in Pregnancy
Ramos, G. A., & Moore, T. R. (2011) · Avery's Diseases of the Newborn · doi:10.1016/b978-1-4377-0134-0.10009-5 · Cited by 302 · see citing works
Immanuel, J., & Simmons, D. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0943-7 · Cited by 264 · see citing works
Sweeting, A. N., Ross, G. P., Hyett, J., Molyneaux, L., Constantino, M., Harding, A. J., & Wong, J. (2016) · Diabetes Care · doi:10.2337/dc15-0433 · Cited by 263 · see citing works
“The seminal Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study (1) unequivocally demonstrated a continuouspositive relationshipbetweenmaternal blood glucose levels (BGLs) and several adverse maternal and neonatal outcomes, while intervention studies (7,8) have shown that treatment of GDM after 24 weeks of gestat…”
BackgroundMild gestational diabetes mellitus and long-term child health
Landon, M. B., Rice, M. M., Varner, M. W., Casey, B. M., Reddy, U. M., Wapner, R. J., Rouse, D. J., Biggio, J. R., Thorp, J. M., Chien, E. K., et al. (2015) · Diabetes Care · doi:10.2337/dc14-2159 · Cited by 248 · see citing works
Self-citationGestational diabetes mellitus.
Coustan, D. (2013) · Clinical Chemistry · doi:10.1373/clinchem.2013.203331 · Cited by 3,119 · see citing works
Alfadhli, E. M. (2015) · Saudi Medical Journal · doi:10.15537/smj.2015.4.10307 · Cited by 245 · see citing works
Abell, S. K., de Courten, B. V., Boyle, J. A., & Teede, H. J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160613442 · Cited by 243 · see citing works
“Randomised controlled trials (RCTs) have demonstrated improved maternal and neonatal outcomes with subsequent treatment of GDM [50,51].”
BackgroundCombined diet and exercise interventions for preventing gestational diabetes mellitus
Shepherd, E. S., Gomersall, J. S., Tieu, J., Han, S., Crowther, C. A., & Middleton, P. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010443.pub3 · Cited by 237 · see citing works
Saeedi, M., Cao, Y., Fadl, H., Gustafson, H., & Simmons, D. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108642 · Cited by 234 · see citing works
Mack, L. R., & Tomich, P. G. (2017) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2017.02.002 · Cited by 237 · see citing works
Early nutrition programming of long-term health
Koletzko, B. V., Brands, B. A., Poston, L., Godfrey, K. M., & Demmelmair, H. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000596 · Cited by 232 · see citing works
“indirectly support the hypothesis that obesity is associated with an increased risk of gestational diabetes, and two studies have shown that improved glycaemic control in women with gestational diabetes is associated with a reduction of macrosomia or a composite end point including macrosomia((26,27)).”
Luoto, R. M., Kinnunen, T. I., Aittasalo, M., Kolu, P., Raitanen, J. A., Ojala, K., Mansikkamäki, K., Lamberg, S., Vasankari, T. J., Komulainen, T., et al. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001036 · Cited by 229 · see citing works
“Both trials had composite outcomes including perinatal mortality and neonatal complications associated with maternal hyperglycemia [29,30].”
BackgroundSong, C., Li, J., Leng, J., Ma, R. C., & Yang, X. (2016) · Obesity Reviews · doi:10.1111/obr.12442 · Cited by 227 · see citing works
“Nevertheless, those women at high risk of GDM may also benefit from lifestyle intervention as many trails (7) including ours (61) had showed that lifestyle intervention can improve pregnancy outcomes in GDM.”
BackgroundMoyer, V. A., & on behalf of the U.S. Preventive Services Task Force* (2014) · Annals of Internal Medicine · doi:10.7326/m13-2905 · Cited by 223 · see citing works
Sovio, U., Murphy, H. R., & Smith, G. C. S. (2016) · Diabetes Care · doi:10.2337/dc16-0160 · Cited by 219 · see citing works
“Largescale randomized controlled trials (RCTs) have confirmed that screening and treatment for GDM are associated with improved short-term outcomes (5,6) but have failed to show reduced rates of childhood obesity (7,8).”
Backgroundβ-cell adaptation in pregnancy
Baeyens, L., Hindi, S., Sorenson, R. L., & German, M. S. (2016) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12716 · Cited by 210 · see citing works
“In addition, glucose-lowering interventions, even in pregnancies with mild hyperglycaemia, improve outcomes.(83)”
BackgroundGestational Diabetes Mellitus—Recent Literature Review
Modzelewski, R., Stefanowicz-Rutkowska, M. M., Matuszewski, W., & Bandurska-Stankiewicz, E. M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11195736 · Cited by 223 · see citing works
“Patients who cannot achieve glycemic targets with a properly balanced diet and elimination of dietary errors should be treated pharmacologically [29].”
BackgroundThe fetal glucose steal: an underappreciated phenomenon in diabetic pregnancy
Desoyé, G., & Nolan, C. J. (2016) · Diabetologia · doi:10.1007/s00125-016-3931-6 · Cited by 217 · see citing works
“However, the rate of neonatal hypoglycaemia needing intravenous glucose therapy was not significantly reduced in the GDM treatment arms [2, 3].”
BackgroundInfluentialTreatments for gestational diabetes
Alwan, N. A., Tuffnell, D. J., & West, J. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003395.pub2 · Cited by 216 · see citing works
Kim, S. Y., England, J. L., Sharma, J. A., & Njoroge, T. (2011) · Experimental Diabetes Research · doi:10.1155/2011/541308 · Cited by 193 · see citing works
“(4) When possible, randomized trials for the treatment for mild gestational DM should include long-term followup of offspring assess the effects of maternal interventions during pregnancy on infant and child outcomes [38].”
Background
- Authors
- Landon, M. B., Spong, C. Y., Thom, E., Carpenter, M. W., Ramin, S. M., Casey, B., Wapner, R. J., Varner, M. W., Rouse, D. J., Thorp, J. M., Sciscione, A., Catalano, P., Harper, M., Saade, G., Lain, K. Y., Sorokin, Y., Peaceman, A. M., Tolosa, J. E., & Anderson, G. B.
- Affiliations
- The Ohio State University (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- George Washington University (US)
- Brown University (US)
- The University of Texas Health Science Center at Houston (US)
- The University of Texas Southwestern Medical Center (US)
- Columbia University (US)
- University of Utah (US)
- University of Alabama at Birmingham (US)
- Drexel University (US)
- Case Western Reserve University (US)
- Wake Forest University Health Sciences (US)
- The University of Texas Medical Branch at Galveston (US)
- University of Pittsburgh (US)
- Wayne State University (US)
- Northwestern University (US)
- Oregon Health & Science University (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2009-10
- Volume
- 361
- Issue
- 14
- Pages
- 1339-1348
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC2804874
- OpenAlex
- W2000357287
- Cited by
- 2,122
- References
- 38
- Citations by year
- 2026: 97 · 2025: 102 · 2024: 109 · 2023: 109 · 2022: 118 · 2021: 145 · 2020: 150 · 2019: 131 · 2018: 153 · 2017: 122 · 2016: 123 · 2015: 127 · 2014: 133 · 2013: 119 · 2012: 121
- FWCI
- 145.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (2r24hd050924-06)
- National Center for Research Resources (C06RR011234, M01RR000080, UL1RR024989, UL1RR025755, UL1RR025764, M01RR000034)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD40512, HD53118, U01HD036801, R24 HD-050924, HD27917, U10HD040544, U10HD034208, HD-27915, U10HD040512, HD34116, UG1HD034116, HD40545, HD34136, (HD40500, UG1HD053097, U10HD027915, U10HD040545, U10HD040560, HD 40544, HD-27860, HD40560, HD53097, U10HD027917, U10HD036801, U10HD027860, U10HD021410, HD 34208, HD 36801, U10HD053097, U10HD034116, HD27869, [HD21410, U10HD040500, U10HD040485, U10HD053118, U10HD027869, U10HD034136, UG1HD034208, U24HD036801, UG1HD040500, UG1HD040512, UG1HD027869, UG1HD040544, UG1HD040485, UG1HD027915, UG1HD040560, UG1HD040545, HD 40485)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- gestational diabetes mellitus, dietary intervention, self-monitoring of blood glucose, insulin therapy, perinatal outcomes, stillbirth, neonatal complications, birth weight, large for gestational age, shoulder dystocia, cesarean section, preeclampsia, gestational hypertension, fetal overgrowth
- MeSH terms
- Adult, Birth Weight, Cesarean Section, Combined Modality Therapy, Female, Fetal Macrosomia, Glucose Tolerance Test, Humans, Hypoglycemic Agents, Infant, Newborn, Infant, Newborn, Diseases, Insulin, Pregnancy, Pregnancy Outcome, Body Mass Index, Diabetes, Gestational, Premature Birth, Stillbirth, Perinatal Mortality
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-09-28.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-09-28.
Cited sources are checked by gpt-6-sol.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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