Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians
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In Danish type 2 diabetic subjects, several silent nucleotide substitutions were found in the PP1 and ISPK-1 genes.
“Several silent nucleotide substitutions were found in the PP1 and ISPK-1 genes in the Danish population”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [227]
In Danish type 2 diabetic subjects, skeletal muscle mRNA levels of the PP1 and ISPK-1 genes were normal.
“the mRNA levels of both genes were normal in skeletal muscle.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [227]
No structural gene abnormalities in the catalytic subunit of PP1 were detected in Pima Indians with type 2 diabetes.
“No structural gene abnormalities in the catalytic subunit of PP1 were detected in Pima Indians.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [227]
Cites
Pathogenesis of NIDDM. A balanced overview.
DeFronzo, R. A., Bonadonna, R. C., & Ferrannini, E. (1992) · Diabetes Care · doi:10.2337/diacare.15.3.318 · Cited by 2,085 · see citing works
The Structure And Regulation Of Protein Phosphatases
Cohen, P. T. W. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.58.1.453 · Cited by 143 · see citing works
Self-citationKida, Y., Puente, A. E.-D., Bogardus, C., & Mott, D. M. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114462 · Cited by 116 · see citing works
Self-citationStructure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes
Khew‐Goodall, Y., Mayer, R. E., Maurer, F., Stone, S. R., & Hemmings, B. A. (1991) · Biochemistry · doi:10.1021/bi00215a014 · Cited by 101 · see citing works
Procházka, M., Lillioja, S., Tait, J. F., et al. (1993) · Diabetes · doi:10.2337/diabetes.42.4.514 · Cited by 57 · see citing works
Genetic control of diabetogenesis in NOD/Lt mice. Development and analysis of congenic stocks
Prochazka, M., SERREZE, D. V., Worthen, S. M., et al. (1989) · Diabetes · doi:10.2337/diabetes.38.11.1446 · Cited by 38 · see citing works
Self-citationPathogenesis of NIDDM in Pima Indians
Bogardus, C., Lillioja, S., & Bennett, P. H. (1991) · Diabetes Care · doi:10.2337/diacare.14.7.685 · Cited by 23 · see citing works
Self-citationA rapid method to isolate (GT)n repeats from yeast artificial chromosomes
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Standards for reporting alleles at highly polymorphic loci: a proposal
Spurr, N. K. (1992) · Human Molecular Genetics · doi:10.1093/hmg/1.3.211 · Cited by 6 · see citing works
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Pathogenesis of insulin resistance in skeletal muscle
Abdul-Ghani, M. A., & DeFronzo, R. A. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/476279 · Cited by 670 · see citing works
- Authors
- Prochazka, M., Mochizuki, H., Baier, L. J., Cohen, P. T. W., & Bogardus, C.
- Affiliations
- National Institutes of Health (US)
- University of Dundee (GB)
- Venue
- Diabetologia
- Published
- 1995-03-01
- Volume
- 38
- Issue
- 4
- Pages
- 461-466
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W1993503228
- Cited by
- 26
- References
- 9
- Citations by year
- 2018: 2 · 2015: 1 · 2012: 1
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service
- National Center for Research Resources (1P41-RR03655, P41RR003655)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- protein phosphatase 1, PPP1CB, insulin resistance, Pima Indians, glycogen synthase, skeletal muscle, exon-intron structure, genetic linkage, type 2 diabetes, obesity, insulin-stimulated glucose uptake, fasting insulin
- MeSH terms
- Base Sequence, Child, Preschool, Exons, Genetic Markers, Humans, Indians, North American, Insulin Resistance, Introns, Genetic Linkage, Molecular Sequence Data, Phosphoprotein Phosphatases, Polymorphism, Genetic, Genetic Variation, Polymerase Chain Reaction, Alternative Splicing, DNA Primers, White People, Macromolecular Substances
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