Cited by 124Genetic Associations and EpidemiologyDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes and associated disorders

Insulin receptor substrate-1 gene mutations in NIDDM; implications for the study of polygenic disease

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Hitman, G. A., Hawrami, K., McCarthy, M. I., Viswanathan, M., Snehalatha, C., Ramachandran, A., Tuomilehto, J., Tuomilehto-Wolf, E. +2 more·1995·Diabetologia

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Crossref · 10.1007/bf00410287

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  • A common IRS-1 gene mutation (Gly-972-Arg) has been associated with type 2 diabetes, insulin resistance, and obesity, but its physiologic significance remains to be established.

    “A common mutation in the IRS-1 gene (Gly-972-Arg) has been associated with type 2 diabetes, insulin resistance, and obesity, but the physiologic significance of this mutation remains to be established [170].”

    From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [170]

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Authors
Hitman, G. A., Hawrami, K., McCarthy, M. I., Viswanathan, M., Snehalatha, C., Ramachandran, A., Tuomilehto, J., Tuomilehto-Wolf, E., Nissinen, A., & Pedersen, O.
Affiliations
  • Royal London Hospital (GB)
  • Steno Diabetes Center Copenhagen (DK)
Venue
Diabetologia
Published
1995-04
Volume
38
Issue
4
Pages
481-486
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
OpenAlex
W2061866413
Cited by
124
References
35
Citations by year
2021: 1 · 2019: 2 · 2018: 3 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 5
FWCI
3.10
Type
journal article
Language
en
Open access
Locations
  • Diabetologia (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust
  • Diabetesforeningen
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
IRS-1, type 2 diabetes, missense mutations, genetic susceptibility, polygenic disease, South Indian population, Finnish population, ethnic differences
MeSH terms
Adult, Aged, Alanine, Arginine, Base Sequence, Codon, Diabetes Mellitus, Type 2, Female, Finland, Genotype, Glycine, Humans, India, Male, Middle Aged, Molecular Sequence Data, Pedigree, Phosphoproteins, Proline, Reference Values, Risk Factors, Restriction Mapping, Deoxyribonucleases, Type II Site-Specific, Case-Control Studies, Polymerase Chain Reaction, Point Mutation, DNA Primers, Insulin Receptor Substrate Proteins

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