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Cited by 24Cardiac and Coronary Surgery TechniquesInflammation biomarkers and pathwaysNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Inflammatory response of neutrophil granulocytes and monocytes after cardiopulmonary bypass in pediatric cardiac surgery

Gessler, Peter, Pfenninger, Juerg, Pfammatter, Jean-Pierre, Carrel, Thierry, Dahinden, Clemens·2002·Intensive Care Medicine
DOI 10.1007/s00134-002-1525-x
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Abstract

Objective To determine whether the activation state of polymorphonuclear neutrophils (PMNs) and monocytes contributes to the inflammatory response after cardiopulmonary bypass (CPB) in pediatric cardiac surgery.Design Observational prospective clinical study.Setting Pediatric intensive care unit of a university hospital.Patients Twenty pediatric patients before and after open heart surgery with CPB.Measurements Cell counts of circulating PMNs and monocytes as well as phenotypic and functional analysis of these cells, and plasma levels of myeloperoxidase.Results Levels of myeloperoxidase (a marker of PMN degranulation) were significantly elevated after CPB (2.9+/-1.6 ng/ml before CPB versus 13.7+/-6.5 ng/ml after CPB, p=0.0001). However, PMN function, as measured by surface expression of CD11b/CD18 and phagocytic respiratory burst, was reduced. In contrast, the phagocytic respiratory burst of circulating monocytes was increased in some patients and there was a correlation with the increase of monocyte cell count after CPB (r=0.63, p=0.015).Conclusions After the end of CPB, there was an ongoing inflammatory process. In particular, there was an activation of monocytes after the end of CPB.

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Crossref · 10.1007/s00134-002-1525-x

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Metadata

Authors
Gessler, P., Pfenninger, J., Pfammatter, J.-P., Carrel, T., & Dahinden, C.
Affiliations
  • University Children's Hospital Zurich (CH)
  • University Hospital of Bern (CH)
  • University of Bern (CH)
Corresponding author
Gessler, Peter
ORCID
Venue
Intensive Care Medicine
Publisher
Springer Science and Business Media LLC
Published
2002-12-01
Volume
28
Issue
12
Pages
1786-1791
ISSN
  • 0342-4642 (ISSN-L)
  • 1432-1238
DOI
10.1007/s00134-002-1525-x
OpenAlex
W2093572200
Cited by
24
References
31
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2017: 2 · 2016: 1 · 2014: 2 · 2012: 2
FWCI
0.95
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Intensive Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
cardiopulmonary bypass, pediatric cardiac surgery, neutrophil activation, monocyte activation, inflammation, myeloperoxidase, neutrophil degranulation, CD11b/CD18, respiratory burst, phagocytosis, postoperative inflammation
MeSH terms
Adolescent, C-Reactive Protein, Cardiopulmonary Bypass, Child, Child, Preschool, Female, Flow Cytometry, Cardiac Surgical Procedures, Humans, Infant, Inflammation, Male, Monocytes, Peroxidase, Neutrophils, Prospective Studies, Least-Squares Analysis, Cytokines

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