The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Plasma neutrophil gelatinase-associated lipocalin is an early biomarker for acute kidney injury in an adult ICU population
Open accessAbstract
PURPOSE: Neutrophil gelatinase-associated lipocalin (NGAL) is a useful marker for acute kidney injury (AKI), particularly when the timing of renal insult is known. However, its performance in an adult critical care setting has not been well described. We performed this study to estimate the diagnostic accuracy of plasma NGAL for early detection of AKI and need for renal replacement therapy (RRT) in an adult intensive care unit (ICU). METHODS: We enrolled 307 consecutive adult patients admitted to a general medical-surgical ICU; 301 were included in the final analysis. Serial blood samples were analyzed for plasma NGAL using a standardized clinical platform. The primary outcome was AKI, defined as an increase in creatinine of at least 50% from baseline or a reduction in urine output to <0.5 ml/kg/h for >6 h. RESULTS: Of 301 patients, 133 (44%) had AKI during their ICU stay. Plasma NGAL was a good diagnostic marker for AKI development within the next 48 h (area under ROC 0.78, 95% CI 0.65-0.90), and for RRT use (area under ROC 0.82, 95% CI 0.70-0.95). Peak plasma NGAL concentrations increased with worsening AKI severity (R = 0.554, P < 0.001). CONCLUSIONS: Plasma NGAL is a useful early marker for AKI in a heterogeneous adult ICU population, in which the timing of renal insult is largely unknown. It allows the diagnosis of AKI up to 48 h prior to a clinical diagnosis based on AKI consensus definitions. Additionally, it predicts need for RRT and correlates with AKI severity. Early identification of high risk patients may allow potentially beneficial therapies to be initiated early in the disease process before irreversible injury occurs.
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Self-citationMishra, J., Dent, C., Tarabishi, R., Mitsnefes, M. M., Ma, Q., Kelly, C., Ruff, S. M., Zahedi, K., Shao, M., Bean, J., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)74811-x · Cited by 2,394
Early detection of acute renal failure by serum cystatin C
Herget-rosenTHAL, S., Marggraf, G., Hüsing, J., Göring, F., Pietruck, F., Janssen, O., Philipp, T., & Kribben, A. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00861.x · Cited by 897
Urine NGAL Predicts Severity of Acute Kidney Injury After Cardiac Surgery: A Prospective Study
Bennett, M., Dent, C. L., Ma, Q., Dastrala, S., Grenier, F., Workman, R., Syed, H., Ali, S., Barasch, J., & Devarajan, P. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04010907 · Cited by 765
Early acute kidney injury and sepsis: a multicentre evaluation
Bagshaw, S. M., George, C., Bellomo, R., & the ANZICS Database Management Committee (2008) · Critical Care · doi:10.1186/cc6863 · Cited by 685
Urinary biomarkers in the early diagnosis of acute kidney injury
Han, W. K., Waikar, S. S., Johnson, A., Betensky, R. A., Dent, C. L., Devarajan, P., & Bonventre, J. V. (2008) · Kidney International · doi:10.1038/sj.ki.5002715 · Cited by 585
Parikh, C. R., Abraham, E., Ancukiewicz, M., & Edelstein, C. L. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005030236 · Cited by 563
Liangos, O., Perianayagam, M. C., Vaidya, V. S., Han, W. K., Wald, R., Tighiouart, H., MacKinnon, R. W., Li, L., Balakrishnan, V. S., Pereira, B. J. G., et al. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006030221 · Cited by 510
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Cited by
Zarbock, A., Kellum, J. A., Schmidt, C., Van Aken, H., Wempe, C., Pavenstädt, H., Boanta, A., Gerß, J., & Meersch, M. (2016) · JAMA · doi:10.1001/jama.2016.5828 · Cited by 1,143
Chakraborty, S., Kaur, S., Guha, S., & Batra, S. K. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.03.008 · Cited by 503
Neutrophil Gelatinase-Associated Lipocalin: A� Promising Biomarker for Human Acute Kidney Injury
Devarajan, P. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.10.12 · Cited by 332
Flechet, M., Güiza, F., Schetz, M., Wouters, P., Vanhorebeek, I., Derese, I., Gunst, J., Spriet, I., Casaer, M., Van den Berghe, G., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4678-3 · Cited by 169
Metadata
- Authors
- Cruz, D. N., de Cal, M., Garzotto, F., Perazella, M. A., Lentini, P., Corradi, V., Piccinni, P., & Ronco, C.
- Venue
- Intensive Care Medicine
- Published
- 2009-12-03
- Volume
- 36
- Issue
- 3
- Pages
- 444-451
- ISSN
- 0342-4642 (ISSN-L)
- 1432-1238
- OpenAlex
- W2000347404
- Cited by
- 347
- References
- 22
- FWCI
- 21.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cruz, D. N., de Cal, M., Garzotto, F., Perazella, M. A., Lentini, P., Corradi, V., Piccinni, P., & Ronco, C. (2010). Plasma neutrophil gelatinase-associated lipocalin is an early biomarker for acute kidney injury in an adult ICU population. Intensive Care Medicine. https://doi.org/10.1007/s00134-009-1711-1
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