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Cited by 131Respiratory Support and MechanismsNeonatal Respiratory Health ResearchAirway Management and Intubation Techniques

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome

Guervilly, Christophe, Bisbal, Magali, Forel, Jean Marie, Mechati, Malika, Lehingue, Samuel, Bourenne, Jeremy, Perrin, Gilles, Rambaud, Romain, Adda, Melanie, Hraiech, Sami, Marchi, Elisa, Roch, Antoine, Gainnier, Marc, Papazian, Laurent·2017·Intensive Care Medicine
DOI 10.1007/s00134-016-4653-4
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Abstract

Purpose To investigate whether neuromuscular blocking agents (NMBA) exert beneficial effects in acute respiratory distress syndrome (ARDS) by reason of their action on respiratory mechanics, particularly transpulmonary pressures (P L).Methods A prospective randomised controlled study in patients with moderate to severe ARDS within 48 h of the onset of ARDS. All patients were monitored by means of an oesophageal catheter and followed up for 48 h. Moderate ARDS patients were randomised into two groups according to whether they were given a 48-h continuous infusion of cisatracurium besylate or not (control group). Severe ARDS patients did not undergo randomisation and all received cisatracurium besylate per protocol. The changes during the 48-h study period in oxygenation and in respiratory mechanics, including inspiratory and expiratory P L and driving pressure, were assessed and compared. Delta P L (∆P L) was defined as inspiratory P L minus expiratory P L.Results Thirty patients were included, 24 with moderate ARDS and 6 with severe ARDS. NMBA infusion was associated with an improvement in oxygenation in both moderate and severe ARDS, accompanied by a decrease in both plateau pressure and total positive end-expiratory pressure. The mean inspiratory and expiratory P L were higher in the moderate ARDS group receiving NMBA than in the control group. In contrast, there was no change in either driving pressure or ∆P L related to NMBA administration.Conclusions NMBA could exert beneficial effects in patients with moderate ARDS, at least in part, by limiting expiratory efforts.

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Metadata

Authors
Guervilly, C., Bisbal, M., Forel, J. M., Mechati, M., Lehingue, S., Bourenne, J., Perrin, G., Rambaud, R., Adda, M., Hraiech, S., Marchi, E., Roch, A., Gainnier, M., & Papazian, L.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Aix-Marseille Université (FR)
Corresponding author
Guervilly, Christophe
ORCID
Venue
Intensive Care Medicine
Publisher
Springer Science and Business Media LLC
Published
2016-12-24
Volume
43
Issue
3
Pages
408-418
ISSN
  • 0342-4642 (ISSN-L)
  • 1432-1238
DOI
10.1007/s00134-016-4653-4
OpenAlex
W2562857078
Cited by
131
References
37
Citations by year
2026: 9 · 2025: 10 · 2024: 17 · 2023: 12 · 2022: 24 · 2021: 8 · 2020: 17 · 2019: 13 · 2018: 12 · 2017: 9
FWCI
10.14
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Intensive Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
Assistance Publique Hôpitaux de Marseille (AO 2011-005720)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Airway Management and Intubation Techniques
Keywords
neuromuscular blocking agents, cisatracurium, acute respiratory distress syndrome, transpulmonary pressure, respiratory mechanics, driving pressure, plateau pressure, positive end-expiratory pressure, oxygenation, mechanical ventilation
MeSH terms
Aged, Atracurium, Blood Gas Analysis, Female, Humans, Male, Middle Aged, Neuromuscular Blocking Agents, Positive-Pressure Respiration, Prospective Studies, Pulmonary Circulation, Respiration, Artificial, Respiratory Distress Syndrome, Risk Factors, Severity of Illness Index, Time Factors, Respiratory Mechanics, Statistics, Nonparametric, Administration, Intravenous

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