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Disuse rescues the age-impaired adaptive response to external loading in mice
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“The absence of bone benefits in endurance runners could also be related to desensitisation of the bone by regular low-level habitual activity [36], and/or saturation of the response to high-magnitude loading after a very small number of loading cycles [37, 38].”
From Hip and spine bone mineral density are greater in master sprinters, but not endurance runners compared with non-athletic controls (2018) · cites this paper as [36]
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Research works printed but not linked: 21
- Lanyon L, Skerry T (2001) Postmenopausal osteoporosis as a failure of bone’s adaptation to functional loading: a hypothesis. J Bone Miner Res 16:1937–1947. doi: 10.1359/jbmr.2001.16.11.1937 · DOI
- Meakin LB, Galea GL, Sugiyama T et al (2014) Age-Related impairment of bones’ adaptive response to loading in mice is associated with gender-related deficiencies in osteoblasts but no change in osteocytes. J Bone Miner Res. doi: 10.1002/jbmr.2222 · DOI
- Srinivasan S, Agans SC, King KA et al (2003) Enabling bone formation in the aged skeleton via rest-inserted mechanical loading. Bone 33:946–955 · DOI
- Turner CH, Takano Y, Owan I (1995) Aging changes mechanical loading thresholds for bone formation in rats. J Bone Miner Res 10:1544–1549. doi: 10.1002/jbmr.5650101016 · DOI · Paper page
- Lynch ME, Main RP, Xu Q et al (2011) Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging. Bone 49:439–446. doi: 10.1016/j.bone.2011.05.017 · DOI
- Main RP, Lynch ME, van der Meulen MCH (2014) Load-induced changes in bone stiffness and cancellous and cortical bone mass following tibial compression diminish with age in female mice. J Exp Biol 217:1775–1783. doi: 10.1242/jeb.085522 · DOI
- Holguin N, Brodt MD, Sanchez ME, Silva MJ (2014) Aging diminishes lamellar and woven bone formation induced by tibial compression in adult C57BL/6. Bone 65:83–91. doi: 10.1016/j.bone.2014.05.006 · DOI
- De Souza RL, Pitsillides AA, Lanyon LE et al (2005) Sympathetic nervous system does not mediate the load-induced cortical new bone formation. J Bone Miner Res 20:2159–2168. doi: 10.1359/JBMR.050812 · DOI
- Meakin LB, Sugiyama T, Galea GL et al (2013) Male mice housed in groups engage in frequent fighting and show a lower response to additional bone loading than females or individually housed males that do not fight. Bone 54:113–117. doi: 10.1016/j.bone.2013.01.029 · DOI
- Patel TK, Brodt MD, Silva MJ (2014) Experimental and finite element analysis of strains induced by axial tibial compression in young-adult and old female C57Bl/6 mice. J Biomech 47:451–457. doi: 10.1016/j.jbiomech.2013.10.052 · DOI
- Moustafa A, Sugiyama T, Prasad J et al (2011) Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered. Osteoporos Int. doi: 10.1007/s00198-011-1656-4 · DOI
- Sugiyama T, Meakin LB, Browne WJ et al (2012) Bones’ adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition. J Bone Miner Res 27:1784–1793. doi: 10.1002/jbmr.1599 · DOI
- Sugiyama T, Price JS, Lanyon LE (2010) Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones. Bone 46:314–321. doi: 10.1016/j.bone.2009.08.054 · DOI
- De Souza RL, Matsuura M, Eckstein F et al (2005) Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element. Bone 37:810–818. doi: 10.1016/j.bone.2005.07.022 · DOI · Paper page
- Sugiyama T, Meakin LB, Galea GL et al (2011) Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice. Bone 49:133–139. doi: 10.1016/j.bone.2011.03.775 · DOI
- Bouxsein ML, Boyd SK, Christiansen BA et al (2010) Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res 25:1468–1486. doi: 10.1002/jbmr.141 · DOI · Paper page
- Rubin CT, Bain SD, McLeod KJ (1992) Suppression of the osteogenic response in the aging skeleton. Calcif Tissue Int 50:306–313 · DOI · Paper page
- Zaman G, Saxon LK, Sunters A et al (2010) Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse. Bone 46:628–642. doi: 10.1016/j.bone.2009.10.021 · DOI
- Lloyd SA, Loiselle AE, Zhang Y, Donahue HJ (2013) Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling. Bone 57:76–83. doi: 10.1016/j.bone.2013.07.022 · DOI
- Lloyd SA, Loiselle AE, Zhang Y, Donahue HJ (2014) Shifting paradigms on the role of connexin43 in the skeletal response to mechanical load. J Bone Miner Res 29:275–286 · DOI
- Yang Z, Shen Y, Tan S et al (2014) Inhibition of FSS-induced actin cytoskeleton reorganization by silencing LIMK2 gene increases the mechanosensitivity of primary osteoblasts. Bone. doi: 10.1016/j.bone.2014.12.024 · DOI
Cited by
Piasecki, J., McPhee, J. S., Hannam, K., Deere, K. C., Elhakeem, A., Piasecki, M., Degens, H., Tobias, J. H., & Ireland, A. (2018) · Archives of Osteoporosis · doi:10.1007/s11657-018-0486-9 · Cited by 50
Metadata
- Authors
- Meakin, L. B., Delisser, P. J., Galea, G. L., Lanyon, L. E., & Price, J. S.
- Venue
- Osteoporosis International
- Published
- 2015-04-29
- Volume
- 26
- Issue
- 11
- Pages
- 2703-2708
- ISSN
- 0937-941X
- 1433-2965
- Cited by
- 20
- References
- 0
- Language
- en
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.