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Disuse rescues the age-impaired adaptive response to external loading in mice

Meakin, L. B., Delisser, P. J., Galea, G. L., Lanyon, L. E., Price, J. S.·2015·Osteoporosis International

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Research works printed but not linked: 21

  1. Lanyon L, Skerry T (2001) Postmenopausal osteoporosis as a failure of bone’s adaptation to functional loading: a hypothesis. J Bone Miner Res 16:1937–1947. doi: 10.1359/jbmr.2001.16.11.1937 · DOI
  2. Meakin LB, Galea GL, Sugiyama T et al (2014) Age-Related impairment of bones’ adaptive response to loading in mice is associated with gender-related deficiencies in osteoblasts but no change in osteocytes. J Bone Miner Res. doi: 10.1002/jbmr.2222 · DOI
  3. Srinivasan S, Agans SC, King KA et al (2003) Enabling bone formation in the aged skeleton via rest-inserted mechanical loading. Bone 33:946–955 · DOI
  4. Turner CH, Takano Y, Owan I (1995) Aging changes mechanical loading thresholds for bone formation in rats. J Bone Miner Res 10:1544–1549. doi: 10.1002/jbmr.5650101016 · DOI · Paper page
  5. Lynch ME, Main RP, Xu Q et al (2011) Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging. Bone 49:439–446. doi: 10.1016/j.bone.2011.05.017 · DOI
  6. Main RP, Lynch ME, van der Meulen MCH (2014) Load-induced changes in bone stiffness and cancellous and cortical bone mass following tibial compression diminish with age in female mice. J Exp Biol 217:1775–1783. doi: 10.1242/jeb.085522 · DOI
  7. Holguin N, Brodt MD, Sanchez ME, Silva MJ (2014) Aging diminishes lamellar and woven bone formation induced by tibial compression in adult C57BL/6. Bone 65:83–91. doi: 10.1016/j.bone.2014.05.006 · DOI
  8. De Souza RL, Pitsillides AA, Lanyon LE et al (2005) Sympathetic nervous system does not mediate the load-induced cortical new bone formation. J Bone Miner Res 20:2159–2168. doi: 10.1359/JBMR.050812 · DOI
  9. Meakin LB, Sugiyama T, Galea GL et al (2013) Male mice housed in groups engage in frequent fighting and show a lower response to additional bone loading than females or individually housed males that do not fight. Bone 54:113–117. doi: 10.1016/j.bone.2013.01.029 · DOI
  10. Patel TK, Brodt MD, Silva MJ (2014) Experimental and finite element analysis of strains induced by axial tibial compression in young-adult and old female C57Bl/6 mice. J Biomech 47:451–457. doi: 10.1016/j.jbiomech.2013.10.052 · DOI
  11. Moustafa A, Sugiyama T, Prasad J et al (2011) Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered. Osteoporos Int. doi: 10.1007/s00198-011-1656-4 · DOI
  12. Sugiyama T, Meakin LB, Browne WJ et al (2012) Bones’ adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition. J Bone Miner Res 27:1784–1793. doi: 10.1002/jbmr.1599 · DOI
  13. Sugiyama T, Price JS, Lanyon LE (2010) Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones. Bone 46:314–321. doi: 10.1016/j.bone.2009.08.054 · DOI
  14. De Souza RL, Matsuura M, Eckstein F et al (2005) Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element. Bone 37:810–818. doi: 10.1016/j.bone.2005.07.022 · DOI · Paper page
  15. Sugiyama T, Meakin LB, Galea GL et al (2011) Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice. Bone 49:133–139. doi: 10.1016/j.bone.2011.03.775 · DOI
  16. Bouxsein ML, Boyd SK, Christiansen BA et al (2010) Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res 25:1468–1486. doi: 10.1002/jbmr.141 · DOI · Paper page
  17. Rubin CT, Bain SD, McLeod KJ (1992) Suppression of the osteogenic response in the aging skeleton. Calcif Tissue Int 50:306–313 · DOI · Paper page
  18. Zaman G, Saxon LK, Sunters A et al (2010) Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse. Bone 46:628–642. doi: 10.1016/j.bone.2009.10.021 · DOI
  19. Lloyd SA, Loiselle AE, Zhang Y, Donahue HJ (2013) Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling. Bone 57:76–83. doi: 10.1016/j.bone.2013.07.022 · DOI
  20. Lloyd SA, Loiselle AE, Zhang Y, Donahue HJ (2014) Shifting paradigms on the role of connexin43 in the skeletal response to mechanical load. J Bone Miner Res 29:275–286 · DOI
  21. Yang Z, Shen Y, Tan S et al (2014) Inhibition of FSS-induced actin cytoskeleton reorganization by silencing LIMK2 gene increases the mechanosensitivity of primary osteoblasts. Bone. doi: 10.1016/j.bone.2014.12.024 · DOI

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Metadata

Authors
Meakin, L. B., Delisser, P. J., Galea, G. L., Lanyon, L. E., & Price, J. S.
Venue
Osteoporosis International
Published
2015-04-29
Volume
26
Issue
11
Pages
2703-2708
ISSN
  • 0937-941X
  • 1433-2965
Cited by
20
References
0
Language
en

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.