Sex hormone-binding globulin and risk of fracture in older adults: systematic review and meta-analysis of observational studies
Abstract
We conducted a meta-analysis of observational study to clarify the association between sex hormone-binding globulin (SHBG) levels and the risk of fracture in older adults. We found that higher SHBG levels were associated with an increased risk of fracture in older adults. Introduction The association between SHBG levels and the risk of fracture in older adults remains elusive. We aim to clarify this association by conducting a meta-analysis of observational studies. Methods PubMed and Web of Science databases were searched for relevant observational studies investigating the association between SHBG levels and the risk of fracture in older adults. The relative risks (RRs) with 95% confidence intervals (CIs) from each study were transformed into a continuous variable for each 1 μg/dL increase in SHBG and were pooled under a random-effects model. Results A total of 16 observational studies were included in the present meta-analysis. The summary RR of fracture risk associated with each 1 μg/dL increase in SHBG was 1.18 (95% CI 1.11, 1.26); no statistically significant heterogeneity was observed across studies (I 2 = 0%, P = 0.67). The positive association was also evident in men (RR 1.22, 95% CI 1.12, 1.33) and women (RR 1.15, 95% CI, 1.05, 1.26). By site of fracture, higher SHBG levels were positively associated with higher risks of hip fracture (RR 1.43, 95% CI 1.23, 1.65), vertebral fracture (RR 1.31, 95% CI 1.12, 1.54), and non-vertebral fracture (RR 1.21, 95% CI 1.06, 1.38)…
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According to a meta-analysis, each increase of 1 μg/dL SHBG would lead to an additional fracture risk of 22%.
“In fact, according to a meta-analysis, each increase of 1 µg/dL SHBG would lead to an additional fracture risk of 22% [156].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [156]
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Body mass index as a predictor of fracture risk: A meta-analysis
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Narinx, N., David, K., Walravens, J., Vermeersch, P., Claessens, F., Fiers, T., Lapauw, B., Antonio, L., & Vanderschueren, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04562-1 · Cited by 96 · see citing works
- Authors
- Hidayat, K., Du, X., & Shi, B.-M.
- Affiliations
- First Affiliated Hospital of Soochow University (CN)
- Corresponding author
- Hidayat, K.
- Shi, B.-M.
- ORCID
- Venue
- Osteoporosis International
- Published
- 2018-07-24
- Volume
- 29
- Issue
- 10
- Pages
- 2171-2180
- ISSN
- 0937-941X (ISSN-L)
- 1433-2965
- OpenAlex
- W2884493206
- Cited by
- 16
- References
- 2
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 3
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Osteoporosis International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Suzhou Science and Technology Bureau (SYS201741)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- sex hormone-binding globulin, fracture risk, older adults, hip fracture, vertebral fractures, non-vertebral fractures, sex differences, osteoporosis biomarkers
- MeSH terms
- Hip Fractures, Humans, Risk Factors, Sex Hormone-Binding Globulin, Biomarkers, Spinal Fractures, Osteoporotic Fractures, Observational Studies as Topic
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