Mechanical Strain and Bone Cell Function: A Review

Mechanical Strain Effect on Bone-Resorbing Activity and Messenger RNA Expressions of Marker Enzymes in Isolated Osteoclast Culture

Kurata, K., Uemura, T., Nemoto, A., Tateishi, T., MURAKAMI, T., HIGAKI, H., Miura, H., & Iwamoto, Y. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.4.722 · Cited by 81

Role of cytoskeleton in shear stress-induced endothelial nitric oxide production

Knudsen, H. L., & Frangos, J. A. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.1.h347 · Cited by 81

Skeletal Strain Patterns in Relation to Exercise Training During Growth

Biewener, A. A., & Bertram, J. E. A. (1993) · Journal of Experimental Biology · doi:10.1242/jeb.185.1.51 · Cited by 80

Early strain-related changes in cultured embryonic chick tibiotarsi parallel those associated with adaptive modeling in vivo

Dallas, S. L., Zaman, G., Pead, M. J., & Lanyon, L. E. (1993) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650080302 · Cited by 79

The osteocyte as a wiring transmission system.

Marotti, G. (2000) · PubMed · Cited by 79

Spatial and temporal distribution of CD44 and osteopontin in fracture callus

Yamazaki, M., Nakajima, F., Ogasawara, A., Moriya, H., Majeska, R. J., & Einhorn, T. A. (1999) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.81b3.0810508 · Cited by 75

Effect of High-Impact and Low-Repetition Training on Bones in Ovariectomized Rats

Honda, A., Umemura, Y., & Nagasawa, S. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.9.1688 · Cited by 74

Bone remodeling of diaphyseal surfaces by torsional loads: Theoretical predictions

Cowin, S. C. (1987) · Journal of Biomechanics · doi:10.1016/0021-9290(87)90028-5 · Cited by 74

Why do bone strength and "mass" in aging adults become unresponsive to vigorous exercise? Insights of the Utah paradigm

Frost, H. M. (1999) · Journal of Bone and Mineral Metabolism · doi:10.1007/s007740050070 · Cited by 74

VARIATIONS IN THE BONE STATUS OF CONTRALATERAL AND REGIONAL SITES IN YOUNG ATHLETIC WOMEN.

Lee, E. J., Long, K. A., Risser, W. L., Poindexter, H. B. W., Gibbons, W. E., & Goldzieher, J. W. (1995) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199505001-00169 · Cited by 71

Comparative morphometric changes in rat cortical bone following ovariectomy and/or immobilization

Bagi, C. M., Mecham, M., Weiss, J. A., & Miller, S. C. (1993) · Bone · doi:10.1016/8756-3282(93)90318-5 · Cited by 71

Bone mineral changes: the second manned Skylab mission.

Vogel, J. M., & Whittle, M. W. (1976) · PubMed · Cited by 70

Preliminary evidence for impaired estrogen receptor-α protein expression in osteoblasts and osteocytes from men with idiopathic osteoporosis

Braidman, I. P., Baris, C., Wood, L., Selby, P. L., Adams, J. E., Freemont, A. J., & Hoyland, J. A. (2000) · Bone · doi:10.1016/s8756-3282(00)00246-5 · Cited by 70

The Effect of In Vivo Mechanical Loading on Estrogen Receptor α Expression in Rat Ulnar Osteocytes

Ehrlich, P. J., Noble, B., JESSOP, H. L., Stevens, H. Y., Mosley, J. R., & Lanyon, L. E. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.9.1646 · Cited by 70

The effect of environmental cues on the differentiation of myofibroblasts in peritoneal granulation tissue

(2000) · doi:10.1002/1096-9896(2000)9999:9999 · Cited by 70

Histomorphometric study on the osteocyte lacuno-canalicular network in animals of different species. I. Woven-fibered and parallel-fibered bones.

Remaggi, F., Canè, V., Palumbo, C., & Ferretti, M. (1998) · PubMed · Cited by 69

Prostaglandin E2 Increases the Skeletal Response to Mechanical Loading

Tang, L., Cullen, D. M., Yee, J. A., Jee, W. S. S., & Kimmel, D. B. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.2.276 · Cited by 66

Structural changes in rat bone subjected to long-term, in vivo mechanical loading

Turner, C. H., Woltman, T. A., & Belongia, D. A. (1992) · Bone · doi:10.1016/8756-3282(92)90084-a · Cited by 66

Estrogen enhances mechanical stress-induced prostaglandin production by bone cells from elderly women

Joldersma, M., Klein‐Nulend, J., Oleksik, A. M., Heyligers, I. C., & Burger, E. H. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.3.e436 · Cited by 65

Mechanical loading and sex hormone interactions in organ cultures of rat ulna

Cheng, M. Z., Zaman, G., Rawlinson, S. C. F., Suswillo, R. F. L., & Lanyon, P. L. E. (1996) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650110411 · Cited by 63

Bone "mass" and the "mechanostat"

Frost, H. M. (1987) · Medical Entomology and Zoology · Cited by 63

The role of prostaglandins and nitric oxide in the response of bone to mechanical forces

Chambers, T. J., Fox, S. W., Jagger, C., Lean, J. M., & Chow, J. W. M. (1999) · Osteoarthritis and Cartilage · doi:10.1053/joca.1998.0231 · Cited by 62

Bone and body mass changes during space flight

Schneider, V. B., Oganov, V. S., LeBlanc, A., Rakmonov, A., Taggart, L., Bakulin, A. V., Huntoon, C. L., Grigoriev, A. I., & Varonin, L. (1995) · Acta Astronautica · doi:10.1016/0094-5765(95)00131-x · Cited by 60

Modelling communication-enabled traffic interactions

Siebinga, O., Zgonnikov, A., & Abbink, D. A. (2023) · Royal Society Open Science · doi:10.1098/rsos.230537 · Cited by 57

Bone loss during long term space flight is prevented by the application of a short term impulsive mechanical stimulus

Goodship, A. E., Cunningham, J. L., Oganov, V. S., Darling, J., Miles, A. W., & Owen, G. W. (1998) · Acta Astronautica · doi:10.1016/s0094-5765(98)00144-1 · Cited by 56

Human Bone Cell Hyperpolarization Response to Cyclical Mechanical Strain Is Mediated by an Interleukin-1β Autocrine/Paracrine Loop

Salter, D. M., Wallace, W. H., Robb, J., Caldwell, H., & Wright, M. O. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.9.1746 · Cited by 54

Estrogen enhances the stimulation of bone collagen synthesis by loading and exogenous prostacyclin, but not prostaglandin E2, in organ cultures of rat ulnae

Cheng, M. Z., Zaman, G., & Lanyon, L. E. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090606 · Cited by 53

Osteopontin in Skeletal Tissue Homeostasis: An Emerging Picture of the Autocrine/Paracrine Functions of the Extracellular Matrix

Gerstenfeld, L. C. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.6.850 · Cited by 47

Does the mechanical milieu associated with high-speed running lead to adaptive changes in diaphyseal growing bone?

Judex, S., & Zernicke, R. F. (2000) · Bone · doi:10.1016/s8756-3282(99)00256-2 · Cited by 46

Why does intermittent hydrostatic pressure enhance the mineralization process in fetal cartilage?

Tanck, E., van Driel, W. D., Hagen, J.-W., Burger, E. H., Blankevoort, L., & Huiskes, R. (1999) · Journal of Biomechanics · doi:10.1016/s0021-9290(98)00165-1 · Cited by 44

Effect of ovarian steroid deficiency on oestrogen receptor ? expression in bone

Hoyland, J. A., Baris, C., Wood, L., Baird, P., Selby, P. L., Freemont, A. J., & Braidman, I. P. (1999) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199907)188:3<294::aid-path361>3.0.co;2-y · Cited by 43

Mechanical signaling in the development of postmenopausal osteoporosis

Turner, R. T. (1999) · Lupus · doi:10.1177/096120339900800512 · Cited by 42

Anabolic effect of prostaglandin E2 on cortical bone of aged male rats comes mainly from modeling-dependent bone gain

Yao, W., Jee, W. S. S., Zhou, H., et al. (1999) · Bone · doi:10.1016/s8756-3282(99)00220-3 · Cited by 39

Cancellous bone of aged rats maintains its capacity to respond vigorously to the anabolic effects of prostaglandin E2 by modeling-dependent bone gain

Cui, L., Ma, Y. F., Yao, W., Zhou, H., Setterberg, R. B., Tony, L. C., & Jee, W. S. S. (2001) · Journal of Bone and Mineral Metabolism · doi:10.1007/s007740170057 · Cited by 30

Exercise Maintains Bone Mass, but Do People Maintain Exercise?

Nelson, D. A., & Bouxsein, M. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.2.202 · Cited by 29

Primary human bone cultures from older patients do not respond at continuum levels of in vivo strain magnitudes

Stanford, C. M., Welsch, F., Kastner, N., Thomas, G. W., Zaharias, R. S., Holtman, K. R., & Brand, R. A. (2000) · Journal of Biomechanics · doi:10.1016/s0021-9290(99)00173-6 · Cited by 28

Impaired Estrogen Sensitivity in Bone by Inhibiting Both Estrogen Receptor α and β Pathways

Ogawa, S., Fujita, M., Ishii, Y., Tsurukami, H., Hirabayashi, M., Ikeda, K., Orimo, A., Hosoi, T., Ueda, M., Nakamura, T., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909675199 · Cited by 22

[The mechanical overloading of living bone: initial plastic deformations and adaptation hypertrophy].

Tschantz, P., & Rutishauser, E. (1968) · PubMed · Cited by 20

Devices and Techniques for in Vitro Mechanical Stimulation of Bone Cells

Brown, T. D. (2001) · CRC Press eBooks · doi:10.1201/b14263-33 · Cited by 4

Control of osteoblast function and regulation of bone mass

Harada, S.-I., & Rodan, G. A. (2003) · Nature · doi:10.1038/nature01660 · Cited by 1,444

Osteocytes, mechanosensing and Wnt signaling

Bonewald, L. F., & Johnson, M. L. (2008) · Bone · doi:10.1016/j.bone.2007.12.224 · Cited by 1,076

Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.

Tatsumi, S., Ishii, K., Amizuka, N., Li, M., Kobayashi, T., Kohno, K., Ito, M., Takeshita, S., & Ikeda, K. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.001 · Cited by 848

The aging of Wolff’s “law”: Ontogeny and responses to mechanical loading in cortical bone

Pearson, O. M., & Lieberman, D. E. (2004) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20155 · Cited by 745

Exercise and Bone Mass in Adults

Guadalupe-Grau, A., Fuentes, T., Guerra, B., & Calbet, J. A. L. (2009) · Sports Medicine · doi:10.2165/00007256-200939060-00002 · Cited by 397