Osteocytes, mechanosensing and Wnt signaling

Bonewald, Lynda F.; Johnson, Mark L.

doi:10.1016/j.bone.2007.12.224

Cited by 1,076Bone Metabolism and DiseasesBone health and osteoporosis researchWnt/β-catenin signaling in development and cancer

Osteocytes, mechanosensing and Wnt signaling

Open access

Bonewald, Lynda F., Johnson, Mark L.·2008·Bone

DOI 10.1016/j.bone.2007.12.224PMC PMC2349095

Open this paper in CoChat — free account

Abstract

The majority of bone cell biology focuses on activity on the surface of the bone with little attention paid to the activity that occurs below the surface. However, with recent new discoveries, osteocytes, cells embedded within the mineralized matrix of bone, are becoming the target of intensive investigation. In this article, the distinctions between osteoblasts and their descendants, osteocytes, are reviewed. Osteoblasts are defined as cells that make bone matrix and osteocytes are thought to translate mechanical loading into biochemical signals that affect bone (re)modeling. Osteoblasts and osteocytes should have similarities as would be expected of cells of the same lineage, yet these cells also have distinct differences, particularly in their responses to mechanical loading and utilization of the various biochemical pathways to accomplish their respective functions. For example, the Wnt/beta-catenin signaling pathway is now recognized as an important regulator of bone mass and bone cell functions. This pathway is important in osteoblasts for differentiation, proliferation and the synthesis bone matrix, whereas osteocytes appear to use the Wnt/beta-catenin pathway to transmit signals of mechanical loading to cells on the bone surface. New emerging evidence suggests that the Wnt/beta-catenin pathway in osteocytes may be triggered by crosstalk with the prostaglandin pathway in response to loading which then leads to a decrease in expression of negative regulators of the pathway such as Sost and Dkk1. The study of osteocyte biology is becoming an intense area of research interest and this review will examine some of the recent findings that are reshaping our understanding of bone/bone cell biology.

Integrity signals

Registry

Crossref · 10.1016/j.bone.2007.12.224

Cites

120 of 120 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Mechanical unloading downregulates anabolic factors and stimulates osteocytes to produce sclerostin and DKK-1 (inhibitors of osteoblast activity) and factors that stimulate local osteoclastogenesis.
“On the other hand, mechanical unloading downregulates anabolic factors and stimulates osteocytes to produce sclerostin and DKK-1, which are inhibitors of osteoblast activity [185–188], as well as specific factors that stimulate local osteoclastogenesis [189].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [189]

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis
Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0395 · Cited by 2,575 · see citing works
β‐catenin is a target for the ubiquitin–proteasome pathway
Aberle, H., Bauer, A., Stappert, J., Kispert, A., & Kemler, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.3797 · Cited by 2,533 · see citing works
LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development
Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235 · see citing works
Bone “mass” and the “mechanostat”: A proposal
Frost, H. M. (1987) · The Anatomical Record · doi:10.1002/ar.1092190104 · Cited by 2,132 · see citing works
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057 · see citing works
Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone.
Weinstein, R. S., Jilka, R. L., Parfitt, A. M., & Manolagas, S. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2799 · Cited by 1,753 · cited 1× · see citing works
“We have further examined the role of theWnt/β-catenin signaling pathway in bone with regard to dexamethasone induced apoptosis of osteocytes, which has been postulated to be the major mechanism underlying glucocorticoid mediated osteoporosis [125,77].”
Background
High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., & Lifton, R. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013444 · Cited by 1,591 · see citing works
Regulation of bone formation by applied dynamic loads.
Rubin, C. T., & Lanyon, L. E. (1984) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-198466030-00012 · Cited by 1,564 · see citing works
Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling
Li, X., Zhang, Y., Kang, H., Liu, W., Liu, P., Zhang, J., Harris, S. E., & Wu, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413274200 · Cited by 1,366 · cited 1× · see citing works
“Regulation of the Wnt/β-catenin signaling pathway is vested largely in proteins that either act as competitive binders of Wnts, notably the sFRP family of proteins, or act at the level of Lrp5; including the osteocyte specific protein, sclerostin (the Sost gene product) (73)(32), Wise (52) and the Dickkopf (Dkk) prote…”
Background
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis
Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/er.21.2.115 · Cited by 1,318 · see citing works
Regulation of bone mass by mechanical strain magnitude
Rubin, C. T., & Lanyon, L. E. (1985) · Calcified Tissue International · doi:10.1007/bf02553711 · Cited by 1,297 · see citing works
A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait
Little, R. D., Folz, C., Manning, S. P., Swain, P. M., Zhao, S.-C., Eustace, B., Lappe, M. M., Spitzer, L., Zweier, S., Braunschweiger, K., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/338450 · Cited by 1,282 · see citing works
Self-citation
A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses
Weinbaum, S., Cowin, S. C., & Zeng, Y. (1994) · Journal of Biomechanics · doi:10.1016/0021-9290(94)90010-8 · Cited by 1,266 · see citing works
Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β
Behrens, J., Jerchow, B., Würtele, M., Grimm, J., Asbrand, C., Wirtz, R. M., Kühl, M., Wedlich, D., & Birchmeier, W. (1998) · Science · doi:10.1126/science.280.5363.596 · Cited by 1,255 · see citing works
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin
Ikeda, S., Kishida, S., Yamamoto, H., Murai, H., Koyama, S., & Kikuchi, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1371 · Cited by 1,248 · see citing works
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.
Delcommenne, M., Tan, C., Gray, V., Rue, L., Woodgett, J., & Dedhar, S. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.19.11211 · Cited by 1,149 · see citing works
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
Balemans, W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.537 · Cited by 1,147 · see citing works
An LDL-receptor-related protein mediates Wnt signalling in mice
Pinson, K. I., Brennan, J., Monkley, S. J., Avery, B. J., & Skarnes, W. C. (2000) · Nature · doi:10.1038/35035124 · Cited by 1,086 · see citing works
Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling
Mao, B., Wu, W., Davidson, G., Marhold, J., Li, M., Mechler, B. M., Delius, H., Hoppe, D., Stannek, P., Walter, C., et al. (2002) · Nature · doi:10.1038/nature756 · Cited by 1,038 · see citing works
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
DasGupta, R., & Fuchs, E. V. (1999) · Development · doi:10.1242/dev.126.20.4557 · Cited by 995 · see citing works
Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation
Bilić, J., Huang, Y., Davidson, G. R., Zimmermann, T., Cruciat, C., Bienz, M., & Niehrs, C. (2007) · Science · doi:10.1126/science.1137065 · Cited by 923 · see citing works
Prostaglandin E 2 Promotes Colon Cancer Cell Growth Through a G s -Axin-ß-Catenin Signaling Axis
Castellone, M. D., Teramoto, H., Williams, B. O., Druey, K. M., & Gutkind, J. S. (2005) · Science · doi:10.1126/science.1116221 · Cited by 884 · see citing works
The Wnt/Ca2+ pathway
Kühl, M., Sheldahl, L. C., Park, M., Miller, J. R., & Moon, R. T. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)02028-x · Cited by 862 · see citing works
Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.
Tatsumi, S., Ishii, K., Amizuka, N., Li, M., Kobayashi, T., Kohno, K., Ito, M., Takeshita, S., & Ikeda, K. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.001 · Cited by 848 · see citing works
Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β
Hart, M. J., Santos, R. D. L., Albert, I., Rubinfeld, B., & Polakis, P. G. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70226-x · Cited by 836 · see citing works
Wnt signaling in osteoblasts and bone diseases
Westendorf, J. J., Kahler, R. A., & Schroeder, T. M. (2004) · Gene · doi:10.1016/j.gene.2004.06.044 · Cited by 805 · see citing works
Sensitivity of osteocytes to biomechanical stress in vitro
Klein‐Nulend, J., van der Plas, A., Semeins, C. M., Ajubi, N. E., Erangos, J. A., Nijweide, P. J., & Burger, E. H. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.5.7896017 · Cited by 776 · see citing works
Functional Interaction Between ß-Catenin and FOXO in Oxidative Stress Signaling
Essers, M. A. G., Smits, L. M. M., Barker, N., Polderman, P. E., Burgering, B. M. T., & Korswagen, H. C. (2005) · Science · doi:10.1126/science.1109083 · Cited by 741 · see citing works
Beyond the gap: functions of unpaired connexon channels
Goodenough, D. A., & Paul, D. L. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1072 · Cited by 729 · see citing works
Identification of a 52 kb deletion downstream of the <i>SOST</i> gene in patients with van Buchem disease
Balemans, W., Patel, N., Ebeling, M., Van Hul, E., Wuyts, W., Lacza, C., Dioszegi, M., Dikkers, F. G., Hildering, P., Willems, P. J., et al. (2002) · Journal of Medical Genetics · doi:10.1136/jmg.39.2.91 · Cited by 698 · see citing works
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R., & Alessi, D. R. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600633 · Cited by 594 · see citing works
Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction
Davidson, G. R., Wu, W., Shen, J., Bilić, J., Fenger, U., Stannek, P., Glinka, A., & Niehrs, C. (2005) · Nature · doi:10.1038/nature04170 · Cited by 581 · see citing works
Establishment of an Osteocyte-like Cell Line, MLO-Y4
Kato, Y., Windle, J. J., Koop, B. A., Mundy, G. R., & Bonewald, L. F. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.12.2014 · Cited by 549 · see citing works
Self-citation
Wnt/β-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone
Robinson, J. A., Chatterjee‐Kishore, M., Yaworsky, P. J., Cullen, D. M., Zhao, W., Li, C., Kharode, Y. P., Sauter, L., Babij, P., Brown, E. L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602308200 · Cited by 522 · see citing works
Self-citation
Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass
Morvan, F., Boulukos, K. E., Clément-Lacroix, P., Roman‐Roman, S., Suc-Royer, I., Vayssière, B., Ammann, P., Martin, P., Pinho, S., Pognonec, P., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060311 · Cited by 521 · see citing works
Mechanical Strain and Bone Cell Function: A Review
Ehrlich, P. J., & Lanyon, L. E. (2002) · Osteoporosis International · doi:10.1007/s001980200095 · Cited by 509 · see citing works
High Bone Mass in Mice Expressing a Mutant LRP5 Gene
Babij, P., Zhao, W., Small, C. G., Kharode, Y. P., Yaworsky, P. J., Bouxsein, M., Reddy, P. S., Bodine, P. V. N., Robinson, J. A., Bhat, B. M., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.6.960 · Cited by 497 · see citing works
Mechanical aspects of mesenchymal morphogenesis
OSTER, G. F., Murray, J. D., & Harris, A. K. (1983) · Development · doi:10.1242/dev.78.1.83 · Cited by 496 · see citing works
Mechanotransduction and strain amplification in osteocyte cell processes
Han, Y., Cowin, S. C., Schaffler, M. B., & Weinbaum, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407429101 · Cited by 495 · see citing works
Mechanical Strain Opens Connexin 43 Hemichannels in Osteocytes: A Novel Mechanism for the Release of Prostaglandin
Cherian, P. P., Siller-Jackson, A. J., Gu, S., Wang, X., Bonewald, L. F., Sprague, E., & Jiang, J. X. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-10-0912 · Cited by 481 · see citing works
Self-citation
Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism
Malone, A. M. D., Anderson, C. T., Tummala, P., Kwon, R. Y., Johnston, T. R., Stearns, T., & Jacobs, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700636104 · Cited by 477 · see citing works
Effects of biomechanical stress on bones in animals
Burr, D. B., Robling, A. G., & Turner, C. H. (2002) · Bone · doi:10.1016/s8756-3282(02)00707-x · Cited by 469 · see citing works
Differential effect of steady versus oscillating flow on bone cells
Jacobs, C. R., Yellowley, C. E., DAVIS, B., Zhou, Z., Cimbala, J. M., & Donahue, H. J. (1998) · Journal of Biomechanics · doi:10.1016/s0021-9290(98)00114-6 · Cited by 453 · see citing works
The chromatin remodelling factor Brg‐1 interacts with β‐catenin to promote target gene activation
Barker, N., Hurlstone, A. F. L., Musisi, H., Miles, A., Bienz, M., & Clevers, H. C. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4935 · Cited by 452 · see citing works
Casein kinase I transduces Wnt signals
Peters, J. M., McKay, R. M., McKay, J. P., & Graff, J. M. (1999) · Nature · doi:10.1038/43830 · Cited by 447 · see citing works
Osteocytes, strain detection, bone modeling and remodeling
Lanyon, L. E. (1993) · Calcified Tissue International · doi:10.1007/bf01673415 · Cited by 439 · see citing works
The many adaptations of bone
Currey, J. D. (2003) · Journal of Biomechanics · doi:10.1016/s0021-9290(03)00124-6 · Cited by 439 · see citing works
The Wnt Co-receptor LRP5 Is Essential for Skeletal Mechanotransduction but Not for the Anabolic Bone Response to Parathyroid Hormone Treatment
Sawakami, K., Robling, A. G., Ai, M., Pitner, N. D., Liu, D., Warden, S. J., Li, J., Maye, P. F., Rowe, D. W., Duncan, R. L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601000200 · Cited by 397 · see citing works
SOST/sclerostin, an osteocyte-derived negative regulator of bone formation
van Bezooijen, R. L., ten Dijke, P., Papapoulos, S. E., & Löwik, C. W. G. M. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.02.005 · Cited by 368 · see citing works
Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice
Lane, N. E., Yao, W., Balooch, M., Nalla, R. K., Balooch, G., Habelitz, S., Kinney, J. H., & Bonewald, L. F. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.051103 · Cited by 355 · see citing works
Bone Density Ligand, Sclerostin, Directly Interacts With LRP5 but Not LRP5G171V to Modulate Wnt Activity
Ellies, D. L., Viviano, B. L., McCarthy, J. J., Rey, J., Itasaki, N., Saunders, S., & Krumlauf, R. K. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060810 · Cited by 350 · see citing works
Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production
Reich, K. M., Gay, C. V., & Frangos, J. A. (1990) · Journal of Cellular Physiology · doi:10.1002/jcp.1041430113 · Cited by 347 · see citing works
Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?
Mlodzik, M. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02770-1 · Cited by 341 · see citing works
Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation
Li, X., Liu, P., Liu, W., Maye, P. F., Zhang, J., Zhang, Y., Hurley, M. M., Guo, C., Boskey, A. L., Sun, L., et al. (2005) · Nature Genetics · doi:10.1038/ng1614 · Cited by 341 · see citing works
Akt Participation in the Wnt Signaling Pathway through Dishevelled
Fukumoto, S., Hsieh, C.-M., Maemura, K., Layne, M. D., Yet, S., Lee, K.-H., Matsui, T., Rosenzweig, A., Taylor, W. G., Rubin, J. S., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000880200 · Cited by 335 · see citing works
MLO-Y4 Osteocyte-Like Cells Support Osteoclast Formation and Activation
Zhao, S., Kato, Y., Zhang, Y., Harris, S., Ahuja, S. S., & Bonewald, L. F. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.11.2068 · Cited by 322 · see citing works
Self-citation
Wise, a context-dependent activator and inhibitor of Wnt signalling
Itasaki, N., Jones, C. M., Mercurio, S., Rowe, A., Domingos, P. M., Smith, J. C., & Krumlauf, R. (2003) · Development · doi:10.1242/dev.00674 · Cited by 321 · see citing works
A Wnt canon orchestrating osteoblastogenesis
Hartmann, C. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.01.001 · Cited by 314 · see citing works
Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins
Chen, A. E., Ginty, D. D., & Fan, C.-M. (2005) · Nature · doi:10.1038/nature03126 · Cited by 309 · see citing works
Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription
Sakanaka, C., Weiss, J. B., & Williams, L. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3020 · Cited by 302 · see citing works
E11/gp38 Selective Expression in Osteocytes: Regulation by Mechanical Strain and Role in Dendrite Elongation
Zhang, K., Barragan‐Adjemian, C., Ye, L., Kotha, S. P., Dallas, M., Lu, Y., Zhao, S., Harris, M. A., Harris, S. E., Feng, J. Q., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02120-05 · Cited by 299 · see citing works
Self-citation
Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin level
Nakamura, T., Hamada, F., Ishidate, T., Anai, K., Kawahara, K., Toyoshima, K., & Akiyama, T. (1998) · Genes to Cells · doi:10.1046/j.1365-2443.1998.00198.x · Cited by 295 · see citing works
A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy
Kamioka, H., Honjo, T., & Takano‐Yamamoto, T. (2001) · Bone · doi:10.1016/s8756-3282(00)00421-x · Cited by 287 · see citing works
Wnt signaling and osteoblastogenesis
Bodine, P. V. N., & Komm, B. S. (2006) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9002-4 · Cited by 286 · see citing works
Wnt but Not BMP Signaling Is Involved in the Inhibitory Action of Sclerostin on BMP-Stimulated Bone Formation
van Bezooijen, R. L., Svensson, J. P., Eefting, D., Visser, A., van der Horst, G., Karperien, M., Quax, P. H. A., Vrieling, H., Papapoulos, S. E., ten Dijke, P., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061002 · Cited by 283 · see citing works
Mechanosensation and transduction in osteocytes
Bonewald, L. F. (2006) · BoneKEy-Osteovision · doi:10.1138/20060233 · Cited by 283 · see citing works
Self-citation
Domains of Axin Involved in Protein–Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization
Fagotto, F., Jho, E., Zeng, L., Kurth, T., Joos, T., Kaufmann, C. M., & Costantini, F. D. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.4.741 · Cited by 269 · see citing works
In Vivo Tracer Transport Through the Lacunocanalicular System of Rat Bone in an Environment Devoid of Mechanical Loading
Tate, M. L. K., Niederer, P. F., & Knothe, U. R. (1998) · Bone · doi:10.1016/s8756-3282(97)00234-2 · Cited by 263 · see citing works
Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin
Itoh, K., Krupnik, V. E., & Sokol, S. Y. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70229-5 · Cited by 257 · see citing works
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling
Sun, T., Lu, B., Feng, J., Reinhard, C., Jan, Y. N., Fantl, W. J., & Williams, L. T. (2001) · Nature Cell Biology · doi:10.1038/35083016 · Cited by 255 · see citing works
Cilia-like Structures and Polycystin-1 in Osteoblasts/Osteocytes and Associated Abnormalities in Skeletogenesis and Runx2 Expression
Xiao, Z., Zhang, S., Mahlios, J., Zhou, G., Magenheimer, B. S., Guo, D., Dallas, S. L., Maser, R., Calvet, J. P., Bonewald, L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604772200 · Cited by 254 · see citing works
Self-citation
Osteocyte lacunae tissue strain in cortical bone
Nicolella, D. P., Moravits, D. E., Gale, A. M., Bonewald, L. F., & Lankford, J. (2005) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2005.04.032 · Cited by 253 · see citing works
Self-citation
Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development.Preprint
Greco, T. L., Takada, S., Newhouse, M. M., McMahon, J. A., McMahon, A. P., & Camper, S. A. (1996) · Genes & Development · doi:10.1101/gad.10.3.313 · Cited by 253 · see citing works
Reduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling
Ai, M., Holmen, S. L., Hul, W. V., Williams, B. O., & Warman, M. L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.4946-4955.2005 · Cited by 253 · see citing works
Casein kinase 2 associates with and phosphorylates Dishevelled
Willert, K., Brink, M., Wodarz, A., Varmus, H., & Nusse, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3089 · Cited by 249 · see citing works
Regulation of Wnt/LRP Signaling by Distinct Domains of Dickkopf Proteins
Brott, B. K., & Sokol, S. Y. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.17.6100-6110.2002 · Cited by 234 · see citing works
Regulation of Armadillo by a Drosophila APC Inhibits Neuronal Apoptosis during Retinal Development
Ahmed, Y. F., Hayashi, S., Levine, A. J., & Wieschaus, E. F. (1998) · Cell · doi:10.1016/s0092-8674(00)81461-0 · Cited by 220 · see citing works
Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene
Kalajzić, I., Braut, A., Guo, D., Jiang, X., Kronenberg, M. S., Mina, M., Harris, M. A., Harris, S. E., & Rowe, D. W. (2004) · Bone · doi:10.1016/j.bone.2004.03.006 · Cited by 220 · see citing works
Stress fractures
Giladi, M., Milgrom, C., Simkin, A., et al. (1991) · The American Journal of Sports Medicine · doi:10.1177/036354659101900617 · Cited by 218 · see citing works
Expression of Functional Gap Junctions and Regulation by Fluid Flow in Osteocyte-Like MLO-Y4 Cells
Cheng, B., Zhao, S., Luo, J., Sprague, E. A., Bonewald, L. F., & Jiang, J. X. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.2.249 · Cited by 211 · see citing works
Self-citation
Wnt signaling promotes oncogenic transformation by inhibiting c-Myc–induced apoptosis
You, Z., Saims, D., Chen, S., Zhang, Z., D, D. C. G., Guan, K., MacDougald, O. A., Brown, A. M. C., Evan, G. I., Kitajewski, J., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201110 · Cited by 209 · see citing works
Axil, a Member of the Axin Family, Interacts with Both Glycogen Synthase Kinase 3β and β-Catenin and Inhibits Axis Formation ofXenopus Embryos
Yamamoto, H., Kishida, S., Uochi, T., Ikeda, S., Koyama, S., Asashima, M., & Kikuchi, A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2867 · Cited by 199 · see citing works
PGE2 Is Essential for Gap Junction-Mediated Intercellular Communication between Osteocyte-Like MLO-Y4 Cells in Response to Mechanical Strain
Cheng, B., Kato, Y., Zhao, S., Luo, J., Sprague, E. A., Bonewald, L. F., & Jiang, J. X. (2001) · Endocrinology · doi:10.1210/endo.142.8.8338 · Cited by 186 · see citing works
Self-citation
Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain
Rawlinson, S. C. F., Pitsillides, A. A., & Lanyon, L. E. (1996) · Bone · doi:10.1016/s8756-3282(96)00260-8 · Cited by 185 · see citing works
Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: A role for prostacyclin in adaptive bone remodeling?
Rawlinson, S. C. F., Haj, A. J. E., Minter, S. L., Tavares, I. A., Bennett, A. B., & Lanyon, L. E. (1991) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650061212 · Cited by 185 · see citing works
Conditioned medium from osteocytes stimulates the proliferation of bone marrow mesenchymal stem cells and their differentiation into osteoblasts
Heino, T. J., Hentunen, T. A., & Väänänen, H. K. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.11.016 · Cited by 184 · see citing works
Tissue strain amplification at the osteocyte lacuna: A microstructural finite element analysis
Bonivtch, A. R., Bonewald, L. F., & Nicolella, D. P. (2007) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2006.10.040 · Cited by 166 · see citing works
Self-citation
Interaction among Gsk-3, Gbp, Axin, and APC in Xenopus Axis Specification
Farr, G. H., Ferkey, D. M., Yost, C., Pierce, S. B., Weaver, C. I., & Kimelman, D. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.4.691 · Cited by 161 · see citing works
Up-regulation of the Wnt, Estrogen Receptor, Insulin-like Growth Factor-I, and Bone Morphogenetic Protein Pathways in C57BL/6J Osteoblasts as Opposed to C3H/HeJ Osteoblasts in Part Contributes to the Differential Anabolic Response to Fluid Shear
Lau, K. ‐. W., Kapur, S., Kesavan, C., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509205200 · Cited by 161 · see citing works
Fluid Shear Stress Induces ?-Catenin Signaling in Osteoblasts
Norvell, S. M., Alvarez, M. B., Bidwell, J. P., & Pavalko, F. M. (2004) · Calcified Tissue International · doi:10.1007/s00223-004-0213-y · Cited by 154 · see citing works
Matrix mineralization and the differentiation of osteocyte-like cells in culture
Mikuni-Takagaki, Y., Kakai, Y., Satoyoshi, M., Kawano, E., Suzuki, Y., Kawase, T., & Saito, S. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650100209 · Cited by 144 · see citing works
Mechanical stimulation in vivo reduces osteocyte expression of sclerostin.
Robling, A. G., Bellido, T., & Turner, C. H. (2006) · PubMed · Cited by 141 · see citing works
The effect of cytoskeletal disruption on pulsatile fluid flow-induced nitric oxide and prostaglandin E2 release in osteocytes and osteoblasts
McGarry, J. G., Klein‐Nulend, J., & Prendergast, P. J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.175 · Cited by 139 · see citing works
Distinct responses of different populations of bone cells to mechanical stress
Mikuni‐Takagaki, Y., Suzuki, Y., Kawase, T., & Saito, S. (1996) · Endocrinology · doi:10.1210/endo.137.5.8612544 · Cited by 138 · see citing works
CD44 expression in human bone: A novel marker of osteocytic differentiation
Hughes, D. E., Salter, D. M., & Simpson, R. J. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090106 · Cited by 134 · see citing works
Bone Marrow Cell Differentiation Induced by Mechanically Damaged Osteocytes in 3D Gel-Embedded Culture
Kurata, K., Heino, T. J., HIGAKI, H., & Väänänen, H. K. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060106 · Cited by 133 · see citing works
Osteoblasts and osteocytes respond differently to oscillatory and unidirectional fluid flow profiles
Ponik, S. M., Triplett, J. W., & Pavalko, F. M. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21089 · Cited by 131 · see citing works
Fluid Flow Induction of Cyclo-Oxygenase 2 Gene Expression in Osteoblasts Is Dependent on an Extracellular Signal-Regulated Kinase Signaling Pathway
Wadhwa, S., Godwin, S. L., Peterson, D. R., Epstein, M. A. F., Raisz, L. G., & Pilbeam, C. C. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.2.266 · Cited by 131 · see citing works
Osteocytic osteolysis observed in rats to which parathyroid hormone was continuously administered
Tazawa, K., Hoshi, K., Kawamoto, S., Tanaka, M., Ejiri, S., & Ozawa, H. (2004) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-004-0519-x · Cited by 124 · see citing works
Fluid pressure relaxation depends upon osteonal microstructure: modeling an oscillatory bending experiment
Wang, L., Fritton, S. P., Cowin, S. C., et al. (1999) · Journal of Biomechanics · doi:10.1016/s0021-9290(99)00059-7 · Cited by 112 · see citing works
Modeling Tracer Transport in an Osteon under Cyclic Loading
Wang, L., Cowin, S. C., Weinbaum, S., & Fritton, S. P. (2000) · Annals of Biomedical Engineering · doi:10.1114/1.1317531 · Cited by 108 · see citing works
Machine vision photogrammetry: a technique for measurement of microstructural strain in cortical bone
Nicolella, D. P., Nicholls, A. E., Lankford, J., & Davy, D. T. (2001) · Journal of Biomechanics · doi:10.1016/s0021-9290(00)00163-9 · Cited by 106 · see citing works
Identification of osteocytes in osteoblast-like cell cultures using a monoclonal antibody specifically directed against osteocytes
Nijweide, P. J., & Mulder, R. J. P. (1986) · Histochemistry and Cell Biology · doi:10.1007/bf00482961 · Cited by 100 · see citing works
Nano?Microscale Models of Periosteocytic Flow Show Differences in Stresses Imparted to Cell Body and Processes
Anderson, E. J., Kaliyamoorthy, S., Alexander, J. I. D., et al. (2005) · Annals of Biomedical Engineering · doi:10.1007/s10439-005-8962-y · Cited by 96 · see citing works
Biochemical and histological studies on various bone cell preparations
Nijweide, P. J., van der Plas, A., & Scherft, J. P. (1981) · Calcified Tissue International · doi:10.1007/bf02409485 · Cited by 96 · see citing works
Isolated primary osteocytes express functional gap junctions in vitro
Gu, G., Nars, M., Hentunen, T. A., Metsikkö, K., & Väänänen, H. K. (2005) · Cell and Tissue Research · doi:10.1007/s00441-005-0066-3 · Cited by 91 · see citing works
A Finite Element Analysis for the Prediction of Load-induced Fluid Flow and Mechanochemical Transduction in Bone
Steck, R., Niederer, P. F., & Tate, M. L. K. (2002) · Journal of Theoretical Biology · doi:10.1006/jtbi.2003.3163 · Cited by 89 · see citing works
Alkaline phosphatase in osteoblasts is down-regulated by pulsatile fluid flow
Hillsley, M., & Frangos, J. A. (1997) · Calcified Tissue International · doi:10.1007/s002239900185 · Cited by 88 · see citing works
Fluid flow induces COX-2 expression in MC3T3-E1 osteoblasts via a PKA signaling pathway
Wadhwa, S., Choudhary, S., Voznesensky, M. A., Epstein, M. A. F., Raisz, L. G., & Pilbeam, C. C. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02124-1 · Cited by 86 · see citing works
On bone adaptation due to venous stasis
Wang, L., Fritton, S. P., Weinbaum, S., & Cowin, S. C. (2003) · Journal of Biomechanics · doi:10.1016/s0021-9290(03)00241-0 · Cited by 77 · see citing works
Bio Imaging of Intracellular NO Production in Single Bone Cells After Mechanical Stimulation
Vatsa, A., Mizuno, D., Smit, T. H., Schmidt, C. F., MacKintosh, F. C., & Klein‐Nulend, J. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060720 · Cited by 76 · see citing works
Fluid Shear Stress Induces Less Calcium Response in a Single Primary Osteocyte Than in a Single Osteoblast: Implication of Different Focal Adhesion Formation
Kamioka, H., Sugawara, Y., Murshid, S. A., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060408 · Cited by 70 · see citing works
Effects of fluid shear stress on bone cells
Williams, J. L., Iannotti, J. P., Ham, A., et al. (1994) · Biorheology · doi:10.3233/bir-1994-31204 · Cited by 64 · see citing works
GSK3α exhibits β‐catenin and tau directed kinase activities that are modulated by Wnt
Asuni, A. A., Hooper, C., Reynolds, C. H., Lovestone, S., Anderton, B. H., & Killick, R. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05243.x · Cited by 64 · see citing works
Vitamin D-enhanced osteocytic and osteoclastic bone resorption
Baylink, D. J., Sipe, J., Wergedal, J. R., et al. (1973) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1973.224.6.1345 · Cited by 50 · see citing works
Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: Morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen
Sundberg, J. P., Sundberg, B. A., & Beamer, W. G. (1997) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199709)20:1 · Cited by 38 · see citing works
The Gene for High Bone Mass
Johnson, M. L., Picconi, J. L., & Recker, R. R. (2002) · The Endocrinologist · doi:10.1097/00019616-200209000-00012 · Cited by 37 · see citing works
Self-citation
Mixing Mechanisms and Net Solute Transport in Bone
Tate, M. L. K. (2001) · Annals of Biomedical Engineering · doi:10.1114/1.1397788 · Cited by 25 · see citing works
Kinases and G proteins join the Wnt receptor complex
Quaiser, T., Anton, R., & Kühl, M. (2006) · BioEssays · doi:10.1002/bies.20386 · Cited by 18 · see citing works

Flagged first, then by citations

Sorted by citations

The amazing osteocyte
Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287 · see citing works
Self-citation
WNT signaling in bone homeostasis and disease: From human mutations to treatments
Baron, R., & Kneissel, M. (2013) · Nature Medicine · doi:10.1038/nm.3074 · Cited by 2,093 · see citing works
Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044 · see citing works
The Osteocyte: An Endocrine Cell … and More
Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042 · see citing works
Self-citation
Estrogens and androgens in skeletal physiology and pathophysiology
Almeida, M., Laurent, M. R., Dubois, V., Claessens, F., O'Brien, C. A., Bouillon, R., Vanderschueren, D., & Manolagas, S. C. (2017) · Physiological Reviews · doi:10.1152/physrev.00033.2015 · Cited by 860 · see citing works
Mechanical regulation of bone remodeling
Wang, L., You, X., Zhang, L., Zhang, C., & Zou, W. (2022) · Bone Research · doi:10.1038/s41413-022-00190-4 · Cited by 641 · see citing works
Role of Thyroid Hormones in Skeletal Development and Bone Maintenance
Bassett, J. H. D., & Williams, G. R. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1106 · Cited by 540 · see citing works
Mechanosensation and transduction in osteocytes
Klein-Nulend, J., Bakker, A. D., Bacabac, R. G., Vatsa, A., & Weinbaum, S. (2013) · Bone · doi:10.1016/j.bone.2012.10.013 · Cited by 528 · see citing works
Molecular mechanosensors in osteocytes
Qin, L., Liu, W., Cao, H., & Xiao, G. (2020) · Bone Research · doi:10.1038/s41413-020-0099-y · Cited by 484 · see citing works
Osteocyte-Driven Bone Remodeling
Bellido, T. (2014) · Calcified Tissue International · doi:10.1007/s00223-013-9774-y · Cited by 384 · see citing works
Alcohol and bone: review of dose effects and mechanisms
Maurel, D. B., Boisseau, N., Benhamou, C. L., & Jaffre, C. (2012) · Osteoporosis International · doi:10.1007/s00198-011-1787-7 · Cited by 343 · see citing works
Osteocyte: the unrecognized side of bone tissue
Rochefort, G. Y., Pallu, S., & Benhamou, C. L. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1194-5 · Cited by 268 · see citing works
Osteoporosis: Mechanism, Molecular Target and Current Status on Drug Development
Li, H., Xiao, Z., Quarles, L. D., & Li, W. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867327666200330142432 · Cited by 226 · see citing works
Osteocyte apoptosis and control of bone resorption following ovariectomy in mice
Emerton, K. B., Hu, B., Woo, A. A., Sinofsky, A., Hernandez, C., Majeska, R. J., Jepsen, K. J., & Schaffler, M. B. (2010) · Bone · doi:10.1016/j.bone.2009.11.006 · Cited by 220 · see citing works
Bone-on-a-chip: Microfluidic technologies and microphysiologic models of bone tissue
Mansoorifar, A., Gordon, R., Bergan, R. C., & Bertassoni, L. E. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202006796 · Cited by 142 · see citing works
Serum leptin, parathyroid hormone, 1,25-dihydroxyvitamin D, fibroblast growth factor 23, bone alkaline phosphatase, and sclerostin relationships in obesity
Grethen, E., Hill, K. M., Jones, R., Cacucci, B. M., Gupta, C. E., Acton, A., Considine, R. V., & Peacock, M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2280 · Cited by 136 · see citing works
Gut Microbiome and Osteoporosis
Ding, K., Hua, F., & Ding, W. (2020) · Aging and disease · doi:10.14336/ad.2019.0523 · Cited by 134 · see citing works
Exendin-4 increases bone mineral density in type 2 diabetic OLETF rats potentially through the down-regulation of SOST/sclerostin in osteocytes
Kim, J.-Y., Lee, S.-K., Jo, K.-J., Song, D.-Y., Lim, D.-M., Park, K.-Y., Bonewald, L. F., & Kim, B.-J. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.01.001 · Cited by 137 · see citing works
Self-citation
The Osteoblast to Osteocyte Transition: Epigenetic Changes and Response to the Vitamin D<sub>3</sub>Hormone
St. John, H. C., Bishop, K. A., Meyer, M. B., Benkusky, N. A., Leng, N., Kendziorski, C., Bonewald, L. F., & Pike, J. W. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1091 · Cited by 127 · see citing works
Self-citation
Meox2Cre-mediated disruption of CSF-1 leads to osteopetrosis and osteocyte defects
Harris, S. E., MacDougall, M., Horn, D., Woodruff, K., Zimmer, S. N., Rebel, V. I., Fajardo, R., Feng, J. Q., Gluhak-Heinrich, J., Harris, M. A., et al. (2012) · Bone · doi:10.1016/j.bone.2011.09.038 · Cited by 116 · see citing works
Osteocyte Network; a Negative Regulatory System for Bone Mass Augmented by the Induction of Rankl in Osteoblasts and Sost in Osteocytes at Unloading
Moriishi, T., Fukuyama, R., Ito, M., Miyazaki, T., Maeno, T., Kawai, Y., Komori, H., & Komori, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040143 · Cited by 105 · see citing works
Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial
Emaus, N., Gjesdal, C. G., Almås, B., Christensen, M., Grimsgaard, A. S., Berntsen, G. K. R., Salomonsen, L., & Fønnebø, V. (2010) · Osteoporosis International · doi:10.1007/s00198-009-1126-4 · Cited by 102 · see citing works
Exosomes: Mediators of bone diseases, protection, and therapeutics potential
Behera, J., & Tyagi, N. (2018) · Oncoscience · doi:10.18632/oncoscience.421 · Cited by 101 · see citing works
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction
Sato, T., Verma, S., Andrade, C. D. C., Omeara, M., Campbell, N., Wang, J. S., Cetinbas, M., Lang, A., Ausk, B. J., Brooks, D. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17099-3 · Cited by 86 · see citing works
Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone
Rolvien, T., Krause, M., Jeschke, A., Yorgan, T., Püschel, K., Schinke, T., Busse, B., Demay, M. B., & Amling, M. (2017) · Bone · doi:10.1016/j.bone.2017.06.022 · Cited by 74 · see citing works
A review of mathematical modeling of bone remodeling from a systems biology perspective
Cook, C. V., Lighty, A. M., Smith, B. J., & Ford Versypt, A. N. (2024) · Frontiers in Systems Biology · doi:10.3389/fsysb.2024.1368555 · Cited by 25 · see citing works
Osteocyte Wnt/β-catenin pathway activation upon mechanical loading is altered in ovariectomized mice
Jackson, E., Lara-Castillo, N., Akhter, M. P., Dallas, M., Scott, J. M., Ganesh, T., & Johnson, M. L. (2021) · Bone Reports · doi:10.1016/j.bonr.2021.101129 · Cited by 13 · see citing works
Self-citation
Glutamate receptor agonists and glutamate transporter antagonists regulate differentiation of osteoblast lineage cells
Xie, W., Dolder, S., Siegrist, M., Wetterwald, A., & Hofstetter, W. (2016) · Calcified Tissue International · doi:10.1007/s00223-016-0129-3 · Cited by 12 · see citing works

Osteocyte Deficiency in Hip Fractures
Delgado‐Calle, J., Arozamena, J., García-Renedo, R. J., García‐Ibarbia, C., Pascual-Carra, M. A., González-Macı́as, J., & Riancho, J. A. (2011) · Calcified Tissue International · doi:10.1007/s00223-011-9522-0 · Cited by 43 · see citing works
Osteocyte — A new target for the treatment of osteoporosis
Wu, X., Wu, X., & Yuan, L. (2013) · Zhonghua neifenmi daixie zazhi · doi:10.3760/cma.j.issn.1000-6699.2013.07.023
Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350 · see citing works
Faculty Opinions recommendation of Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin.
Ott, S. M. (2008) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1103314.559346
Does Osteocyte Sclerostin Response to Unloading and Exercise Vary across Bone Compartments?
Metzger, C. E., Lee, T. V., McBurnett, P. K., et al. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000493280.92872.3e

Authors: Bonewald, L. F., & Johnson, M. L.
Affiliations: University of Missouri–Kansas City (US)
ORCID: Bonewald, Lynda F.
Johnson, Mark L.
Venue: Bone
Publisher: Elsevier BV
Published: 2008-04
Volume: 42
Issue: 4
Pages: 606-615
ISSN: 1873-2763 (ISSN-L)
8756-3282
DOI: 10.1016/j.bone.2007.12.224
PMC: PMC2349095
OpenAlex: W2011828467
Cited by: 1,076
References: 120
Citations by year: 2026: 28 · 2025: 32 · 2024: 24 · 2023: 58 · 2022: 49 · 2021: 58 · 2020: 64 · 2019: 75 · 2018: 59 · 2017: 73 · 2016: 71 · 2015: 74 · 2014: 63 · 2013: 71 · 2012: 67
FWCI: 5.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Bone (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR053949, P01AR046798)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Keywords: osteocytes, osteoblasts, mechanosensing, Wnt/β-catenin signaling, mechanical loading, bone remodeling, prostaglandin signaling, sclerostin, DKK1, bone matrix synthesis, osteocyte differentiation
MeSH terms: Animals, Humans, Models, Biological, Osteocytes, Stress, Mechanical, Biosensing Techniques, Signal Transduction, Wnt Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Osteocytes, mechanosensing and Wnt signaling

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks