Nrf2-mediated redox signaling in arsenic carcinogenesis: a review
Abstract
Arsenic is a ubiquitous toxic metalloid whose natural leaching from geogenic resources of earths crust into groundwater has become a dreadful health hazard to millions of people across the globe. Arsenic has been documented as a top most potent human carcinogen by Agency of Toxic Substances and Disease Registry. There have been a number of schools of opinions regarding the underlying mechanism of arsenic-induced carcinogenicity, but the theory of oxidative stress generated by arsenic has gained much importance. Imbalance in the cellular redox state and its associated complications have been closely associated with nuclear factor-erythroid 2-related factor 2 (Nrf2), a basic-leucine zipper transcription factor that activates the antioxidant responsive element and electrophilic responsive element, thereby upregulating the expression of a variety of downstream genes. This review has been framed on the lines of differential molecular responses of Nrf2 on arsenic exposure as well as the chemopreventive strategy which may be improvised to regulate Nrf2 in order to combat arsenic-induced oxidative stress and its long-term carcinogenic effect.
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Chronic exposure to arsenic can lead to arsenicosis, including skin lesions, blackfoot disease, peripheral vascular disease, and cancers.
“In addition, it is well-established fact that chronic exposure to arsenic can lead to arsenicosis, including skin lesions, blackfoot disease, peripheral vascular disease, and cancers.”
From Arsenic Contamination of Groundwater: A Review of Sources, Prevalence, Health Risks, and Strategies for Mitigation (2014) · cites this paper as [68]
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Background
- Authors
- Sinha, D., Biswas, J., & Bishayee, A.
- Affiliations
- Chittaranjan National Cancer Institute (IN)
- American University of Health Sciences (US)
- Corresponding author
- Sinha, Dona
- Bishayee, Anupam
- Venue
- Archives of Toxicology
- Published
- 2012-08-23
- Volume
- 87
- Issue
- 2
- Pages
- 383-396
- ISSN
- 0340-5761 (ISSN-L)
- 1432-0738
- OpenAlex
- W1997484425
- Cited by
- 81
- References
- 7
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 7 · 2016: 3 · 2015: 5 · 2014: 12 · 2013: 7
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- arsenic, Nrf2, redox signaling, oxidative stress, arsenic carcinogenesis, antioxidant response element, chemoprevention, groundwater arsenic contamination, transcription factors
- MeSH terms
- Animals, Arsenicals, Carcinogens, Gene Expression Regulation, Humans, Signal Transduction, Oxidative Stress, Chemoprevention, Arsenic Poisoning, NF-E2-Related Factor 2
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