Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

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NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

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Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

Chen, W., Sun, Z., Wang, X.-J., Jiang, T., Huang, Z., Fang, D., & Zhang, D. D. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.029 · Cited by 638 · see citing works

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A., & Hayes, J. D. (2013) · Oncogene · doi:10.1038/onc.2012.388 · Cited by 657 · see citing works

Dual roles of Nrf2 in cancer

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The Dual Roles of NRF2 in Cancer

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Structural basis of Keap1 interactions with Nrf2

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Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors

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Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products

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Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

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Transcriptional Regulation of NF-E2 p45-related Factor (NRF2) Expression by the Aryl Hydrocarbon Receptor-Xenobiotic Response Element Signaling Pathway

Miao, W., Hu, L., Scrivens, P. J., & Batist, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412081200 · Cited by 541 · see citing works

The KEAP1–NRF2 System in Cancer

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Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

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Phosphorylation of Nrf2 at Ser40 by Protein Kinase C in Response to Antioxidants Leads to the Release of Nrf2 from INrf2, but Is Not Required for Nrf2 Stabilization/Accumulation in the Nucleus and Transcriptional Activation of Antioxidant Response Element-mediated NAD(P)H:Quinone Oxidoreductase-1 Gene Expression

Bloom, D. A., & Jaiswal, A. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307633200 · Cited by 523 · see citing works

Glycogen Synthase Kinase-3β Inhibits the Xenobiotic and Antioxidant Cell Response by Direct Phosphorylation and Nuclear Exclusion of the Transcription Factor Nrf2

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Nrf2 as a novel molecular target for chemoprevention

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Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

Nioi, P., McMahon, M. J., Itoh, K., Yamamoto, M. P., & Hayes, J. D. (2003) · Biochemical Journal · doi:10.1042/bj20030754 · Cited by 508 · see citing works

Nox enzymes and new thinking on reactive oxygen: A double-edged sword revisited

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Glucosinolates, isothiocyanates and human health

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Dimerization of Substrate Adaptors Can Facilitate Cullin-mediated Ubiquitylation of Proteins by a “Tethering” Mechanism

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Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

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Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin

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Nrf2 at the heart of oxidative stress and cardiac protection

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Nrf2 Defends the Lung from Oxidative Stress

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The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress

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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

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Nrf2 Is a Key Transcription Factor That Regulates Antioxidant Defense in Macrophages and Epithelial Cells: Protecting against the Proinflammatory and Oxidizing Effects of Diesel Exhaust Chemicals

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The complexity of the Nrf2 pathway: beyond the antioxidant response

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Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

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FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT

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Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging

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Redox homeostasis: The Golden Mean of healthy living

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Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

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Cullin‐based ubiquitin ligases: Cul3–BTB complexes join the family

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Redox-regulated Turnover of Nrf2 Is Determined by at Least Two Separate Protein Domains, the Redox-sensitive Neh2 Degron and the Redox-insensitive Neh6 Degron

McMahon, M. J., Thomas, N., Itoh, K., Yamamoto, M. P., & Hayes, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403061200 · Cited by 406 · see citing works

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

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The cancer chemopreventive actions of phytochemicals derived from glucosinolates

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Identification of Sensor Cysteines in Human Keap1 Modified by the Cancer Chemopreventive Agent Sulforaphane

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Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver

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Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1

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Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

Baird, L., Llères, D., Swift, S., & Dinkova‐Kostova, A. T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305687110 · Cited by 386 · see citing works

The Carboxy-Terminal Neh3 Domain of Nrf2 Is Required for Transcriptional Activation

Nioi, P., Nguyen, T., Sherratt, P. J., & Pickett, C. B. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.10895-10906.2005 · Cited by 383 · see citing works

Activation of NRF2 by Nitrosative Agents and H2O2 Involves KEAP1 Disulfide Formation

Fourquet, S., Guérois, R., Biard, D. S. F., & Tolédano, M. B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.051714 · Cited by 378 · see citing works

The Role of Keap1 in Cellular Protective Responses

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Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway

Chen, G., Song, C.-C., Pantopoulos, K., Wei, X., Zheng, H., & Luo, Z. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.01.012 · Cited by 373 · see citing works

Nrf2: A Potential Molecular Target for Cancer Chemoprevention by Natural Compounds

Jeong, W., Jun, M., & Kong, A. T. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.99 · Cited by 371 · see citing works

Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1–Nrf2 regulatory pathway

Motohashi, H., Katsuoka, F., Engel, J. D., & Yamamoto, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305902101 · Cited by 363 · see citing works

Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors

Nioi, P., & Hayes, J. D. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.05.023 · Cited by 359 · see citing works

Nrf2 Controls Constitutive and Inducible Expression of ARE-driven Genes through a Dynamic Pathway Involving Nucleocytoplasmic Shuttling by Keap1

Nguyen, T., Sherratt, P. J., Nioi, P., Yang, C. S., & Pickett, C. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503074200 · Cited by 341 · see citing works

Heme Induces Ubiquitination and Degradation of the Transcription Factor Bach1

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Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases

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The Nrf2–Keap1 defence pathway: Role in protection against drug-induced toxicity

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Nrf2—a therapeutic target for the treatment of neurodegenerative diseases

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The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosisPreprint

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Elucidating mechanisms of drug-induced toxicity

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NRF2 as a regulator of cell metabolism and inflammation in cancer

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Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

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Generation of a Stable Antioxidant Response Element–Driven Reporter Gene Cell Line and Its Use to Show Redox-Dependent Activation of Nrf2 by Cancer Chemotherapeutic Agents

Wang, X. J., Hayes, J. D., & Wolf, C. R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2298 · Cited by 317 · see citing works

Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2

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Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium

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Chemoprevention through the Keap1–Nrf2 signaling pathway by phase 2 enzyme inducers

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Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

Wang, X. J., Hayes, J. D., Henderson, C. J., & Wolf, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709483104 · Cited by 310 · see citing works

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus

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Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases

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Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

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Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

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Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

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Keap1 Controls Postinduction Repression of the Nrf2-Mediated Antioxidant Response by Escorting Nuclear Export of Nrf2

Sun, Z., Zhang, S., Chan, J. Y., & Zhang, D. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00630-07 · Cited by 332 · see citing works

Keep Harm at Bay: Oxidative Phosphorylation Induces Nrf2-Driven Antioxidant Response Via ERK5/MEF2/miR-23a Signaling to Keap-1

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Chapter 3 Site-Specific Modification of the Electrophile Sensor Protein Keap1 and Activation of Nrf2-Dependent Gene Expression

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Mechanistic Study of Nucleocytoplasmic Trafficking and Reversible Acetylation in Modulating the NRF2-Dependent Antioxidant Response

Sun, Z. (2008) · UA Campus Repository (The University of Arizona)