The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
The Na+/H+ exchanger modulates long-term potentiation in rat hippocampal slices
Abstract
Although present in great variety in the brain, the role of Na(+)/H(+) exchangers (NHEs) in hippocampal plasticity is still unknown and the effect of NHE inhibition on long-term potentiation (LTP) has not been studied yet. As it is conceivable that NHE inhibitors may severely affect mechanisms that are considered to underlie learning and memory we investigated whether the broad-spectrum NHE inhibitor 5'-(N-ethyl-N-isopropyl)-amiloride (EIPA, 10 microM) influences LTP induced by different stimuli based on a theta burst in interface hippocampus slices from 7-8-week-old Wistar and 30-month-old Fischer 344/Brown-Norway F1 hybrid (F344/BN) rats. EIPA did not affect basal synaptic transmission, paired pulse inhibition, or LTP induced by a weak stimulus, but improved the maintenance of the LTP of the population spike induced by a strong tetanus. Our data suggest that NHE activity serves as a negative feedback mechanism to control neuronal excitability and plasticity in both young and senescent animals.
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“Consistent with previous results (Rönicke et al., 2009), we found that EMD87580 increased input-output (I/O) ratios in the ApoE3-KI mice (Figure 7A).”
From Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease (2018) · cites this paper as Rönicke et al., 2009
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“consistent with previous findings that have shown that the NHE inhibitor ethyl-isopropyl amiloride (EIPA) can enhance theta-burst-induced LTP (Rönicke et al., 2009).”
From Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease (2018) · cites this paper as Rönicke et al., 2009
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Cited by
Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease
Xian, X., Pohlkamp, T., Durakoglugil, M. S., Wong, C. H., Beck, J. K., Lane-Donovan, C., Plattner, F., & Herz, J. (2018) · eLife · doi:10.7554/elife.40048 · Cited by 98
Metadata
- Authors
- Rönicke, R., Schröder, U. H., Böhm, K., & Reymann, K. G.
- Venue
- Naunyn-Schmiedeberg's Archives of Pharmacology
- Published
- 2008-10-30
- Volume
- 379
- Issue
- 3
- Pages
- 233-239
- ISSN
- 0028-1298
- 1432-1912
- Cited by
- 11
- References
- 32
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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