The late maintenance of hippocampal LTP: Requirements, phases, ‘synaptic tagging’, ‘late-associativity’ and implications
Abstract
Our review focuses on the mechanisms which enable the late maintenance of hippocampal long-term potentiation (LTP; >3h), a phenomenon which is thought to underlie prolonged memory. About 20 years ago we showed for the first time that the maintenance of LTP - like memory storage--depends on intact protein synthesis and thus, consists of at least two temporal phases. Here we concentrate on mechanisms required for the induction of the transient early-LTP and of the protein synthesis-dependent late-LTP. Our group has shown that the induction of late-LTP requires the associative activation of heterosynaptic inputs, i.e. the synergistic activation of glutamatergic and modulatory, reinforcing inputs within specific, effective time windows. The induction of late-LTP is characterized by novel, late-associative properties such as 'synaptic tagging' and 'late-associative reinforcement'. Both phenomena require the associative setting of synaptic tags as well as the availability of plasticity-related proteins (PRPs) and they are restricted to functional dendritic compartments, in general. 'Synaptic tagging' guarantees input specificity and thus the specific processing of afferent signals for the establishment of late-LTP. 'Late-associative reinforcement' describes a process where early-LTP by the co-activation of modulatory inputs can be transformed into late-LTP in activated synapses where a tag is set. Recent evidence from behavioral experiments, which studied processes of emotional and cognitive reinforcement of LTP, point to the physiological relevance of the above mechanisms during cellular and system's memory formation.
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The onset of an emotional experience activates endogenous forms of neuroplasticity in the hippocampus for a period of seconds to minutes, which is revealed as an enhancement of LTP when tetanizing stimulation occurs in this narrow-time window.
“According to the temporal dynamics model, the onset of an emotional experience activates endogenous forms of neuroplasticity in the hippocampus for a period of seconds to minutes, which is revealed as an enhancement of LTP when tetanizing stimulation occurs in this narrow-time window (Ahmed et al. [209]; Reymann and Frey [242]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Reymann and Frey [242]
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- Authors
- Reymann, K. G., & Frey, J. U.
- Affiliations
- Leibniz Institute for Neurobiology (DE)
- Corresponding author
- Frey, Julietta U.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 52
- Issue
- 1
- Pages
- 24-40
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2012417073
- Cited by
- 331
- References
- 9
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 18 · 2023: 4 · 2022: 9 · 2021: 7 · 2020: 17 · 2019: 13 · 2018: 17 · 2017: 13 · 2016: 15 · 2015: 21 · 2014: 21 · 2013: 24 · 2012: 16
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- hippocampal long-term potentiation, synaptic tagging, protein synthesis-dependent memory, glutamatergic input, dendritic compartments, memory formation, emotional reinforcement
- MeSH terms
- Animals, Hippocampus, Models, Neurological, Synapses, Time Factors, Long-Term Potentiation
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