Cited by 176Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology ResearchMonoclonal and Polyclonal Antibodies Research

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Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific

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Jensen, Brian C., Swigart, Philip M., Simpson, Paul C.·2009·Naunyn-Schmiedeberg's Archives of Pharmacology

DOI 10.1007/s00210-008-0368-6PMC PMC2653258

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Abstract

Commercial antibodies are used widely to quantify and localize the alpha1-adrenergic receptor (AR) subtypes, alpha1A, alpha1B, and alpha1D. We tested ten antibodies, from abcam and Santa Cruz, using western blot with heart and brain tissue from wild-type (WT) mice and mice with systemic knockout (KO) of one or all three subtypes. We found that none of the antibodies detected a band in WT that was absent in the appropriate KO or in the KO that was null for all alpha1-ARs (ABDKO). We conclude that the antibodies we tested are not specific for alpha1-ARs. These results raise caution with prior studies using these reagents. For now, competition radioligand binding is the only reliable approach to quantify the alpha1-AR subtype proteins. Receptor protein localization remains a challenge.

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Additional file 4 of CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in Gαs-Gαi coupling to the β2-adrenergic receptor
Ge, M., Wu, L., He, F., Tai, Y., Fang, R., Han, D., Paipai, G., Liu, H., Hu, Y., Xu, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26647530
Additional file 1 of CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in Gαs-Gαi coupling to the β2-adrenergic receptor
Ge, M., Wu, L., He, F., Tai, Y., Fang, R., Han, D., Paipai, G., Liu, H., Hu, Y., Xu, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24708946
Additional file 5 of CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in Gαs-Gαi coupling to the β2-adrenergic receptor
Ge, M., Wu, L., He, F., Tai, Y., Fang, R., Han, D., Paipai, G., Liu, H., Hu, Y., Xu, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26647533
Additional file 2 of CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in Gαs-Gαi coupling to the β2-adrenergic receptor
Ge, M., Wu, L., He, F., Tai, Y., Fang, R., Han, D., Paipai, G., Liu, H., Hu, Y., Xu, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24709108
Additional file 3 of CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in Gαs-Gαi coupling to the β2-adrenergic receptor
Ge, M., Wu, L., He, F., Tai, Y., Fang, R., Han, D., Paipai, G., Liu, H., Hu, Y., Xu, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26647527
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Authors: Jensen, B. C., Swigart, P. M., & Simpson, P. C.
Affiliations: San Francisco VA Medical Center (US)
Corresponding author: Simpson, Paul C.
ORCID: Jensen, Brian C.
Simpson, Paul C.
Venue: Naunyn-Schmiedeberg's Archives of Pharmacology
Publisher: Springer Science and Business Media LLC
Published: 2008-11-07
Volume: 379
Issue: 4
Pages: 409-412
ISSN: 0028-1298 (ISSN-L)
1432-1912
DOI: 10.1007/s00210-008-0368-6
PMC: PMC2653258
OpenAlex: W2077606276
Cited by: 176
References: 12
Citations by year: 2026: 4 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 6 · 2021: 11 · 2020: 10 · 2019: 11 · 2018: 9 · 2017: 8 · 2016: 14 · 2015: 8 · 2014: 20 · 2013: 14 · 2012: 12
FWCI: 4.12
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Naunyn-Schmiedeberg s Archives of Pharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs
National Heart, Lung, and Blood Institute (R01HL031113)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
Keywords: alpha1-adrenoceptors, commercial antibodies, antibody specificity, receptor knockout mice, receptor localization
MeSH terms: Animals, Antibodies, Antibody Specificity, Brain Chemistry, Mice, Inbred C57BL, Myocardium, Blotting, Western, Receptors, Adrenergic, alpha-1, Mice, Knockout, Mice

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Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific

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