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α-Phellandrene attenuates tissular damage, oxidative stress, and TNF-α levels on acute model ifosfamide-induced hemorrhagic cystitis in mice

Gonçalves, R. L. G., Cunha, F. V. M., Sousa-Neto, B. P. S., Oliveira, L. S. A., Lopes, M. E., Rezende, D. C., Sousa, I. J. O., Nogueira, K. M., Souza, L. K. M., Medeiros, J. V. R., Wong, D. V. T., Pereira, V. M. P., Lima-Júnior, R. C. P., Sousa, D. P., Oliveira, C. P. C., Almeida, F. R. C., Oliveira, Francisco de Assis·2020·Naunyn-Schmiedeberg's Archives of Pharmacology
DOI 10.1007/s00210-020-01869-3
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Abstract

Hemorrhagic cystitis (HC) is the major dose-limiting adverse effect of the clinical use ifosfamide (IFOS). The incidence of this side effect can be as high as 75%. Mesna has been used to reduce the risk of HC, although 5% of patients who get IFOS treatment may still suffer from HC. In previous studies, our group demonstrated that α-phellandrene (α-PHE) possesses anti-inflammatory activity, which opens the door for its study in the attenuation of HC. The objective of this study was to investigate the potential uroprotective effect of the α-PHE in the mouse model of IFOS-induced HC. In order to analyze the reduction of the urothelial damage, the bladder wet weight, hemoglobin content, and the Evans blue dye extravasation from the bladder matrix were evaluated. To investigate the involvement of neutrophil migration and lipid peroxidation and involvement of enzymatic and endogenous non-enzymatic antioxidants, the tissue markers myeloperoxidase (MPO), malondialdehyde, nitrite/nitrate (NOx), superoxide dismutase (SOD), and reduced glutathione (GSH) were evaluated. TNF-α and IL-1β were measured by ELISA immunoassay technique. The results show that pretreatment with α-PHE significantly reduced urothelial damage that was accompanied by a decrease in the activity of MPO, MDA, and NOx levels and prevention of the depletion of SOD and GSH in bladder tissues. In the assessment of cytokines, α-PHE was able to significantly reduce TNF-α level. However, it does not affect the activities of I…

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Cited by

Metadata

Authors
Gonçalves, R. L. G., Cunha, F. V. M., Sousa-Neto, B. P. S., Oliveira, L. S. A., Lopes, M. E., Rezende, D. C., Sousa, I. J. O., Nogueira, K. M., Souza, L. K. M., Medeiros, J. V. R., Wong, D. V. T., Pereira, V. M. P., Lima-Júnior, R. C. P., Sousa, D. P., Oliveira, C. P. C., Almeida, F. R. C., & Oliveira, F. D. A.
Venue
Naunyn-Schmiedeberg's Archives of Pharmacology
Publisher
Springer Science and Business Media LLC
Published
2020-05-15
Volume
393
Issue
10
Pages
1835-1848
ISSN
  • 0028-1298
  • 1432-1912
DOI
10.1007/s00210-020-01869-3
Cited by
27
References
1
Language
en
Update notices
correction (2020-10-16)
Licence
Funders
FAPEPI (EDITAL FAPEPI/MS­DECIT/CNPq/SESAPI N° 002/2016 – PPSUS (Projeto PPSUS ­ EFP_00012091) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES/Brazil) for their financial support.)

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