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Cited by 2,152Antioxidant Activity and Oxidative StressExercise and Physiological ResponsesPhytochemicals and Antioxidant Activities

The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state

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Kurutas, Ergul Belge·2015·Nutrition Journal
DOI 10.1186/s12937-016-0186-5PMC PMC4960740
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Abstract

Remarkable interest has risen in the idea that oxidative/nitrosative stress is mediated in the etiology of numerous human diseases. Oxidative/Nitrosative stress is the result of an disequilibrium in oxidant/antioxidant which reveals from continuous increase of Reactive Oxygen and Reactive Nitrogen Species production. The aim of this review is to emphasize with current information the importance of antioxidants which play the role in cellular responce against oxidative/nitrosative stress, which would be helpful in enhancing the knowledge of any biochemist, pathophysiologist, or medical personnel regarding this important issue. Products of lipid peroxidation have commonly been used as biomarkers of oxidative/nitrosative stress damage. Lipid peroxidation generates a variety of relatively stable decomposition end products, mainly α, β-unsaturated reactive aldehydes, such as malondialdehyde, 4-hydroxy-2-nonenal, 2-propenal (acrolein) and isoprostanes, which can be measured in plasma and urine as an indirect index of oxidative/nitrosative stress. Antioxidants are exogenous or endogenous molecules that mitigate any form of oxidative/nitrosative stress or its consequences. They may act from directly scavenging free radicals to increasing antioxidative defences. Antioxidant deficiencies can develop as a result of decreased antioxidant intake, synthesis of endogenous enzymes or increased antioxidant utilization. Antioxidant supplementation has become an increasingly popular practice to maintain optimal body function. However, antoxidants exhibit pro-oxidant activity depending on the specific set of conditions. Of particular importance are their dosage and redox conditions in the cell.

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Authors
Kurutas, E. B.
Venue
Nutrition Journal
Publisher
Springer Science and Business Media LLC
Published
2015-12
Volume
15
Issue
1
Pages
71-71
ISSN
1475-2891 (ISSN-L)
DOI
10.1186/s12937-016-0186-5
PMC
PMC4960740
OpenAlex
W2485662396
Cited by
2,152
References
209
Citations by year
2026: 92 · 2025: 193 · 2024: 249 · 2023: 326 · 2022: 385 · 2021: 376 · 2020: 330 · 2019: 116 · 2018: 56 · 2017: 22 · 2016: 5 · 2013: 1
FWCI
2.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrition Journal (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
antioxidants, oxidative stress, nitrosative stress, reactive oxygen species, reactive nitrogen species, lipid peroxidation, malondialdehyde, 4-hydroxynonenal, acrolein, isoprostanes, free radical scavenging, antioxidant supplementation, pro-oxidant activity, antioxidant deficiency, redox conditions
MeSH terms
Antioxidants, Gene Expression Regulation, Humans, Protein Kinases, Transcription Factors, Lipid Peroxidation, Randomized Controlled Trials as Topic, Protein Tyrosine Phosphatases, Reactive Oxygen Species, Oxidative Stress, Dietary Supplements, Reactive Nitrogen Species

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