Cited by 117Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorAlcohol Consumption and Health Effects
Noradrenergic targets for the treatment of alcohol use disorder
Open accessHaass-Koffler, Carolina L., Swift, Robert M., Leggio, Lorenzo·2018·Psychopharmacology
Abstract
The role of norepinephrine (NE) in the development of alcohol use disorder (AUD) has been studied over the past several decades. However, the NE system has been largely ignored for many years as a potential target for medication development for AUD. More recently, preclinical and clinical studies have demonstrated the potential value of targeting NE signaling for developing new pharmacological treatments for AUD. This review contributes to a special issue of Psychopharmacology focused on promising targets for alcohol addiction. Specifically, this review coalesces preclinical and clinical neuroscience that re-evaluate the noradrenergic system, and in particular the alpha-1 receptor, as a potential target for AUD.
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α1 antagonists such as prazosin and doxazosin have been shown to decrease alcohol consumption.
“α1 antagonists such as prazosin and doxazosin have been shown to decrease alcohol consumption and are a growing interest (reviewed in Haass-Koffler et al. 2018).”
From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Haass-Koffler et al. 2018
Guanfacine is posited as a treatment for individuals with both AUD and high levels of uncontrollable stress, with clinical trials currently underway.
“Guanfacine, an α2 agonist, is posited as a treatment with individuals with both AUD and high levels of uncontrollable stress (see Sinha 2022), with clinical trials currently underway (NCT03137082, see Haass-Koffler et al. 2018).”
From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Haass-Koffler et al. 2018
Adrenergic drugs are a growing area of interest as a novel treatment for AUD.
“Adrenergic drugs are a growing area of interest as a novel treatment for AUD (Haass-Koffler et al. 2018).”
From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Haass-Koffler et al. 2018
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Cites
The structure and function of G-protein-coupled receptors
Rosenbaum, D. M., Rasmussen, S. G. F., & Kobilka, B. K. (2009) · Nature · doi:10.1038/nature08144 · Cited by 2,534 · see citing works
Brain stress systems in the amygdala and addiction
Koob, G. F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.038 · Cited by 388 · see citing works
The role of biogenic amine signaling in the bed nucleus of the stria terminals in alcohol abuse
Kash, T. L. (2012) · Alcohol · doi:10.1016/j.alcohol.2011.12.004 · Cited by 58 · cited 5× · see citing works
“Studies on NE in the amygdala, the bed nucleus of the stria terminalis (BNST) (Kash 2012), and the paraventricular nucleus of the * Carolina L.”
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Flagged first, then by citations
Research works printed but not linked: 92
- ABERCROMBIE ED KELLER RW JR ZIGMOND MJ 1988 Characterization of hippocampal norepinephrine release as measured by microdialysis perfusion: pharmacological and behavioral studies Neuroscience 27 897 904 3252176
- ADINOFF B 1994 Double-blind study of alprazolam, diazepam, clonidine, and placebo in the alcohol withdrawal syndrome: preliminary findings Alcoholism, clinical and experimental research 18 873 8 7978098
- AGHAJANIAN GK VANDERMAELEN CP 1982 alpha 2-adrenoceptor-mediated hyperpolarization of locus coeruleus neurons: intracellular studies in vivo Science 215 1394 6 6278591
- AHLENIUS S CARLSSON A ENGEL J SVENSSON T SODERSTEN P 1973 Antagonism by alpha methyltyrosine of the ethanol-induced stimulation and euphoria in man Clin Pharmacol Ther 14 586 91 4723267
- AHLQUIST RP 1948 A study of the adrenotropic receptors Am J Physiol 153 586 600 18882199
- AKDUMAN B CRAWFORD ED 2001 Terazosin, doxazosin, and prazosin: current clinical experience Urology 58 49 54 11750252
- ALONSO G SZAFARCZYK A BALMEFREZOL M ASSENMACHER I 1986 Immunocytochemical evidence for stimulatory control by the ventral noradrenergic bundle of parvocellular neurons of the paraventricular nucleus secreting corticotropin releasing hormone and vasopressin in rats Brain Res 397 297 307 3099973
- AMIT Z BROWN ZW LEVITAN DE OGREN SO 1977 Noradrenergic mediation of the positive reinforcing properties of ethanol: I. Suppression of ethanol consumption in laboratory rats following dopamine-beta-hydroxylase inhibition Arch Int Pharmacodyn Ther 230 65 75 603310
- BAILLY D SERVANT D BLANDIN N BEUSCART R PARQUET PJ 1992 Effects of beta-blocking drugs in alcohol withdrawal: a double-blind comparative study with propranolol and diazepam Biomed Pharmacother 46 419 24 1363375
- BECKER HC 2012 Effects of alcohol dependence and withdrawal on stress responsiveness and alcohol consumption Alcohol Res 34 448 58 23584111 PMC3860383
- BEGLEITER H 1974 Propranolol and alcohol consumption in the rat Am J Drug Alcohol Abuse 1 107 10 4467717
- BERLAN M MONTASTRUC JL LAFONTAN M 1992 Pharmacological prospects for alpha 2-adrenoceptor antagonist therapy Trends Pharmacol Sci 13 277 82 1354903
- BJORKQVIST SE 1975 Clonidine in alcohol withdrawal Acta Psychiatr Scand 52 256 63 1103576
- CORRODI H FUXE K HOKFELT T 1966 The effect of ethanol on the activity of central catecholamine neurones in rat brain J Pharm Pharmacol 18 821 3 4381667
- DOXEY JC LANE AC ROACH AG VIRDEE NK 1984 Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine Naunyn-Schmiedeberg’s archives of pharmacology 325 136 44 6144048
- DOXEY JC ROACH AG SMITH CF 1983 Studies on RX 781094: a selective, potent and specific antagonist of alpha 2-adrenoceptors British journal of pharmacology 78 489 505 6132640 PMC2044721
- DURCAN MJ LISTER RG LINNOILA M 1989a Behavioral effects of alpha 2 adrenoceptor antagonists and their interactions with ethanol in tests of locomotion, exploration and anxiety in mice Psychopharmacology 97 189 93 2567025
- DURCAN MJ LISTER RG LINNOILA M 1989b Interactions of alpha 2-adrenoceptor antagonists with medetomidine and with ethanol in a holeboard test Neuropharmacology 28 275 81 2566945
- DURCAN MJ WOZNIAK KM LISTER RG LINNOILA M 1989c Attenuation of hypothermic effects of ethanol by alpha 2-adrenoceptor blockers European journal of pharmacology 166 381 6 2572427
- EGLI RE KASH TL CHOO K SAVCHENKO V MATTHEWS RT BLAKELY RD WINDER DG 2005 Norepinephrine modulates glutamatergic transmission in the bed nucleus of the stria terminalis Neuropsychopharmacology 30 657 68 15602500
- EGLI RE WINDER DG 2003 Dorsal and ventral distribution of excitable and synaptic properties of neurons of the bed nucleus of the stria terminalis J Neurophysiol 90 405 14 12649311
- FITZGERALD PJ 2013 Elevated Norepinephrine may be a Unifying Etiological Factor in the Abuse of a Broad Range of Substances: Alcohol, Nicotine, Marijuana, Heroin, Cocaine, and Caffeine Subst Abuse 7 171 83 24151426 PMC3798293
- FOX HC ANDERSON GM TUIT K HANSEN J KIMMERLING A SIEDLARZ KM MORGAN PT SINHA R 2012 Prazosin effects on stress- and cue-induced craving and stress response in alcohol-dependent individuals: preliminary findings Alcohol Clin Exp Res 36 351 60 21919922 PMC3243763
- FOX HC BERGQUIST KL HONG KI SINHA R 2007 Stress-induced and alcohol cue-induced craving in recently abstinent alcohol-dependent individuals Alcohol Clin Exp Res 31 395 403 17295723
- FREDRIKSSON I JAYARAM-LINDSTROM N WIRF M NYLANDER E NYSTROM E JARDEMARK K STEENSLAND P 2015 Evaluation of guanfacine as a potential medication for alcohol use disorder in long-term drinking rats: behavioral and electrophysiological findings Neuropsychopharmacology 40 1130 40 25359257 PMC4367455
- FROEHLICH JC HAUSAUER B FISCHER S WISE B RASMUSSEN DD 2015 Prazosin Reduces Alcohol Intake in an Animal Model of Alcohol Relapse Alcohol Clin Exp Res 39 1538 46 26207767 PMC4515780
- FUNK D COEN K TAMADON S LI Z LOUGHLIN A LE AD 2016 Effects of prazosin and doxazosin on yohimbine-induced reinstatement of alcohol seeking in rats Psychopharmacology (Berl) 233 2197 207 27020784
- GILPIN NW KOOB GF 2010 Effects of beta-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats Psychopharmacology (Berl) 212 431 9 20676608 PMC2966867
- GIOVANNITTI JA JR THOMS SM CRAWFORD JJ 2015 Alpha-2 adrenergic receptor agonists: a review of current clinical applications Anesth Prog 62 31 9 25849473 PMC4389556
- GOLD MS POTTASH AC SWEENEY DR KLEBER HD 1980 Opiate withdrawal using clonidine. A safe, effective, and rapid nonopiate treatment JAMA 243 343 6 7351747
- GROSS G HANFT G MEHDORN HM 1989 Demonstration of alpha 1A- and alpha 1B-adrenoceptor binding sites in human brain tissue Eur J Pharmacol 169 325 8 2572438
- HAASS-KOFFLER CL AKHLAGHI F SWIFT RM LEGGIO L 2017a Altering ethanol pharmacokinetics to treat alcohol use disorder: Can you teach an old dog new tricks? J Psychopharmacol 31 812 818 28093021 PMC5768306
- HAASS-KOFFLER CL AKHLAGHI F SWIFT RM LEGGIO L 2017b Altering ethanol pharmacokinetics to treat alcohol use disorder: Can you teach an old dog new tricks? J Psychopharmacol 269881116684338 PMC5768306 28093021
- HAASS-KOFFLER CL GOODYEAR K ZYWIAK WH MAGILL M ELTINGE SE WALLACE PM LONG VM JAYARAM-LINDSTROM N SWIFT RM KENNA GA LEGGIO L 2017c Higher pretreatment blood pressure is associated with greater alcohol drinking reduction in alcohol-dependent individuals treated with doxazosin Drug Alcohol Depend 177 23 28 28551590 PMC5534374
- HAASS-KOFFLER CL LEGGIO L DAVIDSON D SWIFT RM 2015 Effects of idazoxan on alcohol pharmacokinetics and intoxication: a preliminary human laboratory study Alcohol Clin Exp Res 39 594 602 25833022 PMC4384190
- HAASS-KOFFLER CL LEGGIO L KENNA GA 2014 Pharmacological approaches to reducing craving in patients with alcohol use disorders CNS Drugs 28 343 60 24573997 PMC3990000
- HAWLEY RJ MAJOR LF SCHULMAN EA LAKE CR 1981 CSF levels of norepinephrine during alcohol withdrawal Arch Neurol 38 289 92 7224914
- HOFNER K JONAS U 2002 Alfuzosin: a clinically uroselective alpha1-blocker World J Urol 19 405 12 12022709
- HORWITZ RI GOTTLIEB LD KRAUS ML 1989 The efficacy of atenolol in the outpatient management of the alcohol withdrawal syndrome. Results of a randomized clinical trial Arch Intern Med 149 1089 93 2719503
- KAYE B CUSSANS NJ FAULKNER JK STOPHER DA REID JL 1986 The metabolism and kinetics of doxazosin in man, mouse, rat and dog Br J Clin Pharmacol 21 Suppl 1 19S 25S 2939865 PMC1400758
- KEANEY F STRANG J GOSSOP M MARSHALL EJ FARRELL M WELCH S HAHN B GONZALEZ A 2001 A double-blind randomized placebo-controlled trial of lofexidine in alcohol withdrawal: lofexidine is not a useful adjunct to chlordiazepoxide Alcohol Alcohol 36 426 30 11524309
- KENNA GA HAASS-KOFFLER CL ZYWIAK WH EDWARDS SM BRICKLEY MB SWIFT RM LEGGIO L 2016 Role of the alpha1 blocker doxazosin in alcoholism: a proof-of-concept randomized controlled trial Addict Biol 21 904 14 26037245 PMC4668239
- KENT JM MATHEW SJ GORMAN JM 2002 Molecular targets in the treatment of anxiety Biol Psychiatry 52 1008 30 12437941
- KOOB G KREEK MJ 2007 Stress, dysregulation of drug reward pathways, and the transition to drug dependence Am J Psychiatry 164 1149 59 17671276 PMC2837343
- KOOB GF 2008 A role for brain stress systems in addiction Neuron 59 11 34 18614026 PMC2748830
- KOOB GF LE MOAL M 1997 Drug abuse: hedonic homeostatic dysregulation Science 278 52 8 9311926
- KOVACS GL SORONCZ M TEGYEI I 2002 Plasma catecholamines in ethanol tolerance and withdrawal in mice Eur J Pharmacol 448 151 6 12144935
- KREEK MJ KOOB GF 1998 Drug dependence: stress and dysregulation of brain reward pathways Drug Alcohol Depend 51 23 47 9716928
- LANGER SZ 1980 Presynaptic regulation of the release of catecholamines Pharmacol Rev 32 337 62 6267618
- LE AD FUNK D JUZYTSCH W COEN K NAVARRE BM CIFANI C SHAHAM Y 2011 Effect of prazosin and guanfacine on stress-induced reinstatement of alcohol and food seeking in rats Psychopharmacology (Berl) 218 89 99 21318567 PMC3168954
- LE AD HARDING S JUZYTSCH W FUNK D SHAHAM Y 2005 Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats Psychopharmacology (Berl) 179 366 73 15551068
- LI TK LUMENG L MCBRIDE WJ WALLER MB 1979 Progress toward a voluntary oral consumption model of alcoholism Drug Alcohol Depend 4 45 60 41697
- LISTER RG DURCAN MJ NUTT DJ LINNOILA M 1989 Attenuation of ethanol intoxication by alpha-2 adrenoceptor antagonists Life sciences 44 111 9 2563566
- LITTEN RZ BRADLEY AM MOSS HB 2010 Alcohol biomarkers in applied settings: recent advances and future research opportunities Alcohol Clin Exp Res 34 955 67 20374219
- MAO L ABDEL-RAHMAN AA 1996 Synergistic behavioral interaction between ethanol and clonidine in rats: role of alpha-2 adrenoceptors The Journal of pharmacology and experimental therapeutics 279 443 9 8930144
- MARINELLI PW FUNK D JUZYTSCH W HARDING S RICE KC SHAHAM Y LE AD 2007 The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats Psychopharmacology (Berl) 195 345 55 17705061
- MCDOUGLE CJ KRYSTAL JH PRICE LH HENINGER GR CHARNEY DS 1995 Noradrenergic response to acute ethanol administration in healthy subjects: comparison with intravenous yohimbine Psychopharmacology (Berl) 118 127 35 7617798
- MCELLIGOTT ZA KLUG JR NOBIS WP PATEL S GRUETER BA KASH TL WINDER DG 2010 Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress Proc Natl Acad Sci U S A 107 2271 6 20133871 PMC2836642
- MCLEOD SD CAIRNCROSS KD 1995 Preliminary evidence of a synergistic alpha 1- and beta 1-adrenoceptor regulation of rat pineal hydroxyindole-O-methyltransferase Gen Comp Endocrinol 97 283 8 7789743
- MICHEL MC SCHAFERS RF GOEPEL M 2000 Alpha-blockers and lower urinary tract function: more than smooth muscle relaxation? BJU Int 86 Suppl 2 23 8 discussion 28–30 11501614
- MIRIJELLO A D’ANGELO C FERRULLI A VASSALLO G ANTONELLI M CAPUTO F LEGGIO L GASBARRINI A ADDOLORATO G 2015 Identification and management of alcohol withdrawal syndrome Drugs 75 353 65 25666543 PMC4978420
- O’NEIL ML BECKWITH LE KINCAID CL RASMUSSEN DD 2013 The alpha1-adrenergic receptor antagonist, doxazosin, reduces alcohol drinking in alcohol-preferring (P) Rats Alcohol Clin Exp Res 37 202 12 22758213 PMC3470781
- PATKAR AA GOPALAKRISHNAN R NAIK PC MURRAY HW VERGARE MJ MARSDEN CA 2003 Changes in plasma noradrenaline and serotonin levels and craving during alcohol withdrawal Alcohol Alcohol 38 224 31 12711656
- PETRAKIS IL DESAI N GUEORGUIEVA R ARIAS A O’BRIEN E JANE JS SEVARINO K SOUTHWICK S RALEVSKI E 2016 Prazosin for Veterans with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence: A Clinical Trial Alcohol Clin Exp Res 40 178 86 26683790
- PICHOT C GHIGNONE M QUINTIN L 2012 Dexmedetomidine and clonidine: from second- to first-line sedative agents in the critical care setting? J Intensive Care Med 27 219 37 21525113
- QIN K SETHI PR LAMBERT NA 2008 Abundance and stability of complexes containing inactive G protein-coupled receptors and G proteins FASEB J 22 2920 7 18434433 PMC2493464
- RASKIND MA MILLARD SP PETRIE EC PETERSON K WILLIAMS T HOFF DJ HART K HOLMES H HILL J DANIELS C HENDRICKSON R PESKIND ER 2016 Higher Pretreatment Blood Pressure Is Associated With Greater Posttraumatic Stress Disorder Symptom Reduction in Soldiers Treated With Prazosin Biol Psychiatry 27320368
- RASKIND MA PETERSON K WILLIAMS T HOFF DJ HART K HOLMES H HOMAS D HILL J DANIELS C CALOHAN J MILLARD SP ROHDE K O’CONNELL J PRITZL D FEISZLI K PETRIE EC GROSS C MAYER CL FREED MC ENGEL C PESKIND ER 2013 A trial of prazosin for combat trauma PTSD with nightmares in active-duty soldiers returned from Iraq and Afghanistan Am J Psychiatry 170 1003 10 23846759
- RASMUSSEN DD ALEXANDER L MALONE J FEDEROFF D FROEHLICH JC 2014a The alpha2-adrenergic receptor agonist, clonidine, reduces alcohol drinking in alcohol-preferring (P) rats Alcohol 48 543 9 25085719 PMC4163132
- RASMUSSEN DD ALEXANDER LL RASKIND MA FROEHLICH JC 2009 The alpha1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats Alcohol Clin Exp Res 33 264 72 19032582 PMC2692839
- RASMUSSEN DD BECKWITH LE KINCAID CL FROEHLICH JC 2014b Combining the alpha1 -adrenergic receptor antagonist, prazosin, with the beta-adrenergic receptor antagonist, propranolol, reduces alcohol drinking more effectively than either drug alone Alcohol Clin Exp Res 38 1532 9 24891220 PMC4047654
- REID JL 1986 Alpha-adrenergic receptors and blood pressure control Am J Cardiol 57 6E 12E 2869681
- RIIHIOJA P JAATINEN P OKSANEN H HAAPALINNA A HEINONEN E HERVONEN A 1997 Dexmedetomidine, diazepam, and propranolol in the treatment of ethanol withdrawal symptoms in the rat Alcohol Clin Exp Res 21 804 8 9267529
- SARNYAI Z SHAHAM Y HEINRICHS SC 2001 The role of corticotropin-releasing factor in drug addiction Pharmacol Rev 53 209 43 11356984
- SICA DA 2005 Alpha1-Adrenergic Blockers: Current Usage Considerations The Journal of Clinical Hypertension 7 757 762 16330901 PMC8109532
- SILBERMAN Y ARIWODOLA OJ WEINER JL 2012 beta1-adrenoceptor activation is required for ethanol enhancement of lateral paracapsular GABAergic synapses in the rat basolateral amygdala J Pharmacol Exp Ther 343 451 9 22904357 PMC3477216
- SIMMS JA HAASS-KOFFLER CL BITO-ONON J LI R BARTLETT SE 2012 Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking Neuropsychopharmacology 37 906 18 22048462 PMC3280651
- SIMPSON TL MALTE CA DIETEL B TELL D POCOCK I LYONS R VARON D RASKIND M SAXON AJ 2015 A pilot trial of prazosin, an alpha-1 adrenergic antagonist, for comorbid alcohol dependence and posttraumatic stress disorder Alcohol Clin Exp Res 39 808 17 25827659 PMC4400241
- SIMPSON TL SAXON AJ MEREDITH CW MALTE CA MCBRIDE B FERGUSON LC GROSS CA HART KL RASKIND M 2009 A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence Alcohol Clin Exp Res 33 255 63 18945226
- SOCARANSKY SM ARAGON CM RUSK I AMIT Z OGREN SO 1985 Norepinephrine turnover and voluntary consumption of ethanol in the rat Alcohol 2 339 42 4040381
- SOYKA M MULLER CA 2017 Pharmacotherapy of alcoholism - an update on approved and off-label medications Expert Opin Pharmacother 18 1187 1199 28658981
- STRAHLENDORF HK STRAHLENDORF JC 1983 Ethanol suppression of locus coeruleus neurons: relevancy to the fetal alcohol syndrome Neurobehav Toxicol Teratol 5 221 4 6306495
- SWIFT R OSLIN DW ALEXANDER M FORMAN R 2011 Adherence monitoring in naltrexone pharmacotherapy trials: a systematic review J Stud Alcohol Drugs 72 1012 8 22051215 PMC9798465
- TAKSANDE BG KOTAGALE NR PATEL MR SHELKAR GP UGALE RR CHOPDE CT 2010 Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats European journal of pharmacology 637 89 101 20394743
- THIELE TE CUBERO I VAN DIJK G MEDIAVILLA C BERNSTEIN IL 2000 Ethanol-induced c-fos expression in catecholamine- and neuropeptide Y-producing neurons in rat brainstem Alcohol Clin Exp Res 24 802 9 10888068
- TROVERO F DAVID S BERNARD P PUECH A BIZOT JC TASSIN JP 2016 The Combination of Marketed Antagonists of alpha1b-Adrenergic and 5-HT2A Receptors Inhibits Behavioral Sensitization and Preference to Alcohol in Mice: A Promising Approach for the Treatment of Alcohol Dependence PLoS One 11 e0151242 26968030 PMC4788426
- TRZASKOWSKA E PUCILOWSKI O DYR W KOSTOWSKI W HAUPTMANN M 1986 Suppression of ethanol tolerance and dependence in rats treated with DSP-4, a noradrenergic neurotoxin Drug Alcohol Depend 18 349 53 3816531
- UMHAU JC SCHWANDT ML USALA J GEYER C SINGLEY E GEORGE DT HEILIG M 2011 Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate Neuropsychopharmacology 36 1178 86 21289601 PMC3077446
- WALKER BM RASMUSSEN DD RASKIND MA KOOB GF 2008 alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol Alcohol 42 91 7 18358987 PMC2587143
- WRIGHT DF WINTER HR DUFFULL SB 2011 Understanding the time course of pharmacological effect: a PKPD approach Br J Clin Pharmacol 71 815 23 21272054 PMC3099368
- YAMANAKA Y 1982 Effects of brain biogenic amines on ethanol withdrawal reactions and the development of ethanol dependence in mice Jpn J Pharmacol 32 499 508 7202070
- YAMANAKA Y EGASHIRA T 1982 Effects of ethanol on catecholamine levels and related enzyme activities in different brain regions of rats Jpn J Pharmacol 32 599 606 6127425
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Novel Agents for the Pharmacological Treatment of Alcohol Use Disorder
Burnette, E. M., Nieto, S. J., Grodin, E. N., Meredith, L. R., Hurley, B., Miotto, K., Gillis, A. J., & Ray, L. A. (2022) · Drugs · doi:10.1007/s40265-021-01670-3 · Cited by 169 · see citing works
Vanderkam, P., Solinas, M., Ingrand, I., Doux, N., Ebrahimighavam, S., Jaafari, N., & Lafay‐Chebassier, C. (2021) · Addiction · doi:10.1111/add.15265 · Cited by 25 · see citing works
Russell, N. M., Frier, M. D., Bortolato, M., & Mangieri, R. A. (2026) · Psychopharmacology · doi:10.1007/s00213-025-06938-0 · Cited by 3 · see citing works
- Authors
- Haass-Koffler, C. L., Swift, R. M., & Leggio, L.
- Affiliations
- Brown University (US)
- National Institutes of Health (US)
- Venue
- Psychopharmacology
- Published
- 2018-02-20
- Volume
- 235
- Issue
- 6
- Pages
- 1625-1634
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC5995154
- OpenAlex
- W2793137269
- Cited by
- 117
- References
- 3
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 9 · 2023: 60 · 2022: 13 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 3
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (K01AA023867, ZIA-AA000218)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- alcoholism, norepinephrine, noradrenergic system, alpha1-adrenoceptors, norepinephrine signaling
- MeSH terms
- Adrenergic beta-Antagonists, Alcoholism, Clonidine, Humans, Norepinephrine, Prazosin, Propranolol, Receptors, Adrenergic, Drug Delivery Systems, Adrenergic alpha-2 Receptor Agonists, Adrenergic alpha-1 Receptor Antagonists, Adrenergic Neurons
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