The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Ethanol induces impulsive-like responding in a delay-of-reward operant choice procedure: impulsivity predicts autoshaping
Abstract
Autoshaping conditioned responses (CRs) are reflexive and targeted motor responses expressed as a result of experience with reward. To evaluate the hypothesis that autoshaping may be a form of impulsive responding, within-subjects correlations between performance on autoshaping and impulsivity tasks were assessed in 15 Long-Evans hooded rats. Autoshaping procedures [insertion of retractable lever conditioned stimulus (CS) followed by the response-independent delivery of food (US)] were followed by testing for impulsive-like responding in a two-choice lever-press operant delay-of-reward procedure (immediate small food reward versus delayed large food reward). Delay-of-reward functions revealed two distinct subject populations. Subjects in the Sensitive group (n=7) were more impulsive-like, increasing immediate reward choices at longer delays for large reward, while those in the Insensitive group (n=8) responded predominantly on only one lever. During the prior autoshaping phase, the Sensitive group had performed more autoshaping CRs, and correlations revealed that impulsive subjects acquired the autoshaping CR in fewer trials. In the Sensitive group, acute injections of ethanol (0, 0.25, 0.50, 1.00, 1.50 g/kg) given immediately before delay-of-reward sessions yielded an inverted U-shaped dose-response curve with increased impulsivity induced by the 0.25, 0.50, and 1.00 g/kg doses of ethanol, while choice strategy of the Insensitive group was not influenced by ethanol dose. Ethanol induced impulsive-like responding only in rats that were flexible in their response strategy (Sensitive group), and this group also performed more autoshaping CRs. Data support the hypothesis that autoshaping and impulsivity are linked.
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“Individuals who attribute reward cues with incentive salience find it more difficult to resist such cues, a feature associated with reduced impulse control15,31.”
From A selective role for dopamine in stimulus-reward learning (2011) · cites this paper as [31]
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A selective role for dopamine in stimulus-reward learning
Flagel, S. B., Clark, J. J., Robinson, T. E., Mayo, L., Czuj, A., Willuhn, I., Akers, C. A., Clinton, S. M., Phillips, P. E. M., & Akil, H. (2011) · Nature · doi:10.1038/nature09588 · Cited by 1,026
REVIEW: Understanding the construct of impulsivity and its relationship to alcohol use disorders
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Flagel, S. B., Akil, H., & Robinson, T. E. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.027 · Cited by 561
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Beyond discounting: possible experimental models of impulse control
Monterosso, J. R., & Ainslie, G. W. (1999) · Psychopharmacology · doi:10.1007/pl00005480 · Cited by 370
Metadata
- Authors
- Tomie, A., Aguado, A. S., Pohorecky, L. A., & Benjamin, D.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- ORCID
- Aguado, A. S.
- Venue
- Psychopharmacology
- Published
- 1998-09-15
- Volume
- 139
- Issue
- 4
- Pages
- 376-382
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2072312333
- Cited by
- 108
- References
- 17
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 11 · 2013: 6 · 2012: 2
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r03mh052293-02)
- U.S. Public Health Service (10124-02)
- National Institute on Alcohol Abuse and Alcoholism
- National Institute of Mental Health (MH 52293-02)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- ethanol, impulsivity, autoshaping, reward delay, operant choice, conditioned response, acute ethanol effects, dose-response relationship, response flexibility, rats
- MeSH terms
- Ethanol, Animals, Conditioning, Operant, Impulsive Behavior, Male, Psychomotor Performance, Reward, Rats, Long-Evans, Rats
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