Impulsivity predicts individual susceptibility to high levels of alcohol self-administration
Abstract
Clinical studies indicate large individual differences in susceptibility to alcohol abuse. Poor behavioral self -regulation has been proposed to reflect a predisposing factor. Like humans, only some rats regularly consume large and intoxicating amounts of alcohol. We hypothesized that clinical indications of impaired behavioral self-regulation should be reflected in an animal model of impulse control, and in this study we assessed impulsivity with a delay-of-reward paradigm. We found that three groups representing three levels of impulsivity predicted augmenting levels of alcohol self-administration. Also, overall impulsivity scores were found to be significantly correlated with magnitude of alcohol self-administration. The finding that high impulsivity is linked to elevated consumption represents an animal model that may mirror clinical depictions of an alcohol abuse syndrome. This animal model may help elucidate the neurobiological basis of individual susceptibility to alcohol addiction.
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The relation between impulsive choice and acquisition of self-administration has been inconsistently replicated with other drugs of abuse.
“This finding has been inconsistently replicated, however, with other drugs of abuse”
From Changing Delay Discounting and Impulsive Choice: Implications for Addictions, Prevention, and Human Health (2019) · cites this paper as Poulos et al., 1995
In rats, high impulsivity measured by delay discounting is a vulnerability factor for both alcohol and cocaine self-administration.
“In rats, high impulsivity – measured by delay discounting – is a vulnerability factor for both alcohol (Poulos et al., 1995) and cocaine (Perry and Carroll, 2008; Perry et al., 2005) self-administration.”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Poulos et al., 1995
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“The results of the present experiment contrast with other research showing that impulsivity predicts acquisition of self-administration for cocaine (Perry et al., 2005, 2008a), nicotine (Diergaarde et al., 2008), and alcohol (Poulos et al., 1995).”
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“The correlation between more extreme discounting of delayed rewards in human drug-addicted individuals when compared to matched controls (Bickel & Marsch, 2001) has raised the possibility that the tendency toward selecting SS reinforcers may put one at risk of substance abuse (see Perry et al., 2005; Poulos et al., 19…”
BackgroundRung, J. M., Peck, S., Hinnenkamp, J. E., Preston, E., & Madden, G. J. (2019) · Perspectives on Behavior Science · doi:10.1007/s40614-019-00200-7 · Cited by 65 · see citing works
Stein, J. S., Johnson, P. S., Renda, C. R., Smits, R. R., Liston, K. J., Shahan, T. A., & Madden, G. J. (2013) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0031245 · Cited by 67 · see citing works
“In rats, Poulos et al. (1995) reported that impulsive choice positively predicted subsequent alcohol consumption in a two-bottle test almost identical to the one used here.”
BackgroundMethodResultInfluentialJupp, B., Caprioli, D., & Dalley, J. W. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.010934 · Cited by 65 · see citing works
“Furthermore, impulsive choice has been shown to predict increased alcohol (Oberlin and Grahame, 2009; Poulos et al., 1995) and nicotine (Diergaarde et al.”
BackgroundBehavioral sensitization to ethanol in rats: evidence from the Sprague–Dawley strain
Hoshaw, B. A., & Lewis, M. J. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00489-0 · Cited by 64 · see citing works
Neural Mechanisms of Risk Taking and Relationships with Hazardous Drinking
Claus, E. D., & Hutchison, K. E. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01694.x · Cited by 61 · see citing works
Mouse Lines Selected for Alcohol Consumption Differ on Certain Measures of Impulsivity
Wilhelm, C., Reeves, J. M., Phillips, T. J., & Mitchell, S. H. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00508.x · Cited by 61 · see citing works
“It was hypothesized that ethanol-naı̈ve STDRHI2 mice would score higher on measures of impulsivity (be more averse to delayed reinforcers in the delay discounting task and have decreased behavioral inhibition in the Go ⁄No-go task) compared with STDRLO2 mice, due to the association of alcohol drinking and heightened i…”
BackgroundKrmpotich, T., Mikulich-Gilbertson, S., Sakai, J., Thompson, L., Banich, M. T., & Tanabe, J. (2015) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000129 · Cited by 61 · see citing works
Wheel running as a predictor of cocaine self-administration and reinstatement in female rats
Larson, E. B., & Carroll, M. E. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.10.015 · Cited by 60 · see citing works
“, 2005), impulsivity (Poulos et al., 1995; Perry et al., 2005), and stress reactivity (Piazza et al.”
Olausson, P., Engel, J. A., & Söderpalm, B. (1999) · Psychopharmacology · doi:10.1007/s002130050869 · Cited by 59 · see citing works
“…lower 5-HT neurotransmission in experimental animals produce disinhibition also towards intake of various drugs of abuse (Engel et al. 1992; Roberts et al. 1994), and the propensity of rats to consume ethanol was recently reported to be associated with an increased impulsivity (Poulos et al. 1995).”
BackgroundCervantes, M. C., Laughlin, R. E., & Jentsch, J. D. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3135-4 · Cited by 55 · see citing works
“2009), but more recently impulsivityrelated traits have shown to predict susceptibility to different aspects of addiction-related behaviors (Belin et al. 2008; Boulougouris et al. 2007; Crews and Boettiger 2009; Diergaarde et al. 2008; Economidou et al. 2009; Lee et al. 2007; Perry et al. 2005; Poulos et al. 1995).”
Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models
Jupp, B., & Dalley, J. W. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12787 · Cited by 56 · see citing works
“Similarly, choice impulsivity predicts increased alcohol (Poulos et al., 1995; Oberlin and Grahame, 2009) and nicotine (Diergaarde et al., 2008; Kayir et al., 2014) consumption in rats, as well as resistance to extinction and enhanced relapse propensity to both nicotine (Diergaarde et al., 2008)…”
BackgroundDellu-Hagedorn, F. (2006) · Behavioral and Brain Functions · doi:10.1186/1744-9081-2-10 · Cited by 57 · see citing works
Blunted Dopamine Transmission in Addiction: Potential Mechanisms and Implications for Behavior.
Trifilieff, P., Ducrocq, F., van der Veldt, S., & Martinez, D. (2017) · Seminars in nuclear medicine · doi:10.1053/j.semnuclmed.2016.09.003 · Cited by 47 · see citing works
Delay Discounting Predicts Behavioral Sensitization to Ethanol in Outbred WSC Mice
Mitchell, S. H., Reeves, J. M., Li, N., & Phillips, T. J. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00047.x · Cited by 57 · see citing works
Stein, J. S., Pinkston, J. W., Brewer, A. T., Francisco, M. T., & Madden, G. J. (2012) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.2012.97-305 · Cited by 54 · see citing works
Bidirectional causality between addiction and cognitive deficits
Melugin, P. R., Nolan, S. O., & Siciliano, C. A. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.11.001 · Cited by 54 · see citing works
The role of impulsivity in the aetiology of drug dependence: reward sensitivity versus automaticity
Hogarth, L. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2172-0 · Cited by 50 · see citing works
“…showed the converse pattern: equal rates of self-administration (inconsistent with Anker et al. 2009; Marusich and Bardo 2009; Perry et al. 2005; Perry et al. 2008; Poulos et al. 1995) and perseveration of extinguished self-administration (consistent with Belin et al. 2008; Economidou et al. 2009).”
BackgroundResultInfluentialPoor impulse control predicts inelastic demand for nicotine but not alcohol in rats
Diergaarde, L., van Mourik, Y., Pattij, T., Schoffelmeer, A. N. M., & Vries, T. J. D. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00376.x · Cited by 50 · see citing works
Logue, S. F., Swartz, R. J., & Wehner, J. M. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb05898.x · Cited by 51 · see citing works
Leiserson, V., & Pihl, R. O. (2007) · Journal of Gambling Studies · doi:10.1007/s10899-007-9065-5 · Cited by 49 · see citing works
“Colder & Chassin, 1997; Poulos, Le, & Parker, 1995 ), and antisocial personality disorder (e.g.”
Garcı́a-Lecumberri, C., Torres, I., Martı́n, S., Crespo, J. A., Miguéns, M., Nicanor, C., Higuera‐Matas, A., & Ambrosio, E. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110367444 · Cited by 45 · see citing works
“Thus, impulsivity scores under a delayed reinforcement procedure are positively correlated with the magnitude of alcohol self-administration (Poulos et al., 1995).”
BackgroundDietary additives and the acquisition of cocaine self-administration in rats
Carroll, M. E., & Lac, S. T. (1998) · Psychopharmacology · doi:10.1007/s002130050596 · Cited by 48 · see citing works
Olausson, P., Ericson, M., Löf, E., Engel, J. A., & Söderpalm, B. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00903-7 · Cited by 48 · see citing works
- Authors
- Poulos, C. X., Le, A. D., & Parker, J. L.
- Affiliations
- University of Toronto (CA)
- ORCID
- Parker, J. L.
- Venue
- Behavioural Pharmacology
- Published
- 1995-12
- Volume
- 6
- Issue
- 8
- Pages
- 810???814
- ISSN
- 0955-8810 (ISSN-L)
- OpenAlex
- W1974743544
- Cited by
- 234
- References
- 0
- Citations by year
- 2025: 6 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 3 · 2018: 14 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 12 · 2013: 13 · 2012: 15
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- impulsivity, alcohol self-administration, behavioral self-regulation, reward delay, alcoholism, alcohol abuse
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