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Cited by 26Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Effects of benzodiazepine agonists on punished responding in pigeons and their relationship with clinical doses in humans

Kleven, M. S., Koek, Wouter·1999·Psychopharmacology
DOI 10.1007/s002130050826
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Abstract

Anxiolytic drugs generally produce anticonflict effects in both pigeons and rats, although relatively few anxiolytics have been examined in the pigeon and the procedure has not been as completely validated as the rat model. In this study, we examined the antipunishment effects of a variety of benzodiazepine agonists in pigeons and compared the relationship between their potencies to engender anxiolytic-like effects and their clinical doses in humans. In pigeons whose responding was maintained under a multiple FR30food:FR30food+shock schedule, the benzodiazepine agonists diazepam, flunitrazepam, alprazolam, chlordiazepoxide, lorazepam, flurazepam, bromazepam, medazepam, and clorazepate produced dose-related increases in punished responding, and, with the exception of medazepam, decreased unpunished responding at higher doses. Potencies calculated from the percentage of pigeons showing significant increases in punished responding ranged from 0.081 to 11 mg/kg, and these potencies were invariably lower than those for decreases in unpunished responding by factors ranging from 2.2 to more than 14. The comparison of relative potencies of benzodiazepine receptor agonists in pigeons and humans revealed a high positive correlation (0.90, P<0.005), thus demonstrating the predictive validity of this preclinical animal model for anxiolytic benzodiazepines. The results agree with previous findings of robust anticonflict effects of benzodiazepine receptor agonists and extend further the pharmacological characterization to compounds that have not been examined previously in pigeons.

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Metadata

Authors
Kleven, M. S., & Koek, W.
Affiliations
Pierre Fabre (France) (FR)
ORCID
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1999-01-11
Volume
141
Issue
2
Pages
206-212
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/s002130050826
OpenAlex
W2080256961
Cited by
26
References
16
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2016: 1 · 2014: 1 · 2013: 1
FWCI
0.24
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
benzodiazepine receptor agonists, anxiolytics, anticonflict effect, punished responding, pigeons, drug potency, predictive validity, diazepam, flunitrazepam, alprazolam, lorazepam, clorazepate, medazepam, flurazepam, chlordiazepoxide, bromazepam
MeSH terms
Animals, Benzodiazepines, Conflict, Psychological, Humans, Male, Columbidae, Punishment, Anti-Anxiety Agents

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CoChat. (2026). Citation check: Effects of benzodiazepine agonists on punished responding in pigeons and their relationship with clinical doses in humans. https://app.cochat.ai/papers/10.1007/s002130050826
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Kleven, M. S., & Koek, W. (1999). Effects of benzodiazepine agonists on punished responding in pigeons and their relationship with clinical doses in humans. Psychopharmacology. https://doi.org/10.1007/s002130050826