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Cited by 92Microfluidic and Capillary Electrophoresis ApplicationsAdvanced biosensing and bioanalysis techniquesAnalytical Chemistry and Chromatography

Capillary electrophoresis applied to DNA: Determining and harnessing sequence and structure to advance bioanalyses (2009–2014)

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Durney, Brandon C., Crihfield, Cassandra L., Holland, Lisa A.·2015·Analytical and Bioanalytical Chemistry
DOI 10.1007/s00216-015-8703-5PMC PMC4551542
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Abstract

This review of capillary electrophoresis methods for DNA analyses covers critical advances from 2009 to 2014, referencing 184 citations. Separation mechanisms based on free-zone capillary electrophoresis, Ogston sieving, and reptation are described. Two prevalent gel matrices for gel-facilitated sieving, which are linear polyacrylamide and polydimethylacrylamide, are compared in terms of performance, cost, viscosity, and passivation of electroosmotic flow. The role of capillary electrophoresis in the discovery, design, and characterization of DNA aptamers for molecular recognition is discussed. Expanding and emerging techniques in the field are also highlighted.

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  • Capillary electrophoresis with six-dye detection improved resolution of overlapping size ranges and decreased spectral bleed-through.

    “The second advancement was the introduction of capillary electrophoresis with six-dye detection, which improved the resolution of overlapping size ranges and decreased spectral bleed-through [33].”

    From Genetic Insights into the Economic Toll of Cell Line Misidentification: A Comprehensive Review (2026) · cites this paper as [33]

    The DNA sizing section (page unavailable) says that fluorescent labels distinguish STR fragments whose lengths overlap, resolving them spectrally. It describes four dyes, not six, and does not report decreased spectral bleed-through. Searches for six-dye detection and bleed-through found no supporting passage. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • A set of eight autosomal STR markers (CSF1PO, D5S818, D7S820, D13S317, D16S539, TH01, TPOX, vWA) reduces the probability of identity for African American and Caucasian populations to 4.09 × 10−9 and 1.02 × 10−8, respectively.

    “Initially suggested in the ASN-0002-2011 standard [32], a set of eight autosomal STR markers (CSF1PO, D5S818, D7S820, D13S317, D16S539, TH01, TPOX, and vWA) reduce the probability of identity (POI) for the African American and Caucasian populations to 4.09 × 10−9 and 1.02 × 10−8, respectively [33].”

    From Genetic Insights into the Economic Toll of Cell Line Misidentification: A Comprehensive Review (2026) · cites this paper as [33]

    The DNA sizing section says STRs are used for human identification and probability matching, but it does not report results for the specified eight-marker panel. Searches for the marker names, probability of identity, and both numerical values found no passage giving the claimed estimates for African American or Caucasian populations. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Durney, B. C., Crihfield, C. L., & Holland, L. A.
Affiliations
West Virginia University (US)
Corresponding author
Holland, Lisa A.
ORCID
Holland, Lisa A.
Venue
Analytical and Bioanalytical Chemistry
Publisher
Springer Science and Business Media LLC
Published
2015-05-03
Volume
407
Issue
23
Pages
6923-6938
ISSN
  • 1618-2642 (ISSN-L)
  • 1618-2650
DOI
10.1007/s00216-015-8703-5
PMC
PMC4551542
OpenAlex
W2063530917
Cited by
92
References
0
Citations by year
2026: 9 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 11 · 2020: 12 · 2019: 6 · 2018: 9 · 2017: 10 · 2016: 5 · 2013: 1
FWCI
0.62
Type
journal article
Language
en
Open access
Licence
Locations
  • Analytical and Bioanalytical Chemistry (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation (1212537, 1003907)
  • Division of Chemistry (CHE1212537)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
  • Physical Sciences › Chemistry › Spectroscopy › Analytical Chemistry and Chromatography
Keywords
capillary electrophoresis, DNA separation, reptation, polyacrylamide hydrogel, DNA aptamers, molecular recognition, DNA structure
MeSH terms
DNA, Drug Design, Sequence Analysis, DNA, Electrophoresis, Capillary, Aptamers, Nucleotide

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