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Low Body Size and Elevated Sex-Hormone Binding Globulin Distinguish Men with Idiopathic Vertebral Fracture
Abstract
Factors predisposing to vertebral fracture in men are less well defined compared with women. Most studies of osteoporosis in men have included patients with low bone mineral density (BMD), with or without vertebral fracture, or have included other fractures. To clarify these associations we investigated sex hormone levels, bone markers, and (indirectly) lean body mass (LBM) in 81 men with idiopathic vertebral fracture. Serum testosterone, estradiol, sex-hormone binding globulin (SHBG), 24-hr urinary creatinine (24-hr UCr), urinary free deoxypyridinoline (UfDPD) and serum type I procollagen carboxy-terminal propeptide, type I procollagen amino-terminal propeptide, type I collagen carboxy-terminal telopeptide, and osteocalcin were measured. SHBG was higher and 24-hr UCr lower in osteoporotic subjects. UfDPD was higher when corrected for 24-hr UCr. Serum bone turnover markers were not significantly increased, nor were serum sex hormones (and free hormone indices) significantly decreased in patients. SHBG levels were inversely related with lumbar spine and femoral neck BMD in both patients and control subjects. Free estradiol index was only correlated with BMD in men with osteoporosis. Body size is lower in men with established osteoporosis. The normal free hormone indices suggest that SHBG does not affect free hormone levels whereas the relationship between SHBG (but not sex hormones) and 24-hr UCr points to a relationship between SHBG and LBM. The association of high levels of…
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“A higher serum SHBG was observed in male patients suffering from primary or secondary osteoporosis [146–148].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [148]
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Cited by
Narinx, N., David, K., Walravens, J., Vermeersch, P., Claessens, F., Fiers, T., Lapauw, B., Antonio, L., & Vanderschueren, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04562-1 · Cited by 96
Sex hormone-binding globulin, estradiol, and bone turnover markers in male osteoporosis
Lormeau, C., Soudan, B., d'Herbomez, M., Pigny, P., Duquesnoy, B., & Cortet, B. (2004) · Bone · doi:10.1016/j.bone.2004.01.024 · Cited by 82
Perturbed Sex Steroid Status in Men with Idiopathic Osteoporosis and Their Sons
Van Pottelbergh, I., Goemaere, S., Zmierczak, H., & Kaufman, J. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032081 · Cited by 76
Sex steroids and bone turnover markers in men with symptomatic vertebral fractures
Tuck, S. P., Scane, A. C., Fraser, W. D., Diver, M. J., Eastell, R., & Francis, R. M. (2008) · Bone · doi:10.1016/j.bone.2008.08.123 · Cited by 37
Metadata
- Authors
- Evans, S. F., & Davie, M. W. J.
- Affiliations
- Robert Jones and Agnes Hunt Orthopaedic Hospital (GB)
- Venue
- Calcified Tissue International
- Published
- 2002-01-01
- Volume
- 70
- Issue
- 1
- Pages
- 9-15
- ISSN
- 0171-967X (ISSN-L)
- 1432-0827
- OpenAlex
- W2038271538
- Cited by
- 35
- References
- 0
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Calcified Tissue International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Keywords
- male osteoporosis, sex hormone-binding globulin, lean body mass, bone mineral density, bone turnover markers, free estradiol, testosterone, urinary deoxypyridinoline, insulin-like growth factor I, lumbar spine, femoral neck
- MeSH terms
- Adult, Aged, Aged, 80 and over, Body Constitution, Creatinine, Estradiol, Femur, Humans, Lumbar Vertebrae, Male, Middle Aged, Osteoporosis, Sex Hormone-Binding Globulin, Testosterone, Thoracic Vertebrae, Biomarkers, Absorptiometry, Photon, Bone Density, Spinal Fractures
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