The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Vascular Calcification: An Update on Mechanisms and Challenges in Treatment
Open accessAbstract
Vascular calcification is highly associated with cardiovascular disease mortality, particularly in high-risk patients with diabetes and chronic kidney diseases (CKD). In blood vessels, intimal calcification is associated with atherosclerosis, whereas medial calcification is a nonocclusive process which leads to increased vascular stiffness and reduced vascular compliance. In the valves, calcification of the leaflets can change the mechanical properties of the tissue and result in stenosis. For many decades, vascular calcification has been noted as a consequence of aging. Studies now confirm that vascular calcification is an actively regulated process and shares many features with bone development and metabolism. This review provides an update on the mechanisms of vascular calcification including the emerging roles of the RANK/RANKL/OPG triad, osteoclasts, and microRNAs. Potential treatments adapted from osteoporosis and CKD treatments that are under investigation for preventing and/or regressing vascular calcification are also reviewed.
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Cites
Pervasive roles of microRNAs in cardiovascular biology
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Teriparatide or Alendronate in Glucocorticoid-Induced Osteoporosis
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Bennett, B. J., Scatena, M., Kirk, E. A., Rattazzi, M., Varon, R. M., Averill, M., Schwartz, S. M., Giachelli, C. M., & Rosenfeld, M. E. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000236428.91125.e6 · Cited by 304 · cited 1×
“OPG appears to be protective against vascular calcification since OPG mice developed spontaneous arterial calcification [16] and depleting OPG in ApoE mice increased atherosclerotic lesion progression and calcification [17].”
BackgroundSelf-citationChen, J.-H., & Simmons, C. A. (2011) · Circulation Research · doi:10.1161/circresaha.110.234237 · Cited by 289
Osteoprotegerin Inhibits Vascular Calcification Without Affecting Atherosclerosis in ldlr (−/−) Mice
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Bone formation in cardiac valves: a histopathological study of 128 cases
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Cited by
Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease
Lacolley, P., Regnault, V., Segers, P., & Laurent, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00003.2017 · Cited by 734
Yutzey, K. E., Demer, L. L., Body, S. C., Huggins, G. S., Towler, D. A., Giachelli, C. M., Hofmann-Bowman, M. A., Mortlock, D. P., Rogers, M. B., Sadeghi, M. M., et al. (2014) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.302523 · Cited by 371
Self-citationElastolytic activity of cysteine cathepsins K, S, and V promotes vascular calcification
Andrault, P.-M., Panwar, P., Mackenzie, N. C. W., & Brömme, D. (2019) · Scientific Reports · doi:10.1038/s41598-019-45918-1 · Cited by 43
Gao, J.-W., Hao, Q.-Y., Lu, L.-Y., Han, J.-J., Huang, F.-F., Vuitton, D. A., Wang, J.-F., Zhang, S.-L., & Liu, P.-M. (2022) · British Journal of Sports Medicine · doi:10.1136/bjsports-2021-105092 · Cited by 25
Metadata
- Authors
- Wu, M., Rementer, C., & Giachelli, C. M.
- Venue
- Calcified Tissue International
- Published
- 2013-03-01
- Volume
- 93
- Issue
- 4
- Pages
- 365-373
- ISSN
- 0171-967X (ISSN-L)
- 1432-0827
- OpenAlex
- W2069290111
- Cited by
- 434
- References
- 8
- FWCI
- 18.34
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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