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Quality of Life in Sarcopenia and Frailty
Open accessAbstract
The reduced muscle mass and impaired muscle performance that define sarcopenia in older individuals are associated with increased risk of physical limitation and a variety of chronic diseases. They may also contribute to clinical frailty. A gradual erosion of quality of life (QoL) has been evidenced in these individuals, although much of this research has been done using generic QoL instruments, particularly the SF-36, which may not be ideal in older populations with significant comorbidities. This review and report of an expert meeting presents the current definitions of these geriatric syndromes (sarcopenia and frailty). It then briefly summarizes QoL concepts and specificities in older populations and examines the relevant domains of QoL and what is known concerning QoL decline with these conditions. It calls for a clearer definition of the construct of disability, argues that a disease-specific QoL instrument for sarcopenia/frailty would be an asset for future research, and discusses whether there are available and validated components that could be used to this end and whether the psychometric properties of these instruments are sufficiently tested. It calls also for an approach using utility weighting to provide some cost estimates and suggests that a time trade-off study could be appropriate.
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“In addition, sarcopenia is a major clinical problem in public health of older people; with some adverse outcomes such as disability, poor quality of life, and increased risk of death [2–4].”
From Prevalence of sarcopenia in the world: a systematic review and meta- analysis of general population studies (2017) · cites this paper as [3]
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Metadata
- Authors
- Rizzoli, R., Reginster, J.-Y., Arnal, J.-F., Bautmans, I., Beaudart, C., Bischoff-Ferrari, H., Biver, E., Boonen, S., Brandi, M.-L., Chines, A., Cooper, C., Epstein, S., Fielding, R. A., Goodpaster, B., Kanis, J. A., Kaufman, J.-M., Laslop, A., Malafarina, V., Mañas, L. R., Mitlak, B. H., Oreffo, R. O., Petermans, J., Reid, K., Rolland, Y., Sayer, A. A., Tsouderos, Y., Visser, M., & Bruyère, O.
- Affiliations
- University of Geneva (CH)
- University of Liège (BE)
- Inserm (FR)
- Vrije Universiteit Brussel (BE)
- University of Zurich (CH)
- Universitair Ziekenhuis Leuven (BE)
- University of Florence (IT)
- Amgen (United States) (US)
- MRC Lifecourse Epidemiology Unit (GB)
- Icahn School of Medicine at Mount Sinai (US)
- Tufts University (US)
- University of Pittsburgh (US)
- Ghent University Hospital (BE)
- Austrian Agency for Health and Food Safety (AT)
- Eli Lilly (United States) (US)
- University of Southampton (GB)
- University of Sheffield (GB)
- Université de Toulouse (FR)
- Institut de Recherches Internationales Servier (France) (FR)
- Amsterdam Public Health (NL)
- Corresponding author
- Rizzoli, René
- ORCID
- Rizzoli, René
- Reginster, Jean-Yves
- Arnal, Jean-François
- Bautmans, Ivan
- Beaudart, Charlotte
- Bischoff-Ferrari, Heike
- Biver, Emmanuel
- Brandi, Maria-Luisa
- Chines, Arkadi
- Cooper, Cyrus
- Epstein, Sol
- Fielding, Roger A.
- Goodpaster, Bret
- Kaufman, Jean-Marc
- Laslop, Andrea
- Malafarina, Vincenzo
- Mitlak, Bruce H.
- Oreffo, Richard O.
- Reid, Kieran
- Rolland, Yves
- Sayer, Avan Aihie
- Visser, Marjolein
- Bruyère, Olivier
- Venue
- Calcified Tissue International
- Published
- 2013-07-05
- Volume
- 93
- Issue
- 2
- Pages
- 101-120
- ISSN
- 0171-967X (ISSN-L)
- 1432-0827
- PMC
- PMC3747610
- OpenAlex
- W2000448207
- Cited by
- 425
- References
- 145
- Citations by year
- 2026: 25 · 2025: 20 · 2024: 24 · 2023: 31 · 2022: 47 · 2021: 46 · 2020: 42 · 2019: 45 · 2018: 32 · 2017: 43 · 2016: 32 · 2015: 18 · 2014: 19 · 2013: 1
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Calcified Tissue International (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- HAL (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- ORBi (University of Liège) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Dairy Management
- Cytokinetics
- National Institute for Health and Care Research (NF-SI-0508-10082)
- Servier
- Nestec
- Medical Research Council (MC_UU_12011/2, MC_UU_12011/1)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Keywords
- sarcopenia, frailty, quality of life, older adults, geriatric syndromes, disease-specific quality of life instruments, SF-36, disability, cost estimation, time trade-off, physical limitations, comorbidities
- MeSH terms
- Aged, Aging, Cachexia, Humans, Obesity, Quality of Life, Surveys and Questionnaires, Comorbidity, Frail Elderly, Sarcopenia
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