The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Selective Serotonin Reuptake Inhibitors (SSRIs) and Markers of Bone Turnover in Men
Open accessAbstract
Selective serotonin reuptake inhibitors (SSRIs) have been shown to have a clinically significant impact on bone metabolism. To explore this further, we aimed to determine whether these agents are associated with serum markers of bone turnover utilising a population-based sample of men (n = 1138; 20-96 year) participating in the Geelong Osteoporosis Study. Blood samples were obtained and the bone resorption marker, C-telopeptide (CTx) and formation marker, type 1 procollagen amino-terminal-propeptide (PINP) were measured. Anthropometry and socio-economic status (SES) were determined and information on medication use and lifestyle was obtained via questionnaire. Lifetime mood disorders were assessed using semi-structured clinical interviews. Thirty-seven (3.3%) men reported using SSRIs. Age was an effect modifier in the association between SSRIs and markers of bone turnover. Among younger men (20-60 year; n = 557), adjusted mean CTx and PINP values were 12.4% [16.7 (95% CI 14.6-18.8) vs 19.1 (95% CI 18.7-19.4) pg/ml, p = 0.03] and 13.6% [5.6 (95% CI 4.9-6.3) vs 6.4 (95% CI 6.3-6.6) pg/ml, p = 0.02] lower among SSRI users compared to non-users, respectively. No differences in SSRI use and markers of bone turnover were detected among older men (61-94 year; all p > 0.05). These patterns persisted after further adjustment for activity, alcohol, smoking, SES, depression, bone active medications and other antidepressants. Our data suggest that SSRI use is associated with alterations in bone turnover markers among younger men. The observed decreases in both CTx and PINP are likely to contribute to a low bone turnover state and increased skeletal fragility with this potential imbalance between formation and resorption resulting in subsequent bone loss.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Potential adverse events include impact on bone metabolism, increasing the risk for osteoporosis and fractures (especially with SSRIs).
“impact on bone metabolism, increasing the risk for osteoporosis and fractures (especially with SSRIs)349”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [349]
Citations
Cites
An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
Johnell, O., & Kanis, J. (2006) · Osteoporosis International · doi:10.1007/s00198-006-0172-4 · Cited by 4,770
Antidepressant use in persons aged 12 and over: United States, 2005-2008.
Pratt, L. A., Brody, D. J., & Gu, Q. (2011) · PubMed · Cited by 389
A look behind the scenes: the risk and pathogenesis of primary osteoporosis
Hendrickx, G., Boudin, E., & Hul, W. V. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.48 · Cited by 292
Cohort Profile: Geelong Osteoporosis Study
Pasco, J. A., Nicholson, G. C., & Kotowicz, M. A. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyr148 · Cited by 264
Self-citationWu, Q. F., Bencaz, A. F., Hentz, J. G., & Crowell, M. D. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1778-8 · Cited by 150
Osteoporosis costing all Australians: a new burden of disease analysis – 2012 to 2022
Watts, J. J., Abimanyi-Ochom, J., & Sanders, K. M. (2013) · Cited by 136
Relationship between use of antidepressants and risk of fractures: a meta-analysis
Rabenda, V., Nicolet, D., Beaudart, C., Bruyère, O., & Reginster, J.-Y. (2012) · Osteoporosis International · doi:10.1007/s00198-012-2015-9 · Cited by 125
Lockhart, P., & Guthrie, B. (2011) · British Journal of General Practice · doi:10.3399/bjgp11x593848 · Cited by 123
Hodge, J. M., Wang, Y., Berk, M., Collier, F. M., Fernandes, T. J., Constable, M. J., Pasco, J. A., Dodd, S., Nicholson, G. C., Kennedy, R. L., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.003 · Cited by 122
Self-citationOrtuño, M. J., Robinson, S. T., Subramanyam, P., Paone, R., Huang, Y.-Y., Guo, X.-D. E., Colecraft, H. M., Mann, J. J., & Ducy, P. F. (2016) · Nature Medicine · doi:10.1038/nm.4166 · Cited by 113
Brennan-Olsen, S. L., Henry, M. J., Nicholson, G. C., et al. (2009) · Preventive Medicine · doi:10.1016/j.ypmed.2009.06.021 · Cited by 88
Fernandes, B. S., Hodge, J. M., Pasco, J. A., Berk, M., & Williams, L. J. (2015) · Drugs & Aging · doi:10.1007/s40266-015-0323-4 · Cited by 72
Self-citationPrevalence of osteoporosis in Australian men and women: Geelong Osteoporosis Study
Henry, M. J., Pasco, J. A., Nicholson, G. C., et al. (2011) · The Medical Journal of Australia · doi:10.5694/mja11.10571 · Cited by 71
Self-citationDepression and Bone Metabolism
Williams, L. J., Pasco, J. A., Jacka, F. N., Henry, M. J., Dodd, S., & Berk, M. (2008) · Psychotherapy and Psychosomatics · doi:10.1159/000162297 · Cited by 64
Self-citationPsychiatric disorders, psychotropic medication use and falls among women: an observational study
Williams, L. J., Pasco, J. A., Stuart, A. L., Jacka, F. N., Brennan-Olsen, S. L., Dobbins, A. G., Honkanen, R., Koivumaa-Honkanen, H. T., Rauma, P. H., & Berk, M. (2015) · BMC Psychiatry · doi:10.1186/s12888-015-0439-4 · Cited by 58
Self-citationShea, M. L. O., Garfield, L. D., Teitelbaum, S. L., Civitelli, R., Mulsant, B. H., Reynolds, C. F., Dixon, D. J., Doré, P., & Lenze, E. J. (2013) · Osteoporosis International · doi:10.1007/s00198-012-2170-z · Cited by 45
Treatment of a major depression episode suppresses markers of bone turnover in premenopausal women
Aydin, H., Mutlu, N., & Akbaş, N. B. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.04.005 · Cited by 38
Socioeconomic status, obesity and lifestyle in men: The Geelong Osteoporosis Study
Brennan-Olsen, S. L., Henry, M. J., Nicholson, G. C., Kotowicz, M. A., & Pasco, J. A. (2010) · Journal of Men s Health · doi:10.1016/j.jomh.2009.10.004 · Cited by 38
Self-citationFratzl‐Zelman, N., Roschger, P., Misof, B. M., et al. (2011) · Calcified Tissue International · doi:10.1007/s00223-011-9466-4 · Cited by 31
Bone turnover in elderly men: relationships to change in bone mineral density
Nguyen, T. V., Meier, C., Eisman, J. A., & Seibel, M. J. (2007) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-8-13 · Cited by 31
Effects of Escitalopram on Markers of Bone Turnover: A Randomized Clinical Trial
Diem, S. J., Joffe, H., Larson, J. C., Tsai, J. N., Guthrie, K. A., LaCroix, A. Z., Ensrud, K. E., Freeman, E. W., & Leder, B. Z. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2288 · Cited by 30
Falls and Depression in Men: A Population-Based Study
Stuart, A. L., Pasco, J. A., Jacka, F. N., Berk, M., & Williams, L. J. (2015) · American Journal of Men s Health · doi:10.1177/1557988315609111 · Cited by 13
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- First M, Spitzer R, Gibbon M, Williams J (2002) Structured clinical interview for DSM-IV-TR axis I disorders, research version, non-patient edition. (SCID-I/NP). Biometrics Research, New York State Psychiatric Institute, New York
- Giles C, Ireland P (1996) Dietary questionnaire for epidemiological studies (version 2). The Cancer Council Victoria, Melbourne
Cited by
Sorted by citations
Berk, M., Köhler‐Forsberg, O., Turner, M., Penninx, B. W. J. H., Wrobel, A., Firth, J., Loughman, A., Reavley, N. J., McGrath, J. J., Momen, N. C., et al. (2023) · World Psychiatry · doi:10.1002/wps.21110 · Cited by 336
Self-citation
Metadata
- Authors
- Williams, L. J., Berk, M., Hodge, J. M., Kotowicz, M. A., Stuart, A. L., Chandrasekaran, V., Cleminson, J., & Pasco, J. A.
- Affiliations
- Barwon Health (AU)
- Deakin University (AU)
- Corresponding author
- Williams, Lana J.
- ORCID
- Venue
- Calcified Tissue International
- Published
- 2018-02-13
- Volume
- 103
- Issue
- 2
- Pages
- 125-130
- ISSN
- 0171-967X (ISSN-L)
- 1432-0827
- OpenAlex
- W2793812701
- Cited by
- 30
- References
- 22
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 1
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Calcified Tissue International (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Health and Medical Research Council (299831, 628582, 1009367, 1026265, 1021345, 1104438, 1064272, 1059660)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Keywords
- selective serotonin reuptake inhibitors, bone turnover markers, C-terminal telopeptide, P1NP, men, bone resorption, bone formation, antidepressant side effects, mood disorders, age effect modification, Geelong Osteoporosis Study, low bone turnover, bone loss
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Anthropometry, Antidepressive Agents, Australia, Bone Resorption, Humans, Life Style, Male, Middle Aged, Osteoporosis, Peptide Fragments, Peptides, Procollagen, Social Class, Biomarkers, Bone Density, Bone Remodeling, Selective Serotonin Reuptake Inhibitors, Mood Disorders, Collagen Type I, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
