Detailed postal feedback about prescribing to asthma patients combined with a guideline statement showed no impact: a randomised controlled trial
Abstract
Objective To evaluate the effects of postal feedback with clinically relevant data on general practitioners' prescribing compared with feedback with aggregate data on prescribing patterns of asthma drugs. Methods The study was a randomised, controlled trial. The general practitioners (GPs) in the County of Funen, Denmark (292 GPs representing 178 practices) were randomised to one of three groups receiving different forms of prescriber feedback. The first group received detailed and clinically relevant data on asthma drug prescribing patterns and a guideline statement. These data included tables with counts of asthma patients following classification of each individual's consumption of inhaled beta2-agonists and use of inhaled steroids. The second group received aggregate data on asthma drug prescribing patterns and a guideline statement, and the third group received feedback on an unrelated subject and served as control for the other groups. Each GP received prescriber feedback three times within a 6-month period. The last two letters with prescriber feedback had updated information with the purpose of showing changes in prescribing patterns. Effects were followed for a period of 1 year. The main outcome measures were change in fraction of asthmatics treated with inhaled steroids and incidence rate of treatment with inhaled steroids. Results The three groups had similar baseline characteristics. None of the two types of feedback on prescribing of asthma drugs had a statistically significant impact on GPs' prescribing patterns. Conclusion Mailed prescriber feedback of detailed and clinically relevant data with a guideline statement, without revealing patient identities, has little or no impact on prescribing patterns.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is conflicting evidence regarding the role of peer-comparison in feedback.
“there is conflicting evidence regarding the role of peer‐comparison in feedback (Kiefe 2001; Søndergaard 2002; Wones 1987).”
From Audit and feedback: effects on professional practice and healthcare outcomes (2012) · cites this paper as Søndergaard 2002
Søndergaard 2002 found a small difference when adding peer comparison data to audit and feedback for asthma management (adjusted RD = 2%).
“Søndergaard 2002 and Wones 1987 each found small differences when adding peer comparison data to the audit and feedback for asthma management (adjusted RD = 2%) or inpatient laboratory test utilisation (adjusted change relative to baseline control = 5%), respectively.”
From Audit and feedback: effects on professional practice and healthcare outcomes (2012) · cites this paper as Søndergaard 2002
Cites
Audit and feedback: effects on professional practice and healthcare outcomes
Ivers, N., Jamtvedt, G., Flottorp, S., Young, J. M., Odgaard-Jensen, J., French, S. D., O'Brien, M. A., Johansen, M., Grimshaw, J., & Oxman, A. D. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000259.pub3 · Cited by 5,485 · see citing works
Applied Survival Analysis: Regression Modeling of Time-to-Event Data
Hosmer, D. W., Lemeshow, S. A., & May, S. J. (2008) · Cited by 3,030 · see citing works
Clinical management of asthma in 1999: the Asthma Insights and Reality in Europe (AIRE) study
Rabe, K. F., Vermeire, P., Soriano, J. B., & Maier, W. (2000) · European Respiratory Journal · doi:10.1183/09031936.00.16580200 · Cited by 1,024 · see citing works
Evidence of self-report bias in assessing adherence to guidelines
Adams, A., Soumerai, S., Lomas, J., & Ross-Degnan, D. (1999) · International Journal for Quality in Health Care · doi:10.1093/intqhc/11.3.187 · Cited by 679 · cited 1× · see citing works
“It is a way to avoid the possible bias in estimated selfreported behaviour [14].”
BackgroundThe Danish prescription registries.
Gaist, D., Sørensen, H. T., & Hallas, J. (1997) · PubMed · Cited by 570 · see citing works
Primary non-compliance with prescribed medication in primary care.
Beardon, P. H. G., McGilchrist, M. M., McKendrick, A. D., McDevitt, D. G., & MacDonald, T. M. (1993) · BMJ · doi:10.1136/bmj.307.6908.846 · Cited by 343 · see citing works
Effects of feedback of information on clinical practice: a review.
Mugford, M., Banfield, P., & O'Hanlon, M. (1991) · BMJ · doi:10.1136/bmj.303.6799.398 · Cited by 333 · see citing works
Doctors' decisions and the cost of medical care
Samet, J. H. (1987) · Social Science & Medicine · doi:10.1016/0277-9536(87)90029-3 · Cited by 329 · see citing works
Changing and Learning in the Lives of Physicians
Fox, R., Mazmanian, P. E., Putnam, R. W., & Knowles, M. S. (1989) · Medical Entomology and Zoology · Cited by 201 · see citing works
Randomised controlled trial of effect of feedback on general practitioners' prescribing in Australia
O’Connell, D. L., Henry, D. A., & Tomlins, R. (1999) · BMJ · doi:10.1136/bmj.318.7182.507 · Cited by 133 · see citing works
Effect of physician profiling on utilization
Balas, E. A., Boren, S. A., Brown, G. D., Ewigman, B., Mitchell, J. A., & Perkoff, G. T. (1996) · Journal of General Internal Medicine · doi:10.1007/bf02599025 · Cited by 132 · see citing works
Freemantle, N., & Bloor, K. E. (1996) · BMJ · doi:10.1136/bmj.312.7044.1469 · Cited by 128 · see citing works
Improving Drug Prescribing in a Primary Care Practice
Gehlbach, S. H., Wilkinson, W. E., Hammond, W. E., Clapp, N. E., Finn, A. L., Taylor, W. J., & Rodell, M. (1984) · Medical Care · doi:10.1097/00005650-198403000-00002 · Cited by 124 · see citing works
Hux, J. E., Melady, M. P., & DeBoer, D. P. (1999) · Europe PMC (PubMed Central) · Cited by 100 · see citing works
Lagerløv, P. (2000) · Quality in Health Care · doi:10.1136/qhc.9.3.159 · Cited by 95 · see citing works
Evaluating an Educational Intervention to Improve the Treatment of Asthma in Four European Countries
Schuiling‐Veninga, C. C. M., ØV, P. L., Wahlström, R., MUSKOVA, M., Denig, P., Berkhof, J. H., Kochen, M. M., & Haaijer‐Ruskamp, F. M. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.4.9812136 · Cited by 88 · see citing works
Evaluating and Improving Physician Prescribing
Soumerai, S. B., Majumdar, S. R., & Lipton, H. L. (2000) · Pharmacoepidemiology · doi:10.1002/0470842555.ch30 · Cited by 74 · see citing works
Schectman, J. M., Kanwal, N. K., Schroth, W. S., & Elinsky, E. G. (1995) · Medical Care · doi:10.1097/00005650-199502000-00002 · Cited by 58 · see citing works
Nilsson, G. H., Hjemdahl, P., Hassler, A., Vitols, S., Wallén, N. H., & Krakau, I. (2001) · European Journal of Clinical Pharmacology · doi:10.1007/s002280000242 · Cited by 55 · see citing works
Gaist, D., Hallas, J., HANSEN, N. G., & Gram, L. F. (1996) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1996.03154.x · Cited by 53 · see citing works
Effectiveness of notification and group education in modifying prescribing of regulated analgesics.
Anderson, J. F., McEwan, K. L., & Hrudey, W. P. (1996) · PubMed · Cited by 46 · see citing works
Prescribing patterns for asthma by general practitioners in six European countries
Jepson, G. M. H., BUTLER, T., Gregory, D., & Jones, K. (2000) · Respiratory Medicine · doi:10.1053/rmed.2000.0782 · Cited by 24 · see citing works
Should the corticosteroid to bronchodilator ratio be promoted as a quality prescribing marker?
Frischer, M., Heatlie, H., Chapman, S., Norwood, J., Bashford, J., & Millson, D. S. (1999) · Public Health · doi:10.1038/sj.ph.1900583 · Cited by 15 · see citing works
Chronic bronchitis in Icelandic males: prevalence, sleep disturbances and quality of life
Magnússon, S., & Gíslason, Þ. (1999) · Scandinavian Journal of Primary Health Care · doi:10.1080/028134399750002728 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Audit and feedback: effects on professional practice and healthcare outcomes
Ivers, N., Jamtvedt, G., Flottorp, S., Young, J. M., Odgaard-Jensen, J., French, S. D., O'Brien, M. A., Johansen, M., Grimshaw, J., & Oxman, A. D. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000259.pub3 · Cited by 5,485 · see citing works
British Guideline on the Management of Asthma
British Thoracic Society Scottish Intercollegiate Guidelines Network (2008) · Thorax · doi:10.1136/thx.2008.097741 · Cited by 2,023 · see citing works
Audit and feedback: effects on professional practice and health care outcomes
Jamtvedt, G., Young, J. M., Kristoffersen, D. T., O'Brien, M. A., & Oxman, A. D. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000259.pub2 · Cited by 912 · see citing works
Printed educational materials: effects on professional practice and healthcare outcomes
Giguere, A. M. C., Légaré, F., Grimshaw, J., Turcotte, S., Fiander, M., Grudniewicz, A., Makosso‐Kallyth, S., Wolf, F. M., Farmer, A. P., & Gagnon, M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004398.pub3 · Cited by 879 · see citing works
Jamtvedt, G., Young, J. M., Kristoffersen, D. T., O'Brien, M. A., & Oxman, A. D. (2006) · BMJ Quality & Safety · doi:10.1136/qshc.2006.018549 · Cited by 364 · see citing works
van der Veer, S. N., de Keizer, N. F., Ravelli, A. C. J., Tenkink, S., & Jager, K. J. (2010) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2010.01.011 · Cited by 184 · see citing works
“We found nine analytic studies that used amedical registry as a source for feedback that didnothavequality improvement as its primary goal [9,26–31,62,66].”
BackgroundMethodInfluentialHome care across Europe : current structure and future challenges
Genêt, N., Boerma, W. G. W., Kroneman, M. W., Hutchinson, A., & Saltman, R. B. (2012) · Data Archiving and Networked Services (DANS) · Cited by 182 · see citing works
Clinical performance comparators in audit and feedback: a review of theory and evidence
Gude, W. T., Brown, B. C., van der Veer, S. N., Colquhoun, H. L., Ivers, N. M., Brehaut, J., Landis‐Lewis, Z., Armitage, C. J., de Keizer, N. F., & Peek, N. B. (2019) · Implementation Science · doi:10.1186/s13012-019-0887-1 · Cited by 123 · see citing works
“Two trials comparing feedback with versus without benchmarks, however, both found small increases in effectiveness [53, 54].”
BackgroundInterventions to Modify Health Care Provider Adherence to Asthma Guidelines: A Systematic Review
Okelo, S. O., Butz, A. M., Sharma, R., Diette, G. B., Pitts, S. I., King, T. M., Linn, S. T., Reuben, M., Chelladurai, Y., & Robinson, K. A. (2013) · PEDIATRICS · doi:10.1542/peds.2013-0779 · Cited by 109 · see citing works
How Conducting a Clinical Trial Affects Physicians' Guideline Adherence and Drug Preferences
Andersen, M. T., Kragstrup, J., & Søndergaard, J. (2006) · JAMA · doi:10.1001/jama.295.23.2759 · Cited by 90 · see citing works
“Among users of inhaled 2agonists, the percentage of patients using inhaled steroids has been used as a measure of physicians’ guideline adherence.(7) We calculated this percentage as a period prevalence.”
MethodHerbert, C. P. (2004) · Family Practice · doi:10.1093/fampra/cmh515 · Cited by 83 · see citing works
Audit and feedback: effects on professional practice
Ivers, N. M., Yogasingam, S., Lacroix, M., Brown, K. A., Antony, J., Soobiah, C., Simeoni, M., Willis, T. A., Crawshaw, J., Antonopoulou, V., et al. (2025) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000259.pub4 · Cited by 103 · see citing works
Brusamento, S., Legido‐Quigley, H., Пантели, Д., Turk, E., Knai, C., Saliba, V., Car, J., McKee, M., & Busse, R. (2012) · Health Policy · doi:10.1016/j.healthpol.2012.08.005 · Cited by 74 · see citing works
“In total, two studies assessed the implementation of guidelines on osteoarthritis [19,20,37], four on COPD [13,14,25,33,34], four on hypertension [24,32,36,37], six on coronary heart disease [17,18,23,26,32,36,37], six on asthma [13,14,26,27,30,33,34] and finally seven on type two diabetes mellitus [11,12,15,16,21,22,…”
BackgroundMethodResultInfluentialImpact of pharmaceutical representative visits on GPs' drug preferences
Søndergaard, J., Vach, K., Kragstrup, J., & Andersen, M. T. (2009) · Family Practice · doi:10.1093/fampra/cmp010 · Cited by 56 · see citing works
Akıcı, A., Gören, M. Z., Aypak, C., Bebi̇toğlu, B. T., & Oktay, Ş. (2005) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-005-0960-3 · Cited by 55 · see citing works
“Although some studies from Denmark have discussed the idea that postal prescriber feedback was not effective [ 19 , 20], in a study from the USA it was reported that monitoring, feedback and management of care by telephone improved the treatment of depression at the primary health care level [21].”
BackgroundIs it Possible to Measure Prescribing Quality using only Prescription Data?
Andersen, M. T. (2006) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2006.pto_411.x · Cited by 53 · see citing works
Søndergaard, J., Andersen, M. T., Støvring, H., & Kragstrup, J. (2003) · Scandinavian Journal of Primary Health Care · doi:10.1080/02813430310000564 · Cited by 46 · see citing works
Australian College of Rural and Remote Medicine
Nichols, A., Streeton, M., & Cowie, M. (2002) · Australian Journal of Rural Health · doi:10.1046/j.1440-1584.2002.00480.x · Cited by 33 · see citing works
Dybdahl, T., Andersen, M., S�ndergaard, J., Kragstrup, J., & Kristiansen, I. S. (2004) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-004-0797-1 · Cited by 31 · see citing works
“Previous studies, however, indicate that non-redemption rates are relatively low on Funen [18].”
ResultLim, W. Y., Hss, A. S., Ng, L. M., Jasudass, S. R. J., Sararaks, S., Vengadasalam, P., Hashim, L., & Singh, R. K. P. (2018) · BMC Family Practice · doi:10.1186/s12875-018-0808-4 · Cited by 30 · see citing works
Clinical guidelines for chronic conditions in the European Union
Legido‐Quigley, H., Пантели, Д., Car, J., McKee, M., & Busse, R. (2013) · LSHTM Research Online (London School of Hygiene and Tropical Medicine) · Cited by 27 · see citing works
Søndergaard, J., Andersen, M. T., Kragstrup, J., Hansen, H. P., & Gram, L. F. (2002) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-002-0455-4 · Cited by 24 · see citing works
“Nevertheless, prescriber feedback on its own has not proved to result in substantial improvements in practice patterns [6, 7, 8].”
BackgroundMethodInfluentialTan, N. C., Tay, I., Ngoh, A. S. H., & Tan, M. (2009) · PubMed · Cited by 23 · see citing works
Théophile, H., Miremont‐Salamé, G., Robinson, P., Moore, N. D., Bégaud, B., & Haramburu, F. (2011) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-011-1055-y · Cited by 20 · see citing works
Intervention to Reduce Unnecessary Dispensing of Short-Acting β-Agonists in Patients with Asthma
Wong, M. D., Manley, R. T., Stettin, G., Chen, W. C., & Salmun, L. M. (2010) · Annals of Pharmacotherapy · doi:10.1345/aph.1m697 · Cited by 17 · see citing works
Cotterill, S., Tang, M. Y., Powell, R., Howarth, E., McGowan, L. J., Roberts, J., Brown, B. C., & Rhodes, S. (2020) · Health Services and Delivery Research · doi:10.3310/hsdr08410 · Cited by 15 · see citing works
Impact of a physician-targeted letter on opioid prescribing
Ahomäki, I., Pitkänen, V., Soppi, A., & Saastamoinen, L. (2020) · Journal of Health Economics · doi:10.1016/j.jhealeco.2020.102344 · Cited by 14 · see citing works
Blais, R., Laurier, C., & Paré, M. (2008) · Journal of Asthma · doi:10.1080/02770900701883774 · Cited by 14 · see citing works
Effects of audit and feedback on professional practice in Geriatric Acute Care Units
Konig, C. C., Plank, J., Augustin, T., Habacher, W., Beck, P., Frühwald, T., Pils, K., Sommeregger, U., Dovjak, P., Pinter, G., et al. (2013) · European Geriatric Medicine · doi:10.1016/j.eurger.2013.05.005 · Cited by 11 · see citing works
“2) [25,26].”
Navarro, H. J., Shakeshaft, A. P., Doran, C. M., & Petrie, D. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.01.007 · Cited by 11 · see citing works
Buusman, A., Kragstrup, J., & Andersen, M. T. (2005) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-005-0973-y · Cited by 10 · see citing works
“Redeemed prescriptions were used as proxies forGPs’ prescribing, and the non-redemption rate in the County of Funen is considered low [19].”
MethodUse of physician profiles to influence prescribing of topical corticosteroids.
SKETRIS, I. S., Kephart, G. C., Cooke, C., Skedgel, C. D., & McLean-Veysey, P. R. (2005) · PubMed · Cited by 7 · see citing works
Time trends in quality indicators of colonoscopy
Moritz, V., Bretthauer, M., Holme, Ø., Fagerland, M. W., Løberg, M., Glomsaker, T. B., de Lange, T., Seip, B., Sandvei, P. K., & Hoff, G. S. (2015) · United European Gastroenterology Journal · doi:10.1177/2050640615570147 · Cited by 6 · see citing works
“2015–11:44am] [1–11] //blrnas3.”
Vægter, K., Wahlström, R., Wedel, H., & Svärdsudd, K. (2010) · Upsala Journal of Medical Sciences · doi:10.3109/03009734.2010.487165 · Cited by 6 · see citing works
“In a Danish randomized, controlled trial it was concluded that postal prescribing feedback in addition to clinical guidelines on the diagnosis and treatment of respiratory tract infections did not influence GPs’ prescribing patterns (8,9).”
BackgroundRausell, V. J. R., Soto, M. T., Pérez, M. D. N., Fernández, M. D. I., López, P. J. D. Z.-L., & López-Picazo, J. J. (2005) · Farmacia Hospitalaria · doi:10.1016/s1130-6343(05)73643-6 · Cited by 6 · see citing works
MacBride‐Stewart, S., Marwick, C., Ryan, M., & Guthrie, B. (2022) · British Journal of General Practice · doi:10.3399/bjgp.2021.0695 · Cited by 5 · see citing works
“10 Simple feedback of the number of patients with excess bronchodilator inhaler prescribing in asthma alone 19,20 or within an educational intervention 21–23 has been shown to have no discernible impact on bronchodilator inhaler prescribing; in none of these studies — unlike the one presented here…”
Vægter, K., Wahlström, R., & Svärdsudd, K. (2012) · Upsala Journal of Medical Sciences · doi:10.3109/03009734.2012.713038 · Cited by 3 · see citing works
“Similar but smaller effects were found in three Norwegian studies (7-9) and in another Canadian study (10), when written feedback of prescribing profiles was combined with treatment recommendations.”
Promoting Rational Drug Prescribing in General Practice
Vægter, K. (2013) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Narrow and wide prescribers among general practitioners
Buusman, A., Kragstrup, J., & Andersen, M. T. (2006) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-006-0126-y
“Redeemed prescriptions were used as proxies for GPs’ prescribing and both the non-redemption rate [12] and the inter-county data exchange in the County of Funen are considered low [6].”
MethodFernández‐Urrusuno, R., de la Pisa, B. P., & Balosa, M. C. M. (2011) · Journal of Pharmaceutical Health Services Research · doi:10.1111/j.1759-8893.2011.00047.x
“Some of them showed that mailed prescriber feedback was able to modify antibiotic([10,32]) and antiasthmatic([12]) selection by physicians whereas other authors did not find a positive impact of this strategy.([7,30]) Differences in the implementation of the feedback programmes, duration 1.”
BackgroundGuidance on feedback of outcome data to improve performance in vascular surgery
Li, M., Shalhoub, J., Davies, A. H., & Maruthappu, M. (2016) · British Journal of Hospital Medicine · doi:10.12968/hmed.2016.77.8.476
Current Awareness: Pharmacoepidemiology and Drug Safety
John Wiley & Sons, L. (2003) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.788
de Weerdt, V., Willems, H. C., Hofstra, G., Repping, S., Koolman, X., & van der Hijden, E. J. E. (2025) · BMJ Open Quality · doi:10.1136/bmjoq-2023-002542
- Authors
- Søndergaard, J., Andersen, M., Vach, K., Kragstrup, J., Maclure, M., & Gram, L. F.
- Affiliations
- University of Southern Denmark (DK)
- Venue
- European Journal of Clinical Pharmacology
- Published
- 2002-04-17
- Volume
- 58
- Issue
- 2
- Pages
- 127-132
- ISSN
- 0031-6970 (ISSN-L)
- 1432-1041
- OpenAlex
- W2058444266
- Cited by
- 44
- References
- 24
- Citations by year
- 2025: 2 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 2 · 2013: 4 · 2012: 6
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Clinical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Clinical practice guidelines implementation
- Health Sciences › Health Professions › General Health Professions › Primary Care and Health Outcomes
- Health Sciences › Health Professions › General Health Professions › Healthcare cost, quality, practices
- Keywords
- prescriber feedback, asthma, general practitioners, prescribing patterns, inhaled beta2-agonists, inhaled corticosteroids, guideline adherence, primary care
- MeSH terms
- Adolescent, Adrenal Cortex Hormones, Adrenergic beta-Agonists, Adult, Asthma, Child, Denmark, Family Practice, Feedback, Humans, Middle Aged, Practice Patterns, Physicians', Postal Service, Practice Guidelines as Topic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review