The Relationship between Risk of Hypoglycemia and Use of Cibenzoline and Disopyramide
Abstract
Objective A case-control study was carried out to compare the risks of hypoglycemia caused by disopyramide and cibenzoline. Methods We selected 91 subjects with hypoglycemia from among 14,156 outpatients who consulted the National Cardiovascular Center (NCVC) and received drug therapy between September 1997 and February 1998. We used the fasting blood sugar (FBS) level of 75 mg/dl or less as the cut-off level to screen for hypoglycemia. For each case, five controls matched for gender and age were selected from the clinical division consulted by relevant subjects. Results Ninety-one cases and 455 controls were enrolled in this study. Of 91 cases with hypoglycemia, 8 (8.8%) were treated with cibenzoline and 3 (3.3%) with disopyramide. The percentage of cases treated with cibenzoline was greater than that in the controls (1.5%), and the prescription frequency of cibenzoline during the study period was 2%. With adjustment for potential confounding factors using conditional logistic regression, hypoglycemia was significantly correlated with the use of cibenzoline [OR 8.0 (95% CI 1.7-36.8)], insulin [OR 48.4 (95% CI 8.8-267.2)], and thyroid agents [OR 13.0 (95% CI 1.1-160.4)]. An increased risk of hypoglycemia associated with the use of sulfonylureas was not detected. In additional logistic regression analysis, including the variables with individual sulfonylureas, glibenclamide but not gliclazide significantly increased the risk of hypoglycemia. The use of disopyramide did not aff…
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Cibenzoline causes hypoglycemia via β-cell KATP channel inhibition.
“β -cell K ATP channel inhibition [112]”
From Non-Diabetic Hypoglycemia: Evaluation and Management in Adults (2025) · cites this paper as [112]
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- Authors
- Takada, M., Fujita, S., Katayama, Y., Harano, Y., & Shibakawa, M.
- Affiliations
- National Cerebral and Cardiovascular Center (JP)
- Venue
- European Journal of Clinical Pharmacology
- Published
- 2000-07-19
- Volume
- 56
- Issue
- 4
- Pages
- 335-342
- ISSN
- 0031-6970 (ISSN-L)
- 1432-1041
- OpenAlex
- W2052018231
- Cited by
- 18
- References
- 30
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2021: 1 · 2016: 1 · 2015: 2 · 2014: 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Clinical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- hypoglycemia, cibenzoline, disopyramide, drug-induced hypoglycemia, beta-blockers, sulfonylureas, glibenclamide, gliclazide, insulin, diabetes mellitus, fasting blood glucose
- MeSH terms
- Adult, Aged, Aged, 80 and over, Anti-Arrhythmia Agents, Blood Glucose, Disopyramide, Fasting, Female, Humans, Hypoglycemia, Imidazoles, Male, Middle Aged, Sulfonylurea Compounds, Logistic Models, Case-Control Studies, Potassium Channel Blockers
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