Postsynaptic Density Proteins and Their Role in the Trafficking of Group I Metabotropic Glutamate Receptors
Abstract
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system that regulates multiple different forms of synaptic plasticity, including learning and memory. Glutamate transduces its signal by activating ionotropic glutamate receptors and metabotropic glutamate receptors (mGluRs). Group I mGluRs belong to the G protein-coupled receptor (GPCR) family. Regulation of cell surface expression and trafficking of the glutamate receptors represents an important mechanism that assures proper transmission of information at the synapses. There is growing evidence implicating dysregulated glutamate receptor trafficking in the pathophysiology of several neuropsychiatric disorders. The postsynaptic density (PSD) region consists of many specialized proteins which are assembled beneath the postsynaptic membrane of dendritic spines. Many of these proteins interact with group I mGluRs and have essential roles in group I mGluR-mediated synaptic function and plasticity. This review provides up-to-date information on the molecular determinants regulating cell surface expression and trafficking of group I mGluRs and discusses the role of few of these PSD proteins in these processes. As substantial evidences link mGluR dysfunction and maladaptive functioning of many PSD proteins to the pathophysiology of various neuropsychiatric disorders, understanding the role of the PSD proteins in group I mGluR trafficking may provide opportunities for the development of novel therap…
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Group I mGluRs are regulated by surface expression and trafficking through interactions with specialized PSD proteins.
“Group I mGluRs are regulated by surface expression and trafficking through interactions with specialized PSD proteins.”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [44]
Maladaptive functioning of PSD scaffold proteins is as critical as mGluR dysfunction itself in the pathophysiology of various neuropsychiatric disorders, offering novel targets for therapeutics.
“Maladaptive functioning of these PSD scaffold proteins is as critical as mGluR dysfunction itself in the pathophysiology of various neuropsychiatric disorders, offering novel targets for therapeutics [44].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [44]
Cites
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Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome
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Molecular Physiology of the Neuronal Synapse
Ramírez-Expósito, M. J., Cueto-Ureña, C., & Martínez-Martos, J. M. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48010088 · Cited by 6 · see citing works
“Maladaptive functioning of these PSD scaffold proteins is as critical as mGluR dysfunction itself in the pathophysiology of various neuropsychiatric disorders, offering novel targets for therapeutics [44].”
- Authors
- Aruna, K., Pal, S., Khanna, A., & Bhattacharyya, S.
- Affiliations
- Indian Institute of Science Education and Research Mohali (IN)
- Corresponding author
- Bhattacharyya, Samarjit
- Venue
- The Journal of Membrane Biology
- Published
- 2024-10-06
- Volume
- 257
- Issue
- 5-6
- Pages
- 257-268
- ISSN
- 0022-2631 (ISSN-L)
- 1432-1424
- OpenAlex
- W4403161451
- Cited by
- 6
- References
- 3
- Citations by year
- 2026: 3 · 2025: 3
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- The Journal of Membrane Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- group I metabotropic glutamate receptors, postsynaptic density proteins, receptor trafficking, cell surface expression, synaptic plasticity, G protein-coupled receptors, neuropsychiatric disorders, dendritic spines, glutamate signaling
- MeSH terms
- Animals, Humans, Membrane Proteins, Nerve Tissue Proteins, Neuronal Plasticity, Receptors, Metabotropic Glutamate, Protein Transport, Post-Synaptic Density
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