Postsynaptic Positioning of Endocytic Zones and AMPA Receptor Cycling by Physical Coupling of Dynamin-3 to Homer
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Endocytosis of AMPA receptors and other postsynaptic cargo occurs at endocytic zones (EZs), stably positioned sites of clathrin adjacent to the postsynaptic density (PSD). The tight localization of postsynaptic endocytosis is thought to control spine composition and regulate synaptic transmission. However, the mechanisms that situate the EZ near the PSD and the role of spine endocytosis in synaptic transmission are unknown. Here, we report that a physical link between dynamin-3 and the postsynaptic adaptor Homer positions the EZ near the PSD. Disruption of dynamin-3 or its interaction with Homer uncouples the PSD from the EZ, resulting in synapses lacking postsynaptic clathrin. Loss of the EZ leads to a loss of synaptic AMPA receptors and reduced excitatory synaptic transmission that corresponds with impaired synaptic recycling. Thus, a physical link between the PSD and the EZ ensures localized endocytosis and recycling by recapturing and maintaining a proximate pool of cycling AMPA receptors.
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DNM3 participates in the morphogenesis of the postsynaptic density and excitatory synaptic transmission.
“DNM3 participates in the morphogenesis of the postsynaptic density and excitatory synaptic transmission24”
From Locus for severity implicates CNS resilience in progression of multiple sclerosis (2023) · cites this paper as [24]
The section “The Endocytic Zone Sustains Excitatory Synaptic Transmission” (p. 9) reports that dynamin-3 knockdown reduces excitatory postsynaptic currents, supporting its role in excitatory transmission. The paper shows dynamin-3 positions the endocytic zone near the postsynaptic density (p. 3), but does not establish a role in morphogenesis of the postsynaptic density itself. (LLM, conf=0.88)
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Cites
The dynamin superfamily: universal membrane tubulation and fission molecules?
Praefcke, G. J. K., & McMahon, H. T. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1313 · Cited by 1,370 · see citing works
Liao, D., Hessler, N. A., & Malinow, R. (1995) · Nature · doi:10.1038/375400a0 · Cited by 1,365 · see citing works
Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting
Ehlers, M. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00129-x · Cited by 1,096 · see citing works
Self-citationCoupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins
Tu, J. C., Xiao, B., Naisbitt, S. R., Yuan, J. P., Petralia, R. S., Brakeman, P., Doan, A., Aakalu, V. K., Lanahan, A. A., Sheng, M., et al. (1999) · Neuron · doi:10.1016/s0896-6273(00)80810-7 · Cited by 1,047 · see citing works
Naisbitt, S., Kim, E., Tu, J. C., Xiao, B., Sala, C., Valtschanoff, J., Weinberg, R. J., Worley, P. F., & Sheng, M. (1999) · Neuron · doi:10.1016/s0896-6273(00)80809-0 · Cited by 1,009 · see citing works
Self-citationThe Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View
Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,003 · see citing works
Tu, J. C., Xiao, B., Yuan, J. P., Lanahan, A. A., Leoffert, K., Li, M., Linden, D. J., & Worley, P. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80589-9 · Cited by 862 · see citing works
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.033 · Cited by 792 · see citing works
Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors
Shepherd, J. D., Rumbaugh, G., Wu, J., Chowdhury, S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.034 · Cited by 779 · see citing works
Recycling Endosomes Supply AMPA Receptors for LTP
Park, M., Penick, E. C., Edwards, J. G., Kauer, J. A., & Ehlers, M. D. (2004) · Science · doi:10.1126/science.1102026 · Cited by 730 · see citing works
Self-citationRegulation of Dendritic Spine Morphology and Synaptic Function by Shank and Homer
Sala, C., Piëch, V., Wilson, N. R., Passafaro, M., Liu, G., & Sheng, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00339-7 · Cited by 716 · see citing works
Regulatory mechanisms of AMPA receptors in synaptic plasticity
Derkach, V. A., Oh, M. C., Guire, E. S., & Soderling, T. R. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2055 · Cited by 708 · see citing works
Harnessing actin dynamics for clathrin-mediated endocytosis
Kaksonen, M., Toret, C. P., & Drubin, D. G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1940 · Cited by 706 · see citing works
Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
Lüscher, C., Xia, H., Beattie, E. C., Carroll, R. C., von Zastrow, M., Malenka, R. C., & Nicoll, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)81119-8 · Cited by 692 · see citing works
Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation
O’Brien, R. J., Kamboj, S., Ehlers, M. D., Rosen, K. R., Fischbach, G. D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80624-8 · Cited by 688 · see citing works
Self-citationA Selective Activity-Dependent Requirement for Dynamin 1 in Synaptic Vesicle Endocytosis
Ferguson, S. M., Brasnjo, G., Hayashi, M., Wölfel, M., Collesi, C., Giovedı̀, S., Raimondi, A., Gong, L., Ariel, P., Paradise, S., et al. (2007) · Science · doi:10.1126/science.1140621 · Cited by 516 · see citing works
Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes
Park, M., Salgado, J. M., Ostroff, L., Helton, T. D., Robinson, C. G., Harris, K. M., & Ehlers, M. D. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.040 · Cited by 493 · see citing works
Self-citationSpatial control of coated-pit dynamics in living cells
Gaidarov, I., Santini, F., Warren, R. A., & Keen, J. H. (1999) · Nature Cell Biology · doi:10.1038/8971 · Cited by 427 · see citing works
Dynamin-dependent endocytosis of ionotropic glutamate receptors
Carroll, R. C., Beattie, E. C., Xia, H., Lüscher, C., Altschuler, Y., Nicoll, R. A., Malenka, R. C., & von Zastrow, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.14112 · Cited by 421 · see citing works
Differential Distribution of Dynamin Isoforms in Mammalian Cells
Cao, H., Garcı́a, F., & McNiven, M. A. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.9.2595 · Cited by 402 · see citing works
Direct imaging of lateral movements of AMPA receptors inside synapses
Tardin, C., Cognet, L., Bats, C., Lounis, B., & Choquet, D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg463 · Cited by 384 · see citing works
Dynamics and Regulation of Clathrin Coats at Specialized Endocytic Zones of Dendrites and Spines
Blanpied, T. A., Scott, D. B., & Ehlers, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00979-0 · Cited by 366 · see citing works
Self-citationORGANELLES AND TRAFFICKING MACHINERY FOR POSTSYNAPTIC PLASTICITY
Kennedy, M. J., & Ehlers, M. D. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112808 · Cited by 346 · see citing works
Self-citationRole of Phosphorylation in Regulation of the Assembly of Endocytic Coat Complexes
Slepnev, V. I., Ochoa, G.-C., Butler, M. H., Grabs, D., & Camilli, P. V. D. (1998) · Science · doi:10.1126/science.281.5378.821 · Cited by 311 · see citing works
Ashby, M. C., Maier, S. R., Nishimune, A., & Henley, J. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1235-06.2006 · Cited by 302 · see citing works
Laminar Organization of the NMDA Receptor Complex within the Postsynaptic Density
Valtschanoff, J. G., & Weinberg, R. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01211.2001 · Cited by 301 · see citing works
Self-citationDiffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity
Ehlers, M. D., Heine, M., Groc, L., Lee, M.-C., & Choquet, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.010 · Cited by 300 · see citing works
Self-citationAn Architectural Framework That May Lie at the Core of the Postsynaptic Density
Baron, M. K., Boeckers, T. M., Vaida, B., Faham, S., Gingery, M., Sawaya, M. R., Salyer, D., Gundelfinger, E. D., & Bowie, J. U. (2006) · Science · doi:10.1126/science.1118995 · Cited by 292 · see citing works
Sala, C., Futai, K., Yamamoto, K., Worley, P. F., Hayashi, Y., & Sheng, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06327.2003 · Cited by 288 · see citing works
Surface trafficking of receptors between synaptic and extrasynaptic membranes: and yet they do move!
Triller, A., & Choquet, D. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.01.001 · Cited by 285 · see citing works
Calcium triggers calcineurin-dependent synaptic vesicle recycling in mammalian nerve terminals
Marks, B., & McMahon, H. T. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70297-0 · Cited by 271 · see citing works
Gardner, S. M., Takamiya, K., Xia, J., Suh, J., Johnson, R. C., Yu, S., & Huganir, R. L. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.026 · Cited by 245 · see citing works
Ashby, M. C., De La Rue, S. A., Ralph, G. S., Uney, J., Collingridge, G. L., & Henley, J. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1042-04.2004 · Cited by 244 · see citing works
Lateral organization of endocytic machinery in dendritic spines
Rácz, B., Blanpied, T. A., Ehlers, M., & Weinberg, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1303 · Cited by 227 · see citing works
Self-citationBrown, T. C., Tran, I. C., Backos, D. S., & Esteban, J. A. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.023 · Cited by 221 · see citing works
Endocytosis Optimizes the Dynamic Localization of Membrane Proteins that Regulate Cortical Polarity
Marco, E., Wedlich‐Söldner, R., Li, R., Altschuler, S. J., & Wu, L. F. (2007) · Cell · doi:10.1016/j.cell.2007.02.043 · Cited by 221 · see citing works
A Preformed Complex of Postsynaptic Proteins Is Involved in Excitatory Synapse Development
Gerrow, K., Romorini, S., Nabi, S., Colicos, M. A., Sala, C., & El-Husseini, A. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.015 · Cited by 214 · see citing works
Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues.
Cook, T. A., Urrutia, R. A., & McNiven, M. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.644 · Cited by 187 · see citing works
Cycling of NMDA Receptors during Trafficking in Neurons before Synapse Formation
Washbourne, P., Liu, X.-B., Jones, E. G., & McAllister, A. K. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2555-04.2004 · Cited by 167 · see citing works
Regulating Actin Dynamics at Membranes: A Focus on Dynamin
Schafer, D. A. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00199.x · Cited by 150 · see citing works
Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer
Gray, N. W., Fourgeaud, L., Huang, B., Chen, J., Cao, H., Oswald, B. J., Hémar, A., & McNiven, M. A. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00136-2 · Cited by 143 · see citing works
Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development
Koh, T., Korolchuk, V. I., Wairkar, Y. P., Jiao, W., Evergren, E., Pan, H., Zhou, Y., Venken, K. J. T., Shupliakov, O., Robinson, I. M., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200701030 · Cited by 129 · see citing works
Dynamin as a mover and pincher during cell migration and invasion
Kruchten, A. E., & McNiven, M. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.02963 · Cited by 123 · see citing works
Endocytosis and Degradative Sorting of NMDA Receptors by Conserved Membrane-Proximal Signals
Scott, D. B., Michailidis, I. E., Mu, Y., Logothetis, D. E., & Ehlers, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0780-04.2004 · Cited by 123 · see citing works
Self-citationG protein–coupled receptor/arrestin3 modulation of the endocytic machinery
Santini, F., Gaidarov, I., & Keen, J. H. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110132 · Cited by 109 · see citing works
Cottrell, J. R., Borók, E., Horváth, T. L., & Nedivi, E. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.025 · Cited by 108 · see citing works
Tetrameric Hub Structure of Postsynaptic Scaffolding Protein Homer
Hayashi, M. K., Ames, H. M., & Hayashi, Y. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2731-06.2006 · Cited by 101 · see citing works
Predominant and developmentally regulated expression of dynamin in neurons
Nakatax, T., Iwamoto, A., Noda, Y., Takemura, R., Yoshikura, H., & Hirokawa, N. (1991) · Neuron · doi:10.1016/0896-6273(91)90298-e · Cited by 101 · see citing works
Okamoto, P. M., Gamby, C., Wells, D. G., Fallon, J. R., & Vallee, R. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104927200 · Cited by 81 · see citing works
Multiple Distinct Coiled-coils Are Involved in Dynamin Self-assembly
Okamoto, P. M., Tripet, B., Litowski, J. R., Hodges, R. S., & Vallée, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.15.10277 · Cited by 73 · see citing works
Gray, N. W., Kruchten, A. E., Chen, J., & McNiven, M. A. (2005) · Journal of Cell Science · doi:10.1242/jcs.01711 · Cited by 65 · see citing works
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Ferguson, S. M., & Camilli, P. V. D. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3266 · Cited by 977 · see citing works
Actin in dendritic spines: connecting dynamics to function
Hotulainen, P., & Hoogenraad, C. C. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201003008 · Cited by 815 · see citing works
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686 · see citing works
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Lee, H., & Kirkwood, A. (2011) · Cited by 692 · see citing works
The Postsynaptic Organization of Synapses
Sheng, M., & Kim, E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005678 · Cited by 603 · see citing works
Regulation of AMPA receptor trafficking and synaptic plasticity
Anggono, V., & Huganir, R. L. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.12.006 · Cited by 588 · see citing works
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
Wang, X., McCoy, P. A., Rodriguiz, R. M., Pan, Y., Je, H. S., Roberts, A. C., Kim, C. J., Berrios, J., Colvin, J. S., Bousquet-Moore, D., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr212 · Cited by 537 · see citing works
Self-citationBrain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity
Frischknecht, R., Heine, M., Perrais, D., Seidenbecher, C. I., Choquet, D., & Gundelfinger, E. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2338 · Cited by 554 · see citing works
Modeling Autism by SHANK Gene Mutations in Mice
Jiang, Y.-H., & Ehlers, M. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.016 · Cited by 488 · see citing works
Self-citationMyosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity
Wang, Z., Edwards, J. G., Riley, N., Provance, D. W., Karcher, R., Li, X.-D., Davison, I. G., Ikebe, M., Mercer, J. A., Kauer, J. A., et al. (2008) · Cell · doi:10.1016/j.cell.2008.09.057 · Cited by 470 · see citing works
Self-citationStructural plasticity of dendritic spines
Bosch, M., & Hayashi, Y. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.09.002 · Cited by 415 · see citing works
The postsynaptic density proteins Homer and Shank form a polymeric network structure
Hayashi, M. K., Tang, C., Verpelli, C., Narayanan, R., Stearns, M. H., Xu, R.-M., Li, H., Sala, C., & Hayashi, Y. (2009) · Cell · doi:10.1016/j.cell.2009.01.050 · Cited by 356 · see citing works
Glutamate receptor dynamics in dendritic microdomains.
Newpher, T. M., & Ehlers, M. D. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.030 · Cited by 356 · see citing works
Self-citationDisrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis
Mikasova, L., De Rossi, P., Bouchet, D., Georges, F., Rogemond, V., Didelot, A., Meissirel, C., Honnorat, J., & Groc, L. (2012) · Brain · doi:10.1093/brain/aws092 · Cited by 341 · see citing works
Crystal structure of nucleotide-free dynamin
Faelber, K., Posor, Y., Gao, S., Held, M., Roske, Y., Schulze, D., Haucke, V., Noé, F., & Daumke, O. (2011) · Nature · doi:10.1038/nature10369 · Cited by 301 · see citing works
Petrini, E. M., Lü, J., Cognet, L., Lounis, B., Ehlers, M., & Choquet, D. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.025 · Cited by 296 · see citing works
Self-citationSyntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines
Kennedy, M. J., Davison, I. G., Robinson, C. G., & Ehlers, M. D. (2010) · Cell · doi:10.1016/j.cell.2010.02.042 · Cited by 294 · see citing works
Self-citationFrost, N. A., Shroff, H., Kong, H., Betzig, E., & Blanpied, T. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.026 · Cited by 263 · see citing works
Self-citationLocus for severity implicates CNS resilience in progression of multiple sclerosis
International Multiple Sclerosis Genetics Consortium, Harroud, A., Stridh, P., McCauley, J. L., Saarela, J., van den Bosch, A. M. R., Engelenburg, H. J., Beecham, A. H., Alfredsson, L., Alikhani, K., et al. (2023) · Nature · doi:10.1038/s41586-023-06250-x · Cited by 243 · see citing works
AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging
Henley, J. M., & Wilkinson, K. A. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.1/jhenley · Cited by 236 · see citing works
Overlapping Role of Dynamin Isoforms in Synaptic Vesicle Endocytosis
Raimondi, A., Ferguson, S. M., Lou, X., Armbruster, M., Paradise, S., Giovedı̀, S., Messa, M., Kono, N., Takasaki, J., Cappello, V., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.031 · Cited by 237 · see citing works
The Function of Activity-Regulated Genes in the Nervous System
Loebrich, S., & Nedivi, E. (2009) · Physiological Reviews · doi:10.1152/physrev.00013.2009 · Cited by 235 · see citing works
LTP Requires a Unique Postsynaptic SNARE Fusion Machinery
Jurado, S., Goswami, D., Zhang, Y., Molina, A. J. M., Südhof, T. C., & Malenka, R. C. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.029 · Cited by 232 · see citing works
Emerging Role of Neuronal Exosomes in the Central Nervous System
Chivet, M., Hemming, F. J., Pernet‐Gallay, K., Fraboulet, S., & Sadoul, R. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00145 · Cited by 223 · see citing works
Rocca, D. L., Martin, S., Jenkins, E. L., & Hanley, J. (2008) · Nature Cell Biology · doi:10.1038/ncb1688 · Cited by 228 · see citing works
The Anti-Helminthic Niclosamide Inhibits Wnt/Frizzled1 Signaling
Chen, M., Wang, J., Lü, J., Bond, M. C., Ren, X.-R., Lyerly, H. K., Barak, L. S., & Chen, W. (2009) · Biochemistry · doi:10.1021/bi9009677 · Cited by 213 · see citing works
Using glutamate homeostasis as a target for treating addictive disorders
Reissner, K., & Kalivas, P. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833d41b2 · Cited by 185 · see citing works
A three-step model for the synaptic recruitment of AMPA receptors
Opazo, P., & Choquet, D. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.08.014 · Cited by 190 · see citing works
MAGUKs, Synaptic Development, and Synaptic Plasticity
Zheng, C.-Y., Seabold, G. K., Hořák, M., & Petralia, R. S. (2011) · The Neuroscientist · doi:10.1177/1073858410386384 · Cited by 186 · see citing works
Bossers, K., Meerhoff, G. F., Balesar, R. A., van Dongen, J. W., Kruse, C. G., Swaab, D. F., & Verhaagen, J. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00171.x · Cited by 173 · see citing works
Routes, destinations and delays: recent advances in AMPA receptor trafficking
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Neurogranin enhances synaptic strength through its interaction with calmodulin
Zhong, L., Cherry, T., Bies, C. E., Florence, M. A., & Gerges, N. Z. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.236 · Cited by 158 · see citing works
Mechanics of Dynamin-Mediated Membrane Fission
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Guire, E. S., Oh, M. C., Soderling, T. R., & Derkach, V. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0384-08.2008 · Cited by 151 · see citing works
Functional organization of postsynaptic glutamate receptors
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Regulation of AMPA receptors and synaptic plasticity
Santos, S. D., Carvalho, A. L., Caldeira, M. V., & Duarte, C. B. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.037 · Cited by 139 · see citing works
Spine microdomains for postsynaptic signaling and plasticity
Newpher, T. M., & Ehlers, M. D. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.02.004 · Cited by 140 · see citing works
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Activity-regulated genes as mediators of neural circuit plasticity
Leslie, J. H., & Nedivi, E. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.002 · Cited by 133 · see citing works
Surface dynamics of GluN2B‐NMDA receptors controls plasticity of maturing glutamate synapses
Dupuis, J. P., Ladépêche, L., Seth, H., Bard, L., Varela, J. A., Mikasová, L., Bouchet, D., Rogemond, V., Honnorat, J., Hanse, E., et al. (2014) · The EMBO Journal · doi:10.1002/embj.201386356 · Cited by 132 · see citing works
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting
Awasthi, A., Ramachandran, B., Ahmed, S., Benito, E., Shinoda, Y., Nitzan, N., Heukamp, A. S., Rannio, S., Martens, H., Barth, J., et al. (2018) · Science · doi:10.1126/science.aav1483 · Cited by 133 · see citing works
Perspectives on Remorin Proteins, Membrane Rafts, and Their Role During Plant–Microbe Interactions
Jarsch, I. K., & Ott, T. (2010) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-07-10-0166 · Cited by 133 · see citing works
Mechanisms and Function of Dendritic Exocytosis
Kennedy, M. J., & Ehlers, M. D. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.032 · Cited by 132 · see citing works
Self-citationPlasticity of dendritic spines: subcompartmentalization of signaling
Colgan, L. A., & Yasuda, R. (2014) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170400 · Cited by 124 · see citing works
Revisiting the Role of Clathrin-Mediated Endoytosis in Synaptic Vesicle Recycling
Milosevic, I. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00027 · Cited by 122 · see citing works
Stress and excitatory synapses: From health to disease
Timmermans, W., Xiong, H., Hoogenraad, C. C., & Krugers, H. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.05.043 · Cited by 118 · see citing works
Triad3A Regulates Synaptic Strength by Ubiquitination of Arc
Mabb, A. M., Je, H. S., Wall, M. J., Robinson, C. G., Larsen, R. S., Yuan, Q., Corrêa, S. A. L., & Ehlers, M. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.016 · Cited by 113 · see citing works
Self-citationA Missense Mutation in a Highly Conserved Alternate Exon of Dynamin-1 Causes Epilepsy in Fitful Mice
Boumil, R. M., Letts, V. A., Roberts, M. C., Lenz, C., Mahaffey, C. L., Zhang, Z., Moser, T., & Frankel, W. N. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001046 · Cited by 109 · see citing works
The advantage of channeling nucleotides for very processive functions
Zala, D., Schlattner, U., Desvignes, T., Bobe, J., Roux, A., Chavrier, P., & Boissan, M. (2017) · F1000Research · doi:10.12688/f1000research.11561.2 · Cited by 79 · see citing works
Unified quantitative model of AMPA receptor trafficking at synapses
Czöndör, K., Mondin, M., Garcia, M., Heine, M., Frischknecht, R., Choquet, D., Sibarita, J., & Thoumine, O. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109818109 · Cited by 105 · see citing works
AMPA Receptor Trafficking for Postsynaptic Potentiation
Park, M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00361 · Cited by 102 · see citing works
Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth
Roland, A. B., Ricobaraza, A., Carrel, D., Jordan, B. M., Rico, F., Simon, A., Humbert‐Claude, M., Ferrier, J., McFadden, M. H., Simon Scheuring, A., et al. (2014) · eLife · doi:10.7554/elife.03159 · Cited by 99 · see citing works
AMPA Receptors as Therapeutic Targets for Neurological Disorders
Lee, K., Goodman, L., Fourie, C., Schenk, S., Leitch, B., & Montgomery, J. M. (2015) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2015.10.004 · Cited by 102 · see citing works
Woo, J., Kwon, S., Nam, J., Choi, S., Takahashi, H., Krueger‐Burg, D., Park, J., Lee, Y., Bae, J. Y., Lee, D., et al. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201209132 · Cited by 95 · see citing works
Majer, A., Medina, S. J., Niu, Y., Abrenica, B., Manguiat, K., Frost, K. L., Phillipson, C. S., Sorensen, D. L., & Booth, S. A. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1003002 · Cited by 96 · see citing works
Fast AMPAR trafficking for a high‐frequency synaptic transmission
Choquet, D. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07350.x · Cited by 93 · see citing works
A role for SNAP25 in internalization of kainate receptors and synaptic plasticity
Selak, S., Paternain, A. V., Aller, I. M., Picó, E., Rivera, R., & Lerma, J. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.017 · Cited by 95 · see citing works
Kerr, J. M., & Blanpied, T. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2927-11.2012 · Cited by 91 · see citing works
Self-citationIasevoli, F., Tomasetti, C., & de Bartolomeis, A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0886-y · Cited by 88 · see citing works
Synapse Geometry and Receptor Dynamics Modulate Synaptic Strength
Freche, D., Pannasch, U., Rouach, N., & Holcman, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025122 · Cited by 86 · see citing works
Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity
Clifton, N. E., Trent, S., Thomas, K. L., & Hall, J. (2019) · Complex Psychiatry · doi:10.1159/000500267 · Cited by 85 · see citing works
Examining Form and Function of Dendritic Spines
Lee, K. F. H., Soares, C., & Béïque, J.-C. (2012) · Neural Plasticity · doi:10.1155/2012/704103 · Cited by 82 · see citing works
Sapap3 Deletion Anomalously Activates Short-Term Endocannabinoid-Mediated Synaptic Plasticity
Chen, M., Wan, Y., Ade, K., Ting, J., Feng, G., & Calakos, N. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1701-11.2011 · Cited by 82 · see citing works
A subcortical inhibitory signal for behavioral arrest in the thalamus
Giber, K., Diana, M. A., Plattner, V. M., Dugué, G. P., Bokor, H., Rousseau, C. V., Maglóczky, Z., Havas, L., Hangya, B., Wildner, H., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3951 · Cited by 83 · see citing works
AMPA receptor regulation during synaptic plasticity in hippocampus and neocortex
Lee, H., & Kirkwood, A. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.06.007 · Cited by 769 · see citing works
Organization of the Arp2/3 Complex in Hippocampal Spines
Rácz, B., & Weinberg, R. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0756-08.2008 · Cited by 78 · see citing works
Self-citationArc/Arg3.1 function in long‐term synaptic plasticity: Emerging mechanisms and unresolved issues
Zhang, H., & Bramham, C. R. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14958 · Cited by 71 · see citing works
Regulation of postsynaptic AMPA responses by synaptojanin 1
Gong, L., & Camilli, P. V. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809221105 · Cited by 75 · see citing works
Rosendale, M., Jullié, D., Choquet, D., & Perrais, D. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.081 · Cited by 73 · see citing works
Learning Drives Differential Clustering of Axodendritic Contacts in the Barn Owl Auditory System
McBride, T. J., Rodríguez‐Contreras, A., Trinh, A., Bailey, R., & DeBello, W. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1352-08.2008 · Cited by 75 · see citing works
Lee, S. H., Jin, C., Cai, E., Ge, P., Ishitsuka, Y., Teng, K. W., de Thomaz, A. A., Nall, D., Baday, M., Jeyifous, O., et al. (2017) · eLife · doi:10.7554/elife.27744 · Cited by 76 · see citing works
PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin
Fiuza, M., Rostosky, C. M., Parkinson, G. T., Bygrave, A. M., Halemani, N., Baptista, M., Milosevic, I., & Hanley, J. G. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201701034 · Cited by 71 · see citing works
Tyrosine dephosphorylation regulates AMPAR internalisation in mGluR-LTD
Gladding, C. M., Collett, V. J., Jia, Z., Bashir, Z. I., Collingridge, G. L., & Molnár, E. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.10.014 · Cited by 74 · see citing works
The Regulation of AMPA Receptor Endocytosis by Dynamic Protein-Protein Interactions
Hanley, J. G. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00362 · Cited by 67 · see citing works
The Chemical Inhibitors of Endocytosis: From Mechanisms to Potential Clinical Applications
Szewczyk-Roszczenko, O. K., Roszczenko, P., Shmakova, A., Finiuk, N. S., Holota, S. M., Lesyk, R., Bielawska, A., Vassetzky, Y. S., & Bielawski, K. (2023) · Cells · doi:10.3390/cells12182312 · Cited by 70 · see citing works
Shank3-Rich2 Interaction Regulates AMPA Receptor Recycling and Synaptic Long-Term Potentiation
Raynaud, F., Janossy, A., Dahl, J., Bertaso, F., Perroy, J., Varrault, A., Vidal, M., Worley, P. F., Boeckers, T. M., Bockaert, J., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2725-12.2013 · Cited by 68 · see citing works
Hanley, J. G. (2013) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2013.12.002 · Cited by 66 · see citing works
Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons
Ha, H., Leal‐Ortiz, S., Lalwani, K., Kiyonaka, S., Hamachi, I., Mysore, S. P., Montgomery, J. M., Garner, C. C., Huguenard, J. R., & Kim, S. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00405 · Cited by 66 · see citing works
Dynamin-dependent Membrane Drift Recruits AMPA Receptors to Dendritic Spines
Jaskolski, F., Mayo-Martin, M. B., Jane, D. E., & Henley, J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808401200 · Cited by 65 · see citing works
Prichard, K. L., O’Brien, N. S., Murcia, S. R., Baker, J. R., & McCluskey, A. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.754110 · Cited by 66 · see citing works
Clathrin-Independent Trafficking of AMPA Receptors
Glebov, O. O., Tigaret, C. M., Mellor, J. R., & Henley, J. M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3571-14.2015 · Cited by 62 · see citing works
A network of networks: cytoskeletal control of compartmentalized function within dendritic spines
Frost, N. A., Kerr, J. M., Lu, H. E., & Blanpied, T. A. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.06.009 · Cited by 65 · see citing works
Self-citationPostsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation
Kneussel, M., & Hausrat, T. J. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.01.002 · Cited by 61 · see citing works
New insights in endosomal dynamics and AMPA receptor trafficking
van der Sluijs, P., & Hoogenraad, C. C. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.06.008 · Cited by 64 · see citing works
Synaptic activity regulates AMPA receptor trafficking through different recycling pathways
Zheng, N., Jeyifous, O., Munro, C., Montgomery, J. M., & Green, W. N. (2015) · eLife · doi:10.7554/elife.06878 · Cited by 59 · see citing works
Trafficking of AMPA Receptors at Plasma Membranes of Hippocampal Neurons
Tao-Cheng, J.-H., Crocker, V. T., Winters, C. A., Azzam, R., Chludzinski, J., & Reese, T. S. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4745-10.2011 · Cited by 82 · see citing works
y Valenzuela, I. M.-P., Mouslim, C., & Akaaboune, M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3309-10.2010 · Cited by 59 · see citing works
Probing the Dynamics of Protein–Protein Interactions at Neuronal Contacts by Optical Imaging
Thoumine, O. R., Ewers, H., Heine, M., Groc, L., Frischknecht, R., Giannone, G., Poujol, C., Legros, P., Lounis, B., Cognet, L., et al. (2008) · Chemical Reviews · doi:10.1021/cr078204m · Cited by 58 · see citing works
Costas, J., Carrera, N., Alonso, P., Gurriarán, X., Segalàs, C., Real, E., López‐Solà, C., Mas, S., Gassó, P., Domènech, L., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.34 · Cited by 56 · see citing works
Signaling mechanisms regulating synapse formation and function in mental retardation
Boda, B., Dubos, A., & Müller, D. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.03.012 · Cited by 57 · see citing works
Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling
Gideons, E. S., Lin, P.-Y., Mahgoub, M., Kavalali, E. T., & Monteggia, L. M. (2017) · eLife · doi:10.7554/elife.25480 · Cited by 57 · see citing works
Rosenberg, M. M., Yang, F., Giovanni, M. A., Mohn, J. L., Temburni, M. K., & Jacob, M. H. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.02.006 · Cited by 56 · see citing works
Mammalian plasma membrane proteins as potential biomarkers and drug targets
Ručević, M., Hixson, D. C., & Josić, D. (2011) · Electrophoresis · doi:10.1002/elps.201100212 · Cited by 55 · see citing works
Distinctive phenotype in 9 patients with deletion of chromosome 1q24‐q25
Burkardt, D. D., Rosenfeld, J. A., Helgeson, M. L., Angle, B., Banks, V., Smith, W. E., Gripp, K. W., Moline, J., Moran, R. T., Niyazov, D. M., et al. (2011) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.34049 · Cited by 54 · see citing works
Mechanisms of AMPA Receptor Endosomal Sorting
Parkinson, G. T., & Hanley, J. G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00440 · Cited by 53 · see citing works
Developmental roles for Homer: more than just a pretty scaffold
Foa, L. C., & Gasperini, R. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05726.x · Cited by 52 · see citing works
Deane, E. C., Ilie, A., Sizdahkhani, S., Gupta, M. D., Orlowski, J., & McKinney, R. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2583-12.2013 · Cited by 52 · see citing works
Endosomal trafficking of AMPA-type glutamate receptors
Hirling, H. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.057 · Cited by 50 · see citing works
Proteomic Approaches and Identification of Novel Therapeutic Targets for Alcoholism
Gorini, G., Harris, R. A., & Mayfield, R. D. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.182 · Cited by 49 · see citing works
Role of Phosphoinositides at the Neuronal Synapse
Frère, S. G. A., Chang-Ileto, B., & Paolo, G. D. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-3015-1_5 · Cited by 48 · see citing works
- Authors
- Lu, J., Helton, T. D., Blanpied, T. A., Rácz, B., Newpher, T. M., Weinberg, R. J., & Ehlers, M. D.
- Affiliations
- Duke Medical Center (US)
- University of North Carolina at Chapel Hill (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Ehlers, Michael D.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 55
- Issue
- 6
- Pages
- 874-889
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2597538
- OpenAlex
- W1997282555
- Cited by
- 273
- References
- 51
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 10 · 2023: 8 · 2022: 10 · 2021: 11 · 2020: 13 · 2019: 10 · 2018: 19 · 2017: 11 · 2016: 8 · 2015: 16 · 2014: 15 · 2013: 21 · 2012: 18
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2146 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- DNM3, Homer, postsynaptic density, clathrin, synaptic transmission, dendritic spine morphology, excitatory synapses, receptor recycling, protein-protein interaction
- MeSH terms
- Homer Scaffolding Proteins, Animals, Carrier Proteins, Clathrin, DNA, Electrophysiology, Humans, Immunohistochemistry, Microscopy, Electron, Synaptic Transmission, Neurons, Receptors, AMPA, Patch-Clamp Techniques, Microscopy, Confocal, GTP Phosphohydrolases, Transport Vesicles, Dynamin III, RNA Interference, Lipid Metabolism
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