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Cited by 390

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies

Open access
Pan, Jie, Konstas, Angelos-Aristeidis, Bateman, Brian, Ortolano, Girolamo A., Pile-Spellman, John·2007·Neuroradiology
DOI 10.1007/s00234-006-0183-z
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Abstract

INTRODUCTION: Restoration of blood flow following ischemic stroke can be achieved by means of thrombolysis or mechanical recanalization. However, for some patients, reperfusion may exacerbate the injury initially caused by ischemia, producing a so-called "cerebral reperfusion injury". Multiple pathological processes are involved in this injury, including leukocyte infiltration, platelet and complement activation, postischemic hyperperfusion, and breakdown of the blood-brain barrier. METHODS/RESULTS AND CONCLUSIONS: Magnetic resonance imaging (MRI) can provide extensive information on this process of injury, and may have a role in the future in stratifying patients' risk for reperfusion injury following recanalization. Moreover, different MRI modalities can be used to investigate the various mechanisms of reperfusion injury. Antileukocyte antibodies, brain cooling and conditioned blood reperfusion are potential therapeutic strategies for lessening or eliminating reperfusion injury, and interventionalists may play a role in the future in using some of these therapies in combination with thrombolysis or embolectomy. The present review summarizes the mechanisms of reperfusion injury and focuses on the way each of those mechanisms can be evaluated by different MRI modalities. The potential therapeutic strategies are also discussed.

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Metadata

Authors
Pan, J., Konstas, A.-A., Bateman, B., Ortolano, G. A., & Pile-Spellman, J.
Venue
Neuroradiology
Publisher
Springer Science and Business Media LLC
Published
2006-12-20
Volume
49
Issue
2
Pages
93-102
ISSN
  • 0028-3940 (ISSN-L)
  • 1432-1920
DOI
10.1007/s00234-006-0183-z
OpenAlex
W1970188265
Cited by
390
References
75
FWCI
3.54
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies. https://app.cochat.ai/papers/10.1007/s00234-006-0183-z
The paper
Pan, J., Konstas, A.-A., Bateman, B., Ortolano, G. A., & Pile-Spellman, J. (2007). Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies. Neuroradiology. https://doi.org/10.1007/s00234-006-0183-z

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.