The DOI matches its Crossref record; 189 of the 189 references it cites were found in a registry or an index.
Free Radical Damage in Ischemia‐Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy
Open accessAbstract
Acute ischemic stroke is a common cause of morbidity and mortality worldwide. Thrombolysis with recombinant tissue plasminogen activator and endovascular thrombectomy are the main revascularization therapies for acute ischemic stroke. However, ischemia‐reperfusion injury after revascularization therapy can result in worsening outcomes. Among all possible pathological mechanisms of ischemia‐reperfusion injury, free radical damage (mainly oxidative/nitrosative stress injury) has been found to play a key role in the process. Free radicals lead to protein dysfunction, DNA damage, and lipid peroxidation, resulting in cell death. Additionally, free radical damage has a strong connection with inducing hemorrhagic transformation and cerebral edema, which are the major complications of revascularization therapy, and mainly influencing neurological outcomes due to the disruption of the blood‐brain barrier. In order to get a better clinical prognosis, more and more studies focus on the pharmaceutical and nonpharmaceutical neuroprotective therapies against free radical damage. This review discusses the pathological mechanisms of free radicals in ischemia‐reperfusion injury and adjunctive neuroprotective therapies combined with revascularization therapy against free radical damage.
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Metadata
- Authors
- Sun, M.-S., Jin, H., Sun, X., Huang, S., Zhang, F.-L., Guo, Z.-N., & Yang, Y.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2018-01
- Volume
- 2018
- Issue
- 1
- Pages
- 3804979-3804979
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- OpenAlex
- W2792146494
- Cited by
- 502
- References
- 189
- FWCI
- 32.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Funders
- China Association for Science and Technology
- National Natural Science Foundation of China (81771243)
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- Sun, M.-S., Jin, H., Sun, X., Huang, S., Zhang, F.-L., Guo, Z.-N., & Yang, Y. (2018). Free Radical Damage in Ischemia‐Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy. Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2018/3804979
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